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The map label for this gene is cbbA [H]

Identifier: 114331568

GI number: 114331568

Start: 1661502

End: 1662566

Strand: Direct

Name: cbbA [H]

Synonym: Neut_1581

Alternate gene names: 114331568

Gene position: 1661502-1662566 (Clockwise)

Preceding gene: 114331567

Following gene: 114331569

Centisome position: 62.44

GC content: 48.45

Gene sequence:

>1065_bases
ATGGCACTTGTATCTTTACGCCAGTTACTGGATCATGCAGCTGAAAACGGATATGGGCTTCCGGCTTTTAATGTAAACAA
CCTTGAACAAATTCATGCAATTATGCAGGCGGCTGATGAATGTGATAGCCCGGTAATCATGCAAGGATCGGCTGGCGCCC
GCAAGTATGCTGGTGAAGCATTCCTGCGCCATCTGATTGCCGCAGCAGTTGAAGCCTATCCCCATATTCCGGTTGTAATG
CACCAGGATCATGGCGCCTCACCTTCTGTGTGTATTAATGCCATTCGCAGCGGTTTCTCCAGCGTGATGATGGATGGATC
GCTTGAAGAGGACGGAAAAACGCCTTCATCATTTGAATATAACGTGGATGTCACTGCCAGAGTAGTCGCTATGGCACATG
CTGTAGGCGTTTCCGTGGAGGGCGAGCTAGGTTGCCTGGGATCTCTGGAATCTGGTCAGGGCGAAGCTGAGGATGGCCAC
GGTGCTGAAGGACAACTTTCACATGATCAGTTGCTGACTGATCCTGAAGAAGCTGCCGAGTTCGTCAGAAGAACCGGTGT
GGATGCGCTAGCAATTGCCATCGGTACTTCTCACGGTGCGTATAAATTTACCCGAAAACCCACAGGTGATATCCTCGCCA
TTGAGCGGATCAAAGAAATTCACCAGAGAATTCCCAATACCCATCTGGTTATGCACGGATCCAGTTCCGTTCCTCAGGAA
TGGCTAGAAATCATCCGTGAATATGGTGGTGAAATGAAAGAAACCTATGGTGTACCTGTAGAAGAAATTCAGCAGGGTAT
CAAGTATGGTGTGCGTAAAGTCAATATCGATACGGATATCCGTTTGGCCATGACTGGTGCAATTCGTCGTCATCTGGCCA
GAAACAAAAGCGAGTTTGATCCGCGTAAATTCCTGAAAGATGCCACTGTTGCTGCTAAAGATATCTGCAAAGCACGTTTC
GAAGCATTTGGCTCCGCGGGTCAAGCTGGCAAGATCAAGCCAATCTCGCTGGAAACTATGGCAAACCGTTACCTGAGCGG
CGAACTAAAAGCAATTGTAAAGTAA

Upstream 100 bases:

>100_bases
CCTACAAACAGATTAGCGTATCGGCTTATACACCCGTAAGAACATGAAGTTTGGTTTCATCAGAAAATAAACATATTAAT
TTTATATAAAGGAGACTTGA

Downstream 100 bases:

>100_bases
TCTAAAAACGGGCTAATCCCCAAAGTGCCCCACAAATTCCTGGAAAGATATTCAAATCGGGGATGTGGGGCACTTTTTAT
TCACATCACTAATCAGTGAG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEAFLRHLIAAAVEAYPHIPVVM
HQDHGASPSVCINAIRSGFSSVMMDGSLEEDGKTPSSFEYNVDVTARVVAMAHAVGVSVEGELGCLGSLESGQGEAEDGH
GAEGQLSHDQLLTDPEEAAEFVRRTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHQRIPNTHLVMHGSSSVPQE
WLEIIREYGGEMKETYGVPVEEIQQGIKYGVRKVNIDTDIRLAMTGAIRRHLARNKSEFDPRKFLKDATVAAKDICKARF
EAFGSAGQAGKIKPISLETMANRYLSGELKAIVK

Sequences:

>Translated_354_residues
MALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEAFLRHLIAAAVEAYPHIPVVM
HQDHGASPSVCINAIRSGFSSVMMDGSLEEDGKTPSSFEYNVDVTARVVAMAHAVGVSVEGELGCLGSLESGQGEAEDGH
GAEGQLSHDQLLTDPEEAAEFVRRTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHQRIPNTHLVMHGSSSVPQE
WLEIIREYGGEMKETYGVPVEEIQQGIKYGVRKVNIDTDIRLAMTGAIRRHLARNKSEFDPRKFLKDATVAAKDICKARF
EAFGSAGQAGKIKPISLETMANRYLSGELKAIVK
>Mature_353_residues
ALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEAFLRHLIAAAVEAYPHIPVVMH
QDHGASPSVCINAIRSGFSSVMMDGSLEEDGKTPSSFEYNVDVTARVVAMAHAVGVSVEGELGCLGSLESGQGEAEDGHG
AEGQLSHDQLLTDPEEAAEFVRRTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHQRIPNTHLVMHGSSSVPQEW
LEIIREYGGEMKETYGVPVEEIQQGIKYGVRKVNIDTDIRLAMTGAIRRHLARNKSEFDPRKFLKDATVAAKDICKARFE
AFGSAGQAGKIKPISLETMANRYLSGELKAIVK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=331, Percent_Identity=33.8368580060423, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=33.434650455927, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1788072, Length=331, Percent_Identity=30.5135951661631, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789293, Length=352, Percent_Identity=25, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=370, Percent_Identity=26.7567567567568, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38288; Mature: 38157

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEA
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
FLRHLIAAAVEAYPHIPVVMHQDHGASPSVCINAIRSGFSSVMMDGSLEEDGKTPSSFEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVDVTARVVAMAHAVGVSVEGELGCLGSLESGQGEAEDGHGAEGQLSHDQLLTDPEEAAE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVRRTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHQRIPNTHLVMHGSSSVPQE
HHHHCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLEIIREYGGEMKETYGVPVEEIQQGIKYGVRKVNIDTDIRLAMTGAIRRHLARNKSEFD
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRKFLKDATVAAKDICKARFEAFGSAGQAGKIKPISLETMANRYLSGELKAIVK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
ALVSLRQLLDHAAENGYGLPAFNVNNLEQIHAIMQAADECDSPVIMQGSAGARKYAGEA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
FLRHLIAAAVEAYPHIPVVMHQDHGASPSVCINAIRSGFSSVMMDGSLEEDGKTPSSFEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVDVTARVVAMAHAVGVSVEGELGCLGSLESGQGEAEDGHGAEGQLSHDQLLTDPEEAAE
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHH
FVRRTGVDALAIAIGTSHGAYKFTRKPTGDILAIERIKEIHQRIPNTHLVMHGSSSVPQE
HHHHCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLEIIREYGGEMKETYGVPVEEIQQGIKYGVRKVNIDTDIRLAMTGAIRRHLARNKSEFD
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PRKFLKDATVAAKDICKARFEAFGSAGQAGKIKPISLETMANRYLSGELKAIVK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]