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The map label for this gene is lysS [H]

Identifier: 113475998

GI number: 113475998

Start: 3654024

End: 3655592

Strand: Reverse

Name: lysS [H]

Synonym: Tery_2366

Alternate gene names: 113475998

Gene position: 3655592-3654024 (Counterclockwise)

Preceding gene: 113475999

Following gene: 113475996

Centisome position: 47.17

GC content: 36.52

Gene sequence:

>1569_bases
ATGGCTAAAAGCGAAACCAGGAATGAAGTAGAAGTTCGTTCACAAAAAGTTGATGAATTACGCGCCCAAGGAATAGACCC
CTATCCTAGTCAAGCCATAGAGCGATCGCATACCACTAAGCAAGTAATAGATCTATTTTCTCCACCAGCAAAGGAATTAG
AACCTGGAGAAACAGACCCCAATGAAAAATTCTTAAAGGTTTGCGGTCGTATTACTTCTAAGCGAGATAGTGGTAGTATT
GGTTTTATTAACCTAACAGATGAAACTGGAAAAATTCAACTTAAAATTGAGAAAAAATTAGTAAAGGGCGACCCTGGTTT
AAGCTTTAAACAAGTTCAAAAATTATTAGATGTAGGAGATTTTGTTAGTGCGGAAGGAATAGGTTGTCGTACTAATAGAG
GTGAGTTATCAATTCAGGTAAATAAATTGGATGTGCTCTCCAAAGCTATTATTCCTTTTCCTGACTCTTATTATGGTGTA
AATGACCCAGAAATTTGTCGCCGTCACCGGGAAATGGATTTGGCTGGAAATGCTGAAGCTTTACAGCGTTTTAGAGTGCG
GAGCAAAATTATGCAAAGTATTCGAACATATCTTTGGGATGCTAATTTTTATGAAATAGAAACACCAATTTTACAGTCAA
TTTATGGTGGTGCTGCAGCTCGACCTTTTGTTACTCATCATAATGCTTTAGATGTAGATTTATATTTACGAATTGCTACA
GAATTATTTCTCAAACGGGCAATTTGTGGAGGTTTTGAACGGGTATTTGAATTAGGAAGAGTATTTAGAAATGAAGGAAT
TGATAGTACTCATAATCCTGAGTTTACTTCCCTAGAAGTTTATCAGGCTTATGCAGATTATTTTGAAATTCTGGGCTTGG
TAGAGGATGTTATTTGTTATAGTTTAACCAATATTTTGGGGGATTTAAAACAGATAGAATATCAAGGGCAAACTATTAGT
TTAGAACGTCAATATGACTATAGTCAAAAATATCCTAATTTCACAGGAAAACATTGGCAAGTAAAAACAATGGTGGAAGC
AGTTAAGGATGAAACAGGACTAGATTTTGATAACCTAGAGTTGCCAGAAGCTATTCGAGCAGCAGAAAAATTAAACCTGA
AATTATCCAAATTAGAAACTCAAAGTTTAGGTTATCTTTTATATGCAGTTTTTGATCAAAAAGTAGAGTCAACTTTAATT
CAACCTACTTTTGTGATTGATTTTCCGGTTGAGGTTAGCCCGTTAGCAAAAAGACATCATAGTAAACCAGGTTTTGTGGA
AAGATTTGAGTTGTTTATTCACGGCACAGAATATTCTAATGGTTTCTCCGAGTTAAATGATCCACAAGACCAGCGCCAAC
GTTTTGAGGAACAGATCGCTCAAAGAGAGGCAGGGGATGATGAAGCGCACCCAATGGATGAAGATTTTATTCAAGCGTTA
TCACTGGGGATGCCTAACTGTGGTGGAATGGGTATTGGAGTAGACCGTCTGGTGATGTTGCTGACAAATACTCAAAGTAT
TAGGGATGTCATTATGTTTCCAACTATGCGTTCGACTTTAAAGGATTAA

Upstream 100 bases:

>100_bases
TTTTATTATTTTGGAATAATTTAATTTTTGTGACAGCCCAAAAATATAAAAATGTGGTATTATTTCCTCTTGATTAATAA
TCTAAAGAGTAAAATCACTA

Downstream 100 bases:

>100_bases
GTATTAGAAATTTCTGCAAAATAATCTCAGGAAATTCTATGGAATATTCCTGGTGGGTTACTAGTGTGAGCGTCTTGTTA
CCATACTGGAGAAAGATGCT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MAKSETRNEVEVRSQKVDELRAQGIDPYPSQAIERSHTTKQVIDLFSPPAKELEPGETDPNEKFLKVCGRITSKRDSGSI
GFINLTDETGKIQLKIEKKLVKGDPGLSFKQVQKLLDVGDFVSAEGIGCRTNRGELSIQVNKLDVLSKAIIPFPDSYYGV
NDPEICRRHREMDLAGNAEALQRFRVRSKIMQSIRTYLWDANFYEIETPILQSIYGGAAARPFVTHHNALDVDLYLRIAT
ELFLKRAICGGFERVFELGRVFRNEGIDSTHNPEFTSLEVYQAYADYFEILGLVEDVICYSLTNILGDLKQIEYQGQTIS
LERQYDYSQKYPNFTGKHWQVKTMVEAVKDETGLDFDNLELPEAIRAAEKLNLKLSKLETQSLGYLLYAVFDQKVESTLI
QPTFVIDFPVEVSPLAKRHHSKPGFVERFELFIHGTEYSNGFSELNDPQDQRQRFEEQIAQREAGDDEAHPMDEDFIQAL
SLGMPNCGGMGIGVDRLVMLLTNTQSIRDVIMFPTMRSTLKD

Sequences:

>Translated_522_residues
MAKSETRNEVEVRSQKVDELRAQGIDPYPSQAIERSHTTKQVIDLFSPPAKELEPGETDPNEKFLKVCGRITSKRDSGSI
GFINLTDETGKIQLKIEKKLVKGDPGLSFKQVQKLLDVGDFVSAEGIGCRTNRGELSIQVNKLDVLSKAIIPFPDSYYGV
NDPEICRRHREMDLAGNAEALQRFRVRSKIMQSIRTYLWDANFYEIETPILQSIYGGAAARPFVTHHNALDVDLYLRIAT
ELFLKRAICGGFERVFELGRVFRNEGIDSTHNPEFTSLEVYQAYADYFEILGLVEDVICYSLTNILGDLKQIEYQGQTIS
LERQYDYSQKYPNFTGKHWQVKTMVEAVKDETGLDFDNLELPEAIRAAEKLNLKLSKLETQSLGYLLYAVFDQKVESTLI
QPTFVIDFPVEVSPLAKRHHSKPGFVERFELFIHGTEYSNGFSELNDPQDQRQRFEEQIAQREAGDDEAHPMDEDFIQAL
SLGMPNCGGMGIGVDRLVMLLTNTQSIRDVIMFPTMRSTLKD
>Mature_521_residues
AKSETRNEVEVRSQKVDELRAQGIDPYPSQAIERSHTTKQVIDLFSPPAKELEPGETDPNEKFLKVCGRITSKRDSGSIG
FINLTDETGKIQLKIEKKLVKGDPGLSFKQVQKLLDVGDFVSAEGIGCRTNRGELSIQVNKLDVLSKAIIPFPDSYYGVN
DPEICRRHREMDLAGNAEALQRFRVRSKIMQSIRTYLWDANFYEIETPILQSIYGGAAARPFVTHHNALDVDLYLRIATE
LFLKRAICGGFERVFELGRVFRNEGIDSTHNPEFTSLEVYQAYADYFEILGLVEDVICYSLTNILGDLKQIEYQGQTISL
ERQYDYSQKYPNFTGKHWQVKTMVEAVKDETGLDFDNLELPEAIRAAEKLNLKLSKLETQSLGYLLYAVFDQKVESTLIQ
PTFVIDFPVEVSPLAKRHHSKPGFVERFELFIHGTEYSNGFSELNDPQDQRQRFEEQIAQREAGDDEAHPMDEDFIQALS
LGMPNCGGMGIGVDRLVMLLTNTQSIRDVIMFPTMRSTLKD

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=519, Percent_Identity=38.728323699422, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI194272210, Length=519, Percent_Identity=38.728323699422, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI45439306, Length=338, Percent_Identity=25.1479289940828, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1789256, Length=514, Percent_Identity=44.1634241245136, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1790571, Length=532, Percent_Identity=42.8571428571429, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI87082379, Length=339, Percent_Identity=32.1533923303835, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788173, Length=248, Percent_Identity=24.1935483870968, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=522, Percent_Identity=39.8467432950192, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI17535927, Length=522, Percent_Identity=39.8467432950192, Blast_Score=347, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI71994340, Length=514, Percent_Identity=40.272373540856, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI32566633, Length=271, Percent_Identity=28.7822878228782, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320242, Length=520, Percent_Identity=39.2307692307692, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324256, Length=492, Percent_Identity=33.9430894308943, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323011, Length=336, Percent_Identity=25.297619047619, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24640849, Length=514, Percent_Identity=36.9649805447471, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24640851, Length=514, Percent_Identity=36.9649805447471, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24584738, Length=252, Percent_Identity=25.3968253968254, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 59326; Mature: 59195

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSETRNEVEVRSQKVDELRAQGIDPYPSQAIERSHTTKQVIDLFSPPAKELEPGETDP
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
NEKFLKVCGRITSKRDSGSIGFINLTDETGKIQLKIEKKLVKGDPGLSFKQVQKLLDVGD
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHH
FVSAEGIGCRTNRGELSIQVNKLDVLSKAIIPFPDSYYGVNDPEICRRHREMDLAGNAEA
HHCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHH
LQRFRVRSKIMQSIRTYLWDANFYEIETPILQSIYGGAAARPFVTHHNALDVDLYLRIAT
HHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
ELFLKRAICGGFERVFELGRVFRNEGIDSTHNPEFTSLEVYQAYADYFEILGLVEDVICY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLTNILGDLKQIEYQGQTISLERQYDYSQKYPNFTGKHWQVKTMVEAVKDETGLDFDNLE
HHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
LPEAIRAAEKLNLKLSKLETQSLGYLLYAVFDQKVESTLIQPTFVIDFPVEVSPLAKRHH
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCC
SKPGFVERFELFIHGTEYSNGFSELNDPQDQRQRFEEQIAQREAGDDEAHPMDEDFIQAL
CCCCHHHEEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SLGMPNCGGMGIGVDRLVMLLTNTQSIRDVIMFPTMRSTLKD
HCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
AKSETRNEVEVRSQKVDELRAQGIDPYPSQAIERSHTTKQVIDLFSPPAKELEPGETDP
CCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
NEKFLKVCGRITSKRDSGSIGFINLTDETGKIQLKIEKKLVKGDPGLSFKQVQKLLDVGD
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHH
FVSAEGIGCRTNRGELSIQVNKLDVLSKAIIPFPDSYYGVNDPEICRRHREMDLAGNAEA
HHCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHH
LQRFRVRSKIMQSIRTYLWDANFYEIETPILQSIYGGAAARPFVTHHNALDVDLYLRIAT
HHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
ELFLKRAICGGFERVFELGRVFRNEGIDSTHNPEFTSLEVYQAYADYFEILGLVEDVICY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLTNILGDLKQIEYQGQTISLERQYDYSQKYPNFTGKHWQVKTMVEAVKDETGLDFDNLE
HHHHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
LPEAIRAAEKLNLKLSKLETQSLGYLLYAVFDQKVESTLIQPTFVIDFPVEVSPLAKRHH
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCC
SKPGFVERFELFIHGTEYSNGFSELNDPQDQRQRFEEQIAQREAGDDEAHPMDEDFIQAL
CCCCHHHEEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SLGMPNCGGMGIGVDRLVMLLTNTQSIRDVIMFPTMRSTLKD
HCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]