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The map label for this gene is gmk [H]

Identifier: 116328485

GI number: 116328485

Start: 2137078

End: 2137638

Strand: Reverse

Name: gmk [H]

Synonym: LBL_1833

Alternate gene names: 116328485

Gene position: 2137638-2137078 (Counterclockwise)

Preceding gene: 116328486

Following gene: 116328481

Centisome position: 59.14

GC content: 41.89

Gene sequence:

>561_bases
CTGAATTCTCCCAAACTTTTTGTTCTTTCTTCCGTTGCGGGAGGGGGAAAATCCACACTCATTCAAAAGCTCAGAGAAAA
ACATCCCGATATTCTTTTCTCGATTTCGTGTACTACCCGAGCTCCTCGCCCGGGAGATAAGGAAGGAGTCACGTATTTCT
TTCTAACAAGGGAAGAGTTTAAGAAGGGAATAAAGGATTCTATGTTTTTAGAATGGGCTCTCGTTCACGATCAGTACTAT
GGCACTCCTTTGAAATTTATTGAAGAGGCTTTTCAAAAAGGTTCTTCCGTGATTATGGATATAGACGTCCAGGGTGCGAA
AATCATCAAAGAAAAGTTTCCGGGAAGGATTGTGACGATCTTTATTCTTCCACCGAGCGAAAAGGAATGGGAAAGACGTC
TTCGACATAGGGGAACCGATTCGGAAGAAAGTATCTTGAAAAGAATCCGAAACGGTAAGTCCGAATTGGAACGTCAGAAT
GAATTCGATTATAAGATCGTAAACGACGATCTGAATCAGGCTCTTGCGGATTTGGAGAGAATCATTCTTTCTAAGCCCTA
A

Upstream 100 bases:

>100_bases
ATAGCAATCATCTTATTCTTTCCAATCTAAGAGTGGAATCTCTTGCCAAAAGAATCGAATCCAGCGATAACTCGATCGCT
TCCGAAGAGGAAGATCTAGA

Downstream 100 bases:

>100_bases
ATAAACAATCTCATTTGCAGAAAATGCTCGTCGTAGTTCTTACGAAATCATTTATCTTTCAGAATAATGACCCTACAATT
CTTCAGAGCCGATTTAGTTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MNSPKLFVLSSVAGGGKSTLIQKLREKHPDILFSISCTTRAPRPGDKEGVTYFFLTREEFKKGIKDSMFLEWALVHDQYY
GTPLKFIEEAFQKGSSVIMDIDVQGAKIIKEKFPGRIVTIFILPPSEKEWERRLRHRGTDSEESILKRIRNGKSELERQN
EFDYKIVNDDLNQALADLERIILSKP

Sequences:

>Translated_186_residues
MNSPKLFVLSSVAGGGKSTLIQKLREKHPDILFSISCTTRAPRPGDKEGVTYFFLTREEFKKGIKDSMFLEWALVHDQYY
GTPLKFIEEAFQKGSSVIMDIDVQGAKIIKEKFPGRIVTIFILPPSEKEWERRLRHRGTDSEESILKRIRNGKSELERQN
EFDYKIVNDDLNQALADLERIILSKP
>Mature_186_residues
MNSPKLFVLSSVAGGGKSTLIQKLREKHPDILFSISCTTRAPRPGDKEGVTYFFLTREEFKKGIKDSMFLEWALVHDQYY
GTPLKFIEEAFQKGSSVIMDIDVQGAKIIKEKFPGRIVTIFILPPSEKEWERRLRHRGTDSEESILKRIRNGKSELERQN
EFDYKIVNDDLNQALADLERIILSKP

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=186, Percent_Identity=38.1720430107527, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI226874833, Length=186, Percent_Identity=38.1720430107527, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI4504221, Length=186, Percent_Identity=38.1720430107527, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI186700629, Length=181, Percent_Identity=27.0718232044199, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI186972120, Length=181, Percent_Identity=27.0718232044199, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI186700627, Length=181, Percent_Identity=27.0718232044199, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=27.7173913043478, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=28.4210526315789, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=25.5681818181818, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=25.5681818181818, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI262118255, Length=176, Percent_Identity=25.5681818181818, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=25.5681818181818, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=184, Percent_Identity=47.8260869565217, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI193203132, Length=187, Percent_Identity=39.572192513369, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=177, Percent_Identity=38.9830508474576, Blast_Score=113, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71988041, Length=186, Percent_Identity=27.9569892473118, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=186, Percent_Identity=27.9569892473118, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320662, Length=181, Percent_Identity=40.3314917127072, Blast_Score=134, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21356141, Length=186, Percent_Identity=37.0967741935484, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281362232, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281362230, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078485, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648810, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078487, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648808, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 21433; Mature: 21433

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSPKLFVLSSVAGGGKSTLIQKLREKHPDILFSISCTTRAPRPGDKEGVTYFFLTREEF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEHHHH
KKGIKDSMFLEWALVHDQYYGTPLKFIEEAFQKGSSVIMDIDVQGAKIIKEKFPGRIVTI
HCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCEEEEE
FILPPSEKEWERRLRHRGTDSEESILKRIRNGKSELERQNEFDYKIVNDDLNQALADLER
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHCCCCCEEEECHHHHHHHHHHHH
IILSKP
HHHCCC
>Mature Secondary Structure
MNSPKLFVLSSVAGGGKSTLIQKLREKHPDILFSISCTTRAPRPGDKEGVTYFFLTREEF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEHHHH
KKGIKDSMFLEWALVHDQYYGTPLKFIEEAFQKGSSVIMDIDVQGAKIIKEKFPGRIVTI
HCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCEEEEE
FILPPSEKEWERRLRHRGTDSEESILKRIRNGKSELERQNEFDYKIVNDDLNQALADLER
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHCCCCCEEEECHHHHHHHHHHHH
IILSKP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA