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The map label for this gene is Hgd [H]

Identifier: 113476539

GI number: 113476539

Start: 4619069

End: 4620061

Strand: Reverse

Name: Hgd [H]

Synonym: Tery_2969

Alternate gene names: 113476539

Gene position: 4620061-4619069 (Counterclockwise)

Preceding gene: 113476540

Following gene: 113476538

Centisome position: 59.61

GC content: 41.59

Gene sequence:

>993_bases
ATGTACACCGGACTTAATATAAATATGTCACCAAGTAAAAATACTTCAGAAACAAACCCCCCACTTAATTATCCCACGCT
CGGTATCATTGGTTGTGGAAATATTGGAGGGCGACAAGCAGCTAATTTTATTGCCCAGGGTTACCCAGTTTATGTCTACG
ATATAAATTTAGATAGAATGACAGAGTTAGAGTCTTTAGGCGCTCATATTACCCATAGTTGTGCTGAACTTGCTACCTAT
TCAGATGTAATTTTTACTTCTCTACCTACTCCTGCTGATGTTGTTAGGGCTGTACTAGAGGGTGACGGCAACCTGAGTCA
AGGGTTGCGATCGCGAAGTATTTATATAGATATAACCACTAATTCTCCAGAAACAATATTCAAACTCAGCAAAGCTATGG
AAGAACTGGGGGTTGAGATGTTAGACGCTCCTTTTAATGATTGCCCTGAAGGTGCAAAAAGCGATGGAGGTATGGGTTTA
GCTGTTATGGCAAGTGGTTCTAGGAAAACTTTTGAGAGAGTTGAACCTATCCTCCAACTGATGGCAGATCGCGTTATCTA
TTGTGGGACCTTAGGGAATGGGACTCGATGTAAGCTGATCCATAATGCGGTAAACGCAGTTGCTGTTCAAGCAGTTACAG
AAGGAATTACATTGGGTTTAGCTCAGGGAATTCCCCTAGAAACTATTTGGGATGCTTTACGCTTCGGTGCTTTTGGTCAG
AACGCTGGAGATATTCATGGCTTGCCTCACTATTGGTTTTCCCGACGTTGTGATGACTTGTCTCAGCATCCTGACTTTAC
TGTTAAGTTACTACATAAAGATTTGCAACTAGCTCTAGAGATGGCTAGTCAGCAAAATATATCTGTTCCCCAGTTCAGCT
TGACAGTAAAAGATTATGAAGAAGCAGTGCGCAGGGGGTTTTCTGATTATTCTACTACTAAAGTTCGATGCTTGCAAGAA
GAGCAAGCTAGAGTAATGGCTAAAACTACTTAG

Upstream 100 bases:

>100_bases
CCGAAGCCTTCTGACTCTTTTGCCTAAAGCTTCCTGACCTTTTAACCCTTCTGCCTCCTGCCAGAAAGCATAAGTGTTTT
ACTCTTTTAATAAATCTTCT

Downstream 100 bases:

>100_bases
CGATCGCTCCTAAGATAAAGTCTTAATTAGTTACCTGTAATAAAATTTTTTTTCTCTTTCAAGTTTATATTTCTTCATTT
ACTCCCCTATTCCCTATTAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MYTGLNINMSPSKNTSETNPPLNYPTLGIIGCGNIGGRQAANFIAQGYPVYVYDINLDRMTELESLGAHITHSCAELATY
SDVIFTSLPTPADVVRAVLEGDGNLSQGLRSRSIYIDITTNSPETIFKLSKAMEELGVEMLDAPFNDCPEGAKSDGGMGL
AVMASGSRKTFERVEPILQLMADRVIYCGTLGNGTRCKLIHNAVNAVAVQAVTEGITLGLAQGIPLETIWDALRFGAFGQ
NAGDIHGLPHYWFSRRCDDLSQHPDFTVKLLHKDLQLALEMASQQNISVPQFSLTVKDYEEAVRRGFSDYSTTKVRCLQE
EQARVMAKTT

Sequences:

>Translated_330_residues
MYTGLNINMSPSKNTSETNPPLNYPTLGIIGCGNIGGRQAANFIAQGYPVYVYDINLDRMTELESLGAHITHSCAELATY
SDVIFTSLPTPADVVRAVLEGDGNLSQGLRSRSIYIDITTNSPETIFKLSKAMEELGVEMLDAPFNDCPEGAKSDGGMGL
AVMASGSRKTFERVEPILQLMADRVIYCGTLGNGTRCKLIHNAVNAVAVQAVTEGITLGLAQGIPLETIWDALRFGAFGQ
NAGDIHGLPHYWFSRRCDDLSQHPDFTVKLLHKDLQLALEMASQQNISVPQFSLTVKDYEEAVRRGFSDYSTTKVRCLQE
EQARVMAKTT
>Mature_330_residues
MYTGLNINMSPSKNTSETNPPLNYPTLGIIGCGNIGGRQAANFIAQGYPVYVYDINLDRMTELESLGAHITHSCAELATY
SDVIFTSLPTPADVVRAVLEGDGNLSQGLRSRSIYIDITTNSPETIFKLSKAMEELGVEMLDAPFNDCPEGAKSDGGMGL
AVMASGSRKTFERVEPILQLMADRVIYCGTLGNGTRCKLIHNAVNAVAVQAVTEGITLGLAQGIPLETIWDALRFGAFGQ
NAGDIHGLPHYWFSRRCDDLSQHPDFTVKLLHKDLQLALEMASQQNISVPQFSLTVKDYEEAVRRGFSDYSTTKVRCLQE
EQARVMAKTT

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=306, Percent_Identity=27.1241830065359, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI40556376, Length=292, Percent_Identity=26.027397260274, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1790315, Length=307, Percent_Identity=30.9446254071661, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI145693186, Length=302, Percent_Identity=27.4834437086093, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=264, Percent_Identity=28.030303030303, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=26.9230769230769, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=289, Percent_Identity=26.9896193771626, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24655230, Length=301, Percent_Identity=27.2425249169435, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922568, Length=301, Percent_Identity=27.2425249169435, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574115, Length=314, Percent_Identity=21.656050955414, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 36034; Mature: 36034

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTGLNINMSPSKNTSETNPPLNYPTLGIIGCGNIGGRQAANFIAQGYPVYVYDINLDRM
CCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECHHHH
TELESLGAHITHSCAELATYSDVIFTSLPTPADVVRAVLEGDGNLSQGLRSRSIYIDITT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCCEEEEEEEC
NSPETIFKLSKAMEELGVEMLDAPFNDCPEGAKSDGGMGLAVMASGSRKTFERVEPILQL
CCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
MADRVIYCGTLGNGTRCKLIHNAVNAVAVQAVTEGITLGLAQGIPLETIWDALRFGAFGQ
HHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
NAGDIHGLPHYWFSRRCDDLSQHPDFTVKLLHKDLQLALEMASQQNISVPQFSLTVKDYE
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHH
EAVRRGFSDYSTTKVRCLQEEQARVMAKTT
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYTGLNINMSPSKNTSETNPPLNYPTLGIIGCGNIGGRQAANFIAQGYPVYVYDINLDRM
CCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECHHHH
TELESLGAHITHSCAELATYSDVIFTSLPTPADVVRAVLEGDGNLSQGLRSRSIYIDITT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCCEEEEEEEC
NSPETIFKLSKAMEELGVEMLDAPFNDCPEGAKSDGGMGLAVMASGSRKTFERVEPILQL
CCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
MADRVIYCGTLGNGTRCKLIHNAVNAVAVQAVTEGITLGLAQGIPLETIWDALRFGAFGQ
HHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
NAGDIHGLPHYWFSRRCDDLSQHPDFTVKLLHKDLQLALEMASQQNISVPQFSLTVKDYE
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHH
EAVRRGFSDYSTTKVRCLQEEQARVMAKTT
HHHHCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA