Click here to switch to the map view.

The map label for this gene is hisZ [H]

Identifier: 114798501

GI number: 114798501

Start: 574756

End: 575877

Strand: Direct

Name: hisZ [H]

Synonym: HNE_0578

Alternate gene names: 114798501

Gene position: 574756-575877 (Clockwise)

Preceding gene: 114797537

Following gene: 114800289

Centisome position: 15.51

GC content: 69.34

Gene sequence:

>1122_bases
ATGACCCATGACGCTTTGGTTGCCGTTGCCCGCGCTGTTTTCGAGGCGGCGGGCGGCACGCCGATTGATCCGGATTATGT
TCTGCCAGCGGACATTCCGCTGGAGCTTTCAGGCGAAGCGGTTCGCGCGCGCCTCTGCGTGTTTCCCGATCATCGCGGCG
CCGACATGGTTATGCGGCCCGACCTCACCCTGCCCGTGGCGCAGCGTGAAGCGGCGCGCCGCGAGGCGGGCGAGGCCAGC
GCCAAAACGTACACCTACGCGGCCCGCGCCTTCCGCCAGCCGGTCGCGCCTGACGACCAGCTGGAGTTTACGCAGGTCGG
TCTGGAGCGCTTTGGCTATGAGGCCGGGGCGGAGGCGGACGCAGAGCTTTTTGCGCTGATCCATCGCGCGGTGGAAGCGT
GCGGCGTGCAGCCGTCCGGCGTCATCATGGGCGATCTGGCGATCTTTCCGGCCTTCATTGATGCGCTTGGATTGCCCGGC
GTCACGGCTGATCTTCTGAAGCGGGCCTTCCGTCAGGAGGGCGGGGTGCGCGCCGTGCTCGATGCGGCGGCGCGCCCGCT
GGAGCAGGAGGTTGCGGCGGTTCTGGACGCGGCCGATCCGGCCGGGGCGCTGGGTGAGTTGCTCCTTGCACGCAGTATTC
CGCTGGCCGGCGGGCGCAGTCTGGCAGAAATCGTAGAAGGCCTTCAGGCCCGGCGCGCGGCCATTGAGGCAGGCGGGCTC
AGCCAGCCGGCGCGCGCGGTGCTGATGGCCCTGCGCGAGGTCGATTGTCCGCTGGCGGAGGCGGCAGGCGCGCTTTCGGC
GCTGGCGGAGGCGCATGAATTGCGCGGTGCGGGCGCGGCGATCGAGGCGCTGGGCGCGCGCGCGGACGCCGTTCTGGCCC
GCGTTCCGGCCGCGGTCAGAACGGCCCGCTTCCGCACAGGTTTTGGCCGGCGGTTTACCTATTATGACGGCTTTGTTTTT
GAAGTGCTTGCGCCGGGGCTGGAGCCGACCCAGCCTGTGGCGACGGGCGGGCGCTATGATGGCCTGATCGCGGGCCTTGC
CAACCGGCGCGTCAGCGCAACCGGGGTCGGCGGTGTTGTGCGTCCCGACCGGATGGTGCGGGTACGGAAGGGTGTATCAT
GA

Upstream 100 bases:

>100_bases
TTTCCTCCAATGAGGAATACCGCGAGGCTCGCCCCGGCCAGATCGAAGTGCCCCGCGCGGGTATGATCGAAGCGGTGCGC
GCAATTGTCGAGGCCCAGCG

Downstream 100 bases:

>100_bases
GCCGTGTAACGATTGCCATTCCCTCCAAGGGGCGCCTGAAGGAGCAGACCGAAGCCTGGCTTGCCAGCATTGGCCACACC
GTACGCCAGATTGGCGGCGA

Product: tRNA synthetase class II core domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTHDALVAVARAVFEAAGGTPIDPDYVLPADIPLELSGEAVRARLCVFPDHRGADMVMRPDLTLPVAQREAARREAGEAS
AKTYTYAARAFRQPVAPDDQLEFTQVGLERFGYEAGAEADAELFALIHRAVEACGVQPSGVIMGDLAIFPAFIDALGLPG
VTADLLKRAFRQEGGVRAVLDAAARPLEQEVAAVLDAADPAGALGELLLARSIPLAGGRSLAEIVEGLQARRAAIEAGGL
SQPARAVLMALREVDCPLAEAAGALSALAEAHELRGAGAAIEALGARADAVLARVPAAVRTARFRTGFGRRFTYYDGFVF
EVLAPGLEPTQPVATGGRYDGLIAGLANRRVSATGVGGVVRPDRMVRVRKGVS

