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The map label for this gene is prs1 [H]

Identifier: 116492099

GI number: 116492099

Start: 339882

End: 340862

Strand: Direct

Name: prs1 [H]

Synonym: PEPE_0295

Alternate gene names: 116492099

Gene position: 339882-340862 (Clockwise)

Preceding gene: 116492097

Following gene: 116492100

Centisome position: 18.55

GC content: 39.96

Gene sequence:

>981_bases
ATGTCTGAACATTATTCCGATCCAAAGCTTAAAATTTTTGCTTTGAATTCGAACAAGCCCTTAGCAGAAAAAATTGCTAA
GGCAGTTGGTGTAGAACTCGGGAAAACGTCGGTGGACCGATTCCGAGACGGTGAGATTAGAATTAATATTGAAGAGAGTA
TTCGTGGAGACGAAGTATATATTGTTCAGTCCACATCTGCTCCAGTTAATGATAATTTGATGGAAATGTTGATCATGATT
GATGCTCTAAAGCGTGCTAGTGCTAAGACTATCAACATTGTGATCCCTTATTATGGTTATGCTCGCCAAGATCGTAAGGC
GCGTTCACGTGAACCAATTACAGCTAAATTAGTTGCAAACATGATTGAACGTGCAGGTGCAACACGCATTATTGCATTGG
ATCTTCACGCAGCACAAATCCAAGGTTTCTTCGATATTCCTCTAGATCATTTGATGGGTGCCCCACTATTAGCAGACCAT
TTCATCGAACGTGGTCTTGATCAGGATACTGTAGTTGTATCACCTGATCATGGTGGTGTTACTCGTGCTCGTAAGTTAGC
TGAGTTCTTAAAAGCACCAATCGCTATTATTGATAAACGTCGCCCACGCGCCAATGTTGCTGAAGTTATGAATATCATTG
GTGAAGTTAAGGGCAAACGTTGTATCATGATTGATGATATGATTGATACAGCTGGAACCATTACACTTGGAGCTCAAGCT
TTGATGGATGCTGGAGCTACAGAAGTATACGCAAGTTGTACACATCCTGTTCTTTCAGGTCCAGCTATTGAAAGAATCCA
AAATTCTCCAATTAAGGAATTAATTGTAACGGATTCTATCCAACTTCCAGAAGAGAAGAAGATTGACAAAATTACTAGCA
TTTCGGTTGGTCCATTGATTGGTGAAGCAATTCGCTTGATTCATGAAAACAAGCCTGTTAGTCCGCTATTCAACAACCGT
TTTAGTATTGAAAAAGAATAG

Upstream 100 bases:

>100_bases
ACCAACCGTAAGTAACTTGCTTTTAGGGGGCAAAATGAATTATGATATTATATGGAAAAACTGAATAAACTTAATATTTT
ATAATCTTTTGGAGGCAAAC

Downstream 100 bases:

>100_bases
TTTTAGATATCGCTAATTTTTATTAGTGATCATTAAAAGATCTCGAAATCTATTTTCGAGGTCTTTTTTGGTAGTAAAAG
AATTAAATTTTAATAGAAAT

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK 1; Phosphoribosyl pyrophosphate synthase 1; P-Rib-PP synthase 1; PRPP synthase 1 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSEHYSDPKLKIFALNSNKPLAEKIAKAVGVELGKTSVDRFRDGEIRINIEESIRGDEVYIVQSTSAPVNDNLMEMLIMI
DALKRASAKTINIVIPYYGYARQDRKARSREPITAKLVANMIERAGATRIIALDLHAAQIQGFFDIPLDHLMGAPLLADH
FIERGLDQDTVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPRANVAEVMNIIGEVKGKRCIMIDDMIDTAGTITLGAQA
LMDAGATEVYASCTHPVLSGPAIERIQNSPIKELIVTDSIQLPEEKKIDKITSISVGPLIGEAIRLIHENKPVSPLFNNR
FSIEKE

Sequences:

