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The map label for this gene is luxQ [H]

Identifier: 114799174

GI number: 114799174

Start: 538066

End: 539697

Strand: Direct

Name: luxQ [H]

Synonym: HNE_0543

Alternate gene names: 114799174

Gene position: 538066-539697 (Clockwise)

Preceding gene: 114799921

Following gene: 114800057

Centisome position: 14.52

GC content: 66.61

Gene sequence:

>1632_bases
ATGCCAGTACGTCTCCAGGAAATCACTCTGAATGTAGCGCCCGTGCCGTCAACGACGACCGGCGCGGCTGCCCTTTCCCT
GTTCCTGTCCGATCCGGCCCTCTTCGCCCTGCCGGTTCGTATGCCCGTCACTGATGGCGGCGAGGCGCCCATCGCCCATG
TCACCCGCGCCCGCCTCACCGAAGCGCTGGCCGGCCCCAACGGACGCGACATCTTTGCGGCGCGCCCGGTGCACCATCTC
GTCACCCCCGCGCCGGTTATTGCCGAAGGCACCGTGTCGGTCGCGCTGATCGCCAAACAGGCTGCAGAGCAGGGCACCAG
CGCGCTGACCGACGGCGTCATCGTGATGGAAGAGGGCGCCTATAAAGGCCTCGTCTCGCCCGCTGCATTGCTGAAGGCGC
TGGCCGAAGAAAACACCGCCCGCGCTCGCAACCAACAGGCCAGCCAGCGCCGCATCGAAGAGATGAAGGCGCGCATGGTC
TCCCTCGTCGAAGGGCGCTCCCGCTTTCTGGCGTTCATCGGTCATGAAATCCGCACGCCCCTGACCGGCATCCTCGGCGT
TGCAGACCTGCTGAAGGATCAATCAGTAACCAACGAATCCCGGCGCCTCGCCGAAACCATCTCCAACAGCGGCCAGCATC
TTGAGCGCCTGCTGAACGACCTGCTCGACCTTTCCCGGCTGGAGGCGGGCAAGCTGCCCGTTACCATGCAGCCATTCGAG
CTGCGCCAGTTTGCGTCAGAAACCCGCGACCTCTGGCAACCCAAGCTCGACGCCAAGCGCGTCGGTCTGCGCATCGCAGT
GGCCCGCAGCGCCGAGGCGCGGATCGAGAGCGATGCCGGACGTTTGCGTCAGATCCTGTTCAATCTTGTCTCCAACGCCG
TGAAGTTCACCGATCGCGGCCATGTCACGGTTCAGATGTCGACCGTCCCGGCGGGCGAGGGGCTCTCGCTCGTGATGACC
GTCGCCGATACCGGGCGCGGCATATCTGACGCCGACAAGGCACGCCTGTTTGAAGAGTTCGAGCAGGCAGACGAAACAAC
CGCCACCACGCATGGCGGCTCGGGGCTGGGCCTCAGCATCGCGCGTGCGCTGACCCGCCGGCTCGGCGGCGACATCATGC
TGGCGGACAATGCGGGCGGCGGCTGCCTCTTCACGGTGACCGTGCCGGTGCAGAAGGCTGGCCCGCGCCTGGCGGTCGAG
AACCCCGCGCCGGCGGGGGCAGGGCGCTTTGACCTGGGCGAAATCCTGGTCGCCGAAGACCATGATACGACGGCCTTTGT
CATCCGTGAGGCACTGATTGCGGCCGGTTGGCGGGTCGAGTGCGTCCCGGACGCGACCATTGCCGCGCAGCGTCTGGCCG
TGCGCCGCTATCAGGCAATCCTCAGCGACGTCCACATGCCGGGCGGGGGTGGAGAAGCGGTTCTGCGGGCCGCCCGCTTT
GGGCCCGGCCACAACAGCGCCATTCCGATCCTTGCCTTGACGGCGGATGCCACGCCCGAGCGGCGGGAAGCGTGCGAGAA
GCTGGGCTTCAATGGCCTCATTGAAAAGCCTGTCCGCCCGCGTGCGCTCGTGGCCGCGCTCGCCGATACCCTGCTCAACG
CGCCCCGTGAAAAGCAGGCCAAAGCGATCTGA

Upstream 100 bases:

>100_bases
CAATCGCCGCGAAATCAGCTGACCGCAAACCGCTGGATGTTTGCACGAAGGTAACACTTGTTGGGGATGATCGGGCATTA
ACCATAATGCCCGGTCCCCC

Downstream 100 bases:

>100_bases
CCGGCCGCCTCAGAACGAGCGGCCAATCACCAGATAAGCCGATTGCCGCCCCCCTTCCGACCTGCCGAAGGCAAGGTAAA
CCGGTCCAAGCGCGGTGTTG

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MPVRLQEITLNVAPVPSTTTGAAALSLFLSDPALFALPVRMPVTDGGEAPIAHVTRARLTEALAGPNGRDIFAARPVHHL
VTPAPVIAEGTVSVALIAKQAAEQGTSALTDGVIVMEEGAYKGLVSPAALLKALAEENTARARNQQASQRRIEEMKARMV
SLVEGRSRFLAFIGHEIRTPLTGILGVADLLKDQSVTNESRRLAETISNSGQHLERLLNDLLDLSRLEAGKLPVTMQPFE
LRQFASETRDLWQPKLDAKRVGLRIAVARSAEARIESDAGRLRQILFNLVSNAVKFTDRGHVTVQMSTVPAGEGLSLVMT
VADTGRGISDADKARLFEEFEQADETTATTHGGSGLGLSIARALTRRLGGDIMLADNAGGGCLFTVTVPVQKAGPRLAVE
NPAPAGAGRFDLGEILVAEDHDTTAFVIREALIAAGWRVECVPDATIAAQRLAVRRYQAILSDVHMPGGGGEAVLRAARF
GPGHNSAIPILALTADATPERREACEKLGFNGLIEKPVRPRALVAALADTLLNAPREKQAKAI

Sequences:

>Translated_543_residues
MPVRLQEITLNVAPVPSTTTGAAALSLFLSDPALFALPVRMPVTDGGEAPIAHVTRARLTEALAGPNGRDIFAARPVHHL
VTPAPVIAEGTVSVALIAKQAAEQGTSALTDGVIVMEEGAYKGLVSPAALLKALAEENTARARNQQASQRRIEEMKARMV
SLVEGRSRFLAFIGHEIRTPLTGILGVADLLKDQSVTNESRRLAETISNSGQHLERLLNDLLDLSRLEAGKLPVTMQPFE
LRQFASETRDLWQPKLDAKRVGLRIAVARSAEARIESDAGRLRQILFNLVSNAVKFTDRGHVTVQMSTVPAGEGLSLVMT
VADTGRGISDADKARLFEEFEQADETTATTHGGSGLGLSIARALTRRLGGDIMLADNAGGGCLFTVTVPVQKAGPRLAVE
NPAPAGAGRFDLGEILVAEDHDTTAFVIREALIAAGWRVECVPDATIAAQRLAVRRYQAILSDVHMPGGGGEAVLRAARF
GPGHNSAIPILALTADATPERREACEKLGFNGLIEKPVRPRALVAALADTLLNAPREKQAKAI
>Mature_542_residues
PVRLQEITLNVAPVPSTTTGAAALSLFLSDPALFALPVRMPVTDGGEAPIAHVTRARLTEALAGPNGRDIFAARPVHHLV
TPAPVIAEGTVSVALIAKQAAEQGTSALTDGVIVMEEGAYKGLVSPAALLKALAEENTARARNQQASQRRIEEMKARMVS
LVEGRSRFLAFIGHEIRTPLTGILGVADLLKDQSVTNESRRLAETISNSGQHLERLLNDLLDLSRLEAGKLPVTMQPFEL
RQFASETRDLWQPKLDAKRVGLRIAVARSAEARIESDAGRLRQILFNLVSNAVKFTDRGHVTVQMSTVPAGEGLSLVMTV
ADTGRGISDADKARLFEEFEQADETTATTHGGSGLGLSIARALTRRLGGDIMLADNAGGGCLFTVTVPVQKAGPRLAVEN
PAPAGAGRFDLGEILVAEDHDTTAFVIREALIAAGWRVECVPDATIAAQRLAVRRYQAILSDVHMPGGGGEAVLRAARFG
PGHNSAIPILALTADATPERREACEKLGFNGLIEKPVRPRALVAALADTLLNAPREKQAKAI

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=379, Percent_Identity=29.287598944591, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI48994928, Length=378, Percent_Identity=30.1587301587302, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081816, Length=406, Percent_Identity=31.0344827586207, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789149, Length=306, Percent_Identity=31.3725490196078, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=31.8352059925094, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786912, Length=291, Percent_Identity=29.553264604811, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=29.9595141700405, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=30.1255230125523, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=28.8065843621399, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=26.1044176706827, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=29.3859649122807, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=25.4980079681275, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=246, Percent_Identity=26.0162601626016, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=239, Percent_Identity=26.3598326359833, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=228, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57711; Mature: 57580

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRLQEITLNVAPVPSTTTGAAALSLFLSDPALFALPVRMPVTDGGEAPIAHVTRARLT
CCCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
EALAGPNGRDIFAARPVHHLVTPAPVIAEGTVSVALIAKQAAEQGTSALTDGVIVMEEGA
HHHCCCCCCCEEEECCHHHHCCCCCEEECCCHHHHHHHHHHHHHCCHHHHCCEEEEECCC
YKGLVSPAALLKALAEENTARARNQQASQRRIEEMKARMVSLVEGRSRFLAFIGHEIRTP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
LTGILGVADLLKDQSVTNESRRLAETISNSGQHLERLLNDLLDLSRLEAGKLPVTMQPFE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHH
LRQFASETRDLWQPKLDAKRVGLRIAVARSAEARIESDAGRLRQILFNLVSNAVKFTDRG
HHHHHHHHHHHCCCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEECCCC
HVTVQMSTVPAGEGLSLVMTVADTGRGISDADKARLFEEFEQADETTATTHGGSGLGLSI
EEEEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
ARALTRRLGGDIMLADNAGGGCLFTVTVPVQKAGPRLAVENPAPAGAGRFDLGEILVAED
HHHHHHHCCCCEEEEECCCCEEEEEEEEEHCCCCCEEEECCCCCCCCCCCCCCCEEEECC
HDTTAFVIREALIAAGWRVECVPDATIAAQRLAVRRYQAILSDVHMPGGGGEAVLRAARF
CCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
GPGHNSAIPILALTADATPERREACEKLGFNGLIEKPVRPRALVAALADTLLNAPREKQA
CCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHC
KAI
CCC
>Mature Secondary Structure 
PVRLQEITLNVAPVPSTTTGAAALSLFLSDPALFALPVRMPVTDGGEAPIAHVTRARLT
CCEEEEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
EALAGPNGRDIFAARPVHHLVTPAPVIAEGTVSVALIAKQAAEQGTSALTDGVIVMEEGA
HHHCCCCCCCEEEECCHHHHCCCCCEEECCCHHHHHHHHHHHHHCCHHHHCCEEEEECCC
YKGLVSPAALLKALAEENTARARNQQASQRRIEEMKARMVSLVEGRSRFLAFIGHEIRTP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
LTGILGVADLLKDQSVTNESRRLAETISNSGQHLERLLNDLLDLSRLEAGKLPVTMQPFE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECHHH
LRQFASETRDLWQPKLDAKRVGLRIAVARSAEARIESDAGRLRQILFNLVSNAVKFTDRG
HHHHHHHHHHHCCCCCCHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEECCCC
HVTVQMSTVPAGEGLSLVMTVADTGRGISDADKARLFEEFEQADETTATTHGGSGLGLSI
EEEEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
ARALTRRLGGDIMLADNAGGGCLFTVTVPVQKAGPRLAVENPAPAGAGRFDLGEILVAED
HHHHHHHCCCCEEEEECCCCEEEEEEEEEHCCCCCEEEECCCCCCCCCCCCCCCEEEECC
HDTTAFVIREALIAAGWRVECVPDATIAAQRLAVRRYQAILSDVHMPGGGGEAVLRAARF
CCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
GPGHNSAIPILALTADATPERREACEKLGFNGLIEKPVRPRALVAALADTLLNAPREKQA
CCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHC
KAI
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]