Sequences:

>Translated_373_residues
MTHDALVAVARAVFEAAGGTPIDPDYVLPADIPLELSGEAVRARLCVFPDHRGADMVMRPDLTLPVAQREAARREAGEAS
AKTYTYAARAFRQPVAPDDQLEFTQVGLERFGYEAGAEADAELFALIHRAVEACGVQPSGVIMGDLAIFPAFIDALGLPG
VTADLLKRAFRQEGGVRAVLDAAARPLEQEVAAVLDAADPAGALGELLLARSIPLAGGRSLAEIVEGLQARRAAIEAGGL
SQPARAVLMALREVDCPLAEAAGALSALAEAHELRGAGAAIEALGARADAVLARVPAAVRTARFRTGFGRRFTYYDGFVF
EVLAPGLEPTQPVATGGRYDGLIAGLANRRVSATGVGGVVRPDRMVRVRKGVS
>Mature_372_residues
THDALVAVARAVFEAAGGTPIDPDYVLPADIPLELSGEAVRARLCVFPDHRGADMVMRPDLTLPVAQREAARREAGEASA
KTYTYAARAFRQPVAPDDQLEFTQVGLERFGYEAGAEADAELFALIHRAVEACGVQPSGVIMGDLAIFPAFIDALGLPGV
TADLLKRAFRQEGGVRAVLDAAARPLEQEVAAVLDAADPAGALGELLLARSIPLAGGRSLAEIVEGLQARRAAIEAGGLS
QPARAVLMALREVDCPLAEAAGALSALAEAHELRGAGAAIEALGARADAVLARVPAAVRTARFRTGFGRRFTYYDGFVFE
VLAPGLEPTQPVATGGRYDGLIAGLANRRVSATGVGGVVRPDRMVRVRKGVS

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 38961; Mature: 38830

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDALVAVARAVFEAAGGTPIDPDYVLPADIPLELSGEAVRARLCVFPDHRGADMVMRP
CCHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCEECCHHHEEEEEECCCCCCCCEEECC
DLTLPVAQREAARREAGEASAKTYTYAARAFRQPVAPDDQLEFTQVGLERFGYEAGAEAD
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCH
AELFALIHRAVEACGVQPSGVIMGDLAIFPAFIDALGLPGVTADLLKRAFRQEGGVRAVL
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
DAAARPLEQEVAAVLDAADPAGALGELLLARSIPLAGGRSLAEIVEGLQARRAAIEAGGL
HHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
SQPARAVLMALREVDCPLAEAAGALSALAEAHELRGAGAAIEALGARADAVLARVPAAVR
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TARFRTGFGRRFTYYDGFVFEVLAPGLEPTQPVATGGRYDGLIAGLANRRVSATGVGGVV
HHHHHHCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCC
RPDRMVRVRKGVS
CCHHHHHHHCCCC
>Mature Secondary Structure 
THDALVAVARAVFEAAGGTPIDPDYVLPADIPLELSGEAVRARLCVFPDHRGADMVMRP
CHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCEECCHHHEEEEEECCCCCCCCEEECC
DLTLPVAQREAARREAGEASAKTYTYAARAFRQPVAPDDQLEFTQVGLERFGYEAGAEAD
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCH
AELFALIHRAVEACGVQPSGVIMGDLAIFPAFIDALGLPGVTADLLKRAFRQEGGVRAVL
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
DAAARPLEQEVAAVLDAADPAGALGELLLARSIPLAGGRSLAEIVEGLQARRAAIEAGGL
HHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
SQPARAVLMALREVDCPLAEAAGALSALAEAHELRGAGAAIEALGARADAVLARVPAAVR
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TARFRTGFGRRFTYYDGFVFEVLAPGLEPTQPVATGGRYDGLIAGLANRRVSATGVGGVV
HHHHHHCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCCCC
RPDRMVRVRKGVS
CCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA