Click here to switch to the map view.

The map label for this gene is aslA [H]

Identifier: 114798724

GI number: 114798724

Start: 2265873

End: 2267390

Strand: Direct

Name: aslA [H]

Synonym: HNE_2178

Alternate gene names: 114798724

Gene position: 2265873-2267390 (Clockwise)

Preceding gene: 114798176

Following gene: 114798245

Centisome position: 61.16

GC content: 56.98

Gene sequence:

>1518_bases
ATGCGGACTCTATTGCTTCAAACATTTGGAAAAGGTGCGTTACTCAGCCTAACATTCGTGTTGCCAGGCTGCGTTCAGCC
CCCTCCTCCCGCTCCCGATTCCGTCGCCGAAAAAGAGGCCGCTGCCTCCGAGCAGCCCAACATCGTACTGATTTTTGTTG
ATGATATGGGCTATGCAGACATCGGCTCTTTCGGAAGCCCCATCGCCCGCACACCCAATCTCGACCGCCTGGCAATGGAG
GGACAGAAGTGGACGAGCTTTTACGCGCCTGCGCCGGTATGCACTCCGAGCCGCGCCGGCCTGATGACGGGGCGGCTGGC
CGTCAGATCCGGCATGGCTGGCTTGGTACAGGCCCGTCATGTGCTCTTCCCAACATCAACCGGCGGTCTCCCGCAGAGTG
AAGTCACGATCGCCGAATTGCTCCAGCAGGAAGGTTATGTTTCGGCCGCATTCGGAAAATGGCATATGGGCCACCTTCCA
GAATTTTTGCCTACCTCGCATGGCTTTCAATCCTATTTCGGCATCCCTTACAGTAACGATATGAATATGCCTGGCGGTGG
CGAAACACCTTGGTCGATAGATCTCTTCTTTGAGCCACCTAATATTCAGAACTGGGACGTTCCCCTCATGCAGGATGAGG
AAATCATCGAACGTCCCGCCGATCAGTTCACCCTCACCCAGCGTTACACGGAACGCGCAATCGAGTTCATGGAAACCAGC
CACGCGGAAGGCCAACCCTTCTTCCTGTACCTAGCCCACAACATGCCGCACACGCCCCTGTTCACATCAGAGGGCTTCAC
CGGCGTCAGCGCAGGCGGCGCCTATGGGGATGTCATTGAAGAACTCGACTGGAGCGTTGGCGAAATAGTCGACGCTCTTA
AGGACATGAAGATAGAGAAGAACACGCTCGTCATCTTCACCTCGGACAATGGCCCATGGCTGGCGATGAAAACCCATAGC
GGATCAGCCGGCATGTTGCGCGATGGCAAAGGTACAACCTGGGAAGGCGGTATGCGTGTGCCCGCAATCTTCTGGTGGCC
CGGACAGATTGCGCCGCGCACCGTTACCGATCTTGGGTCAGCGCTTGATCTTATGCCGACATTCGCGGCCATTTCTGGCG
CCCGTCTCCCGGAAGACCGCGTGTATGACGGGTTCGATCTCAGCCCTGCCCTCTTTTCTGAGGGGAGCAGCCCGCGTGAA
ACACTCTACTATTACCGATTCACGGACGTTTTTGCCGTTCGCAAGGGCAAGTATAAGGCGCATTTCAGCACCTATGGCGC
CTTCGGTGGCAGTGGCCGCACCGAACTGGAAACGCCTGAGCTTTATGACATTGAGGCAGACCCAAGCGAGCAGTTCAACA
TTGCCGCGCAACACCCGGAGATCGTCATGGAGCTGAAGGTTCTGGCTGAGAAACAAGCCGCAAGCGTCGAGCCTGTCGAA
AACCAGTTGGAACGCTATCCTCCGGGCGAAAAGCGAGGCGAAGAAGGTACGCGCCCATGGACCGCGGATAGCGAGTAG

Upstream 100 bases:

>100_bases
TGTTAGAACGTTTTTTTCATAATTTAAATAGTTGATTTTTCTGTTTCGTGTTTTTTATGTGACCGGCATAGTAGGTTGAC
AGACAGCGGAGGAATTCAAA

Downstream 100 bases:

>100_bases
TCGTCCTTCGCGAAACTGAAAAAAAAGCCCGCCCGGACTGATCAACTCCGGGCGGGCTTATATTTGATCTGAAAGCGGCG
CGCCTAGTCTTCGGGCCAGA

Product: sulfatase family protein

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MRTLLLQTFGKGALLSLTFVLPGCVQPPPPAPDSVAEKEAAASEQPNIVLIFVDDMGYADIGSFGSPIARTPNLDRLAME
GQKWTSFYAPAPVCTPSRAGLMTGRLAVRSGMAGLVQARHVLFPTSTGGLPQSEVTIAELLQQEGYVSAAFGKWHMGHLP
EFLPTSHGFQSYFGIPYSNDMNMPGGGETPWSIDLFFEPPNIQNWDVPLMQDEEIIERPADQFTLTQRYTERAIEFMETS
HAEGQPFFLYLAHNMPHTPLFTSEGFTGVSAGGAYGDVIEELDWSVGEIVDALKDMKIEKNTLVIFTSDNGPWLAMKTHS
GSAGMLRDGKGTTWEGGMRVPAIFWWPGQIAPRTVTDLGSALDLMPTFAAISGARLPEDRVYDGFDLSPALFSEGSSPRE
TLYYYRFTDVFAVRKGKYKAHFSTYGAFGGSGRTELETPELYDIEADPSEQFNIAAQHPEIVMELKVLAEKQAASVEPVE
NQLERYPPGEKRGEEGTRPWTADSE

Sequences:

>Translated_505_residues
MRTLLLQTFGKGALLSLTFVLPGCVQPPPPAPDSVAEKEAAASEQPNIVLIFVDDMGYADIGSFGSPIARTPNLDRLAME
GQKWTSFYAPAPVCTPSRAGLMTGRLAVRSGMAGLVQARHVLFPTSTGGLPQSEVTIAELLQQEGYVSAAFGKWHMGHLP
EFLPTSHGFQSYFGIPYSNDMNMPGGGETPWSIDLFFEPPNIQNWDVPLMQDEEIIERPADQFTLTQRYTERAIEFMETS
HAEGQPFFLYLAHNMPHTPLFTSEGFTGVSAGGAYGDVIEELDWSVGEIVDALKDMKIEKNTLVIFTSDNGPWLAMKTHS
GSAGMLRDGKGTTWEGGMRVPAIFWWPGQIAPRTVTDLGSALDLMPTFAAISGARLPEDRVYDGFDLSPALFSEGSSPRE
TLYYYRFTDVFAVRKGKYKAHFSTYGAFGGSGRTELETPELYDIEADPSEQFNIAAQHPEIVMELKVLAEKQAASVEPVE
NQLERYPPGEKRGEEGTRPWTADSE
>Mature_505_residues
MRTLLLQTFGKGALLSLTFVLPGCVQPPPPAPDSVAEKEAAASEQPNIVLIFVDDMGYADIGSFGSPIARTPNLDRLAME
GQKWTSFYAPAPVCTPSRAGLMTGRLAVRSGMAGLVQARHVLFPTSTGGLPQSEVTIAELLQQEGYVSAAFGKWHMGHLP
EFLPTSHGFQSYFGIPYSNDMNMPGGGETPWSIDLFFEPPNIQNWDVPLMQDEEIIERPADQFTLTQRYTERAIEFMETS
HAEGQPFFLYLAHNMPHTPLFTSEGFTGVSAGGAYGDVIEELDWSVGEIVDALKDMKIEKNTLVIFTSDNGPWLAMKTHS
GSAGMLRDGKGTTWEGGMRVPAIFWWPGQIAPRTVTDLGSALDLMPTFAAISGARLPEDRVYDGFDLSPALFSEGSSPRE
TLYYYRFTDVFAVRKGKYKAHFSTYGAFGGSGRTELETPELYDIEADPSEQFNIAAQHPEIVMELKVLAEKQAASVEPVE
NQLERYPPGEKRGEEGTRPWTADSE

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=445, Percent_Identity=44.0449438202247, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI146229329, Length=445, Percent_Identity=44.0449438202247, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI6005990, Length=445, Percent_Identity=44.0449438202247, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI146229324, Length=445, Percent_Identity=44.0449438202247, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI4503899, Length=506, Percent_Identity=35.5731225296443, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI53831991, Length=519, Percent_Identity=37.1868978805395, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI45430057, Length=462, Percent_Identity=37.2294372294372, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI146229327, Length=370, Percent_Identity=41.6216216216216, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI58743319, Length=530, Percent_Identity=31.3207547169811, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI31742482, Length=544, Percent_Identity=31.8014705882353, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI109389362, Length=502, Percent_Identity=26.6932270916335, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI59797060, Length=511, Percent_Identity=29.7455968688845, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI71852586, Length=309, Percent_Identity=33.0097087378641, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI38569405, Length=483, Percent_Identity=28.9855072463768, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI38569407, Length=377, Percent_Identity=31.8302387267904, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI71852584, Length=277, Percent_Identity=33.2129963898917, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI157266309, Length=149, Percent_Identity=42.9530201342282, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1790233, Length=497, Percent_Identity=29.5774647887324, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87081924, Length=397, Percent_Identity=27.9596977329975, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790112, Length=389, Percent_Identity=26.4781491002571, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17559078, Length=285, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI115533416, Length=449, Percent_Identity=26.5033407572383, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI115533418, Length=436, Percent_Identity=26.3761467889908, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24666175, Length=390, Percent_Identity=31.025641025641, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI281363223, Length=435, Percent_Identity=28.2758620689655, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24666109, Length=411, Percent_Identity=30.9002433090024, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281366397, Length=426, Percent_Identity=29.5774647887324, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI281366395, Length=426, Percent_Identity=29.5774647887324, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24666163, Length=426, Percent_Identity=29.5774647887324, Blast_Score=152, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 55505; Mature: 55505

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLLLQTFGKGALLSLTFVLPGCVQPPPPAPDSVAEKEAAASEQPNIVLIFVDDMGYAD
CCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
IGSFGSPIARTPNLDRLAMEGQKWTSFYAPAPVCTPSRAGLMTGRLAVRSGMAGLVQARH
CCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCE
VLFPTSTGGLPQSEVTIAELLQQEGYVSAAFGKWHMGHLPEFLPTSHGFQSYFGIPYSND
EEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHCCCCCCHHHHCCCCCCCC
MNMPGGGETPWSIDLFFEPPNIQNWDVPLMQDEEIIERPADQFTLTQRYTERAIEFMETS
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHC
HAEGQPFFLYLAHNMPHTPLFTSEGFTGVSAGGAYGDVIEELDWSVGEIVDALKDMKIEK
CCCCCCEEEEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCEECC
NTLVIFTSDNGPWLAMKTHSGSAGMLRDGKGTTWEGGMRVPAIFWWPGQIAPRTVTDLGS
CEEEEEECCCCCEEEEEECCCCCCCEECCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHH
ALDLMPTFAAISGARLPEDRVYDGFDLSPALFSEGSSPRETLYYYRFTDVFAVRKGKYKA
HHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHCCCCCCCCEEEEEEEEEEEEECCCCEEE
HFSTYGAFGGSGRTELETPELYDIEADPSEQFNIAAQHPEIVMELKVLAEKQAASVEPVE
EEEECCCCCCCCCCCCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHH
NQLERYPPGEKRGEEGTRPWTADSE
HHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTLLLQTFGKGALLSLTFVLPGCVQPPPPAPDSVAEKEAAASEQPNIVLIFVDDMGYAD
CCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCC
IGSFGSPIARTPNLDRLAMEGQKWTSFYAPAPVCTPSRAGLMTGRLAVRSGMAGLVQARH
CCCCCCCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCHHHHHHHCE
VLFPTSTGGLPQSEVTIAELLQQEGYVSAAFGKWHMGHLPEFLPTSHGFQSYFGIPYSND
EEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCHHCCCCCCHHHHCCCCCCCC
MNMPGGGETPWSIDLFFEPPNIQNWDVPLMQDEEIIERPADQFTLTQRYTERAIEFMETS
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHC
HAEGQPFFLYLAHNMPHTPLFTSEGFTGVSAGGAYGDVIEELDWSVGEIVDALKDMKIEK
CCCCCCEEEEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCEECC
NTLVIFTSDNGPWLAMKTHSGSAGMLRDGKGTTWEGGMRVPAIFWWPGQIAPRTVTDLGS
CEEEEEECCCCCEEEEEECCCCCCCEECCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHH
ALDLMPTFAAISGARLPEDRVYDGFDLSPALFSEGSSPRETLYYYRFTDVFAVRKGKYKA
HHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHCCCCCCCCEEEEEEEEEEEEECCCCEEE
HFSTYGAFGGSGRTELETPELYDIEADPSEQFNIAAQHPEIVMELKVLAEKQAASVEPVE
EEEECCCCCCCCCCCCCCCCEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHH
NQLERYPPGEKRGEEGTRPWTADSE
HHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]