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The map label for this gene is purM [H]

Identifier: 114798932

GI number: 114798932

Start: 2366903

End: 2367931

Strand: Direct

Name: purM [H]

Synonym: HNE_2263

Alternate gene names: 114798932

Gene position: 2366903-2367931 (Clockwise)

Preceding gene: 114797633

Following gene: 114797986

Centisome position: 63.88

GC content: 64.92

Gene sequence:

>1029_bases
ATGAACACGCCGTCCAAGACGCCTCTCTCTTATCGTGACGCTGGTGTCGATATTGAGGCAGGCGAGCGCCTCGTTGATGC
CATCTCCCCCATGGCCAAGGCCACCGCACGCGCCGGCGTGATGGGCGGGCTGGGCGGATTTGGCGCCCTGTTTGATCTCA
AGGCCGCAGGCTTCAACGATCCGATCCTCGTCTCGGGCACAGATGGCGTCGGCACCAAGCTGATGCTCGCCTTCGAGACC
GGCATCCACAACACCGTCGGCATCGATCTGGTCGCCATGTGCGCCAATGACGTGCTGGCCCAAGGCGCAGAGCCGCTGTT
TTTCCTCGATTATTTTGCTACCGGCAAGCTCGAAGGCGGCATCGCAGAAGCCGTCATCGCGGGCATCGCCGAAGGTTGCC
GCCGGTCGGGCTGCGCCCTTGTGGGCGGCGAAACCGCCGAAATGCCCGGCATGTATCCCCCCGGCCATTACGATCTGGCT
GGTTTCGTCGTCGGCGCTGTCGACCGGGAAAAAGTGCTCCCCCGCATGGGCGACATGACGCCCGGCGACACGCTGATCGG
CATCGCCTCTTCGGGGCCCCACTCAAATGGCTATTCCCTGATCCGCCGCATCGTGGAGCGCGAAGGCCTCTTCTATGGCG
GTCCCTCGCCCTTCTCCAATTCCGAGACGCTGGGTGAAGCGTTGCTGACGCCGACGCGCCTTTATGCACCGCTCGTCATG
CCGCTGATCCGCTCGGGCCGCATCAAGGGCCTTGCCCATATCACCGGCGGCGGCATCACCGAGAACACCCCCCGCATGTG
CCCGGACACCCTCGTGCCCCGCATCGACCGCGCCGCCTGGACCCCGCCCCCGGTGTTCCACTGGTTGCAGGAAGCCGGAC
AGGTGGACCTGGAAGAAATGCACCGCACCTTCAATATGGGCATCGGCCTTGTTCTCGCCGTCGCGCCCGAAGAGGCAGAC
GCCGTGATCGCAGACCTGAAAGCGGCGGGCGAAGACGCGCGCGTTCTCGGTGAGCTTGCCAGCGCATGA

Upstream 100 bases:

>100_bases
ATACGGGAACCGGCTGCTTCACTTCTGATCCTTCACTGGAACTTGGGCCATCCTCATGCTAACGCGCCGATTCAGGTAAA
CTGAGGGGCTAGAATCCAAG

Downstream 100 bases:

>100_bases
CGCGCCTCAATCTGGCGATCCTGATTTCAGGCCGCGGCTCCAATATGGAGGCCCTGCTGAGCGCCGCCGAAGACCCGGCC
TATCCGGCAAAGCCCGTTCT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MNTPSKTPLSYRDAGVDIEAGERLVDAISPMAKATARAGVMGGLGGFGALFDLKAAGFNDPILVSGTDGVGTKLMLAFET
GIHNTVGIDLVAMCANDVLAQGAEPLFFLDYFATGKLEGGIAEAVIAGIAEGCRRSGCALVGGETAEMPGMYPPGHYDLA
GFVVGAVDREKVLPRMGDMTPGDTLIGIASSGPHSNGYSLIRRIVEREGLFYGGPSPFSNSETLGEALLTPTRLYAPLVM
PLIRSGRIKGLAHITGGGITENTPRMCPDTLVPRIDRAAWTPPPVFHWLQEAGQVDLEEMHRTFNMGIGLVLAVAPEEAD
AVIADLKAAGEDARVLGELASA

