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The map label for this gene is recQ [H]

Identifier: 114797654

GI number: 114797654

Start: 535327

End: 537174

Strand: Direct

Name: recQ [H]

Synonym: HNE_0541

Alternate gene names: 114797654

Gene position: 535327-537174 (Clockwise)

Preceding gene: 114798752

Following gene: 114799921

Centisome position: 14.45

GC content: 68.34

Gene sequence:

>1848_bases
ATGTCCTCCGCCCCCACTCTTCCTGACGCCCGCGCGCTGCTGAAGCGCGTATACGGCTACGACGCGTTCCGCGGCCTGCA
GGAAGATGTCATCCGGGATGTGCTCGAAGGCCGCGATGGCCTCGCCGTCCTGCCCACCGGCGGCGGCAAGTCGCTCTGCT
ACCAGATCCCCGCGCTGCTGCGCGATGGCATCGGCCTCGTCGTCTCGCCGCTGATCGCGCTGATGGCCGACCAGGTCGAT
GCGCTGAAACTCGCGGGCGTGCGCGCCGAACGCCTCGACAGCTCGATGGATTTCAATGCCCGCACCGCCGCCCTGGACGC
GGCCGAGCGCGGCGAGATGGACCTGCTCTACGTCTCGCCTGAAGGCCTCGGCACAGCCCTCGCAGATCGCCTCGCCCGGA
TGAAGGTCTCTCTTATAGCGGTCGATGAAGCCCACTGCGTCAGCCAGTGGGGCCATGATTTCCGCCCGGATTACCGCGCC
CTCGGCCGCCTCAAAGGTCTCTTCCCCGGCGTGCCGCGCCTGGCGGTTACGGCGACCGCCGACGCACGCACCCGCGACGA
CATCCTCACTCAGCTGAACCTCACAAACCCCGCCGTCCATGTCGCGAGCTTCGACCGGCCCAACCTCATCCTCTCGGCCG
AGCCCAAGGAGAGCAACCGCACCGCCCGCGTCGTTCAGCTTGTCAAAGCCCGAACCGGAAACGGGGCAGGGGCCAGCGGC
ATCGTCTATGCCGCCACCCGCAACGCGGTCGAAGATCTGGCCGACGCGCTGGACAAGGCCGGCGTCCCCTCGCTCGCCTA
TCATGCCGGGCTCGACGCCCGTGTGCGCGCCGAACGCCAGCGGAGGTTCCTGCTGGAAGAAGGCCTGGTGATGTGCGCCA
CAGTTGCGTTCGGCATGGGCGTCGACAAGCCGGACGTCCGCTTCGTCATCCATGCCGATCCGCCCAAGACGCTGGAAGCC
TACTGGCAGGAAGTCGGCCGTGGCGGGCGCGACGGGGAGCCTGCCGAGGGCGTCGCCCTGTTCGGCCCGGCAGACATGAA
CCGCTCCCTGCAATGGACCTATTCGAGCGATGCGCCCGATGAGGTCAAACGCGTCCAGCTCACCAAGACGCGCCAGCTGT
TTGCCTTCCTCAATGGCGATGAATGCCGCCGGGGCGCCGTCCGGCGCTATTTCGGCGAGGAGAAAGTCGACCCATGCGGC
GTCTGCGATGTCTGCCGCGGTGAAGTGGGCGAGCGCCATGACGCCACCCGCTACGCCCAGATGGCGGTCTCCGCCGTCCT
GCGTTGCGGCCAGCGCATCGGGCGCGGCCGTCTCGTCCAGCACCTGCTCGGCGAAGCCAAGGACACCTTCGATACCGATC
TCTCCACCCTCTCCACCTTCGGCATCGGCAAGGAACTTCCCAAACAGGGCTGGAACCGGGTGTTCGATGCGCTGATGTTC
GAGGGCCTGATCGCCGAGGGCGGCGAAGCGATGCGTCCGGTCGTCATCGTGCCCGACGCCGACGCCGCCAAGGCCCTCTT
CCGGGGAGACCGGACCGTCTCGCTGCGCGAAGACCTTACCGCCCCGCGCCGTCGCACCCGCACGAAAGGCGCCGCCCGCG
CCGCCGTGCTGGCCGACCTCTCGGCCCGCGACCAGGCGGTGTTCGACGCGCTGCGTCTCTGGCGCACCGGTCTCGCCAAA
GACCGGGGCGTGCCGCCCTATGTCATCTTCCATGACCGCACCCTTGCCGAGATCGCCCGCGAGCGGCCCGTGACGCCTGA
AGCCCTGCGCGAGATCAGCGGTGTCGGGGAGAAGAAGGCGCAGGCTTATGCGGGGGATGTTGCGCGGGTCATTTCTGGCG
CTGAGTGA

Upstream 100 bases:

>100_bases
GCGGTTTGGTTCTTCGGTGTCTGCGCATCTGCAGTTGCCTTGCCTCATTTCTCTACCCACCCCTTGCCCTCCCGCGCGCA
TCTCCTCAGAACACGGGGGC

Downstream 100 bases:

>100_bases
CCGTCAAAGGGTGACCGGACGTGTCCCTCTGCTGTCCCTGAAGTGTCCCGGTTTGTCCTGATCTGTCCCGTGGTGTCCCG
GAACTGTCCCGATCTGTCCG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MSSAPTLPDARALLKRVYGYDAFRGLQEDVIRDVLEGRDGLAVLPTGGGKSLCYQIPALLRDGIGLVVSPLIALMADQVD
ALKLAGVRAERLDSSMDFNARTAALDAAERGEMDLLYVSPEGLGTALADRLARMKVSLIAVDEAHCVSQWGHDFRPDYRA
LGRLKGLFPGVPRLAVTATADARTRDDILTQLNLTNPAVHVASFDRPNLILSAEPKESNRTARVVQLVKARTGNGAGASG
IVYAATRNAVEDLADALDKAGVPSLAYHAGLDARVRAERQRRFLLEEGLVMCATVAFGMGVDKPDVRFVIHADPPKTLEA
YWQEVGRGGRDGEPAEGVALFGPADMNRSLQWTYSSDAPDEVKRVQLTKTRQLFAFLNGDECRRGAVRRYFGEEKVDPCG
VCDVCRGEVGERHDATRYAQMAVSAVLRCGQRIGRGRLVQHLLGEAKDTFDTDLSTLSTFGIGKELPKQGWNRVFDALMF
EGLIAEGGEAMRPVVIVPDADAAKALFRGDRTVSLREDLTAPRRRTRTKGAARAAVLADLSARDQAVFDALRLWRTGLAK
DRGVPPYVIFHDRTLAEIARERPVTPEALREISGVGEKKAQAYAGDVARVISGAE

Sequences:

>Translated_615_residues
MSSAPTLPDARALLKRVYGYDAFRGLQEDVIRDVLEGRDGLAVLPTGGGKSLCYQIPALLRDGIGLVVSPLIALMADQVD
ALKLAGVRAERLDSSMDFNARTAALDAAERGEMDLLYVSPEGLGTALADRLARMKVSLIAVDEAHCVSQWGHDFRPDYRA
LGRLKGLFPGVPRLAVTATADARTRDDILTQLNLTNPAVHVASFDRPNLILSAEPKESNRTARVVQLVKARTGNGAGASG
IVYAATRNAVEDLADALDKAGVPSLAYHAGLDARVRAERQRRFLLEEGLVMCATVAFGMGVDKPDVRFVIHADPPKTLEA
YWQEVGRGGRDGEPAEGVALFGPADMNRSLQWTYSSDAPDEVKRVQLTKTRQLFAFLNGDECRRGAVRRYFGEEKVDPCG
VCDVCRGEVGERHDATRYAQMAVSAVLRCGQRIGRGRLVQHLLGEAKDTFDTDLSTLSTFGIGKELPKQGWNRVFDALMF
EGLIAEGGEAMRPVVIVPDADAAKALFRGDRTVSLREDLTAPRRRTRTKGAARAAVLADLSARDQAVFDALRLWRTGLAK
DRGVPPYVIFHDRTLAEIARERPVTPEALREISGVGEKKAQAYAGDVARVISGAE
>Mature_614_residues
SSAPTLPDARALLKRVYGYDAFRGLQEDVIRDVLEGRDGLAVLPTGGGKSLCYQIPALLRDGIGLVVSPLIALMADQVDA
LKLAGVRAERLDSSMDFNARTAALDAAERGEMDLLYVSPEGLGTALADRLARMKVSLIAVDEAHCVSQWGHDFRPDYRAL
GRLKGLFPGVPRLAVTATADARTRDDILTQLNLTNPAVHVASFDRPNLILSAEPKESNRTARVVQLVKARTGNGAGASGI
VYAATRNAVEDLADALDKAGVPSLAYHAGLDARVRAERQRRFLLEEGLVMCATVAFGMGVDKPDVRFVIHADPPKTLEAY
WQEVGRGGRDGEPAEGVALFGPADMNRSLQWTYSSDAPDEVKRVQLTKTRQLFAFLNGDECRRGAVRRYFGEEKVDPCGV
CDVCRGEVGERHDATRYAQMAVSAVLRCGQRIGRGRLVQHLLGEAKDTFDTDLSTLSTFGIGKELPKQGWNRVFDALMFE
GLIAEGGEAMRPVVIVPDADAAKALFRGDRTVSLREDLTAPRRRTRTKGAARAAVLADLSARDQAVFDALRLWRTGLAKD
RGVPPYVIFHDRTLAEIARERPVTPEALREISGVGEKKAQAYAGDVARVISGAE

Specific function: DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=652, Percent_Identity=32.8220858895706, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI169218196, Length=501, Percent_Identity=35.5289421157685, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI110735439, Length=501, Percent_Identity=35.5289421157685, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI14591902, Length=427, Percent_Identity=37.9391100702576, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI14591904, Length=427, Percent_Identity=37.9391100702576, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI148612816, Length=428, Percent_Identity=37.8504672897196, Blast_Score=255, Evalue=1e-67,
Organism=Homo sapiens, GI51242943, Length=344, Percent_Identity=42.7325581395349, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI51242947, Length=344, Percent_Identity=42.7325581395349, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI284005309, Length=374, Percent_Identity=37.7005347593583, Blast_Score=184, Evalue=3e-46,
Organism=Homo sapiens, GI148613856, Length=340, Percent_Identity=24.4117647058824, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI38201710, Length=340, Percent_Identity=24.4117647058824, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI48994977, Length=598, Percent_Identity=39.2976588628763, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI32564293, Length=511, Percent_Identity=34.4422700587084, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI25145561, Length=645, Percent_Identity=31.6279069767442, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17552866, Length=435, Percent_Identity=38.8505747126437, Blast_Score=276, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71987993, Length=459, Percent_Identity=35.9477124183007, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71987997, Length=459, Percent_Identity=35.9477124183007, Blast_Score=263, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI115533224, Length=333, Percent_Identity=22.8228228228228, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=570, Percent_Identity=34.0350877192982, Blast_Score=309, Evalue=8e-85,
Organism=Drosophila melanogaster, GI24646066, Length=643, Percent_Identity=33.1259720062208, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24664226, Length=426, Percent_Identity=36.6197183098592, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24664230, Length=426, Percent_Identity=36.6197183098592, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI62472181, Length=426, Percent_Identity=36.6197183098592, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI21358123, Length=353, Percent_Identity=35.4107648725212, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 66767; Mature: 66636

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPTLPDARALLKRVYGYDAFRGLQEDVIRDVLEGRDGLAVLPTGGGKSLCYQIPALL
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
RDGIGLVVSPLIALMADQVDALKLAGVRAERLDSSMDFNARTAALDAAERGEMDLLYVSP
HCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECC
EGLGTALADRLARMKVSLIAVDEAHCVSQWGHDFRPDYRALGRLKGLFPGVPRLAVTATA
CCHHHHHHHHHHHHHEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECC
DARTRDDILTQLNLTNPAVHVASFDRPNLILSAEPKESNRTARVVQLVKARTGNGAGASG
CCCHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
IVYAATRNAVEDLADALDKAGVPSLAYHAGLDARVRAERQRRFLLEEGLVMCATVAFGMG
EEEEHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDKPDVRFVIHADPPKTLEAYWQEVGRGGRDGEPAEGVALFGPADMNRSLQWTYSSDAPD
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCHH
EVKRVQLTKTRQLFAFLNGDECRRGAVRRYFGEEKVDPCGVCDVCRGEVGERHDATRYAQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
MAVSAVLRCGQRIGRGRLVQHLLGEAKDTFDTDLSTLSTFGIGKELPKQGWNRVFDALMF
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EGLIAEGGEAMRPVVIVPDADAAKALFRGDRTVSLREDLTAPRRRTRTKGAARAAVLADL
HHHHHCCCCCCCCEEEECCCHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHC
SARDQAVFDALRLWRTGLAKDRGVPPYVIFHDRTLAEIARERPVTPEALREISGVGEKKA
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHCCCHHHH
QAYAGDVARVISGAE
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSAPTLPDARALLKRVYGYDAFRGLQEDVIRDVLEGRDGLAVLPTGGGKSLCYQIPALL
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
RDGIGLVVSPLIALMADQVDALKLAGVRAERLDSSMDFNARTAALDAAERGEMDLLYVSP
HCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECC
EGLGTALADRLARMKVSLIAVDEAHCVSQWGHDFRPDYRALGRLKGLFPGVPRLAVTATA
CCHHHHHHHHHHHHHEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECC
DARTRDDILTQLNLTNPAVHVASFDRPNLILSAEPKESNRTARVVQLVKARTGNGAGASG
CCCHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCC
IVYAATRNAVEDLADALDKAGVPSLAYHAGLDARVRAERQRRFLLEEGLVMCATVAFGMG
EEEEHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VDKPDVRFVIHADPPKTLEAYWQEVGRGGRDGEPAEGVALFGPADMNRSLQWTYSSDAPD
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCHH
EVKRVQLTKTRQLFAFLNGDECRRGAVRRYFGEEKVDPCGVCDVCRGEVGERHDATRYAQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHHHHH
MAVSAVLRCGQRIGRGRLVQHLLGEAKDTFDTDLSTLSTFGIGKELPKQGWNRVFDALMF
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EGLIAEGGEAMRPVVIVPDADAAKALFRGDRTVSLREDLTAPRRRTRTKGAARAAVLADL
HHHHHCCCCCCCCEEEECCCHHHHHHHCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHC
SARDQAVFDALRLWRTGLAKDRGVPPYVIFHDRTLAEIARERPVTPEALREISGVGEKKA
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHCCCHHHH
QAYAGDVARVISGAE
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]