>Translated_326_residues
MSEHYSDPKLKIFALNSNKPLAEKIAKAVGVELGKTSVDRFRDGEIRINIEESIRGDEVYIVQSTSAPVNDNLMEMLIMI
DALKRASAKTINIVIPYYGYARQDRKARSREPITAKLVANMIERAGATRIIALDLHAAQIQGFFDIPLDHLMGAPLLADH
FIERGLDQDTVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPRANVAEVMNIIGEVKGKRCIMIDDMIDTAGTITLGAQA
LMDAGATEVYASCTHPVLSGPAIERIQNSPIKELIVTDSIQLPEEKKIDKITSISVGPLIGEAIRLIHENKPVSPLFNNR
FSIEKE
>Mature_325_residues
SEHYSDPKLKIFALNSNKPLAEKIAKAVGVELGKTSVDRFRDGEIRINIEESIRGDEVYIVQSTSAPVNDNLMEMLIMID
ALKRASAKTINIVIPYYGYARQDRKARSREPITAKLVANMIERAGATRIIALDLHAAQIQGFFDIPLDHLMGAPLLADHF
IERGLDQDTVVVSPDHGGVTRARKLAEFLKAPIAIIDKRRPRANVAEVMNIIGEVKGKRCIMIDDMIDTAGTITLGAQAL
MDAGATEVYASCTHPVLSGPAIERIQNSPIKELIVTDSIQLPEEKKIDKITSISVGPLIGEAIRLIHENKPVSPLFNNRF
SIEKE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=47.0031545741325, Blast_Score=283, Evalue=1e-76,
Organism=Homo sapiens, GI4506129, Length=316, Percent_Identity=45.253164556962, Blast_Score=278, Evalue=3e-75,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=45.859872611465, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=44.8275862068966, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=35.8381502890173, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=34.0116279069767, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=49.2012779552716, Blast_Score=321, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=45.5414012738853, Blast_Score=281, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=45.5414012738853, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=45.5414012738853, Blast_Score=279, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=45.4838709677419, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17570245, Length=333, Percent_Identity=33.3333333333333, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=43.0379746835443, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6319403, Length=313, Percent_Identity=42.4920127795527, Blast_Score=252, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=42.6282051282051, Blast_Score=251, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=40.4040404040404, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=41.7391304347826, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=46.5408805031447, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI45551540, Length=342, Percent_Identity=43.5672514619883, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24651458, Length=349, Percent_Identity=33.810888252149, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24651456, Length=349, Percent_Identity=33.810888252149, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI281362873, Length=349, Percent_Identity=33.810888252149, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24651454, Length=349, Percent_Identity=33.810888252149, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24651462, Length=195, Percent_Identity=38.4615384615385, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24651464, Length=195, Percent_Identity=38.4615384615385, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45552010, Length=195, Percent_Identity=38.4615384615385, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35921; Mature: 35790

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHYSDPKLKIFALNSNKPLAEKIAKAVGVELGKTSVDRFRDGEIRINIEESIRGDEVY
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEHHCCCCCEEE
IVQSTSAPVNDNLMEMLIMIDALKRASAKTINIVIPYYGYARQDRKARSREPITAKLVAN
EEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
MIERAGATRIIALDLHAAQIQGFFDIPLDHLMGAPLLADHFIERGLDQDTVVVSPDHGGV
HHHHCCCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCH
TRARKLAEFLKAPIAIIDKRRPRANVAEVMNIIGEVKGKRCIMIDDMIDTAGTITLGAQA
HHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHCCCCCHHHHHHH
LMDAGATEVYASCTHPVLSGPAIERIQNSPIKELIVTDSIQLPEEKKIDKITSISVGPLI
HHHCCCHHHHHHCCCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHCCCHHHHH
GEAIRLIHENKPVSPLFNNRFSIEKE
HHHHHHHHCCCCCCHHHCCCEECCCC
>Mature Secondary Structure 
SEHYSDPKLKIFALNSNKPLAEKIAKAVGVELGKTSVDRFRDGEIRINIEESIRGDEVY
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEHHCCCCCEEE
IVQSTSAPVNDNLMEMLIMIDALKRASAKTINIVIPYYGYARQDRKARSREPITAKLVAN
EEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHH
MIERAGATRIIALDLHAAQIQGFFDIPLDHLMGAPLLADHFIERGLDQDTVVVSPDHGGV
HHHHCCCCEEEEEEEEHHHHCCEECCCHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCH
TRARKLAEFLKAPIAIIDKRRPRANVAEVMNIIGEVKGKRCIMIDDMIDTAGTITLGAQA
HHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECHHCCCCCHHHHHHH
LMDAGATEVYASCTHPVLSGPAIERIQNSPIKELIVTDSIQLPEEKKIDKITSISVGPLI
HHHCCCHHHHHHCCCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHCCCHHHHH
GEAIRLIHENKPVSPLFNNRFSIEKE
HHHHHHHHCCCCCCHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]