Sequences:

>Translated_342_residues
MNTPSKTPLSYRDAGVDIEAGERLVDAISPMAKATARAGVMGGLGGFGALFDLKAAGFNDPILVSGTDGVGTKLMLAFET
GIHNTVGIDLVAMCANDVLAQGAEPLFFLDYFATGKLEGGIAEAVIAGIAEGCRRSGCALVGGETAEMPGMYPPGHYDLA
GFVVGAVDREKVLPRMGDMTPGDTLIGIASSGPHSNGYSLIRRIVEREGLFYGGPSPFSNSETLGEALLTPTRLYAPLVM
PLIRSGRIKGLAHITGGGITENTPRMCPDTLVPRIDRAAWTPPPVFHWLQEAGQVDLEEMHRTFNMGIGLVLAVAPEEAD
AVIADLKAAGEDARVLGELASA
>Mature_342_residues
MNTPSKTPLSYRDAGVDIEAGERLVDAISPMAKATARAGVMGGLGGFGALFDLKAAGFNDPILVSGTDGVGTKLMLAFET
GIHNTVGIDLVAMCANDVLAQGAEPLFFLDYFATGKLEGGIAEAVIAGIAEGCRRSGCALVGGETAEMPGMYPPGHYDLA
GFVVGAVDREKVLPRMGDMTPGDTLIGIASSGPHSNGYSLIRRIVEREGLFYGGPSPFSNSETLGEALLTPTRLYAPLVM
PLIRSGRIKGLAHITGGGITENTPRMCPDTLVPRIDRAAWTPPPVFHWLQEAGQVDLEEMHRTFNMGIGLVLAVAPEEAD
AVIADLKAAGEDARVLGELASA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=334, Percent_Identity=55.9880239520958, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI209869995, Length=334, Percent_Identity=55.9880239520958, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI209869993, Length=334, Percent_Identity=55.9880239520958, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788845, Length=338, Percent_Identity=53.2544378698225, Blast_Score=347, Evalue=7e-97,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=45.1149425287356, Blast_Score=285, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=53.8461538461538, Blast_Score=372, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=45.1048951048951, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35692; Mature: 35692

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPSKTPLSYRDAGVDIEAGERLVDAISPMAKATARAGVMGGLGGFGALFDLKAAGFND
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
PILVSGTDGVGTKLMLAFETGIHNTVGIDLVAMCANDVLAQGAEPLFFLDYFATGKLEGG
CEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCH
IAEAVIAGIAEGCRRSGCALVGGETAEMPGMYPPGHYDLAGFVVGAVDREKVLPRMGDMT
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCC
PGDTLIGIASSGPHSNGYSLIRRIVEREGLFYGGPSPFSNSETLGEALLTPTRLYAPLVM
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHCHHHHHHHHHH
PLIRSGRIKGLAHITGGGITENTPRMCPDTLVPRIDRAAWTPPPVFHWLQEAGQVDLEEM
HHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHH
HRTFNMGIGLVLAVAPEEADAVIADLKAAGEDARVLGELASA
HHHHHCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MNTPSKTPLSYRDAGVDIEAGERLVDAISPMAKATARAGVMGGLGGFGALFDLKAAGFND
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
PILVSGTDGVGTKLMLAFETGIHNTVGIDLVAMCANDVLAQGAEPLFFLDYFATGKLEGG
CEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCH
IAEAVIAGIAEGCRRSGCALVGGETAEMPGMYPPGHYDLAGFVVGAVDREKVLPRMGDMT
HHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCC
PGDTLIGIASSGPHSNGYSLIRRIVEREGLFYGGPSPFSNSETLGEALLTPTRLYAPLVM
CCCEEEEEECCCCCCCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHCHHHHHHHHHH
PLIRSGRIKGLAHITGGGITENTPRMCPDTLVPRIDRAAWTPPPVFHWLQEAGQVDLEEM
HHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHH
HRTFNMGIGLVLAVAPEEADAVIADLKAAGEDARVLGELASA
HHHHHCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA