Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 114798896

GI number: 114798896

Start: 2400544

End: 2401824

Strand: Direct

Name: pyrC [H]

Synonym: HNE_2303

Alternate gene names: 114798896

Gene position: 2400544-2401824 (Clockwise)

Preceding gene: 114800183

Following gene: 114799781

Centisome position: 64.79

GC content: 66.74

Gene sequence:

>1281_bases
ATGAGCCTGCAGATAATCAATGCACGCCTGCTTGATCCGGCTACGGAGCTTGACGCGCCCGGCGCGATCCTCATCGAAGA
CGGCAAGATCAGCGACATTCGCACAGGCGAAGGCGCGACCTTCAGCGATGCCGCAACCACCATCGACGCAGCCGGCCTCT
GCCTTGCGCCCGGCCTGATCGACCTGCGCGTCAAGACCGGCGAGCCCGGCGACGAGCAGAAGGAAACCCTGCAGACGGCC
TCCCGCGCCGCGCTTTCCGGCGGCATCACCAGCTTTGTCGTGATGCCCGACACGCGCCCCGTCATCGACGATATGGCGCT
GGTCCAGTTTATCGCCGAGCGGGCCCGCGAAACCTCCAAAGCCCGCATCTATCCGGCCGGCGCGCTCACTGTCGGCCTCG
CCGGTCTCGCCATGGCCGAGATTGGCCTGATGGCAGATGCTGGCGCGATCCTGTTCACAAATGGCGATTGCCCCGTCGCC
GACGCACAGGTGATGAAGCGCGCGATGGCCTATGCCGCCAGCCGCGGCGCCACCGTCATGTCCCGCCCCGATGAGCGCGC
GCTGACGGGCAGCGGCGTCATGAATGCCGGCGCCTTTGCCGCCCGCGCGGGCCTCTCGGGCATTCCGCCAGAAGCCGAAT
GGATCGGCGCAATGCGCGACGTGACGCTCGCAGAGCAGACCGGCTGCCGCCTGATCCTCGATCAGGTCTCCACCGCGCGC
ACATTGGAAATCGCCACAGCCGCCCGCAAGCGCGGCGCCAAGGTATTCACCACGGCGGCCGCCCATTCCCTCTTCTTCAA
CGAGCGCGATGTCGGCGACTACCTCACCTATTGCAAGGTGAACCCACCCTTCCGCGACGAGGCAACCCGTCAGGGCCTCA
TCCAGGCCTTGAAAGATGGCGAGATCGACGCCGTCGTCTCCGCTCACGATCCTCAGCCCCCGGAAGAAAAGCGTCTTCCC
TTTGGCGAAGCCGCCTTCGGCGCGGCGGGACTTGAGACGGTGCTCTCAGCCCTCCTGAACCTCCACCATGACGGCCCGCT
GACTTTGCTGGAAGCCCTCGCCCCGGTCACCATTGGCCCGGCCAGCATCCTCGGCCTGCCACAGGGCCGCCTCGCCAAGG
ATGCGCCGGCAGACATCATCCTCTTCAACGCCGGCAAGCCCTGGCTCTGCGAGCGCGAAGACCTCCTCTCCCGCTCCAAG
AACTCCCCCTTCGACGGCCGCCGCCTGCAAGGCCGCGTCATGCGGACGTTCGTGGGCGGGGAAAGCGTCTTCAAGCGGTA
G

Upstream 100 bases:

>100_bases
GCACCATCGCGGACGGGCCGAGCTCGGTCATCACCCAGCAGGTCGAAATGGGCGTCGCCGTGCGCGAAGCCGTCCTCCAC
CTTCTCGCCGGAGGAAAATC

Downstream 100 bases:

>100_bases
GGCATGCAAAAGAAGAATGACCTCACCACAGGCGCCATCGGCCCGGCGCTGATCGCCTTTACGCTGCCCACGCTCGCCGC
CTCGATCCTGCAATCGGCCA

Product: putative dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSLQIINARLLDPATELDAPGAILIEDGKISDIRTGEGATFSDAATTIDAAGLCLAPGLIDLRVKTGEPGDEQKETLQTA
SRAALSGGITSFVVMPDTRPVIDDMALVQFIAERARETSKARIYPAGALTVGLAGLAMAEIGLMADAGAILFTNGDCPVA
DAQVMKRAMAYAASRGATVMSRPDERALTGSGVMNAGAFAARAGLSGIPPEAEWIGAMRDVTLAEQTGCRLILDQVSTAR
TLEIATAARKRGAKVFTTAAAHSLFFNERDVGDYLTYCKVNPPFRDEATRQGLIQALKDGEIDAVVSAHDPQPPEEKRLP
FGEAAFGAAGLETVLSALLNLHHDGPLTLLEALAPVTIGPASILGLPQGRLAKDAPADIILFNAGKPWLCEREDLLSRSK
NSPFDGRRLQGRVMRTFVGGESVFKR

