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The map label for this gene is lgrC [H]

Identifier: 113476538

GI number: 113476538

Start: 4614966

End: 4618961

Strand: Reverse

Name: lgrC [H]

Synonym: Tery_2968

Alternate gene names: 113476538

Gene position: 4618961-4614966 (Counterclockwise)

Preceding gene: 113476539

Following gene: 113476537

Centisome position: 59.6

GC content: 35.71

Gene sequence:

>3996_bases
ATGAATTATCAAGGTATTTCTACTTTAATATCTCCTTCTACCTCTCACATACAGCAAGCAAATTGGTTTCTGTATAAGTT
CAACCCAACGGGTCTAGCAGATAAAATATCTATAGCAATTCAGATGGTAAATTCTGTAGATATTCCAACTGTTAAAAATA
CACTACAAATATTAATGAAACGTCATTCTATTCTCCGTAGTGTATATTCTGAAAAAGATGGAAATATTATTTCCCAGATT
CGGGAAAATGTGGAGATTGACTGGGAAAAAATAGATGCTTATTCCTGGAATAATATCGAATTAAATGAACAATTGTCCGC
TCGAATGAGGCTTCCTTTTAATCTGGAAACTGGTGGAGTATTTCGTGCTTGTTTATTTTGTATTTCGGCAACAGAAAATA
TTTTATTGTTGACTCTGCATCAAATAGCAGGCGATCGCTATTCCATATCAATATTAGTGGATGAATTTGTAACTATTTAC
GAGTCAAAAATTAATAATACTAACTCAAATTTAATCCCAATAAATACGAATTATGTTAATTATATCAATGAAGAATTAGA
ATTTATAAATAGTTCAGAAGGAAAACAAATTGGTGATTATTGGCAGGAAAAGTTAGGGGGTGAATTACCCATCCTAGAAT
TACCAACAAATTTTTCTCGCCCGAGTATTAGAACTTATAATGGTACTGCTCTAAAGTCAACTATAAACTTCCAATTAAAT
CAGAAAATTCAACAACTCGCAAAAACACTAGAAGTCAAAAAGGAAGAGATAATATTAGCAGTATTTAAAGTTCTACTTTA
CCGCTACACAGGAGAAGAAGATATTCTGGTTGGTTTATTACAAAGCCGAGAAAATCAACCATTATTTGAACAAGTAGTTG
GCAATTTTACTAATATTACAGTTCTCAGAAATTTAATCTCAGGAAACATTAAGTTTACAGATTTTTTGAATCAAGTTAGC
AAAAATATATTTGAAGTTGAGAATTATCAAAATTACCCTTATTCTTTGCTTATAAAACAATTAAAATCTGCTAATTTGAG
TCACTATCCAATCTGTCAGGTTGCTTTTAGTTATCATAAATTTCATAAATTATTTGAGGCAAAAGAACTAGAATTAGAAT
ATTATGAACTTCCACAACAAAAAGTAGACTTTGAACTAAATTTAGAAATCATAGAATTACCTGAATCTCTGTTAGCTAAC
TTTAAATATAATAGTGATGTATTAGAGGCTCAAACTGTTGCTCAAATTGCCGAACATTTCCAGAATTTACTAACAGCAGT
TGTCGAAAATCCTGAGACACCAGTGGGTAAATTATCAATGCTGAGTGAAAGGGAAAAACAGAAAATATTAATAGCATGGA
ATGAAACAAAAACAGATTATCCTCAAGACATATCTATTCATCAGTTATTTGAGAGTCAAGTAGAGAAAACCCCAGATGCA
ATAGCAGTAGTTTTTGAGTCAGAAAAGCTGACTTACTCCGAGTTAAATAATAAAGCAAATCAACTCGCTCACTATTTACA
AAAATTGGGAGTAAAACCAAAAGCACACTTAGGCATTTGTGTGGAACGATCTCTCTCAATGGTTATCGGTATATTAGGAA
TTCTCAAAGCAGGAGCAGCTTATGTCCCCCTAGATTCTAGCTACCCCTCAGAACGTTTGGCTTATATGATTTCTGATGCA
CAAGTGTCAGTGTTACTCACCCAGGAATCATTATTGACATCCTTGCCTAAACATCAAGCACAAGTTGTTTGTTTAGATAG
AGACTGGAAAGGGATCAAGGAATTTTCTACCGTAAATTTGAGCAGTGGAGTCACCCCAGAAAATCTAGGTTACATCATCT
ATACCTCGGGTTCCACAGGTAAACCCAAGGGAGTTGCCATGAGTCAACGCGCTTTAGTTAACTTGATTATGTGGCAGCAA
GAAGAAGCAACTGTAGGTCAAGGGGCCAAAACATTACAGTTTACTCCTATTAGTTTTGACGTATCCTTCCAAGAAATTTT
TTCAACCTGGTATTCAGGAGGCACTCTGGTTTTAGTTTCTCAAGAAGTAAGACGTGATAGTTTTGCTTTGATGGCATTCA
TGGTTGAGAGTCAGATAGAGAGAATATTTCTTCCTTTTGTAGCTTTACAGCAGTTAGCTACAGTTGCTCCTCAATGTCAA
GTTTTACCCCCATTCTGTGAAATTGTGACAGCAGGAGAACAATTGCAGGTTACTCCAGACCTAGTGGCATTAATGAACCG
ACTTCCTAACTGTAAAGTCCAAAATCAATATGGACCCTCAGAAAGCCATGTTGTTTCTGCTTACACTTTACAGGGCGCTG
CTACGAATTGGCCAAAACTACCTCCTATTGGTCGTCCTATTGCTAACAATCAACTTTATATTTTCAACACAGATTTACAG
CCAATTCCCATCGGCGTTTCTGGAGAACTGTATATTGGTGGAGTCGGTGTGGCCAATGGTTATCTTAACCGCCCAGACTT
AACTGTAGAAAAATTTATTACTATAGAAGGGAACAAGGAACAGGGAATAGGGAACAGGTTGTATAAAACTGGAGATTTAG
CTCGTTATCTATCTGATGGGAACATCGAGTTTTTAGGTCGCATTGATAACCAAGTGAAAATTAGGGGTTTCCGCATAGAA
ATTGGAGAAATTGAAACTACTCTCAGTCAACACCCTATAGTCAAAGAAACGGTAGTATTATTGAGAGAAGATAAACCTGG
TAATAAACTTTTAGTCGCGTATATTGTGCCTGAAACTGAAGGTGCTCAGAATGTTGTCCCCCAATTAAAACAATATCTGA
AAGAAAAATTGGCGGAATATATGGTGCCTTCAGCTTTTGTGGTGTTGTCGAAACTACCCTTAACTCCCAGTGGGAAAGTT
AACCGTCGCGCTCTACCTGCACCTGATATTTCTAGTTTTAGTCAGAGCGATAATTTTGTGGCTCCGCGCGATCGCATAGA
GCAACAATTAGCACAAATGTGGTCAGAAATTCTAAATATTCATCCAGTAGGAGTTAAAAGTAATTTCTTTGAATTAGGAG
GCCATTCTCTCTTAGCAATTAATTTAATGGCCAAAATCCAGGAGAGCTTTGGCCAACAACTACCTTTATCTACTCTATTC
ACCAACCGGACAATTGAAGATTTAGGCCGTTTAATTCGAGGAGAAAGTCAAGTTAGTTCTTCTTCTATAGTTCCCCTGCA
AACTCAGGGAAATAAACAACCATTTTTTTGCATACATCCTGCCGGAGGTCATGTATTTTATTATCATGATTTATCCCATT
ATTTGGGGAATAATCAACCATTTTATGGGATACAAGCACAGGGATTTAATGAAGGGGAAAAAATCTTCACAAATGTGGAA
GATATGGCTGAATTTTATGTCCAAACTCTACTAGAATTTCAACCAGATGGTCCTTATCAAATTGGCGGTTGGTCTTTTGG
AGGAGTTGTTGCTTTTGAGATGGGACAGCAGTTACTTCAGCAAGGTAAAGAAGTTAGCTTATTGGCTTTGTTAGACCCTT
GGGTTCCCATTTTATTAGACCCTAATAAAAAAATTGATAATTTGTATATGAAGGGTGTATTAAGTCGCTACTTTGGAGGT
ATGTTTGGTATAACTGATTTAGTTACCGAAGATGAATTATTAGGTTTAAAATCAGAAGAACAAATAGAGTTTATAATTGA
TAAGGCAGAGAAATTAAAGTTATTTCCCAAGGAAGCTACTCGGGAACAAAACCGACGCTTTATTGATGTAATAATTGGCA
CTTTGAAGGCAACTTATACTTATAAACGTCATCCTTATCCAGGAAAAGTAACGGTTTTTCGGGCGCAAGAAAAGCATCCC
CATGGCATAGATCCCCAATTAGTCTGGGTAGAAATGTATGCTATTTTAGATGTAGCTGATATAGAGGTAGTTATGGTTCC
TGGTAATCATTTTACATTTATAAAAGAATCAAATAATAAAGTATTAGCAGAATGTTTGAGTGAGCATTTAAAGTAG

Upstream 100 bases:

>100_bases
TCCTAAGATAAAGTCTTAATTAGTTACCTGTAATAAAATTTTTTTTCTCTTTCAAGTTTATATTTCTTCATTTACTCCCC
TATTCCCTATTATATAAACG

Downstream 100 bases:

>100_bases
GCAAGCATTTCCTACGGAATGCTGGCAAACAGTAGTCAGCTATCAGCTAGCCTCCTGGGTCGGAACTTCCTCCAGGTCGG
GATTAGTTCTTAATTCATTA

Product: amino acid adenylation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1331; Mature: 1331

Protein sequence:

>1331_residues
MNYQGISTLISPSTSHIQQANWFLYKFNPTGLADKISIAIQMVNSVDIPTVKNTLQILMKRHSILRSVYSEKDGNIISQI
RENVEIDWEKIDAYSWNNIELNEQLSARMRLPFNLETGGVFRACLFCISATENILLLTLHQIAGDRYSISILVDEFVTIY
ESKINNTNSNLIPINTNYVNYINEELEFINSSEGKQIGDYWQEKLGGELPILELPTNFSRPSIRTYNGTALKSTINFQLN
QKIQQLAKTLEVKKEEIILAVFKVLLYRYTGEEDILVGLLQSRENQPLFEQVVGNFTNITVLRNLISGNIKFTDFLNQVS
KNIFEVENYQNYPYSLLIKQLKSANLSHYPICQVAFSYHKFHKLFEAKELELEYYELPQQKVDFELNLEIIELPESLLAN
FKYNSDVLEAQTVAQIAEHFQNLLTAVVENPETPVGKLSMLSEREKQKILIAWNETKTDYPQDISIHQLFESQVEKTPDA
IAVVFESEKLTYSELNNKANQLAHYLQKLGVKPKAHLGICVERSLSMVIGILGILKAGAAYVPLDSSYPSERLAYMISDA
QVSVLLTQESLLTSLPKHQAQVVCLDRDWKGIKEFSTVNLSSGVTPENLGYIIYTSGSTGKPKGVAMSQRALVNLIMWQQ
EEATVGQGAKTLQFTPISFDVSFQEIFSTWYSGGTLVLVSQEVRRDSFALMAFMVESQIERIFLPFVALQQLATVAPQCQ
VLPPFCEIVTAGEQLQVTPDLVALMNRLPNCKVQNQYGPSESHVVSAYTLQGAATNWPKLPPIGRPIANNQLYIFNTDLQ
PIPIGVSGELYIGGVGVANGYLNRPDLTVEKFITIEGNKEQGIGNRLYKTGDLARYLSDGNIEFLGRIDNQVKIRGFRIE
IGEIETTLSQHPIVKETVVLLREDKPGNKLLVAYIVPETEGAQNVVPQLKQYLKEKLAEYMVPSAFVVLSKLPLTPSGKV
NRRALPAPDISSFSQSDNFVAPRDRIEQQLAQMWSEILNIHPVGVKSNFFELGGHSLLAINLMAKIQESFGQQLPLSTLF
TNRTIEDLGRLIRGESQVSSSSIVPLQTQGNKQPFFCIHPAGGHVFYYHDLSHYLGNNQPFYGIQAQGFNEGEKIFTNVE
DMAEFYVQTLLEFQPDGPYQIGGWSFGGVVAFEMGQQLLQQGKEVSLLALLDPWVPILLDPNKKIDNLYMKGVLSRYFGG
MFGITDLVTEDELLGLKSEEQIEFIIDKAEKLKLFPKEATREQNRRFIDVIIGTLKATYTYKRHPYPGKVTVFRAQEKHP
HGIDPQLVWVEMYAILDVADIEVVMVPGNHFTFIKESNNKVLAECLSEHLK

Sequences:

>Translated_1331_residues
MNYQGISTLISPSTSHIQQANWFLYKFNPTGLADKISIAIQMVNSVDIPTVKNTLQILMKRHSILRSVYSEKDGNIISQI
RENVEIDWEKIDAYSWNNIELNEQLSARMRLPFNLETGGVFRACLFCISATENILLLTLHQIAGDRYSISILVDEFVTIY
ESKINNTNSNLIPINTNYVNYINEELEFINSSEGKQIGDYWQEKLGGELPILELPTNFSRPSIRTYNGTALKSTINFQLN
QKIQQLAKTLEVKKEEIILAVFKVLLYRYTGEEDILVGLLQSRENQPLFEQVVGNFTNITVLRNLISGNIKFTDFLNQVS
KNIFEVENYQNYPYSLLIKQLKSANLSHYPICQVAFSYHKFHKLFEAKELELEYYELPQQKVDFELNLEIIELPESLLAN
FKYNSDVLEAQTVAQIAEHFQNLLTAVVENPETPVGKLSMLSEREKQKILIAWNETKTDYPQDISIHQLFESQVEKTPDA
IAVVFESEKLTYSELNNKANQLAHYLQKLGVKPKAHLGICVERSLSMVIGILGILKAGAAYVPLDSSYPSERLAYMISDA
QVSVLLTQESLLTSLPKHQAQVVCLDRDWKGIKEFSTVNLSSGVTPENLGYIIYTSGSTGKPKGVAMSQRALVNLIMWQQ
EEATVGQGAKTLQFTPISFDVSFQEIFSTWYSGGTLVLVSQEVRRDSFALMAFMVESQIERIFLPFVALQQLATVAPQCQ
VLPPFCEIVTAGEQLQVTPDLVALMNRLPNCKVQNQYGPSESHVVSAYTLQGAATNWPKLPPIGRPIANNQLYIFNTDLQ
PIPIGVSGELYIGGVGVANGYLNRPDLTVEKFITIEGNKEQGIGNRLYKTGDLARYLSDGNIEFLGRIDNQVKIRGFRIE
IGEIETTLSQHPIVKETVVLLREDKPGNKLLVAYIVPETEGAQNVVPQLKQYLKEKLAEYMVPSAFVVLSKLPLTPSGKV
NRRALPAPDISSFSQSDNFVAPRDRIEQQLAQMWSEILNIHPVGVKSNFFELGGHSLLAINLMAKIQESFGQQLPLSTLF
TNRTIEDLGRLIRGESQVSSSSIVPLQTQGNKQPFFCIHPAGGHVFYYHDLSHYLGNNQPFYGIQAQGFNEGEKIFTNVE
DMAEFYVQTLLEFQPDGPYQIGGWSFGGVVAFEMGQQLLQQGKEVSLLALLDPWVPILLDPNKKIDNLYMKGVLSRYFGG
MFGITDLVTEDELLGLKSEEQIEFIIDKAEKLKLFPKEATREQNRRFIDVIIGTLKATYTYKRHPYPGKVTVFRAQEKHP
HGIDPQLVWVEMYAILDVADIEVVMVPGNHFTFIKESNNKVLAECLSEHLK
>Mature_1331_residues
MNYQGISTLISPSTSHIQQANWFLYKFNPTGLADKISIAIQMVNSVDIPTVKNTLQILMKRHSILRSVYSEKDGNIISQI
RENVEIDWEKIDAYSWNNIELNEQLSARMRLPFNLETGGVFRACLFCISATENILLLTLHQIAGDRYSISILVDEFVTIY
ESKINNTNSNLIPINTNYVNYINEELEFINSSEGKQIGDYWQEKLGGELPILELPTNFSRPSIRTYNGTALKSTINFQLN
QKIQQLAKTLEVKKEEIILAVFKVLLYRYTGEEDILVGLLQSRENQPLFEQVVGNFTNITVLRNLISGNIKFTDFLNQVS
KNIFEVENYQNYPYSLLIKQLKSANLSHYPICQVAFSYHKFHKLFEAKELELEYYELPQQKVDFELNLEIIELPESLLAN
FKYNSDVLEAQTVAQIAEHFQNLLTAVVENPETPVGKLSMLSEREKQKILIAWNETKTDYPQDISIHQLFESQVEKTPDA
IAVVFESEKLTYSELNNKANQLAHYLQKLGVKPKAHLGICVERSLSMVIGILGILKAGAAYVPLDSSYPSERLAYMISDA
QVSVLLTQESLLTSLPKHQAQVVCLDRDWKGIKEFSTVNLSSGVTPENLGYIIYTSGSTGKPKGVAMSQRALVNLIMWQQ
EEATVGQGAKTLQFTPISFDVSFQEIFSTWYSGGTLVLVSQEVRRDSFALMAFMVESQIERIFLPFVALQQLATVAPQCQ
VLPPFCEIVTAGEQLQVTPDLVALMNRLPNCKVQNQYGPSESHVVSAYTLQGAATNWPKLPPIGRPIANNQLYIFNTDLQ
PIPIGVSGELYIGGVGVANGYLNRPDLTVEKFITIEGNKEQGIGNRLYKTGDLARYLSDGNIEFLGRIDNQVKIRGFRIE
IGEIETTLSQHPIVKETVVLLREDKPGNKLLVAYIVPETEGAQNVVPQLKQYLKEKLAEYMVPSAFVVLSKLPLTPSGKV
NRRALPAPDISSFSQSDNFVAPRDRIEQQLAQMWSEILNIHPVGVKSNFFELGGHSLLAINLMAKIQESFGQQLPLSTLF
TNRTIEDLGRLIRGESQVSSSSIVPLQTQGNKQPFFCIHPAGGHVFYYHDLSHYLGNNQPFYGIQAQGFNEGEKIFTNVE
DMAEFYVQTLLEFQPDGPYQIGGWSFGGVVAFEMGQQLLQQGKEVSLLALLDPWVPILLDPNKKIDNLYMKGVLSRYFGG
MFGITDLVTEDELLGLKSEEQIEFIIDKAEKLKLFPKEATREQNRRFIDVIIGTLKATYTYKRHPYPGKVTVFRAQEKHP
HGIDPQLVWVEMYAILDVADIEVVMVPGNHFTFIKESNNKVLAECLSEHLK

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=505, Percent_Identity=23.1683168316832, Blast_Score=91, Evalue=9e-18,
Organism=Homo sapiens, GI156151445, Length=586, Percent_Identity=23.037542662116, Blast_Score=89, Evalue=4e-17,
Organism=Homo sapiens, GI115511026, Length=515, Percent_Identity=21.3592233009709, Blast_Score=89, Evalue=4e-17,
Organism=Homo sapiens, GI58082049, Length=508, Percent_Identity=20.8661417322835, Blast_Score=86, Evalue=3e-16,
Organism=Homo sapiens, GI42544132, Length=521, Percent_Identity=19.5777351247601, Blast_Score=81, Evalue=9e-15,
Organism=Homo sapiens, GI157311624, Length=508, Percent_Identity=19.8818897637795, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI157311622, Length=508, Percent_Identity=19.8818897637795, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI28416953, Length=120, Percent_Identity=37.5, Blast_Score=76, Evalue=2e-13,
Organism=Homo sapiens, GI122937307, Length=505, Percent_Identity=20.7920792079208, Blast_Score=75, Evalue=6e-13,
Organism=Escherichia coli, GI1786801, Length=1335, Percent_Identity=26.3670411985019, Blast_Score=408, Evalue=1e-114,
Organism=Escherichia coli, GI1786810, Length=539, Percent_Identity=24.860853432282, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI145693145, Length=556, Percent_Identity=23.021582733813, Blast_Score=96, Evalue=2e-20,
Organism=Escherichia coli, GI1788107, Length=577, Percent_Identity=23.2235701906412, Blast_Score=94, Evalue=7e-20,
Organism=Escherichia coli, GI221142682, Length=537, Percent_Identity=21.2290502793296, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=1064, Percent_Identity=21.7105263157895, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17556356, Length=775, Percent_Identity=24.7741935483871, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17538037, Length=550, Percent_Identity=22, Blast_Score=103, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=528, Percent_Identity=21.780303030303, Blast_Score=90, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=552, Percent_Identity=21.9202898550725, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=547, Percent_Identity=20.4753199268739, Blast_Score=78, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=374, Percent_Identity=24.0641711229947, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=951, Percent_Identity=27.3396424815983, Blast_Score=286, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6319699, Length=209, Percent_Identity=26.7942583732057, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24648676, Length=618, Percent_Identity=25.8899676375405, Blast_Score=183, Evalue=8e-46,
Organism=Drosophila melanogaster, GI18859661, Length=528, Percent_Identity=22.5378787878788, Blast_Score=77, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24582852, Length=573, Percent_Identity=24.0837696335079, Blast_Score=77, Evalue=9e-14,
Organism=Drosophila melanogaster, GI62472339, Length=145, Percent_Identity=28.9655172413793, Blast_Score=75, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667955, Length=145, Percent_Identity=28.9655172413793, Blast_Score=75, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24667959, Length=145, Percent_Identity=28.9655172413793, Blast_Score=75, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 150126; Mature: 150126

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQGISTLISPSTSHIQQANWFLYKFNPTGLADKISIAIQMVNSVDIPTVKNTLQILMK
CCCCCCHHHCCCCHHHHCCCCEEEEEECCCCCHHHHHHHEEECCCCCCCHHHHHHHHHHH
RHSILRSVYSEKDGNIISQIRENVEIDWEKIDAYSWNNIELNEQLSARMRLPFNLETGGV
HHHHHHHHHHCCCCHHHHHHHHCCCCCCEEECCCCCCCEEECCHHHHHEECCEECCCCHH
FRACLFCISATENILLLTLHQIAGDRYSISILVDEFVTIYESKINNTNSNLIPINTNYVN
HHHHHHHHHCCCCEEEEEEHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEECCHHHH
YINEELEFINSSEGKQIGDYWQEKLGGELPILELPTNFSRPSIRTYNGTALKSTINFQLN
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCEEEEEECHHHH
QKIQQLAKTLEVKKEEIILAVFKVLLYRYTGEEDILVGLLQSRENQPLFEQVVGNFTNIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHH
VLRNLISGNIKFTDFLNQVSKNIFEVENYQNYPYSLLIKQLKSANLSHYPICQVAFSYHK
HHHHHHHCCCCHHHHHHHHHHHHEEHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
FHKLFEAKELELEYYELPQQKVDFELNLEIIELPESLLANFKYNSDVLEAQTVAQIAEHF
HHHHHHHHHCCCHHHHCCHHHCCEEEEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHH
QNLLTAVVENPETPVGKLSMLSEREKQKILIAWNETKTDYPQDISIHQLFESQVEKTPDA
HHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCE
IAVVFESEKLTYSELNNKANQLAHYLQKLGVKPKAHLGICVERSLSMVIGILGILKAGAA
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCE
YVPLDSSYPSERLAYMISDAQVSVLLTQESLLTSLPKHQAQVVCLDRDWKGIKEFSTVNL
EEECCCCCCHHHHEEEECCCEEEEEEEHHHHHHHCCCCCEEEEEEECCCCCHHHHCEEEC
SSGVTPENLGYIIYTSGSTGKPKGVAMSQRALVNLIMWQQEEATVGQGAKTLQFTPISFD
CCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCEEEEEEEEEC
VSFQEIFSTWYSGGTLVLVSQEVRRDSFALMAFMVESQIERIFLPFVALQQLATVAPQCQ
CCHHHHHHHHHCCCEEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VLPPFCEIVTAGEQLQVTPDLVALMNRLPNCKVQNQYGPSESHVVSAYTLQGAATNWPKL
CCCCHHHHHCCCCEEEECHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCC
PPIGRPIANNQLYIFNTDLQPIPIGVSGELYIGGVGVANGYLNRPDLTVEKFITIEGNKE
CCCCCCCCCCEEEEEECCCCEEEECCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCC
QGIGNRLYKTGDLARYLSDGNIEFLGRIDNQVKIRGFRIEIGEIETTLSQHPIVKETVVL
CCCCHHHHHCHHHHHHHCCCCEEEEEECCCEEEEEEEEEEECHHHHHHHCCCCHHHEEEE
LREDKPGNKLLVAYIVPETEGAQNVVPQLKQYLKEKLAEYMVPSAFVVLSKLPLTPSGKV
EECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
NRRALPAPDISSFSQSDNFVAPRDRIEQQLAQMWSEILNIHPVGVKSNFFELGGHSLLAI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEH
NLMAKIQESFGQQLPLSTLFTNRTIEDLGRLIRGESQVSSSSIVPLQTQGNKQPFFCIHP
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEC
AGGHVFYYHDLSHYLGNNQPFYGIQAQGFNEGEKIFTNVEDMAEFYVQTLLEFQPDGPYQ
CCCEEEEEECHHHHHCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCEE
IGGWSFGGVVAFEMGQQLLQQGKEVSLLALLDPWVPILLDPNKKIDNLYMKGVLSRYFGG
ECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCC
MFGITDLVTEDELLGLKSEEQIEFIIDKAEKLKLFPKEATREQNRRFIDVIIGTLKATYT
HHHHHHHCCCHHHCCCCCCCHHHHHHCCHHHHCCCCCHHHHHHCCCCHHHHHHHHHHEEE
YKRHPYPGKVTVFRAQEKHPHGIDPQLVWVEMYAILDVADIEVVMVPGNHFTFIKESNNK
EECCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHEEECEEEEEECCCEEEEEEECCCH
VLAECLSEHLK
HHHHHHHHHCC
>Mature Secondary Structure
MNYQGISTLISPSTSHIQQANWFLYKFNPTGLADKISIAIQMVNSVDIPTVKNTLQILMK
CCCCCCHHHCCCCHHHHCCCCEEEEEECCCCCHHHHHHHEEECCCCCCCHHHHHHHHHHH
RHSILRSVYSEKDGNIISQIRENVEIDWEKIDAYSWNNIELNEQLSARMRLPFNLETGGV
HHHHHHHHHHCCCCHHHHHHHHCCCCCCEEECCCCCCCEEECCHHHHHEECCEECCCCHH
FRACLFCISATENILLLTLHQIAGDRYSISILVDEFVTIYESKINNTNSNLIPINTNYVN
HHHHHHHHHCCCCEEEEEEHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCEEEECCHHHH
YINEELEFINSSEGKQIGDYWQEKLGGELPILELPTNFSRPSIRTYNGTALKSTINFQLN
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEECCCCEEEEEECHHHH
QKIQQLAKTLEVKKEEIILAVFKVLLYRYTGEEDILVGLLQSRENQPLFEQVVGNFTNIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCHHHH
VLRNLISGNIKFTDFLNQVSKNIFEVENYQNYPYSLLIKQLKSANLSHYPICQVAFSYHK
HHHHHHHCCCCHHHHHHHHHHHHEEHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
FHKLFEAKELELEYYELPQQKVDFELNLEIIELPESLLANFKYNSDVLEAQTVAQIAEHF
HHHHHHHHHCCCHHHHCCHHHCCEEEEEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHH
QNLLTAVVENPETPVGKLSMLSEREKQKILIAWNETKTDYPQDISIHQLFESQVEKTPDA
HHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCE
IAVVFESEKLTYSELNNKANQLAHYLQKLGVKPKAHLGICVERSLSMVIGILGILKAGAA
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCE
YVPLDSSYPSERLAYMISDAQVSVLLTQESLLTSLPKHQAQVVCLDRDWKGIKEFSTVNL
EEECCCCCCHHHHEEEECCCEEEEEEEHHHHHHHCCCCCEEEEEEECCCCCHHHHCEEEC
SSGVTPENLGYIIYTSGSTGKPKGVAMSQRALVNLIMWQQEEATVGQGAKTLQFTPISFD
CCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCEEEEEEEEEC
VSFQEIFSTWYSGGTLVLVSQEVRRDSFALMAFMVESQIERIFLPFVALQQLATVAPQCQ
CCHHHHHHHHHCCCEEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VLPPFCEIVTAGEQLQVTPDLVALMNRLPNCKVQNQYGPSESHVVSAYTLQGAATNWPKL
CCCCHHHHHCCCCEEEECHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCC
PPIGRPIANNQLYIFNTDLQPIPIGVSGELYIGGVGVANGYLNRPDLTVEKFITIEGNKE
CCCCCCCCCCEEEEEECCCCEEEECCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCC
QGIGNRLYKTGDLARYLSDGNIEFLGRIDNQVKIRGFRIEIGEIETTLSQHPIVKETVVL
CCCCHHHHHCHHHHHHHCCCCEEEEEECCCEEEEEEEEEEECHHHHHHHCCCCHHHEEEE
LREDKPGNKLLVAYIVPETEGAQNVVPQLKQYLKEKLAEYMVPSAFVVLSKLPLTPSGKV
EECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
NRRALPAPDISSFSQSDNFVAPRDRIEQQLAQMWSEILNIHPVGVKSNFFELGGHSLLAI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEH
NLMAKIQESFGQQLPLSTLFTNRTIEDLGRLIRGESQVSSSSIVPLQTQGNKQPFFCIHP
HHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEC
AGGHVFYYHDLSHYLGNNQPFYGIQAQGFNEGEKIFTNVEDMAEFYVQTLLEFQPDGPYQ
CCCEEEEEECHHHHHCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCEE
IGGWSFGGVVAFEMGQQLLQQGKEVSLLALLDPWVPILLDPNKKIDNLYMKGVLSRYFGG
ECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCC
MFGITDLVTEDELLGLKSEEQIEFIIDKAEKLKLFPKEATREQNRRFIDVIIGTLKATYT
HHHHHHHCCCHHHCCCCCCCHHHHHHCCHHHHCCCCCHHHHHHCCCCHHHHHHHHHHEEE
YKRHPYPGKVTVFRAQEKHPHGIDPQLVWVEMYAILDVADIEVVMVPGNHFTFIKESNNK
EECCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHEEECEEEEEECCCEEEEEEECCCH
VLAECLSEHLK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA