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The map label for this gene is argD [H]

Identifier: 114797121

GI number: 114797121

Start: 576992

End: 578179

Strand: Direct

Name: argD [H]

Synonym: HNE_0580

Alternate gene names: 114797121

Gene position: 576992-578179 (Clockwise)

Preceding gene: 114800289

Following gene: 114798085

Centisome position: 15.57

GC content: 65.32

Gene sequence:

>1188_bases
ATGGAAGATCCCCGCCAGCACATCCTTCCCGTTTACCGCCCGCCGGAGGAAGTGTTCGTGCAGGGCGAAGGCGTCTACCT
CTTCACCGAGGACGGGCGACGCTATCTGGATTTCATCGCCGGCATCGCGGTTACCGCGCTCGGCCACGCCCATCCGGCGA
TGGTCGAAGCCCTGCGCGATCAGGCCGGCAAGCTCTGGCACACGTCCAACATGTTCCGCGTGAAGGGGCAGGAGGAGCTG
GCCGACAAGATCTGCCGCGACAGCTTCGCAGACCGGGTGTTCTTCACCAATTCGGGCACCGAGGCGATCGAGTGCGCGAT
CAAGGCGGCGCGCAAGTATCACTGGGCGGCGGGCAATGCTGACCGGCTCGACATCATCACCTTTACCGGCGCCTTCCATG
GCCGCTCCATCGGGGCGATCAATGCGGGCGGCAATCCGAAATACCTGGAAGGCTTCGGGCCGAAACTTCCCGGCTTCGTG
CATCTGGAATGGGGCGACCATGACGCGCTCAAGGCAGCCGTCGCCGCTTCCACGGCCGCTGCCGTCCTGGTCGAGCCCGT
GCAGGGCGAGGGCGGCGTTCGCGCCATGCCCGAGCAATGCCTCAAAGGCCTGCGCGACCTCTGCAACGAACACGGCGTCC
TGCTGATCTATGATGAAGTCCAGTGCGGCATGGGCCGCACCGGCCAGCTCTGGGGCTATCAGTGGGCGGCTGGCGCTGAT
CCCGACATCCTCTGCGCCGCCAAGGGCATCGGCGGGGGCTTTCCGTTCGGCGCCTGTCTGATGACCGAAGCGGTCGGGGA
ACCGATGCAGCCGGGCAGCCATGGCTCGACCTATGGCGGCAATCCGCTGGCCATGGCGGTCGGAAATGTGGTCTGGGACA
TCATCTCCAGCGAGGAGTTCCTCGCCAATGTCCGCCGTGTTTCCGGAACGCTTCAGCAGGGCCTCAAAAGCCTCGCCGAC
AGCCACCCCGACAAGGTCGAGGGGGTTACCGGCAAAGGGTTGCTCACCGGGCTGCGCCTGAAAGCGGATCCGAAAAACCT
GCAGGGCATCTGCCGCGATGGCGGGCTGTTGACGGGGGTCGCCGGGAACAATGTCCTGCGCCTCGCTCCGCCGCTCATCA
TTGATGACGCCCAGGTGCGGGACGCCATCGGCATGATTGACGCCGCGCTTACGGAATGGACGCCGTAA

Upstream 100 bases:

>100_bases
CGGGAGCAATTGTTGACTCCCTCTGCGGTCCGCCCCATGCGTGGCGCCACAAAATCCGCAATCCCCTCCAGCCCCCCCGT
GACATTCAGAGGAGTCTCAG

Downstream 100 bases:

>100_bases
GCCGGGCCTCGCCGCCGCCGGATTTCGAAACGCTCAACGCATACGCCTGCCGCCTGAACAGGGGGCGGGCGGATGCTTTT
GTCTTGCGCGCGGAACGGGA

Product: acetylornithine/succinylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MEDPRQHILPVYRPPEEVFVQGEGVYLFTEDGRRYLDFIAGIAVTALGHAHPAMVEALRDQAGKLWHTSNMFRVKGQEEL
ADKICRDSFADRVFFTNSGTEAIECAIKAARKYHWAAGNADRLDIITFTGAFHGRSIGAINAGGNPKYLEGFGPKLPGFV
HLEWGDHDALKAAVAASTAAAVLVEPVQGEGGVRAMPEQCLKGLRDLCNEHGVLLIYDEVQCGMGRTGQLWGYQWAAGAD
PDILCAAKGIGGGFPFGACLMTEAVGEPMQPGSHGSTYGGNPLAMAVGNVVWDIISSEEFLANVRRVSGTLQQGLKSLAD
SHPDKVEGVTGKGLLTGLRLKADPKNLQGICRDGGLLTGVAGNNVLRLAPPLIIDDAQVRDAIGMIDAALTEWTP

Sequences:

>Translated_395_residues
MEDPRQHILPVYRPPEEVFVQGEGVYLFTEDGRRYLDFIAGIAVTALGHAHPAMVEALRDQAGKLWHTSNMFRVKGQEEL
ADKICRDSFADRVFFTNSGTEAIECAIKAARKYHWAAGNADRLDIITFTGAFHGRSIGAINAGGNPKYLEGFGPKLPGFV
HLEWGDHDALKAAVAASTAAAVLVEPVQGEGGVRAMPEQCLKGLRDLCNEHGVLLIYDEVQCGMGRTGQLWGYQWAAGAD
PDILCAAKGIGGGFPFGACLMTEAVGEPMQPGSHGSTYGGNPLAMAVGNVVWDIISSEEFLANVRRVSGTLQQGLKSLAD
SHPDKVEGVTGKGLLTGLRLKADPKNLQGICRDGGLLTGVAGNNVLRLAPPLIIDDAQVRDAIGMIDAALTEWTP
>Mature_395_residues
MEDPRQHILPVYRPPEEVFVQGEGVYLFTEDGRRYLDFIAGIAVTALGHAHPAMVEALRDQAGKLWHTSNMFRVKGQEEL
ADKICRDSFADRVFFTNSGTEAIECAIKAARKYHWAAGNADRLDIITFTGAFHGRSIGAINAGGNPKYLEGFGPKLPGFV
HLEWGDHDALKAAVAASTAAAVLVEPVQGEGGVRAMPEQCLKGLRDLCNEHGVLLIYDEVQCGMGRTGQLWGYQWAAGAD
PDILCAAKGIGGGFPFGACLMTEAVGEPMQPGSHGSTYGGNPLAMAVGNVVWDIISSEEFLANVRRVSGTLQQGLKSLAD
SHPDKVEGVTGKGLLTGLRLKADPKNLQGICRDGGLLTGVAGNNVLRLAPPLIIDDAQVRDAIGMIDAALTEWTP

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=389, Percent_Identity=34.1902313624679, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI13994255, Length=450, Percent_Identity=31.1111111111111, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI284507298, Length=304, Percent_Identity=34.8684210526316, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=27.8846153846154, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=26.9230769230769, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI24119277, Length=418, Percent_Identity=25.1196172248804, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=27.319587628866, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI188536080, Length=429, Percent_Identity=23.3100233100233, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI38679950, Length=429, Percent_Identity=23.3100233100233, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI38679946, Length=429, Percent_Identity=23.3100233100233, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1789759, Length=383, Percent_Identity=45.1697127937337, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=42.0654911838791, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI145693181, Length=387, Percent_Identity=33.5917312661499, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=34.8894348894349, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=33.0024813895782, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=31.3397129186603, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786349, Length=316, Percent_Identity=31.6455696202532, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=387, Percent_Identity=34.8837209302326, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=30.8558558558559, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=385, Percent_Identity=31.1688311688312, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=417, Percent_Identity=27.0983213429257, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71981843, Length=157, Percent_Identity=31.8471337579618, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17541228, Length=434, Percent_Identity=22.5806451612903, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=37.3134328358209, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323470, Length=395, Percent_Identity=32.4050632911392, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324386, Length=406, Percent_Identity=24.8768472906404, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=362, Percent_Identity=26.2430939226519, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI21357415, Length=380, Percent_Identity=35.2631578947368, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI28574759, Length=453, Percent_Identity=31.3465783664459, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=30.8035714285714, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI21356575, Length=413, Percent_Identity=27.1186440677966, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI281366494, Length=410, Percent_Identity=23.6585365853659, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24667139, Length=410, Percent_Identity=23.6585365853659, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24667143, Length=410, Percent_Identity=23.6585365853659, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42155; Mature: 42155

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDPRQHILPVYRPPEEVFVQGEGVYLFTEDGRRYLDFIAGIAVTALGHAHPAMVEALRD
CCCCHHHCCCCCCCCHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QAGKLWHTSNMFRVKGQEELADKICRDSFADRVFFTNSGTEAIECAIKAARKYHWAAGNA
HCCCEEECCCEEEECCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHEECCCCC
DRLDIITFTGAFHGRSIGAINAGGNPKYLEGFGPKLPGFVHLEWGDHDALKAAVAASTAA
CCEEEEEEECCCCCCCEEEEECCCCCCHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHEE
AVLVEPVQGEGGVRAMPEQCLKGLRDLCNEHGVLLIYDEVQCGMGRTGQLWGYQWAAGAD
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEECCCCC
PDILCAAKGIGGGFPFGACLMTEAVGEPMQPGSHGSTYGGNPLAMAVGNVVWDIISSEEF
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHH
LANVRRVSGTLQQGLKSLADSHPDKVEGVTGKGLLTGLRLKADPKNLQGICRDGGLLTGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEEECCCHHHHHHHCCCCEEEEE
AGNNVLRLAPPLIIDDAQVRDAIGMIDAALTEWTP
CCCCEEEECCCEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEDPRQHILPVYRPPEEVFVQGEGVYLFTEDGRRYLDFIAGIAVTALGHAHPAMVEALRD
CCCCHHHCCCCCCCCHHHEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QAGKLWHTSNMFRVKGQEELADKICRDSFADRVFFTNSGTEAIECAIKAARKYHWAAGNA
HCCCEEECCCEEEECCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHEECCCCC
DRLDIITFTGAFHGRSIGAINAGGNPKYLEGFGPKLPGFVHLEWGDHDALKAAVAASTAA
CCEEEEEEECCCCCCCEEEEECCCCCCHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHEE
AVLVEPVQGEGGVRAMPEQCLKGLRDLCNEHGVLLIYDEVQCGMGRTGQLWGYQWAAGAD
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEECCCCC
PDILCAAKGIGGGFPFGACLMTEAVGEPMQPGSHGSTYGGNPLAMAVGNVVWDIISSEEF
CCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHH
LANVRRVSGTLQQGLKSLADSHPDKVEGVTGKGLLTGLRLKADPKNLQGICRDGGLLTGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCEEECCCHHHHHHHCCCCEEEEE
AGNNVLRLAPPLIIDDAQVRDAIGMIDAALTEWTP
CCCCEEEECCCEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]