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The map label for this gene is tkt1 [H]

Identifier: 114331564

GI number: 114331564

Start: 1655283

End: 1657301

Strand: Direct

Name: tkt1 [H]

Synonym: Neut_1577

Alternate gene names: 114331564

Gene position: 1655283-1657301 (Clockwise)

Preceding gene: 114331554

Following gene: 114331565

Centisome position: 62.2

GC content: 47.25

Gene sequence:

>2019_bases
ATGAAGGAAGCATTCAACGACTTTGGTGCACCAGTATTCAATAATTTGACCAGTGCAATTCGCGCATTGGCCATGGATGC
AGTCCAGAAAGCCAATTCCGGTCACCCGGGCATGCCAATGGGTATGGCAGAAATTGCAGAAGTGTTATGGATTCACCACA
TGCGCCACAATCCGGCAAACCCCGAGTGGGCAGACCGTGATCGTTTTGTATTATCAAACGGGCATGGCTCCATGCTGATA
TATGCGCTGCTCCACCTCACTGGTTATGATCTGTCCATTGAAGATATAAAAAATTTCCGGCAGCTTCATTCAAAAACTCC
CGGACATCCTGAGTATGGTTATACCCCAGGCGTTGAAACTACAACAGGGCCGCTGGGGCAAGGCCTTACCAATGCTGTCG
GTATGGCACTGGCCGAAAAAATTCTGGCGGAAGAATTCAACCGGCCTTATTTCCCGATCATGGATCATCACACCTATGTA
TTTCTGGGGGACGGTTGCCTGATGGAAGGCATTTCACATGAGGCTTGTTCGCTGGCAGGAACACTGCAATTAGGCAAGCT
AATTTGCTTTTACGATGATAACGGCATCTCAATTGACGGGCATGTCGAAGGATGGTTTACAGACAACACTCCGAAACGTT
TCGAATCTTATGGCTGGCATGTTGTTCCAAATGTTAATGGGCACGACCCCGTGGCAATACAAGCAGCCATTGAAACAGCC
AAGAAAGTACAGGACAAGCCCACACTGATCTGCTGTAAAACAGTAATCGGGATGGGTTCACCCAATAAGGCCAACACCAG
CTCCATTCACGGAGCGGCACTCGGAAAAGATGAAATTGCTGCTGCCCGTCCTCATATTGGCTGGAATTATCTGCCGTTTG
AAATTCCACAAGAAGTTTATGATGCATGGGATGCCCGTACCAAAGGCCAGGCGTTGGAGTCCGCCTGGAACACCATGTTC
GCGGAATACAGCAAAAAATACCCTGCCGAAGCTGTCGAATTTACTCGCAGAATGGCCGGTGAGTTACCTATCAAATGGGT
TGATCATGTTGAGGGAATTATCAGTCAGATTAACGCCAGAGAAGAAAGTATCGCTACCAGAAAAGCATCACAAAATTCAA
TTGAGGCGCTAGCGCCGGTACTGCCCGAGCTGATCGGTGGATCAGCCGATCTCACTGGCTCCAATCTCACCATGTGGTCA
GGATCCAAAGTAACCAGCGGCAATACTACTGGAAATTATATTCACTACGGTGTACGGGAATTCGGTATGAGTGCAATCAT
GAACGGCCTGTCACTGCATGGCGGAATTATCCCCTACGGTGGAACCTTCCTGATGTTTTCAGAATATGCCAGAAATGCCT
TACGTATGGCAGCATTAATGAAAATTCGCAATATTTTTGTATTTACCCATGATTCAATCGGGCTGGGTGAGGATGGACCA
ACTCATCAACCGGTTGAACAAACCGCCACATTACGCATGGCCCCCAATATGGATGTATGGCGCCCATGTGATACAGTTGA
ATCTATCGTTTCATGGGTGGCTGCTATAGAACGCAGAGAAGGCCCCACGTCTCTCATATTCAGCCGCCAGAATCTGCCTT
TCCAGAAACGAGATGCAGCAACGATCAGCCTGATTAAGAAAGGAGGATACATTCTTTCTGAAGCAGCAAATGGAAACCCG
CGAGTAATTATCATAGCAACTGGCTCAGAAGTTGGACTTGCAATGGGCGCACAGAAGGTTCTAGCTGAAAACGGTGTTGC
AGTACGTGTTGTATCAATGCCCTGTACCAATATTTTTGATAAACAGGATCTGGCGTACCGGGATAGTGTCTTGCCAAAGG
GAATTAGACGCGTGGCTGTAGAGGCCGGTGTAACCGATTTCTGGCGTAAATACGTCGGACTTGAAGGAGAAGTGGTTGGA
ATCGATAAATTCGGTGAATCAGCTCCTGCAGAAGAATTATTCGAATATTTTGGCTTTACTGTTGAAAATGTCGTAAACGC
GGTAAAAAGAATTATATAA

Upstream 100 bases:

>100_bases
AGAGATAATGGCCTCTTTTGCCGGTTTTTGTTGGTCATCATGTGGTGCATCACATTGCGGGCGGCAGTTTCAGTTTTTGA
ATAATCGAGGACGAGAGCAA

Downstream 100 bases:

>100_bases
ACGCGGAAAGTTCTTTTCTTGTCTGCAAAACAGGTTTTTAGTAAAAAATACGGAGATAAAGGGATGGCAATTAGAGTTGG
CATTAATGGTTTTGGTCGTA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MKEAFNDFGAPVFNNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHMRHNPANPEWADRDRFVLSNGHGSMLI
YALLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQGLTNAVGMALAEKILAEEFNRPYFPIMDHHTYV
FLGDGCLMEGISHEACSLAGTLQLGKLICFYDDNGISIDGHVEGWFTDNTPKRFESYGWHVVPNVNGHDPVAIQAAIETA
KKVQDKPTLICCKTVIGMGSPNKANTSSIHGAALGKDEIAAARPHIGWNYLPFEIPQEVYDAWDARTKGQALESAWNTMF
AEYSKKYPAEAVEFTRRMAGELPIKWVDHVEGIISQINAREESIATRKASQNSIEALAPVLPELIGGSADLTGSNLTMWS
GSKVTSGNTTGNYIHYGVREFGMSAIMNGLSLHGGIIPYGGTFLMFSEYARNALRMAALMKIRNIFVFTHDSIGLGEDGP
THQPVEQTATLRMAPNMDVWRPCDTVESIVSWVAAIERREGPTSLIFSRQNLPFQKRDAATISLIKKGGYILSEAANGNP
RVIIIATGSEVGLAMGAQKVLAENGVAVRVVSMPCTNIFDKQDLAYRDSVLPKGIRRVAVEAGVTDFWRKYVGLEGEVVG
IDKFGESAPAEELFEYFGFTVENVVNAVKRII

Sequences:

>Translated_672_residues
MKEAFNDFGAPVFNNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHMRHNPANPEWADRDRFVLSNGHGSMLI
YALLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQGLTNAVGMALAEKILAEEFNRPYFPIMDHHTYV
FLGDGCLMEGISHEACSLAGTLQLGKLICFYDDNGISIDGHVEGWFTDNTPKRFESYGWHVVPNVNGHDPVAIQAAIETA
KKVQDKPTLICCKTVIGMGSPNKANTSSIHGAALGKDEIAAARPHIGWNYLPFEIPQEVYDAWDARTKGQALESAWNTMF
AEYSKKYPAEAVEFTRRMAGELPIKWVDHVEGIISQINAREESIATRKASQNSIEALAPVLPELIGGSADLTGSNLTMWS
GSKVTSGNTTGNYIHYGVREFGMSAIMNGLSLHGGIIPYGGTFLMFSEYARNALRMAALMKIRNIFVFTHDSIGLGEDGP
THQPVEQTATLRMAPNMDVWRPCDTVESIVSWVAAIERREGPTSLIFSRQNLPFQKRDAATISLIKKGGYILSEAANGNP
RVIIIATGSEVGLAMGAQKVLAENGVAVRVVSMPCTNIFDKQDLAYRDSVLPKGIRRVAVEAGVTDFWRKYVGLEGEVVG
IDKFGESAPAEELFEYFGFTVENVVNAVKRII
>Mature_672_residues
MKEAFNDFGAPVFNNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHMRHNPANPEWADRDRFVLSNGHGSMLI
YALLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQGLTNAVGMALAEKILAEEFNRPYFPIMDHHTYV
FLGDGCLMEGISHEACSLAGTLQLGKLICFYDDNGISIDGHVEGWFTDNTPKRFESYGWHVVPNVNGHDPVAIQAAIETA
KKVQDKPTLICCKTVIGMGSPNKANTSSIHGAALGKDEIAAARPHIGWNYLPFEIPQEVYDAWDARTKGQALESAWNTMF
AEYSKKYPAEAVEFTRRMAGELPIKWVDHVEGIISQINAREESIATRKASQNSIEALAPVLPELIGGSADLTGSNLTMWS
GSKVTSGNTTGNYIHYGVREFGMSAIMNGLSLHGGIIPYGGTFLMFSEYARNALRMAALMKIRNIFVFTHDSIGLGEDGP
THQPVEQTATLRMAPNMDVWRPCDTVESIVSWVAAIERREGPTSLIFSRQNLPFQKRDAATISLIKKGGYILSEAANGNP
RVIIIATGSEVGLAMGAQKVLAENGVAVRVVSMPCTNIFDKQDLAYRDSVLPKGIRRVAVEAGVTDFWRKYVGLEGEVVG
IDKFGESAPAEELFEYFGFTVENVVNAVKRII

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=680, Percent_Identity=26.0294117647059, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI4507521, Length=680, Percent_Identity=26.0294117647059, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI133778974, Length=678, Percent_Identity=24.9262536873156, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI225637459, Length=694, Percent_Identity=22.1902017291066, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI225637461, Length=651, Percent_Identity=21.8125960061444, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI225637463, Length=647, Percent_Identity=21.6383307573416, Blast_Score=100, Evalue=5e-21,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=66.6666666666667, Blast_Score=943, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=660, Percent_Identity=62.7272727272727, Blast_Score=885, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=677, Percent_Identity=24.6676514032496, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=50.3003003003003, Blast_Score=626, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=46.3378176382661, Blast_Score=579, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24666278, Length=593, Percent_Identity=24.6205733558179, Blast_Score=133, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45551847, Length=281, Percent_Identity=32.7402135231317, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45550715, Length=281, Percent_Identity=32.7402135231317, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24645119, Length=246, Percent_Identity=32.9268292682927, Blast_Score=103, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73568; Mature: 73568

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAFNDFGAPVFNNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHMRHNPAN
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
PEWADRDRFVLSNGHGSMLIYALLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVET
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TTGPLGQGLTNAVGMALAEKILAEEFNRPYFPIMDHHTYVFLGDGCLMEGISHEACSLAG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEEEECCCHHHHCCCHHHHHHHH
TLQLGKLICFYDDNGISIDGHVEGWFTDNTPKRFESYGWHVVPNVNGHDPVAIQAAIETA
HEEECCEEEEECCCCEEECCCEEEEECCCCCHHHHHCCCEEECCCCCCCCEEHHHHHHHH
KKVQDKPTLICCKTVIGMGSPNKANTSSIHGAALGKDEIAAARPHIGWNYLPFEIPQEVY
HHHCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHH
DAWDARTKGQALESAWNTMFAEYSKKYPAEAVEFTRRMAGELPIKWVDHVEGIISQINAR
HHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
EESIATRKASQNSIEALAPVLPELIGGSADLTGSNLTMWSGSKVTSGNTTGNYIHYGVRE
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECCCCCCCCEEEHHHHH
FGMSAIMNGLSLHGGIIPYGGTFLMFSEYARNALRMAALMKIRNIFVFTHDSIGLGEDGP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCC
THQPVEQTATLRMAPNMDVWRPCDTVESIVSWVAAIERREGPTSLIFSRQNLPFQKRDAA
CCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHH
TISLIKKGGYILSEAANGNPRVIIIATGSEVGLAMGAQKVLAENGVAVRVVSMPCTNIFD
HHHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
KQDLAYRDSVLPKGIRRVAVEAGVTDFWRKYVGLEGEVVGIDKFGESAPAEELFEYFGFT
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEHHCCCCCCCHHHHHHHHCCC
VENVVNAVKRII
HHHHHHHHHHHC
>Mature Secondary Structure
MKEAFNDFGAPVFNNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHMRHNPAN
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
PEWADRDRFVLSNGHGSMLIYALLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVET
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
TTGPLGQGLTNAVGMALAEKILAEEFNRPYFPIMDHHTYVFLGDGCLMEGISHEACSLAG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCEEEEECCCHHHHCCCHHHHHHHH
TLQLGKLICFYDDNGISIDGHVEGWFTDNTPKRFESYGWHVVPNVNGHDPVAIQAAIETA
HEEECCEEEEECCCCEEECCCEEEEECCCCCHHHHHCCCEEECCCCCCCCEEHHHHHHHH
KKVQDKPTLICCKTVIGMGSPNKANTSSIHGAALGKDEIAAARPHIGWNYLPFEIPQEVY
HHHCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHH
DAWDARTKGQALESAWNTMFAEYSKKYPAEAVEFTRRMAGELPIKWVDHVEGIISQINAR
HHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
EESIATRKASQNSIEALAPVLPELIGGSADLTGSNLTMWSGSKVTSGNTTGNYIHYGVRE
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECCCCCCCCEEEHHHHH
FGMSAIMNGLSLHGGIIPYGGTFLMFSEYARNALRMAALMKIRNIFVFTHDSIGLGEDGP
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCC
THQPVEQTATLRMAPNMDVWRPCDTVESIVSWVAAIERREGPTSLIFSRQNLPFQKRDAA
CCCCHHHCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHH
TISLIKKGGYILSEAANGNPRVIIIATGSEVGLAMGAQKVLAENGVAVRVVSMPCTNIFD
HHHHHHCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
KQDLAYRDSVLPKGIRRVAVEAGVTDFWRKYVGLEGEVVGIDKFGESAPAEELFEYFGFT
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEHHCCCCCCCHHHHHHHHCCC
VENVVNAVKRII
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]