Sequences:

>Translated_426_residues
MSLQIINARLLDPATELDAPGAILIEDGKISDIRTGEGATFSDAATTIDAAGLCLAPGLIDLRVKTGEPGDEQKETLQTA
SRAALSGGITSFVVMPDTRPVIDDMALVQFIAERARETSKARIYPAGALTVGLAGLAMAEIGLMADAGAILFTNGDCPVA
DAQVMKRAMAYAASRGATVMSRPDERALTGSGVMNAGAFAARAGLSGIPPEAEWIGAMRDVTLAEQTGCRLILDQVSTAR
TLEIATAARKRGAKVFTTAAAHSLFFNERDVGDYLTYCKVNPPFRDEATRQGLIQALKDGEIDAVVSAHDPQPPEEKRLP
FGEAAFGAAGLETVLSALLNLHHDGPLTLLEALAPVTIGPASILGLPQGRLAKDAPADIILFNAGKPWLCEREDLLSRSK
NSPFDGRRLQGRVMRTFVGGESVFKR
>Mature_425_residues
SLQIINARLLDPATELDAPGAILIEDGKISDIRTGEGATFSDAATTIDAAGLCLAPGLIDLRVKTGEPGDEQKETLQTAS
RAALSGGITSFVVMPDTRPVIDDMALVQFIAERARETSKARIYPAGALTVGLAGLAMAEIGLMADAGAILFTNGDCPVAD
AQVMKRAMAYAASRGATVMSRPDERALTGSGVMNAGAFAARAGLSGIPPEAEWIGAMRDVTLAEQTGCRLILDQVSTART
LEIATAARKRGAKVFTTAAAHSLFFNERDVGDYLTYCKVNPPFRDEATRQGLIQALKDGEIDAVVSAHDPQPPEEKRLPF
GEAAFGAAGLETVLSALLNLHHDGPLTLLEALAPVTIGPASILGLPQGRLAKDAPADIILFNAGKPWLCEREDLLSRSKN
SPFDGRRLQGRVMRTFVGGESVFKR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786722, Length=422, Percent_Identity=28.1990521327014, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322218, Length=192, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI18859883, Length=425, Percent_Identity=24.7058823529412, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44934; Mature: 44803

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQIINARLLDPATELDAPGAILIEDGKISDIRTGEGATFSDAATTIDAAGLCLAPGLI
CCEEEEEHHHCCCHHHCCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHCCHHHCCCEE
DLRVKTGEPGDEQKETLQTASRAALSGGITSFVVMPDTRPVIDDMALVQFIAERARETSK
EEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
ARIYPAGALTVGLAGLAMAEIGLMADAGAILFTNGDCPVADAQVMKRAMAYAASRGATVM
CEEEECCHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEE
SRPDERALTGSGVMNAGAFAARAGLSGIPPEAEWIGAMRDVTLAEQTGCRLILDQVSTAR
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHH
TLEIATAARKRGAKVFTTAAAHSLFFNERDVGDYLTYCKVNPPFRDEATRQGLIQALKDG
HHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCC
EIDAVVSAHDPQPPEEKRLPFGEAAFGAAGLETVLSALLNLHHDGPLTLLEALAPVTIGP
CEEEEEECCCCCCCHHHCCCCCCHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
ASILGLPQGRLAKDAPADIILFNAGKPWLCEREDLLSRSKNSPFDGRRLQGRVMRTFVGG
HHHCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
ESVFKR
HHHHCC
>Mature Secondary Structure 
SLQIINARLLDPATELDAPGAILIEDGKISDIRTGEGATFSDAATTIDAAGLCLAPGLI
CEEEEEHHHCCCHHHCCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHCCHHHCCCEE
DLRVKTGEPGDEQKETLQTASRAALSGGITSFVVMPDTRPVIDDMALVQFIAERARETSK
EEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
ARIYPAGALTVGLAGLAMAEIGLMADAGAILFTNGDCPVADAQVMKRAMAYAASRGATVM
CEEEECCHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEE
SRPDERALTGSGVMNAGAFAARAGLSGIPPEAEWIGAMRDVTLAEQTGCRLILDQVSTAR
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHCCHH
TLEIATAARKRGAKVFTTAAAHSLFFNERDVGDYLTYCKVNPPFRDEATRQGLIQALKDG
HHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCC
EIDAVVSAHDPQPPEEKRLPFGEAAFGAAGLETVLSALLNLHHDGPLTLLEALAPVTIGP
CEEEEEECCCCCCCHHHCCCCCCHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
ASILGLPQGRLAKDAPADIILFNAGKPWLCEREDLLSRSKNSPFDGRRLQGRVMRTFVGG
HHHCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
ESVFKR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA