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The map label for this gene is pyrH

Identifier: 113477238

GI number: 113477238

Start: 5808783

End: 5809517

Strand: Reverse

Name: pyrH

Synonym: Tery_3779

Alternate gene names: 113477238

Gene position: 5809517-5808783 (Counterclockwise)

Preceding gene: 113477239

Following gene: 113477237

Centisome position: 74.96

GC content: 43.81

Gene sequence:

>735_bases
ATGAGGAAAATTTATCAACGGGTTTTGCTCAAGTTAAGTGGCGAAGCCTTGATGGGTAGTCTGGGCTATGGCATTGACCC
AGCGGTAGTCCAAGGTATTGCTCAGGAAGTGGCCGAAGTTGCGGCCACAGGAATCCAAATAGCAATTGTTGTTGGAGGCG
GTAATATTTTTAGAGGGGTGAAAGCAGCCTCTAAGGGAATGGACAGGGCCACAGCAGATTATGTTGGTATGATTGCCACT
GTGATGAATGCTATCACTTTACAGGACGCTCTAGAACAAGTAGGGGTACCAACAAGGGTCCAAACAGCGATTGCTATGCA
GGAATTGGCCGAACCTTATATTCGTCGCCGAGCCATTCGCCATCTAGAAAAAGGTCGAGTGGTAGTTTTTGGTGCAGGTT
CTGGTAATCCATTTTTTACTACTGACACTACTGCTGCTCTGAGGGCAGCAGAAATTGAGGCAGAGGTAATTTTTAAGGCT
ACCAAAGTCGATGGGGTCTATGATTCTGACCCACATAAGAATCAAGAGGCCAAACGGTACGAGTCCCTAAGTTATGGGGA
AGTATTAACTCTAGATTTACGGGTGATGGATAGTACGGCGATCGCTCTTTGTAAAGAAAATAATATCCCAATTATTGTAT
TTAACCTTTCAGTTTCGGGTAATATCTGTAAAGCTGTTATGGGAGAAAAAATTGGAACTATTGTAGGAGGTTTTCATGAA
TCTAAAAGAAGCTGA

Upstream 100 bases:

>100_bases
CAATCTGCTGTAATTATCAAAAATTTTAAGATACTTAAAAAAAGTAACTCAACTGGTATCGTATTGTGGAAGCAACTTTA
GTTGAGAAAGCATTCACATT

Downstream 100 bases:

>100_bases
AGAGAAAATGCAAAAAGCTATTGAAGCGACTAAAAATTCCTTCAATACTGTTAGAACTGGAAGAGCTAATGCTTCTCTTT
TGGACAGAGTAATGGTGGAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MRKIYQRVLLKLSGEALMGSLGYGIDPAVVQGIAQEVAEVAATGIQIAIVVGGGNIFRGVKAASKGMDRATADYVGMIAT
VMNAITLQDALEQVGVPTRVQTAIAMQELAEPYIRRRAIRHLEKGRVVVFGAGSGNPFFTTDTTAALRAAEIEAEVIFKA
TKVDGVYDSDPHKNQEAKRYESLSYGEVLTLDLRVMDSTAIALCKENNIPIIVFNLSVSGNICKAVMGEKIGTIVGGFHE
SKRS

Sequences:

>Translated_244_residues
MRKIYQRVLLKLSGEALMGSLGYGIDPAVVQGIAQEVAEVAATGIQIAIVVGGGNIFRGVKAASKGMDRATADYVGMIAT
VMNAITLQDALEQVGVPTRVQTAIAMQELAEPYIRRRAIRHLEKGRVVVFGAGSGNPFFTTDTTAALRAAEIEAEVIFKA
TKVDGVYDSDPHKNQEAKRYESLSYGEVLTLDLRVMDSTAIALCKENNIPIIVFNLSVSGNICKAVMGEKIGTIVGGFHE
SKRS
>Mature_244_residues
MRKIYQRVLLKLSGEALMGSLGYGIDPAVVQGIAQEVAEVAATGIQIAIVVGGGNIFRGVKAASKGMDRATADYVGMIAT
VMNAITLQDALEQVGVPTRVQTAIAMQELAEPYIRRRAIRHLEKGRVVVFGAGSGNPFFTTDTTAALRAAEIEAEVIFKA
TKVDGVYDSDPHKNQEAKRYESLSYGEVLTLDLRVMDSTAIALCKENNIPIIVFNLSVSGNICKAVMGEKIGTIVGGFHE
SKRS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=48.2905982905983, Blast_Score=240, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_TRIEI (Q10Y48)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_723299.1
- ProteinModelPortal:   Q10Y48
- SMR:   Q10Y48
- STRING:   Q10Y48
- GeneID:   4243727
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_3779
- NMPDR:   fig|203124.1.peg.996
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q10Y48
- ProtClustDB:   PRK00358
- BioCyc:   TERY203124:TERY_3779-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26133; Mature: 26133

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: BINDING 53-53 BINDING 54-54 BINDING 58-58 BINDING 73-73 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIYQRVLLKLSGEALMGSLGYGIDPAVVQGIAQEVAEVAATGIQIAIVVGGGNIFRGV
CHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHH
KAASKGMDRATADYVGMIATVMNAITLQDALEQVGVPTRVQTAIAMQELAEPYIRRRAIR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
HLEKGRVVVFGAGSGNPFFTTDTTAALRAAEIEAEVIFKATKVDGVYDSDPHKNQEAKRY
HHHCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHH
ESLSYGEVLTLDLRVMDSTAIALCKENNIPIIVFNLSVSGNICKAVMGEKIGTIVGGFHE
HCCCCCCEEEEEEEEECCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHH
SKRS
CCCC
>Mature Secondary Structure
MRKIYQRVLLKLSGEALMGSLGYGIDPAVVQGIAQEVAEVAATGIQIAIVVGGGNIFRGV
CHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHH
KAASKGMDRATADYVGMIATVMNAITLQDALEQVGVPTRVQTAIAMQELAEPYIRRRAIR
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
HLEKGRVVVFGAGSGNPFFTTDTTAALRAAEIEAEVIFKATKVDGVYDSDPHKNQEAKRY
HHHCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHH
ESLSYGEVLTLDLRVMDSTAIALCKENNIPIIVFNLSVSGNICKAVMGEKIGTIVGGFHE
HCCCCCCEEEEEEEEECCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHH
SKRS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA