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The map label for this gene is dsbD [H]

Identifier: 114799507

GI number: 114799507

Start: 3334570

End: 3336636

Strand: Reverse

Name: dsbD [H]

Synonym: HNE_3155

Alternate gene names: 114799507

Gene position: 3336636-3334570 (Counterclockwise)

Preceding gene: 114800476

Following gene: 114797215

Centisome position: 90.06

GC content: 63.96

Gene sequence:

>2067_bases
ATGGACGAGCGCCGGGCTGAGGCGGAGCTGATTGCCGATCGCGTCAGTGTGGCGCCTGGCGACACATTTTATGCCGCTCT
CAAAATGACAATGGATGAGGGCTGGCACGTTTACTGGCAGAATGCCGGGGATGCGGGTCTGCCACCCCGGCTGATACTGG
AAGAGGGAACGAGCCTCCCCGAGGACGCTGTTGGCGCGTTTCTCTGGCCCCTGCCGCATCTGATCCCCGTCGTTGAAGGC
GAGATCATGGATTATGGCTATGATGACGAGGTCATCTTCGCCTTTCCGGTCACTGTGCCGGAGGATGCCAGCGGTGAAGT
CCGGCTTGTGGCTGAAGCTGATTACCTGATCTGCGAATCCATCTGCATTCCCGAAACGGCGGATGTTTCGTTGACGCTGC
CCGTCGGCGCGCCGATCGAGAATGCGGTTGCGGGCGCAGAAATCGGCAAATGGATTGCCCGTGTACCGGTAGATTTCGCC
GGCGAAGCGCGGATTGATGACGCCGCTGAACCCTGGACCCTGTCGCTGCGCCAGCCGGGCGGTTTTCCCGAAGGCGCGCA
GATCCGTTTCTTTCCGTTCAAGCATGAAATCAGCCACCCGGCGGCCCAGCCCCAGAAAGCTGGCGCTGAGGGTGCAAGTC
TCAGCCTGACGCCGGACCGGGCGGGCAGCATCGCAGAGACGCTGGATGGCGTAATCCGGATCGATGTGCCGGGCGCCGAG
CCTGTGGGCTACGAAATCTCGGCAAGCCGCGGTGAAGCGTTTGCAGGCACGGCCGACCGGAATGTGCAATCTGCGCTTCC
TGGCACAGGCGCAGGGGCGCCCGATGGAGCCGGCGACGGAGCCGCGCTTGGCTGGCAGCGAATTGCAACGCTTGCCTTCT
TCGCGCTCATCGGCGGCATCATTCTCAATCTCATGCCCTGCGTGCTGCCGGTGCTGTCGATGAAAGCCATCGGTATGGTG
CAGGCCGCCTCGACGGGCCATGCAGGTGAACTCAAATCGCACGGGCTCTGGTATACGGGCGGTGTGCTGGTGTCTTTCCT
TGCGCTGGCGGGCGCGCTGCTGGCGGTGCGCCAGGCAACGGGATCGGCAACGCTTGGCTTCCAGCTGCAACATGCGCCCA
CGGTCGCCATCCTCACCCTCGTCATGTTTGCTGTCGGCCTCTGGCTGATGGGCTATTTTGAGCTTGGGAGCTCTGTCCAG
AATCTGGGCGGCAGCCTCGCCAATCGCAGCGGCGCGGCGGGCGCTTTCTTTACCGGCATTCTTGCCGCCGTGGTGGGCGC
GCCCTGTGTCGGGCCGTTCCTCGGCGCGGCTTTGGGCGCCGTCATCGGCCAGCCGGCCCCGGCCGTGATCGCCGTGTTCC
TCGCCATGGGCTTTGGCATGGCGCTGCCTTTCCTGATCCTCAGCTTCGTGCCGGGCCTGCACCGCATACTGCCCAAGCCC
GGCAAATGGATGGACACGCTGAAACAGGCGTTCGCCTTCCCGATGTTCCTGACGGCGGCCTGGCTTCTCTCGGTTGTTGC
CGGTCTTGCAGGGGCAGGGGCGGTCGGGTGGACGCTTGCGGGGGCCACGACGCTGGTATTTGCCATCTGGCTTGGCCGTC
AGGGCGGCGCGGTGCGCAAGGGCGTGGCCGCTGTTGCGCTGGGCGCAGCGTTCATCTATCCGGCTGTTCAGGCGAATGTG
CCCGATACCTCTGTTGCCGGCAGCAGCGAAGCGGCCTTCACCGGCGCCTATGGCGAAGCTGCCTGGAGCCCGGAAACGGT
CGAGGCGATGCTGGCCGATGGCCGCCCCGTGTTCGTGGACTTCACGGCCAGCTGGTGCGCGAGCTGTCAGGTCAACAAGC
TGACAACGCTGAAGACCCGCAAGGTGCAGGACGCCTTCAAGAGTGCCAATGTGGCCTTCCTGGTGGCGGACTTTACCCAG
AAAGACCCGATGATTGCTGAGGAACTGAAACTGCGCGCGCGCGCCGGTGTGCCGATGTATCTCTGGTATCCGGCCGGGGC
GAGCGAGCCGCAGATACTGCCGGAACTTCTCACTCAAGAACTTGTCATTGGACTTGTCGAAGGCTGA

Upstream 100 bases:

>100_bases
GAGAAGTCTGACGGAGCGGCTGCAGATGACAGGGTTTTTCCGGCGTATTGCCATGGCCGCAATCAGCCTTTCGGCGCTTG
CAGGGCTTGGCCATGCGCAG

Downstream 100 bases:

>100_bases
CAGGCCTATACTTTCTGACACTGAAAATATTCGAGACAGGAGACGACGATGATACTTTCCCGCCGCCACTTGAGCCTTGC
TGCAGGGATGGCCGCAGCCG

Product: DsbD family thioredoxin

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 688; Mature: 688

Protein sequence:

>688_residues
MDERRAEAELIADRVSVAPGDTFYAALKMTMDEGWHVYWQNAGDAGLPPRLILEEGTSLPEDAVGAFLWPLPHLIPVVEG
EIMDYGYDDEVIFAFPVTVPEDASGEVRLVAEADYLICESICIPETADVSLTLPVGAPIENAVAGAEIGKWIARVPVDFA
GEARIDDAAEPWTLSLRQPGGFPEGAQIRFFPFKHEISHPAAQPQKAGAEGASLSLTPDRAGSIAETLDGVIRIDVPGAE
PVGYEISASRGEAFAGTADRNVQSALPGTGAGAPDGAGDGAALGWQRIATLAFFALIGGIILNLMPCVLPVLSMKAIGMV
QAASTGHAGELKSHGLWYTGGVLVSFLALAGALLAVRQATGSATLGFQLQHAPTVAILTLVMFAVGLWLMGYFELGSSVQ
NLGGSLANRSGAAGAFFTGILAAVVGAPCVGPFLGAALGAVIGQPAPAVIAVFLAMGFGMALPFLILSFVPGLHRILPKP
GKWMDTLKQAFAFPMFLTAAWLLSVVAGLAGAGAVGWTLAGATTLVFAIWLGRQGGAVRKGVAAVALGAAFIYPAVQANV
PDTSVAGSSEAAFTGAYGEAAWSPETVEAMLADGRPVFVDFTASWCASCQVNKLTTLKTRKVQDAFKSANVAFLVADFTQ
KDPMIAEELKLRARAGVPMYLWYPAGASEPQILPELLTQELVIGLVEG

Sequences:

>Translated_688_residues
MDERRAEAELIADRVSVAPGDTFYAALKMTMDEGWHVYWQNAGDAGLPPRLILEEGTSLPEDAVGAFLWPLPHLIPVVEG
EIMDYGYDDEVIFAFPVTVPEDASGEVRLVAEADYLICESICIPETADVSLTLPVGAPIENAVAGAEIGKWIARVPVDFA
GEARIDDAAEPWTLSLRQPGGFPEGAQIRFFPFKHEISHPAAQPQKAGAEGASLSLTPDRAGSIAETLDGVIRIDVPGAE
PVGYEISASRGEAFAGTADRNVQSALPGTGAGAPDGAGDGAALGWQRIATLAFFALIGGIILNLMPCVLPVLSMKAIGMV
QAASTGHAGELKSHGLWYTGGVLVSFLALAGALLAVRQATGSATLGFQLQHAPTVAILTLVMFAVGLWLMGYFELGSSVQ
NLGGSLANRSGAAGAFFTGILAAVVGAPCVGPFLGAALGAVIGQPAPAVIAVFLAMGFGMALPFLILSFVPGLHRILPKP
GKWMDTLKQAFAFPMFLTAAWLLSVVAGLAGAGAVGWTLAGATTLVFAIWLGRQGGAVRKGVAAVALGAAFIYPAVQANV
PDTSVAGSSEAAFTGAYGEAAWSPETVEAMLADGRPVFVDFTASWCASCQVNKLTTLKTRKVQDAFKSANVAFLVADFTQ
KDPMIAEELKLRARAGVPMYLWYPAGASEPQILPELLTQELVIGLVEG
>Mature_688_residues
MDERRAEAELIADRVSVAPGDTFYAALKMTMDEGWHVYWQNAGDAGLPPRLILEEGTSLPEDAVGAFLWPLPHLIPVVEG
EIMDYGYDDEVIFAFPVTVPEDASGEVRLVAEADYLICESICIPETADVSLTLPVGAPIENAVAGAEIGKWIARVPVDFA
GEARIDDAAEPWTLSLRQPGGFPEGAQIRFFPFKHEISHPAAQPQKAGAEGASLSLTPDRAGSIAETLDGVIRIDVPGAE
PVGYEISASRGEAFAGTADRNVQSALPGTGAGAPDGAGDGAALGWQRIATLAFFALIGGIILNLMPCVLPVLSMKAIGMV
QAASTGHAGELKSHGLWYTGGVLVSFLALAGALLAVRQATGSATLGFQLQHAPTVAILTLVMFAVGLWLMGYFELGSSVQ
NLGGSLANRSGAAGAFFTGILAAVVGAPCVGPFLGAALGAVIGQPAPAVIAVFLAMGFGMALPFLILSFVPGLHRILPKP
GKWMDTLKQAFAFPMFLTAAWLLSVVAGLAGAGAVGWTLAGATTLVFAIWLGRQGGAVRKGVAAVALGAAFIYPAVQANV
PDTSVAGSSEAAFTGAYGEAAWSPETVEAMLADGRPVFVDFTASWCASCQVNKLTTLKTRKVQDAFKSANVAFLVADFTQ
KDPMIAEELKLRARAGVPMYLWYPAGASEPQILPELLTQELVIGLVEG

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=400, Percent_Identity=28.75, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 71571; Mature: 71571

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERRAEAELIADRVSVAPGDTFYAALKMTMDEGWHVYWQNAGDAGLPPRLILEEGTSLP
CCCHHHHHHHHHHHHCCCCCCCEEEHHEEECCCCCEEEEECCCCCCCCCHHEECCCCCCC
EDAVGAFLWPLPHLIPVVEGEIMDYGYDDEVIFAFPVTVPEDASGEVRLVAEADYLICES
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCHHHHC
ICIPETADVSLTLPVGAPIENAVAGAEIGKWIARVPVDFAGEARIDDAAEPWTLSLRQPG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCC
GFPEGAQIRFFPFKHEISHPAAQPQKAGAEGASLSLTPDRAGSIAETLDGVIRIDVPGAE
CCCCCCEEEEEECHHHHCCCCCCCHHCCCCCCEEEECCCCCCCHHHHCCCEEEEECCCCC
PVGYEISASRGEAFAGTADRNVQSALPGTGAGAPDGAGDGAALGWQRIATLAFFALIGGI
CCCEEEECCCCCEECCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ILNLMPCVLPVLSMKAIGMVQAASTGHAGELKSHGLWYTGGVLVSFLALAGALLAVRQAT
HHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCC
GSATLGFQLQHAPTVAILTLVMFAVGLWLMGYFELGSSVQNLGGSLANRSGAAGAFFTGI
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHH
LAAVVGAPCVGPFLGAALGAVIGQPAPAVIAVFLAMGFGMALPFLILSFVPGLHRILPKP
HHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GKWMDTLKQAFAFPMFLTAAWLLSVVAGLAGAGAVGWTLAGATTLVFAIWLGRQGGAVRK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
GVAAVALGAAFIYPAVQANVPDTSVAGSSEAAFTGAYGEAAWSPETVEAMLADGRPVFVD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEE
FTASWCASCQVNKLTTLKTRKVQDAFKSANVAFLVADFTQKDPMIAEELKLRARAGVPMY
ECHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEE
LWYPAGASEPQILPELLTQELVIGLVEG
EEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDERRAEAELIADRVSVAPGDTFYAALKMTMDEGWHVYWQNAGDAGLPPRLILEEGTSLP
CCCHHHHHHHHHHHHCCCCCCCEEEHHEEECCCCCEEEEECCCCCCCCCHHEECCCCCCC
EDAVGAFLWPLPHLIPVVEGEIMDYGYDDEVIFAFPVTVPEDASGEVRLVAEADYLICES
HHHHHHHHHHHHHHHHHHCCHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCHHHHC
ICIPETADVSLTLPVGAPIENAVAGAEIGKWIARVPVDFAGEARIDDAAEPWTLSLRQPG
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCC
GFPEGAQIRFFPFKHEISHPAAQPQKAGAEGASLSLTPDRAGSIAETLDGVIRIDVPGAE
CCCCCCEEEEEECHHHHCCCCCCCHHCCCCCCEEEECCCCCCCHHHHCCCEEEEECCCCC
PVGYEISASRGEAFAGTADRNVQSALPGTGAGAPDGAGDGAALGWQRIATLAFFALIGGI
CCCEEEECCCCCEECCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ILNLMPCVLPVLSMKAIGMVQAASTGHAGELKSHGLWYTGGVLVSFLALAGALLAVRQAT
HHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCC
GSATLGFQLQHAPTVAILTLVMFAVGLWLMGYFELGSSVQNLGGSLANRSGAAGAFFTGI
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHH
LAAVVGAPCVGPFLGAALGAVIGQPAPAVIAVFLAMGFGMALPFLILSFVPGLHRILPKP
HHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GKWMDTLKQAFAFPMFLTAAWLLSVVAGLAGAGAVGWTLAGATTLVFAIWLGRQGGAVRK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
GVAAVALGAAFIYPAVQANVPDTSVAGSSEAAFTGAYGEAAWSPETVEAMLADGRPVFVD
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCEEEEE
FTASWCASCQVNKLTTLKTRKVQDAFKSANVAFLVADFTQKDPMIAEELKLRARAGVPMY
ECHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEE
LWYPAGASEPQILPELLTQELVIGLVEG
EEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]