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The map label for this gene is alr

Identifier: 114331518

GI number: 114331518

Start: 1601211

End: 1602296

Strand: Direct

Name: alr

Synonym: Neut_1531

Alternate gene names: 114331518

Gene position: 1601211-1602296 (Clockwise)

Preceding gene: 114331517

Following gene: 114331522

Centisome position: 60.17

GC content: 49.91

Gene sequence:

>1086_bases
ATGTATCGCCCGATTCGTGCTCTCATTGACTGTACTGCTTTACAGCACAACCTTTCTGTTGTCCGCAGCCACACTCGCCA
GGCTCGCATTATGGCTGTTGTCAAAGCCGATGCCTACGGCCATGGCTTGCTCCGTACCACACAAGCATTAAATACAGCGG
ATGGATTTGCTGTACTTGAGCTGGAAGCAGCGATCCAGCTAAGGGAAGCCGGATTTAATCAACCTGTTTTACTTCTGGAA
GGATTTTTCTCGGCAGAGGAGCTTGAGGCAATCGATCATTATCAGCTCAGTACGGTTATTCACAGTCATGAGCAGCTATC
ACTACTGCTGGCACACAGAAAGACAGGAAAACCGGATATCTACCTCAAGATCAATACTGGCATGAATCGCCTTGGTTTCA
GGCCTGAAGAAGAAAGTTACGTATTCAACAGAATCAGGCAATGGCGTTCAGATACCAGTATTACACTGATGACACATTTT
TCCTGTGCGGATGACGCTCTGGAAGCAGATCAAGTTAATCAGCAACTGGATCAGTTTGCAGCACTTCACGATGTAAAAGA
AAATAATCTACCCCAAACGCTAGCTAATTCTGCAGCAATTTTACGTTACCCCGGAACACATGCGGACTGGGTACGTCCTG
GTATAGTCCTCTACGGAGCATCGCCCCTGCCGGACAAAACAGGTATTGAACTGGGGTTACGGCCTGTCATGACACTGACC
AGCCAGATCATCGCTGTGCAACAGCTTGATCCATCAGACAGAGTAGGCTACGGCGGGCAGTTTATCGCAAACCAGCCAAT
GCGTATCGGAGTTGTTGCAGCCGGTTACGCAGATGGATATCCACGTCATGCCCCTACCGGAACCCCGGTACTGGTTAATG
GCCAGCGCACGCGGCTGGTCGGGCGTATTTCAATGGATATGCTAACTGTCGATCTGAACGGGATTAGCGAAGCCGGGGTG
GGAAGCCCGGTAACCCTCTGGGGAGAAGGACTACCGGTAGAAGAAGTTGCAAAATCGGCACAAACTATCAGTTACGAGCT
ACTGACAGCACTCTCTCCCAGAGTACCGAGCATCAGCATAAGCTAA

Upstream 100 bases:

>100_bases
GGAAAGGTAGCTGTGCTAGCAGTTGCTCATTACTATTTCCAGGGCGGCACCATCTGTAAACTGTTGATTCTTTTTCGATT
CCCTAACCTCAATTGTACAA

Downstream 100 bases:

>100_bases
TGATTACAGATTTTTTGTTAATACCTGATTATTCAACTTTGGCATTTTTACGCAACGACTCAACCACCGCTGCAAACTTG
CGCTGTAATACCCGCTGCTG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MYRPIRALIDCTALQHNLSVVRSHTRQARIMAVVKADAYGHGLLRTTQALNTADGFAVLELEAAIQLREAGFNQPVLLLE
GFFSAEELEAIDHYQLSTVIHSHEQLSLLLAHRKTGKPDIYLKINTGMNRLGFRPEEESYVFNRIRQWRSDTSITLMTHF
SCADDALEADQVNQQLDQFAALHDVKENNLPQTLANSAAILRYPGTHADWVRPGIVLYGASPLPDKTGIELGLRPVMTLT
SQIIAVQQLDPSDRVGYGGQFIANQPMRIGVVAAGYADGYPRHAPTGTPVLVNGQRTRLVGRISMDMLTVDLNGISEAGV
GSPVTLWGEGLPVEEVAKSAQTISYELLTALSPRVPSISIS

Sequences:

>Translated_361_residues
MYRPIRALIDCTALQHNLSVVRSHTRQARIMAVVKADAYGHGLLRTTQALNTADGFAVLELEAAIQLREAGFNQPVLLLE
GFFSAEELEAIDHYQLSTVIHSHEQLSLLLAHRKTGKPDIYLKINTGMNRLGFRPEEESYVFNRIRQWRSDTSITLMTHF
SCADDALEADQVNQQLDQFAALHDVKENNLPQTLANSAAILRYPGTHADWVRPGIVLYGASPLPDKTGIELGLRPVMTLT
SQIIAVQQLDPSDRVGYGGQFIANQPMRIGVVAAGYADGYPRHAPTGTPVLVNGQRTRLVGRISMDMLTVDLNGISEAGV
GSPVTLWGEGLPVEEVAKSAQTISYELLTALSPRVPSISIS
>Mature_361_residues
MYRPIRALIDCTALQHNLSVVRSHTRQARIMAVVKADAYGHGLLRTTQALNTADGFAVLELEAAIQLREAGFNQPVLLLE
GFFSAEELEAIDHYQLSTVIHSHEQLSLLLAHRKTGKPDIYLKINTGMNRLGFRPEEESYVFNRIRQWRSDTSITLMTHF
SCADDALEADQVNQQLDQFAALHDVKENNLPQTLANSAAILRYPGTHADWVRPGIVLYGASPLPDKTGIELGLRPVMTLT
SQIIAVQQLDPSDRVGYGGQFIANQPMRIGVVAAGYADGYPRHAPTGTPVLVNGQRTRLVGRISMDMLTVDLNGISEAGV
GSPVTLWGEGLPVEEVAKSAQTISYELLTALSPRVPSISIS

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=361, Percent_Identity=50.415512465374, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1790487, Length=350, Percent_Identity=44.8571428571429, Blast_Score=308, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_NITEC (Q0AFV7)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747740.1
- ProteinModelPortal:   Q0AFV7
- SMR:   Q0AFV7
- STRING:   Q0AFV7
- GeneID:   4273404
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1531
- NMPDR:   fig|335283.3.peg.1813
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   GTHADWV
- PhylomeDB:   Q0AFV7
- ProtClustDB:   CLSK585733
- BioCyc:   NEUT335283:NEUT_1531-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39543; Mature: 39543

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRPIRALIDCTALQHNLSVVRSHTRQARIMAVVKADAYGHGLLRTTQALNTADGFAVLE
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEE
LEAAIQLREAGFNQPVLLLEGFFSAEELEAIDHYQLSTVIHSHEQLSLLLAHRKTGKPDI
EHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
YLKINTGMNRLGFRPEEESYVFNRIRQWRSDTSITLMTHFSCADDALEADQVNQQLDQFA
EEEECCCCHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
ALHDVKENNLPQTLANSAAILRYPGTHADWVRPGIVLYGASPLPDKTGIELGLRPVMTLT
HHHHHHCCCCCHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHH
SQIIAVQQLDPSDRVGYGGQFIANQPMRIGVVAAGYADGYPRHAPTGTPVLVNGQRTRLV
HHHHEEEECCCCCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCEEECCCCEEEE
GRISMDMLTVDLNGISEAGVGSPVTLWGEGLPVEEVAKSAQTISYELLTALSPRVPSISI
EEEEEEEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEC
S
C
>Mature Secondary Structure
MYRPIRALIDCTALQHNLSVVRSHTRQARIMAVVKADAYGHGLLRTTQALNTADGFAVLE
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHCCCCCEEEEE
LEAAIQLREAGFNQPVLLLEGFFSAEELEAIDHYQLSTVIHSHEQLSLLLAHRKTGKPDI
EHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
YLKINTGMNRLGFRPEEESYVFNRIRQWRSDTSITLMTHFSCADDALEADQVNQQLDQFA
EEEECCCCHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
ALHDVKENNLPQTLANSAAILRYPGTHADWVRPGIVLYGASPLPDKTGIELGLRPVMTLT
HHHHHHCCCCCHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHH
SQIIAVQQLDPSDRVGYGGQFIANQPMRIGVVAAGYADGYPRHAPTGTPVLVNGQRTRLV
HHHHEEEECCCCCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCEEECCCCEEEE
GRISMDMLTVDLNGISEAGVGSPVTLWGEGLPVEEVAKSAQTISYELLTALSPRVPSISI
EEEEEEEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA