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The map label for this gene is dbh2 [H]

Identifier: 114331606

GI number: 114331606

Start: 1703415

End: 1704572

Strand: Direct

Name: dbh2 [H]

Synonym: Neut_1620

Alternate gene names: 114331606

Gene position: 1703415-1704572 (Clockwise)

Preceding gene: 114331603

Following gene: 114331607

Centisome position: 64.01

GC content: 47.67

Gene sequence:

>1158_bases
ATGAACATGAAAAATCGCCGCATCGCTCATCTGGATATGGATGCTTTTTATGCTTCGGTAGAACTGCTGCGTTATCCGGA
ATTACGAGGGTTGCCTGTCGTCATTGGTGGCCGATCCGTTCACCAACCAATCATGCAACAGAATGGAACTTGTTTATATG
CAAAGCTGCGCGAATATTCCGGTCGTGGCGTAGTAACAACTTCAACTTACGAAGCGCGTGCATACGGAATTTTTTCAGCG
ATGGGGATCATGCAGGCGGCAAAGCTGGCACCCGACGCCATATTGTTACCAGCAGATTTCGATACTTATCATCATTATTC
GCGGTTATTTAAAAATGCAGTCGCTAACATCGCTCCGCATATAGAAGATCGTGGTATCGATGAAATTTATATCGACCTGA
GCAAACATCCCGATGAAACAACTCCACTTGCACTGCGTATCAAACAGGCGGTACATGAAACCACTGGGTTATCCTGCTCG
ATTGGAGTAGCTCCCAACAAACTGCTGGCAAAAATCTGCTCTGATCTCGAAAAACCGAATGGATTGACTATCCTGACACA
TGCTGATATCCCACATCGAATCTGGCCTTTACCCGTTCATAAAATCAATGGCATTGGCCCCAAAACGCAAGCGAAACTCG
CAGATCTGGGTATCCATAAAATTGGAGAGTTAGCCAATGCTGAGCCCGGTTTGCTCCAGATTCACTTTGGTCAGCGTTAC
GCACTGCAGTTGCATCACGCAGCACTTGGCAACGACAATCGTCCGGTGGTAACCAGCTCGGAACCCAAATCAATCAGCCG
CGAAACTACCTTTGAACGAGATTTGCACGCACGCCAGGATCGGGAAAAACTATCCGCTATTTTTACCGGATTATGCACAC
ATATTGCGGAAGATTTGCATCACAAAGGCTATGTCGGGCGAACTATCGGCATCAAGCTACGATATGAAGATTTTCAAACC
GTCACACGCGATCAAACTTTATGTACCCCCACCGCTGATGCAACCACCATTCGCAAGGCTGCTGGAAACTGCCTTCGGCG
CGTTCCCCTCGAACAAAAACTGAGATTGCTCGGCGTTCGTGCCAGCAACCTGTCCCGAGCTGATGAACTCATGAAAGAAA
GCCATCTTTTCCAGGAAGAACTGTTTTGTAGCCGATAG

Upstream 100 bases:

>100_bases
ATTTCGCCAGTACAGCTTGGGCAGCCGGCCCGATTATTTTCACAGCCAGTGATTACAGCTTTTTTATACACTGGAATCTG
CTCAAAAACATTCTTGCTTC

Downstream 100 bases:

>100_bases
AAAGTCTATATTCCGTAAATTTATCTGCAGAATATCCCCTGAAAATCCCTGTGAGTTCACTAAACATCTAGAACACCCTA
TTGATTCTCACCCGCCATAT

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: Pol IV 2 [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MNMKNRRIAHLDMDAFYASVELLRYPELRGLPVVIGGRSVHQPIMQQNGTCLYAKLREYSGRGVVTTSTYEARAYGIFSA
MGIMQAAKLAPDAILLPADFDTYHHYSRLFKNAVANIAPHIEDRGIDEIYIDLSKHPDETTPLALRIKQAVHETTGLSCS
IGVAPNKLLAKICSDLEKPNGLTILTHADIPHRIWPLPVHKINGIGPKTQAKLADLGIHKIGELANAEPGLLQIHFGQRY
ALQLHHAALGNDNRPVVTSSEPKSISRETTFERDLHARQDREKLSAIFTGLCTHIAEDLHHKGYVGRTIGIKLRYEDFQT
VTRDQTLCTPTADATTIRKAAGNCLRRVPLEQKLRLLGVRASNLSRADELMKESHLFQEELFCSR

Sequences:

>Translated_385_residues
MNMKNRRIAHLDMDAFYASVELLRYPELRGLPVVIGGRSVHQPIMQQNGTCLYAKLREYSGRGVVTTSTYEARAYGIFSA
MGIMQAAKLAPDAILLPADFDTYHHYSRLFKNAVANIAPHIEDRGIDEIYIDLSKHPDETTPLALRIKQAVHETTGLSCS
IGVAPNKLLAKICSDLEKPNGLTILTHADIPHRIWPLPVHKINGIGPKTQAKLADLGIHKIGELANAEPGLLQIHFGQRY
ALQLHHAALGNDNRPVVTSSEPKSISRETTFERDLHARQDREKLSAIFTGLCTHIAEDLHHKGYVGRTIGIKLRYEDFQT
VTRDQTLCTPTADATTIRKAAGNCLRRVPLEQKLRLLGVRASNLSRADELMKESHLFQEELFCSR
>Mature_385_residues
MNMKNRRIAHLDMDAFYASVELLRYPELRGLPVVIGGRSVHQPIMQQNGTCLYAKLREYSGRGVVTTSTYEARAYGIFSA
MGIMQAAKLAPDAILLPADFDTYHHYSRLFKNAVANIAPHIEDRGIDEIYIDLSKHPDETTPLALRIKQAVHETTGLSCS
IGVAPNKLLAKICSDLEKPNGLTILTHADIPHRIWPLPVHKINGIGPKTQAKLADLGIHKIGELANAEPGLLQIHFGQRY
ALQLHHAALGNDNRPVVTSSEPKSISRETTFERDLHARQDREKLSAIFTGLCTHIAEDLHHKGYVGRTIGIKLRYEDFQT
VTRDQTLCTPTADATTIRKAAGNCLRRVPLEQKLRLLGVRASNLSRADELMKESHLFQEELFCSR

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI154350220, Length=336, Percent_Identity=27.0833333333333, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI84043967, Length=341, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI7706681, Length=342, Percent_Identity=26.9005847953216, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI7705344, Length=229, Percent_Identity=33.1877729257642, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI5729982, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786425, Length=323, Percent_Identity=33.1269349845201, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787432, Length=237, Percent_Identity=24.8945147679325, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193205700, Length=236, Percent_Identity=33.0508474576271, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193205702, Length=236, Percent_Identity=33.0508474576271, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19923006, Length=429, Percent_Identity=26.1072261072261, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21355641, Length=356, Percent_Identity=28.6516853932584, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24644984, Length=356, Percent_Identity=28.6516853932584, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 42983; Mature: 42983

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKNRRIAHLDMDAFYASVELLRYPELRGLPVVIGGRSVHQPIMQQNGTCLYAKLREYS
CCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCEEEEEHHHCC
GRGVVTTSTYEARAYGIFSAMGIMQAAKLAPDAILLPADFDTYHHYSRLFKNAVANIAPH
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCC
IEDRGIDEIYIDLSKHPDETTPLALRIKQAVHETTGLSCSIGVAPNKLLAKICSDLEKPN
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCC
GLTILTHADIPHRIWPLPVHKINGIGPKTQAKLADLGIHKIGELANAEPGLLQIHFGQRY
CEEEEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEE
ALQLHHAALGNDNRPVVTSSEPKSISRETTFERDLHARQDREKLSAIFTGLCTHIAEDLH
EEEEEHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKGYVGRTIGIKLRYEDFQTVTRDQTLCTPTADATTIRKAAGNCLRRVPLEQKLRLLGVR
HCCCCCEEEEEEEEEHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC
ASNLSRADELMKESHLFQEELFCSR
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMKNRRIAHLDMDAFYASVELLRYPELRGLPVVIGGRSVHQPIMQQNGTCLYAKLREYS
CCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCEEEEEHHHCC
GRGVVTTSTYEARAYGIFSAMGIMQAAKLAPDAILLPADFDTYHHYSRLFKNAVANIAPH
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCC
IEDRGIDEIYIDLSKHPDETTPLALRIKQAVHETTGLSCSIGVAPNKLLAKICSDLEKPN
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCC
GLTILTHADIPHRIWPLPVHKINGIGPKTQAKLADLGIHKIGELANAEPGLLQIHFGQRY
CEEEEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEE
ALQLHHAALGNDNRPVVTSSEPKSISRETTFERDLHARQDREKLSAIFTGLCTHIAEDLH
EEEEEHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKGYVGRTIGIKLRYEDFQTVTRDQTLCTPTADATTIRKAAGNCLRRVPLEQKLRLLGVR
HCCCCCEEEEEEEEEHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC
ASNLSRADELMKESHLFQEELFCSR
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]