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The map label for this gene is hisG [H]

Identifier: 114800289

GI number: 114800289

Start: 575874

End: 576584

Strand: Direct

Name: hisG [H]

Synonym: HNE_0579

Alternate gene names: 114800289

Gene position: 575874-576584 (Clockwise)

Preceding gene: 114798501

Following gene: 114797121

Centisome position: 15.54

GC content: 64.98

Gene sequence:

>711_bases
ATGAGCCGTGTAACGATTGCCATTCCCTCCAAGGGGCGCCTGAAGGAGCAGACCGAAGCCTGGCTTGCCAGCATTGGCCA
CACCGTACGCCAGATTGGCGGCGAGCGGGGCTACACCGCAGAGATCGAAGGGCTGGACGCCGAAGTGCGTCTCCTGTCGG
CCAGCGAGATCGCGCAGGGGCTCATCGAAGGCAGCCTGCATCTCGGTGTCACCGGCGAAGACCTTCTGCATGATCAGGCC
CCGGATGGCCCGGCCGATTTTGAAGTGCTCAAACGCCTTGGCTTTGGCGGGGCAGATGTGGTCGTCGCCGTGCCTCAGGC
ATGGTTTGATGTCGACACGATGGCCGACCTTGAAGCGGCTGGCGCCGCCTTCCGCAAGGCCCATCACCGCCGCCTGCGCG
TGGCGACGAAATACCTGCGCATCACCCGGCGCTTCTTTGCCCAGAAATCGGTGGGGGAATACCGCCTCGTCGAGAGCGCG
GGGGCGACCGAAGCGGCGCCTGCGACCGGCACGGCGGACGTGATCGTCGATATTACGACCACCGGGGCCACCCTGCGGGC
CAATGGTCTCAAAGTGCTCGATGACGGGGTGATCCTGCAAAGCGAGGCTTCGCTGACCCGGTCGGTGCGCGCGCCGTGGA
GCGACGCGGCGGAGACTATCGTAGCCTCATTGCTGCGTCAGCCCCGCACAGAGGCAAAACGCCCTATTTGA

Upstream 100 bases:

>100_bases
ATGGCCTGATCGCGGGCCTTGCCAACCGGCGCGTCAGCGCAACCGGGGTCGGCGGTGTTGTGCGTCCCGACCGGATGGTG
CGGGTACGGAAGGGTGTATC

Downstream 100 bases:

>100_bases
ATTTTTTTTGGACACATTCTTGACACATGCCCAAAATCGTTGCCGTATGGGTAGGCAAGTTTCTGGGAGGAAACGCTGCA
AACGGTGGAGGGGCGTAGCG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSRVTIAIPSKGRLKEQTEAWLASIGHTVRQIGGERGYTAEIEGLDAEVRLLSASEIAQGLIEGSLHLGVTGEDLLHDQA
PDGPADFEVLKRLGFGGADVVVAVPQAWFDVDTMADLEAAGAAFRKAHHRRLRVATKYLRITRRFFAQKSVGEYRLVESA
GATEAAPATGTADVIVDITTTGATLRANGLKVLDDGVILQSEASLTRSVRAPWSDAAETIVASLLRQPRTEAKRPI

Sequences:

>Translated_236_residues
MSRVTIAIPSKGRLKEQTEAWLASIGHTVRQIGGERGYTAEIEGLDAEVRLLSASEIAQGLIEGSLHLGVTGEDLLHDQA
PDGPADFEVLKRLGFGGADVVVAVPQAWFDVDTMADLEAAGAAFRKAHHRRLRVATKYLRITRRFFAQKSVGEYRLVESA
GATEAAPATGTADVIVDITTTGATLRANGLKVLDDGVILQSEASLTRSVRAPWSDAAETIVASLLRQPRTEAKRPI
>Mature_235_residues
SRVTIAIPSKGRLKEQTEAWLASIGHTVRQIGGERGYTAEIEGLDAEVRLLSASEIAQGLIEGSLHLGVTGEDLLHDQAP
DGPADFEVLKRLGFGGADVVVAVPQAWFDVDTMADLEAAGAAFRKAHHRRLRVATKYLRITRRFFAQKSVGEYRLVESAG
ATEAAPATGTADVIVDITTTGATLRANGLKVLDDGVILQSEASLTRSVRAPWSDAAETIVASLLRQPRTEAKRPI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=218, Percent_Identity=30.2752293577982, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25293; Mature: 25162

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVTIAIPSKGRLKEQTEAWLASIGHTVRQIGGERGYTAEIEGLDAEVRLLSASEIAQG
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHEEECHHHHHHH
LIEGSLHLGVTGEDLLHDQAPDGPADFEVLKRLGFGGADVVVAVPQAWFDVDTMADLEAA
HHHCCEEECCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHCHHHHHHHHHH
GAAFRKAHHRRLRVATKYLRITRRFFAQKSVGEYRLVESAGATEAAPATGTADVIVDITT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCCEEEEEEEC
TGATLRANGLKVLDDGVILQSEASLTRSVRAPWSDAAETIVASLLRQPRTEAKRPI
CCCEEEECCEEEECCCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure 
SRVTIAIPSKGRLKEQTEAWLASIGHTVRQIGGERGYTAEIEGLDAEVRLLSASEIAQG
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHEEECHHHHHHH
LIEGSLHLGVTGEDLLHDQAPDGPADFEVLKRLGFGGADVVVAVPQAWFDVDTMADLEAA
HHHCCEEECCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHCHHHHHHHHHH
GAAFRKAHHRRLRVATKYLRITRRFFAQKSVGEYRLVESAGATEAAPATGTADVIVDITT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCCEEEEEEEC
TGATLRANGLKVLDDGVILQSEASLTRSVRAPWSDAAETIVASLLRQPRTEAKRPI
CCCEEEECCEEEECCCEEEECHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA