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The map label for this gene is adhI [H]

Identifier: 113476426

GI number: 113476426

Start: 4413483

End: 4414592

Strand: Reverse

Name: adhI [H]

Synonym: Tery_2840

Alternate gene names: 113476426

Gene position: 4414592-4413483 (Counterclockwise)

Preceding gene: 113476427

Following gene: 113476424

Centisome position: 56.96

GC content: 37.12

Gene sequence:

>1110_bases
ATGGAAATCAAAGCAGCAGTAGCTTTTGAAGCAGGAAAACCATTAACCATAGAAACCATTAATTTAGAAGGCCCCAAAGC
TGGAGAAGTAATGGTAGAAATTAAAGCAACTGGAGTTTGCCATACTGATGCTTATACTCTTTCCGGTGCTGACCCCGAAG
GTTTATTTCCCAGCATTTTAGGCCATGAAGGGGCAGGAGTTGTTGTAGAAGTTGGGCATGGTGTTACTCATCTTAAACCA
GGAGACCATGTTATCCCTCTATATGTCCCAGAATGTCGTCAGTGTGAATATTGTCTCAGCATGAAAACTAATTTATGTCA
AGCAATTAGAACTACTCAAGGTCGTGGCGTTATGCCAAATGGTACAAGTAGATTCTCATTAAATGGGGAGATAATACATC
ATTATATGGGAACTTCAACTTTTGCCAACTATACAGTCTTACCTGAAATTTCTTTAGCAAAAATTCGCAAAGATGCTCCT
TTTGACAAGGTTTGTTATATAGGTTGTGGAGTTACAACTGGCATTGGAGCTGTTATTAATACTGCAAAAGTAGAAGTAGG
AGCAAAAGTCATTGTATTTGGTTTAGGAGGAATTGGTTTAAATGTAATTCAAGGTGCCAAAATGGTAGGTGCTGATATGA
TTGTTGGGGTTGATATTAATCCGGCAAAACAAGAACTAGCAAAAAAATTTGGGATGACACATTTTGTTAATCCCAAGGAA
GTAGAAGGAGATTTAGTTCCTTATTTAGTAGATTTAACAAAGGGAGGTGCGGACTATACTTTTGAATGTATTGGTAATAT
TAATGTTATGCGTCAAGCTTTGGAATGTTGTCATAAAGGTTGGGGTATGAGTGTAATTATTGGTGTAGCAGGTGCAGGAG
AAGAAATTAGTACTCGTCCGTTTCAGTTAGTAACAGGAAGAGTGTGGAAAGGTTCAGCTTTTGGAGGAGCAAAAGGTCGT
ACAGATGTACCAAAAATTGTTGATTGGTATATGGAAGGAAAGATTAATATTGACGATTTAATTACTAATGTTATGCCATT
GGAAAAAATTAATGAAGCTTTTGATTTAATGCACGAAGGTAAGTCTATTCGTAGTGTTGTAACTTTCTAG

Upstream 100 bases:

>100_bases
ACAAAATATTATTATATTTTTTTCTTGCTTATTTTTTTGACTTTACATAAACTATTATCACCCATTATTTTCATAATGTC
AATTTTAGGAAAACCGCAAA

Downstream 100 bases:

>100_bases
ATAAGCAAAGCAAGAAAGATTATTTTTGTAGATTTGGTTGAGGTAAAAAAAACCAAAATTATCAACTTAAAATTAAAAGT
TAAATCTTAAAAGATAGAGT

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MEIKAAVAFEAGKPLTIETINLEGPKAGEVMVEIKATGVCHTDAYTLSGADPEGLFPSILGHEGAGVVVEVGHGVTHLKP
GDHVIPLYVPECRQCEYCLSMKTNLCQAIRTTQGRGVMPNGTSRFSLNGEIIHHYMGTSTFANYTVLPEISLAKIRKDAP
FDKVCYIGCGVTTGIGAVINTAKVEVGAKVIVFGLGGIGLNVIQGAKMVGADMIVGVDINPAKQELAKKFGMTHFVNPKE
VEGDLVPYLVDLTKGGADYTFECIGNINVMRQALECCHKGWGMSVIIGVAGAGEEISTRPFQLVTGRVWKGSAFGGAKGR
TDVPKIVDWYMEGKINIDDLITNVMPLEKINEAFDLMHEGKSIRSVVTF

Sequences:

>Translated_369_residues
MEIKAAVAFEAGKPLTIETINLEGPKAGEVMVEIKATGVCHTDAYTLSGADPEGLFPSILGHEGAGVVVEVGHGVTHLKP
GDHVIPLYVPECRQCEYCLSMKTNLCQAIRTTQGRGVMPNGTSRFSLNGEIIHHYMGTSTFANYTVLPEISLAKIRKDAP
FDKVCYIGCGVTTGIGAVINTAKVEVGAKVIVFGLGGIGLNVIQGAKMVGADMIVGVDINPAKQELAKKFGMTHFVNPKE
VEGDLVPYLVDLTKGGADYTFECIGNINVMRQALECCHKGWGMSVIIGVAGAGEEISTRPFQLVTGRVWKGSAFGGAKGR
TDVPKIVDWYMEGKINIDDLITNVMPLEKINEAFDLMHEGKSIRSVVTF
>Mature_369_residues
MEIKAAVAFEAGKPLTIETINLEGPKAGEVMVEIKATGVCHTDAYTLSGADPEGLFPSILGHEGAGVVVEVGHGVTHLKP
GDHVIPLYVPECRQCEYCLSMKTNLCQAIRTTQGRGVMPNGTSRFSLNGEIIHHYMGTSTFANYTVLPEISLAKIRKDAP
FDKVCYIGCGVTTGIGAVINTAKVEVGAKVIVFGLGGIGLNVIQGAKMVGADMIVGVDINPAKQELAKKFGMTHFVNPKE
VEGDLVPYLVDLTKGGADYTFECIGNINVMRQALECCHKGWGMSVIIGVAGAGEEISTRPFQLVTGRVWKGSAFGGAKGR
TDVPKIVDWYMEGKINIDDLITNVMPLEKINEAFDLMHEGKSIRSVVTF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=61.8528610354223, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=47.1544715447154, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=46.7914438502674, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=46.3414634146341, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=46.4864864864865, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=46.4864864864865, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=46.070460704607, Blast_Score=344, Evalue=7e-95,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=44.4141689373297, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=44.5983379501385, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI156627571, Length=354, Percent_Identity=23.728813559322, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=62.059620596206, Blast_Score=456, Evalue=1e-130,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=25.7894736842105, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1790045, Length=352, Percent_Identity=26.9886363636364, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081918, Length=353, Percent_Identity=28.6118980169972, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI226510992, Length=349, Percent_Identity=24.6418338108883, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787863, Length=359, Percent_Identity=23.9554317548747, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786825, Length=265, Percent_Identity=26.7924528301887, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790718, Length=365, Percent_Identity=23.8356164383562, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=372, Percent_Identity=25.5376344086022, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=58.9812332439678, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=58.6666666666667, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=58.8235294117647, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562584, Length=371, Percent_Identity=28.3018867924528, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=27.9569892473118, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=359, Percent_Identity=26.7409470752089, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=371, Percent_Identity=26.1455525606469, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=362, Percent_Identity=25.414364640884, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=56.4032697547684, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6323961, Length=365, Percent_Identity=27.6712328767123, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=28.7323943661972, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=360, Percent_Identity=28.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=27.4193548387097, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=377, Percent_Identity=28.3819628647215, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=372, Percent_Identity=28.7634408602151, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=27.8688524590164, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=325, Percent_Identity=25.8461538461538, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=27.9245283018868, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=64.4021739130435, Blast_Score=493, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39487; Mature: 39487

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKAAVAFEAGKPLTIETINLEGPKAGEVMVEIKATGVCHTDAYTLSGADPEGLFPSIL
CCCEEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGVVVEVGHGVTHLKPGDHVIPLYVPECRQCEYCLSMKTNLCQAIRTTQGRGVMPN
CCCCCEEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GTSRFSLNGEIIHHYMGTSTFANYTVLPEISLAKIRKDAPFDKVCYIGCGVTTGIGAVIN
CCCEEEECCCEEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHH
TAKVEVGAKVIVFGLGGIGLNVIQGAKMVGADMIVGVDINPAKQELAKKFGMTHFVNPKE
HEEEECCCEEEEEECCCCCHHHHCCCEEECCEEEEEECCCHHHHHHHHHHCCEECCCHHH
VEGDLVPYLVDLTKGGADYTFECIGNINVMRQALECCHKGWGMSVIIGVAGAGEEISTRP
CCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
FQLVTGRVWKGSAFGGAKGRTDVPKIVDWYMEGKINIDDLITNVMPLEKINEAFDLMHEG
EEEEECEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCC
KSIRSVVTF
CHHHHHHCC
>Mature Secondary Structure
MEIKAAVAFEAGKPLTIETINLEGPKAGEVMVEIKATGVCHTDAYTLSGADPEGLFPSIL
CCCEEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGVVVEVGHGVTHLKPGDHVIPLYVPECRQCEYCLSMKTNLCQAIRTTQGRGVMPN
CCCCCEEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
GTSRFSLNGEIIHHYMGTSTFANYTVLPEISLAKIRKDAPFDKVCYIGCGVTTGIGAVIN
CCCEEEECCCEEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHH
TAKVEVGAKVIVFGLGGIGLNVIQGAKMVGADMIVGVDINPAKQELAKKFGMTHFVNPKE
HEEEECCCEEEEEECCCCCHHHHCCCEEECCEEEEEECCCHHHHHHHHHHCCEECCCHHH
VEGDLVPYLVDLTKGGADYTFECIGNINVMRQALECCHKGWGMSVIIGVAGAGEEISTRP
CCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCC
FQLVTGRVWKGSAFGGAKGRTDVPKIVDWYMEGKINIDDLITNVMPLEKINEAFDLMHEG
EEEEECEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCC
KSIRSVVTF
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]