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The map label for this gene is rnd [H]

Identifier: 114797633

GI number: 114797633

Start: 2360145

End: 2361311

Strand: Direct

Name: rnd [H]

Synonym: HNE_2258

Alternate gene names: 114797633

Gene position: 2360145-2361311 (Clockwise)

Preceding gene: 114799805

Following gene: 114798932

Centisome position: 63.7

GC content: 62.47

Gene sequence:

>1167_bases
ATGACTGACAACACCCTGACCCCCATCACAGAGCAGTCCGCGCTCGAAGATCTGTGCGGCGCGCTCTCCGAATCCGACTT
TGTCTGCGTGGACACCGAGTTCCACCGGGAGACGACCTATTGGCCTGAGCTGTGCCTGATCCAGGCGTCTGCGCCGGGCG
TGGAGGGTCTGATAGACCCCAGGGCCGAGGATCTCGACATTCGTCCTTTCCTCGATCTGATCGCCTCTGACCGGCAGCTG
AAAGTGTTTCACGCCGCCCGGCAGGACATCGAGATTTTCAATCGCCTGATCGGCCATCCGCCGGGTCCGATCTTTGATAC
CCAGGTCGCGGCCATGGCGCTCGGCTTTGGCGATTCGATATCCTACGACAATCTGATCCAGCGCGTTCTGCGCAAGCATA
TCGACAAATCCAGCCAGTTTACCGACTGGATGCGCCGCCCGCTCAGCCAGAAACAGCTCGTCTATGCCCTCGGCGATGTC
ACCCATCTGCGCGATGCCTATCTGAAAATGCGCGATGAGCTGGAAAAAGCCGGCCGCATGAACTGGGTGCGCGAGGAGAT
GGCCGAGCTTGAAGATCCGGCCACTTACGACACCGACCCCATGAATGCCTGGCAGCGCCTGAAGCTGCGCATGCCCAAGA
AAGACTATGCCGCCATCGTGGTCGCCGTCGCCGCCTGGCGCGAGCGCACGGCGCAGGAGCTGGACAAGCCGCGCCGGCGC
ATCCTCAAGGATGATGCCATCCAGGAAATCGCCGCCCAGAAGCCGCGCAGCGAGGAAGACTTCAACCAGCTGCGCGCGGT
GCCCAACGGCTTCATCCGCTCCAAGCACGGGCAAGGCCTGGTCGACGCCATCAAGGAAGCGCTGGCCAATCCGGACGCCT
TTGCCCCGGAGCTGACGCGTCCCGTGCAGAATGCCCAGATCCCGGCCGGGGCGCCAGAGCTGCTCAAGGTGCTCCTGAAG
CACGTCTCGGACGAAAACAATGTCGTCCCGCGCCTGATCGCCAATTCCAGTGACATCGACCGGATTGCGCGCGGGGAGAC
CAGCGAAGACATCGCGGCGATGACCGGCTGGCGCTACGACATGTTCGGACAGAAAGCGATTGCGCTGCTCTCCGGCAAGC
TGGCCGTGTCCTTCAATGGCGGACAGGTGCGCCTGTTCGACGTTTAG

Upstream 100 bases:

>100_bases
ATCGGGCGAATTCTCCGGAAAATCGCTTGAGTCAGAAAGAAGCGGCGTAGGGCACAGACCCCCTCGCCTTTGTCAAGTTG
GTGCGATAAGCGCTCAGGGG

Downstream 100 bases:

>100_bases
GCCGCGCCTAGCGCACCAGCGTCGCCGATTTCAGCCTCAGCATGCTTGCCGCCTGGGAGAGGCGGCGTTCCACCGTTTCC
GAAATCAGATTGGCATCCTT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTDNTLTPITEQSALEDLCGALSESDFVCVDTEFHRETTYWPELCLIQASAPGVEGLIDPRAEDLDIRPFLDLIASDRQL
KVFHAARQDIEIFNRLIGHPPGPIFDTQVAAMALGFGDSISYDNLIQRVLRKHIDKSSQFTDWMRRPLSQKQLVYALGDV
THLRDAYLKMRDELEKAGRMNWVREEMAELEDPATYDTDPMNAWQRLKLRMPKKDYAAIVVAVAAWRERTAQELDKPRRR
ILKDDAIQEIAAQKPRSEEDFNQLRAVPNGFIRSKHGQGLVDAIKEALANPDAFAPELTRPVQNAQIPAGAPELLKVLLK
HVSDENNVVPRLIANSSDIDRIARGETSEDIAAMTGWRYDMFGQKAIALLSGKLAVSFNGGQVRLFDV

Sequences:

>Translated_388_residues
MTDNTLTPITEQSALEDLCGALSESDFVCVDTEFHRETTYWPELCLIQASAPGVEGLIDPRAEDLDIRPFLDLIASDRQL
KVFHAARQDIEIFNRLIGHPPGPIFDTQVAAMALGFGDSISYDNLIQRVLRKHIDKSSQFTDWMRRPLSQKQLVYALGDV
THLRDAYLKMRDELEKAGRMNWVREEMAELEDPATYDTDPMNAWQRLKLRMPKKDYAAIVVAVAAWRERTAQELDKPRRR
ILKDDAIQEIAAQKPRSEEDFNQLRAVPNGFIRSKHGQGLVDAIKEALANPDAFAPELTRPVQNAQIPAGAPELLKVLLK
HVSDENNVVPRLIANSSDIDRIARGETSEDIAAMTGWRYDMFGQKAIALLSGKLAVSFNGGQVRLFDV
>Mature_387_residues
TDNTLTPITEQSALEDLCGALSESDFVCVDTEFHRETTYWPELCLIQASAPGVEGLIDPRAEDLDIRPFLDLIASDRQLK
VFHAARQDIEIFNRLIGHPPGPIFDTQVAAMALGFGDSISYDNLIQRVLRKHIDKSSQFTDWMRRPLSQKQLVYALGDVT
HLRDAYLKMRDELEKAGRMNWVREEMAELEDPATYDTDPMNAWQRLKLRMPKKDYAAIVVAVAAWRERTAQELDKPRRRI
LKDDAIQEIAAQKPRSEEDFNQLRAVPNGFIRSKHGQGLVDAIKEALANPDAFAPELTRPVQNAQIPAGAPELLKVLLKH
VSDENNVVPRLIANSSDIDRIARGETSEDIAAMTGWRYDMFGQKAIALLSGKLAVSFNGGQVRLFDV

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4505917, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788105, Length=347, Percent_Identity=29.3948126801153, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17531757, Length=267, Percent_Identity=27.7153558052434, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=336, Percent_Identity=22.9166666666667, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI161078302, Length=268, Percent_Identity=26.1194029850746, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43704; Mature: 43573

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNTLTPITEQSALEDLCGALSESDFVCVDTEFHRETTYWPELCLIQASAPGVEGLIDP
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCCEEEEECCCCCCCCCCCC
RAEDLDIRPFLDLIASDRQLKVFHAARQDIEIFNRLIGHPPGPIFDTQVAAMALGFGDSI
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
SYDNLIQRVLRKHIDKSSQFTDWMRRPLSQKQLVYALGDVTHLRDAYLKMRDELEKAGRM
CHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NWVREEMAELEDPATYDTDPMNAWQRLKLRMPKKDYAAIVVAVAAWRERTAQELDKPRRR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKDDAIQEIAAQKPRSEEDFNQLRAVPNGFIRSKHGQGLVDAIKEALANPDAFAPELTR
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHC
PVQNAQIPAGAPELLKVLLKHVSDENNVVPRLIANSSDIDRIARGETSEDIAAMTGWRYD
CHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHCCCCHHHHHHHHCCCHH
MFGQKAIALLSGKLAVSFNGGQVRLFDV
HHHHHHHHHHCCCEEEEECCCEEEEEEC
>Mature Secondary Structure 
TDNTLTPITEQSALEDLCGALSESDFVCVDTEFHRETTYWPELCLIQASAPGVEGLIDP
CCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCCEEEEECCCCCCCCCCCC
RAEDLDIRPFLDLIASDRQLKVFHAARQDIEIFNRLIGHPPGPIFDTQVAAMALGFGDSI
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
SYDNLIQRVLRKHIDKSSQFTDWMRRPLSQKQLVYALGDVTHLRDAYLKMRDELEKAGRM
CHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NWVREEMAELEDPATYDTDPMNAWQRLKLRMPKKDYAAIVVAVAAWRERTAQELDKPRRR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKDDAIQEIAAQKPRSEEDFNQLRAVPNGFIRSKHGQGLVDAIKEALANPDAFAPELTR
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHC
PVQNAQIPAGAPELLKVLLKHVSDENNVVPRLIANSSDIDRIARGETSEDIAAMTGWRYD
CHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHCCCCHHHHHHHHCCCHH
MFGQKAIALLSGKLAVSFNGGQVRLFDV
HHHHHHHHHHCCCEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]