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The map label for this gene is yogA [H]

Identifier: 114799638

GI number: 114799638

Start: 3133304

End: 3134278

Strand: Reverse

Name: yogA [H]

Synonym: HNE_2975

Alternate gene names: 114799638

Gene position: 3134278-3133304 (Counterclockwise)

Preceding gene: 114798413

Following gene: 114799877

Centisome position: 84.6

GC content: 64.0

Gene sequence:

>975_bases
ATGAAGTCTCTCGTCGTAAGTGAGCTTGCTCCGGACTTTGCCGGAACGAGCCTGAAAGATCTTCCCCTGCCGGAGCCAAA
GGCCGGGGAGGTCCGCGTCGCCATCAAGGCCGCCAGTCTCAACTTTCCGGACCTTCTGATGACGGAGGGAAAATACCAGC
TCAAACCCGAACTGCCCTTCACGCTCGGCATGGAGCTTGCCGGCGTCGTGGACGCCGTCGGGGAGGGGGTCACTGCCTTC
CAGCCCGGCGATGAAGTGGCAGGGGGCAGCCGCATCGGCGCCTTCTCAGAATACATCACGCTGCCCGCTGCCGGCCTGCG
CAAAAAACCCGCCACGCTCAGCTTTGCAGAGGCCTCCGCCTATGGCGCGGCCTATCTCACGGCTTACGTCTCGCTGGTCA
TTCGCGGCAATCTCCAACCGGGTGAAACCCTTCTTGTCCACGGCGCCAGCGGCGGCGTCGGCATGGCGGCGGTCGAGGTG
GGCAAGCTCCTCGGCGCCACCGTCATCGCCACCTCTGCGTCAGATGAAAAACTGAAAACCGTAAAGGCCCGCGGCGCCGA
TCACATCATAAACGTCACCCGCGGCTTCCGCGAGGAAGTCAAAGCCCTCACCGGCGGGCGCGGCGCGGACGTGATCTACG
ATCCGGTCGGCGGCGATGTCTTCGATGAGAGCGTCCGCTGCATCGCCTTTGACGGCCGCCTCCTGATCATCGGCTTCACC
TCCGGCCGCATCCCCAGCGTCAGCGTCAACATGCCCCTCATCAAGGGCTTCTCCGTCGTCGGCGTCCGCGCCGGCGAATA
CGGTCGCCAGTTCCCCGAAAAAGGCCGCGCCAATCAGGAAGCCATCTGGAAATGGGCCGAAGACGGCAAGGTAAAACCTT
GCATCCACGCCGAAGTCCCCCTCACCGATTGGCGCCGCGCCTTCGACATGATGCGCAGCCGCGAAGTCGTCGGCAAAGTC
GTCCTGGTGCCCTGA

Upstream 100 bases:

>100_bases
CCCACGCCTTCACCGCCTTCACCTTCCTCTCGCCGGGATCGCGCACGGCCTGCACCGAAATCGCCCGTATGGTCCACGAT
ATGTATGCGGCCAGGAAGGC

Downstream 100 bases:

>100_bases
CCGGAAGTGTCCGGATTTGTCCTGAACTGTCCCCGATCTGTCTCACGCGCAGCTAGACCCTCACCGCCCATCGCAAAGCG
ATGGGCGGTGAGGGCCTCCG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKSLVVSELAPDFAGTSLKDLPLPEPKAGEVRVAIKAASLNFPDLLMTEGKYQLKPELPFTLGMELAGVVDAVGEGVTAF
QPGDEVAGGSRIGAFSEYITLPAAGLRKKPATLSFAEASAYGAAYLTAYVSLVIRGNLQPGETLLVHGASGGVGMAAVEV
GKLLGATVIATSASDEKLKTVKARGADHIINVTRGFREEVKALTGGRGADVIYDPVGGDVFDESVRCIAFDGRLLIIGFT
SGRIPSVSVNMPLIKGFSVVGVRAGEYGRQFPEKGRANQEAIWKWAEDGKVKPCIHAEVPLTDWRRAFDMMRSREVVGKV
VLVP

Sequences:

>Translated_324_residues
MKSLVVSELAPDFAGTSLKDLPLPEPKAGEVRVAIKAASLNFPDLLMTEGKYQLKPELPFTLGMELAGVVDAVGEGVTAF
QPGDEVAGGSRIGAFSEYITLPAAGLRKKPATLSFAEASAYGAAYLTAYVSLVIRGNLQPGETLLVHGASGGVGMAAVEV
GKLLGATVIATSASDEKLKTVKARGADHIINVTRGFREEVKALTGGRGADVIYDPVGGDVFDESVRCIAFDGRLLIIGFT
SGRIPSVSVNMPLIKGFSVVGVRAGEYGRQFPEKGRANQEAIWKWAEDGKVKPCIHAEVPLTDWRRAFDMMRSREVVGKV
VLVP
>Mature_324_residues
MKSLVVSELAPDFAGTSLKDLPLPEPKAGEVRVAIKAASLNFPDLLMTEGKYQLKPELPFTLGMELAGVVDAVGEGVTAF
QPGDEVAGGSRIGAFSEYITLPAAGLRKKPATLSFAEASAYGAAYLTAYVSLVIRGNLQPGETLLVHGASGGVGMAAVEV
GKLLGATVIATSASDEKLKTVKARGADHIINVTRGFREEVKALTGGRGADVIYDPVGGDVFDESVRCIAFDGRLLIIGFT
SGRIPSVSVNMPLIKGFSVVGVRAGEYGRQFPEKGRANQEAIWKWAEDGKVKPCIHAEVPLTDWRRAFDMMRSREVVGKV
VLVP

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI18379349, Length=311, Percent_Identity=32.1543408360129, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI194239674, Length=311, Percent_Identity=29.5819935691318, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI13236495, Length=311, Percent_Identity=29.5819935691318, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI22538446, Length=318, Percent_Identity=28.3018867924528, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI22538444, Length=318, Percent_Identity=28.3018867924528, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI24308257, Length=327, Percent_Identity=28.1345565749235, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI194239676, Length=173, Percent_Identity=36.9942196531792, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI28557745, Length=248, Percent_Identity=34.2741935483871, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI41872631, Length=312, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI67078404, Length=299, Percent_Identity=26.4214046822742, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI47519420, Length=211, Percent_Identity=33.175355450237, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI67078406, Length=280, Percent_Identity=25.7142857142857, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI90669511, Length=232, Percent_Identity=29.7413793103448, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI197927207, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790485, Length=309, Percent_Identity=32.6860841423948, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787863, Length=303, Percent_Identity=28.0528052805281, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790045, Length=343, Percent_Identity=25.0728862973761, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081918, Length=354, Percent_Identity=26.8361581920904, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=240, Percent_Identity=30.8333333333333, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI212642053, Length=317, Percent_Identity=26.813880126183, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987554, Length=357, Percent_Identity=24.9299719887955, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=304, Percent_Identity=26.9736842105263, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901710, Length=185, Percent_Identity=28.6486486486486, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI133901712, Length=185, Percent_Identity=28.6486486486486, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=310, Percent_Identity=31.6129032258064, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319621, Length=339, Percent_Identity=26.5486725663717, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=335, Percent_Identity=25.3731343283582, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=335, Percent_Identity=25.6716417910448, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=23.6526946107784, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24581345, Length=301, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920632, Length=306, Percent_Identity=30.0653594771242, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221330659, Length=306, Percent_Identity=30.0653594771242, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550423, Length=294, Percent_Identity=25.8503401360544, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34272; Mature: 34272

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLVVSELAPDFAGTSLKDLPLPEPKAGEVRVAIKAASLNFPDLLMTEGKYQLKPELPF
CCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHEEECCCEEECCCCCH
TLGMELAGVVDAVGEGVTAFQPGDEVAGGSRIGAFSEYITLPAAGLRKKPATLSFAEASA
HHCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEHHHHH
YGAAYLTAYVSLVIRGNLQPGETLLVHGASGGVGMAAVEVGKLLGATVIATSASDEKLKT
HHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHH
VKARGADHIINVTRGFREEVKALTGGRGADVIYDPVGGDVFDESVRCIAFDGRLLIIGFT
HHHCCCCCEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCCEEEEECCEEEEEEEC
SGRIPSVSVNMPLIKGFSVVGVRAGEYGRQFPEKGRANQEAIWKWAEDGKVKPCIHAEVP
CCCCCEEEECCCCCCCCEEEEEECCHHHHCCCCCCCCCHHHHEEECCCCCCCCEEECCCC
LTDWRRAFDMMRSREVVGKVVLVP
HHHHHHHHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MKSLVVSELAPDFAGTSLKDLPLPEPKAGEVRVAIKAASLNFPDLLMTEGKYQLKPELPF
CCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHEEECCCEEECCCCCH
TLGMELAGVVDAVGEGVTAFQPGDEVAGGSRIGAFSEYITLPAAGLRKKPATLSFAEASA
HHCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEHHHHH
YGAAYLTAYVSLVIRGNLQPGETLLVHGASGGVGMAAVEVGKLLGATVIATSASDEKLKT
HHHHHHHHHHHHHEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHH
VKARGADHIINVTRGFREEVKALTGGRGADVIYDPVGGDVFDESVRCIAFDGRLLIIGFT
HHHCCCCCEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHCCCCEEEEECCEEEEEEEC
SGRIPSVSVNMPLIKGFSVVGVRAGEYGRQFPEKGRANQEAIWKWAEDGKVKPCIHAEVP
CCCCCEEEECCCCCCCCEEEEEECCHHHHCCCCCCCCCHHHHEEECCCCCCCCEEECCCC
LTDWRRAFDMMRSREVVGKVVLVP
HHHHHHHHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]