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The map label for this gene is proB [H]

Identifier: 113475580

GI number: 113475580

Start: 2961697

End: 2962806

Strand: Reverse

Name: proB [H]

Synonym: Tery_1913

Alternate gene names: 113475580

Gene position: 2962806-2961697 (Counterclockwise)

Preceding gene: 113475582

Following gene: 113475577

Centisome position: 38.23

GC content: 37.48

Gene sequence:

>1110_bases
ATGAATACAATAGTGATCAAAATAGGCACTTCTAGCCTAACTAATTCAGAAACCGGAAATTTAGCCTTATCTACAATTTC
TAGCTTAATTGAAACTATTATCAATTTACGTCAGCAGGGATATCAAGTAGTTTTAGTATCTTCTGGAGCTGTTGGTGTAG
GTTGCGATATATTAGGACTAACCAAAAAGCCTCGAAATATTTCTATGAAACAAGCCATAGCAGCAGTAGGTCAAGGACAA
ATAATGCGAGTTTACAATGACTTGTTTTCATCTTTGCAACAAACAGTTGCCCAGATTTTATTAACAAAAAGTGACCTGTC
ACGACGTAGTAGTTATGTCAATGCCTACAACACATTTCAACAACTTTTTCGACTAGGTGTAGTCCCAATAGTGAATGAAA
ATGATACCACTGCTGTTGAAGAGCTAAATTTTGGGGACAATGATACTCTATCAGCTTTAGTTGCCAGTCTAGTAGAGGCT
GATTGGTTATTCATACTAACTGATGTCGATAGATTATACTCCGCCGACCCGAGAAAAAATCCAGATGCTTTACCCATTAC
CTTAGTAGGGGAAATAGAACAACTCAAAGAACTTAAAGTTCAAGTTGGAGAGTCTGTTAGTGGACGAGGAACTGGGGGAA
TGGTTACAAAAATTGAGGCTGCTAAAATTGCTACTTCTGCTGGAGTCCGAACTGTAATTACTGATGGTAAAGTACCCACT
AATATACAAAAAATCCTCAATGGAGAATCTATAGGTACTCAGTTTGAACCTCAACCAGAACAAGTCAATGGTCGCAAACA
TTGGATTGCCAATGTTTTAGTTCCAGCAGGCCAACTATATCTAGACCAAGGTGCAGTTAAGGCAATTTCTGAGTATGGTA
AATCTCTATTAGCTGCTGGTATTATTCAAGTAGAAGGAGAATTTAATTCATCGGATGCTGTCAAACTATGCAATGAAAAA
GGCCAGGAAATAGCTAGGGGACTTGTGAACTACAGCAGTATTGAATTGCAAAAAATTCTAGGTTGTCGCTCAGAAAATAT
ATCTGATATTTTGGGCTATGTGGGAGCTGAAACAGTTGTACATAGAAATAATCTTTTGCTGACAAATTAA

Upstream 100 bases:

>100_bases
AATGCTAACTATACAAGAGATTGTAATAATTAATATTTTGTAATTAGTTCAAAGCTGATTTTTTGCTTGAGAATTAGTAG
TGGAAAATTCAATTATTTCT

Downstream 100 bases:

>100_bases
ATCATTGTTTCTGGTGGAGCTATATCAGAACCAACAACTAGACTATCTTTAGTGTATTTTAATCCTGGTCTTTGAGTCGT
TTCTAAATGCTGATTTGAAT

Product: gamma-glutamyl kinase

Products: NA

Alternate protein names: Gamma-glutamyl kinase; GK [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNTIVIKIGTSSLTNSETGNLALSTISSLIETIINLRQQGYQVVLVSSGAVGVGCDILGLTKKPRNISMKQAIAAVGQGQ
IMRVYNDLFSSLQQTVAQILLTKSDLSRRSSYVNAYNTFQQLFRLGVVPIVNENDTTAVEELNFGDNDTLSALVASLVEA
DWLFILTDVDRLYSADPRKNPDALPITLVGEIEQLKELKVQVGESVSGRGTGGMVTKIEAAKIATSAGVRTVITDGKVPT
NIQKILNGESIGTQFEPQPEQVNGRKHWIANVLVPAGQLYLDQGAVKAISEYGKSLLAAGIIQVEGEFNSSDAVKLCNEK
GQEIARGLVNYSSIELQKILGCRSENISDILGYVGAETVVHRNNLLLTN

Sequences:

>Translated_369_residues
MNTIVIKIGTSSLTNSETGNLALSTISSLIETIINLRQQGYQVVLVSSGAVGVGCDILGLTKKPRNISMKQAIAAVGQGQ
IMRVYNDLFSSLQQTVAQILLTKSDLSRRSSYVNAYNTFQQLFRLGVVPIVNENDTTAVEELNFGDNDTLSALVASLVEA
DWLFILTDVDRLYSADPRKNPDALPITLVGEIEQLKELKVQVGESVSGRGTGGMVTKIEAAKIATSAGVRTVITDGKVPT
NIQKILNGESIGTQFEPQPEQVNGRKHWIANVLVPAGQLYLDQGAVKAISEYGKSLLAAGIIQVEGEFNSSDAVKLCNEK
GQEIARGLVNYSSIELQKILGCRSENISDILGYVGAETVVHRNNLLLTN
>Mature_369_residues
MNTIVIKIGTSSLTNSETGNLALSTISSLIETIINLRQQGYQVVLVSSGAVGVGCDILGLTKKPRNISMKQAIAAVGQGQ
IMRVYNDLFSSLQQTVAQILLTKSDLSRRSSYVNAYNTFQQLFRLGVVPIVNENDTTAVEELNFGDNDTLSALVASLVEA
DWLFILTDVDRLYSADPRKNPDALPITLVGEIEQLKELKVQVGESVSGRGTGGMVTKIEAAKIATSAGVRTVITDGKVPT
NIQKILNGESIGTQFEPQPEQVNGRKHWIANVLVPAGQLYLDQGAVKAISEYGKSLLAAGIIQVEGEFNSSDAVKLCNEK
GQEIARGLVNYSSIELQKILGCRSENISDILGYVGAETVVHRNNLLLTN

Specific function: Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline [H]

COG id: COG0263

COG function: function code E; Glutamate 5-kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PUA domain [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=286, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI62912457, Length=284, Percent_Identity=30.6338028169014, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786437, Length=364, Percent_Identity=41.4835164835165, Blast_Score=274, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17569969, Length=267, Percent_Identity=33.7078651685393, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17569967, Length=267, Percent_Identity=33.7078651685393, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320506, Length=413, Percent_Identity=39.225181598063, Blast_Score=282, Evalue=5e-77,
Organism=Saccharomyces cerevisiae, GI6321822, Length=417, Percent_Identity=39.568345323741, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI21357643, Length=302, Percent_Identity=30.794701986755, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR001057
- InterPro:   IPR011529
- InterPro:   IPR005715
- InterPro:   IPR019797
- InterPro:   IPR002478
- InterPro:   IPR015947 [H]

Pfam domain/function: PF00696 AA_kinase; PF01472 PUA [H]

EC number: =2.7.2.11 [H]

Molecular weight: Translated: 39707; Mature: 39707

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50890 PUA ; PS00902 GLUTAMATE_5_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIVIKIGTSSLTNSETGNLALSTISSLIETIINLRQQGYQVVLVSSGAVGVGCDILGL
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECEEEEEC
TKKPRNISMKQAIAAVGQGQIMRVYNDLFSSLQQTVAQILLTKSDLSRRSSYVNAYNTFQ
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLFRLGVVPIVNENDTTAVEELNFGDNDTLSALVASLVEADWLFILTDVDRLYSADPRKN
HHHHCCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHCCCCCCC
PDALPITLVGEIEQLKELKVQVGESVSGRGTGGMVTKIEAAKIATSAGVRTVITDGKVPT
CCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCCCCH
NIQKILNGESIGTQFEPQPEQVNGRKHWIANVLVPAGQLYLDQGAVKAISEYGKSLLAAG
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHEECHHHHHHHHHHHHHHHHHC
IIQVEGEFNSSDAVKLCNEKGQEIARGLVNYSSIELQKILGCRSENISDILGYVGAETVV
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCHHHEE
HRNNLLLTN
ECCCEEECC
>Mature Secondary Structure
MNTIVIKIGTSSLTNSETGNLALSTISSLIETIINLRQQGYQVVLVSSGAVGVGCDILGL
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEECEEEEEC
TKKPRNISMKQAIAAVGQGQIMRVYNDLFSSLQQTVAQILLTKSDLSRRSSYVNAYNTFQ
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLFRLGVVPIVNENDTTAVEELNFGDNDTLSALVASLVEADWLFILTDVDRLYSADPRKN
HHHHCCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHHCCCCCCC
PDALPITLVGEIEQLKELKVQVGESVSGRGTGGMVTKIEAAKIATSAGVRTVITDGKVPT
CCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHCCCCEEEEECCCCCH
NIQKILNGESIGTQFEPQPEQVNGRKHWIANVLVPAGQLYLDQGAVKAISEYGKSLLAAG
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHEECHHHHHHHHHHHHHHHHHC
IIQVEGEFNSSDAVKLCNEKGQEIARGLVNYSSIELQKILGCRSENISDILGYVGAETVV
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHCHHHEE
HRNNLLLTN
ECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA