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The map label for this gene is clpP2 [H]

Identifier: 114799921

GI number: 114799921

Start: 537385

End: 537987

Strand: Direct

Name: clpP2 [H]

Synonym: HNE_0542

Alternate gene names: 114799921

Gene position: 537385-537987 (Clockwise)

Preceding gene: 114797654

Following gene: 114799174

Centisome position: 14.5

GC content: 59.2

Gene sequence:

>603_bases
ATGAACACCTTCCGCCTTGATGATGAAGACGAAAATGAATCGACCCCGGCTAACGGTCCAAATACCCTTGTAGAATCAGC
GCTCTTCAAGTCGCGCACGATCCTGCTGACCGGCGGAATTGACTTCAAGCAGGCCCGCATGGTCTGCGAACGCCTGCTCG
CCCTGTCGGCTGAGAGCGACGAGCCGATTCTGATGATCCTCTCTTCGCCCGGCGGCCACGTCGAAAGCGGCGACATGATC
CACGACATGATCAAATTCGTCACCGCCCCGGTAAAAGTTCTCGGCTCCGGCTGGGTCGCTTCGGCCGGCGCGCTGATTTA
TGCGGCGGCCCAGAAGGAAAACCGCTATTCGCTGCCCAATACCCGCTACCTGCTGCATGAACCCCGCGGCGGCGTCGGCG
GCCAGGCCACGGATGTCGAGATTCAGGCGCGCGAAATCATCAAGATGCGCGAACGCCTGAACCGCATCTTTGCCGAAGCA
ACCGGCAAGACTGTGGAGCAGATCAAGAAGGACACCGAGCGTGACTTCTGGATGGGCGCCCAGGAAGCGGTTGACTACGG
TCTTGTCAGCAAGATCATTCGCAATCGCCGCGAAATCAGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCGCTGGGGAATAGTGAGGTGCGTGCCTTGACCCGGCGCCCCTGGCACCGCACCTATAAGGCCAGATTTAAAAAG
AGATTCCTTCCGGAGCCTGC

Downstream 100 bases:

>100_bases
CCGCAAACCGCTGGATGTTTGCACGAAGGTAACACTTGTTGGGGATGATCGGGCATTAACCATAATGCCCGGTCCCCCAT
GCCAGTACGTCTCCAGGAAA

Product: putative ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MNTFRLDDEDENESTPANGPNTLVESALFKSRTILLTGGIDFKQARMVCERLLALSAESDEPILMILSSPGGHVESGDMI
HDMIKFVTAPVKVLGSGWVASAGALIYAAAQKENRYSLPNTRYLLHEPRGGVGGQATDVEIQAREIIKMRERLNRIFAEA
TGKTVEQIKKDTERDFWMGAQEAVDYGLVSKIIRNRREIS

Sequences:

>Translated_200_residues
MNTFRLDDEDENESTPANGPNTLVESALFKSRTILLTGGIDFKQARMVCERLLALSAESDEPILMILSSPGGHVESGDMI
HDMIKFVTAPVKVLGSGWVASAGALIYAAAQKENRYSLPNTRYLLHEPRGGVGGQATDVEIQAREIIKMRERLNRIFAEA
TGKTVEQIKKDTERDFWMGAQEAVDYGLVSKIIRNRREIS
>Mature_200_residues
MNTFRLDDEDENESTPANGPNTLVESALFKSRTILLTGGIDFKQARMVCERLLALSAESDEPILMILSSPGGHVESGDMI
HDMIKFVTAPVKVLGSGWVASAGALIYAAAQKENRYSLPNTRYLLHEPRGGVGGQATDVEIQAREIIKMRERLNRIFAEA
TGKTVEQIKKDTERDFWMGAQEAVDYGLVSKIIRNRREIS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=171, Percent_Identity=38.5964912280702, Blast_Score=133, Evalue=1e-31,
Organism=Escherichia coli, GI1786641, Length=174, Percent_Identity=43.1034482758621, Blast_Score=154, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=36.8421052631579, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI20129427, Length=174, Percent_Identity=37.3563218390805, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22183; Mature: 22183

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTFRLDDEDENESTPANGPNTLVESALFKSRTILLTGGIDFKQARMVCERLLALSAESD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCC
EPILMILSSPGGHVESGDMIHDMIKFVTAPVKVLGSGWVASAGALIYAAAQKENRYSLPN
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCCCCCCC
TRYLLHEPRGGVGGQATDVEIQAREIIKMRERLNRIFAEATGKTVEQIKKDTERDFWMGA
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
QEAVDYGLVSKIIRNRREIS
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTFRLDDEDENESTPANGPNTLVESALFKSRTILLTGGIDFKQARMVCERLLALSAESD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCCCC
EPILMILSSPGGHVESGDMIHDMIKFVTAPVKVLGSGWVASAGALIYAAAQKENRYSLPN
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCCCCCCCC
TRYLLHEPRGGVGGQATDVEIQAREIIKMRERLNRIFAEATGKTVEQIKKDTERDFWMGA
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
QEAVDYGLVSKIIRNRREIS
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA