Click here to switch to the map view.

The map label for this gene is manC2 [H]

Identifier: 113475524

GI number: 113475524

Start: 2840104

End: 2841153

Strand: Reverse

Name: manC2 [H]

Synonym: Tery_1856

Alternate gene names: 113475524

Gene position: 2841153-2840104 (Counterclockwise)

Preceding gene: 113475526

Following gene: 113475522

Centisome position: 36.66

GC content: 44.0

Gene sequence:

>1050_bases
ATGATACCTGTTATTCTTGCTGGTGGAAAAGGAGAACGTTTTTGGCCCCTGAGTCGTAAGCATCGGCCTAAACAGTTTCT
TTCTCTTGACGGTAGTGGTAAAAGTTTGTTACAAACCACAGCACAGAGACTACTCCCATTATCTAATGATTGGGGTGGTT
TATGGGTTGTGACTTCGGCAATGTTGGCCGCAGGTGTGGCACAACAGTTACCCCAAATACCACAGGAAAATATATTGGCA
GAACCGGAAGGAAGGGATACTGCTCCTGCTGTTGCTTGGACAACAATAGAAGCGGCACATCGTTATGGGGAAGATATAGT
TGTTGGATTTTTTCCAGCTGACCATTGGATCGGTGAGCCAGAAATATTCCATAAGACTCTGGAGGCAGCAGCAGAATTGG
CCACTAACCAGGAGGCTATTGTCACCCTAGGTGTGAAACCTTCTTTTCCTTCTACTGGTTATGGGTATATTGAACAGGGA
AAAAAAGCAGGAAATTTTGGCGGGTTTGACGTTTATCAGGTGGCACGGTTTACAGAAAAGCCTAACCGAGAGAAGGCGGA
GGAGTTTTTAGCAACGGGGCGTTTTAGTTGGAATGGCGGTATTTTTGTTTTCAGGGTGGGGGTGATGTTGGCGGAGTTGC
GAAAATATGTGCCAACAATGATGACTGTTTTGGAGACGATGGGTCCTGGGGGTTATTCTCAGTTGGAGAAAAAGAGTATT
GACTATGCAGTGATGGAGAAGACTGATAAGGCTTTTGTGTTACCTGTGGCTTTTGGTTGGGATGATTTGGGTGACTGGAA
TGGTTTGGAACGTTTGGTTAAGGGGGATAGTGTGAATGTGGAGTTGGCTAATCATTTGGGGTTGGATACGAAGAGGTCGA
TTTTTTTTGCTACCGATGATGATGATACTATTGTAACTATTGGTTTGGAGGATGTGGTTGTTGTTAGGGATGGGAATGTG
ACTTTGATTGTTAAAAAGGAGCGATCGCAGGATATTAAGAAGGTTTTGAAGAGTTTGGCTAATCATCCTAAGTTTAAGGA
TTTATTGTAG

Upstream 100 bases:

>100_bases
GCAGTTTAAAAGTTTACTAATCTACTTAATAATTTTGGAGAAACTGACAATCAAAACTTAAAATGGAATTATTTAAGTCT
ATTAAATAATCTAGAATCTG

Downstream 100 bases:

>100_bases
GGGAGGAGAAAGGAAGAAGGAAGCAGGAGGGAATAGTTGTAGGAATAGGTGTAGGTTTGGTTGCGCTGTCGCTTAACCTA
ACAAAAACTTATATGAAAGT

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase 2; GMP 2; GMPP 2 [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MIPVILAGGKGERFWPLSRKHRPKQFLSLDGSGKSLLQTTAQRLLPLSNDWGGLWVVTSAMLAAGVAQQLPQIPQENILA
EPEGRDTAPAVAWTTIEAAHRYGEDIVVGFFPADHWIGEPEIFHKTLEAAAELATNQEAIVTLGVKPSFPSTGYGYIEQG
KKAGNFGGFDVYQVARFTEKPNREKAEEFLATGRFSWNGGIFVFRVGVMLAELRKYVPTMMTVLETMGPGGYSQLEKKSI
DYAVMEKTDKAFVLPVAFGWDDLGDWNGLERLVKGDSVNVELANHLGLDTKRSIFFATDDDDTIVTIGLEDVVVVRDGNV
TLIVKKERSQDIKKVLKSLANHPKFKDLL

Sequences:

>Translated_349_residues
MIPVILAGGKGERFWPLSRKHRPKQFLSLDGSGKSLLQTTAQRLLPLSNDWGGLWVVTSAMLAAGVAQQLPQIPQENILA
EPEGRDTAPAVAWTTIEAAHRYGEDIVVGFFPADHWIGEPEIFHKTLEAAAELATNQEAIVTLGVKPSFPSTGYGYIEQG
KKAGNFGGFDVYQVARFTEKPNREKAEEFLATGRFSWNGGIFVFRVGVMLAELRKYVPTMMTVLETMGPGGYSQLEKKSI
DYAVMEKTDKAFVLPVAFGWDDLGDWNGLERLVKGDSVNVELANHLGLDTKRSIFFATDDDDTIVTIGLEDVVVVRDGNV
TLIVKKERSQDIKKVLKSLANHPKFKDLL
>Mature_349_residues
MIPVILAGGKGERFWPLSRKHRPKQFLSLDGSGKSLLQTTAQRLLPLSNDWGGLWVVTSAMLAAGVAQQLPQIPQENILA
EPEGRDTAPAVAWTTIEAAHRYGEDIVVGFFPADHWIGEPEIFHKTLEAAAELATNQEAIVTLGVKPSFPSTGYGYIEQG
KKAGNFGGFDVYQVARFTEKPNREKAEEFLATGRFSWNGGIFVFRVGVMLAELRKYVPTMMTVLETMGPGGYSQLEKKSI
DYAVMEKTDKAFVLPVAFGWDDLGDWNGLERLVKGDSVNVELANHLGLDTKRSIFFATDDDDTIVTIGLEDVVVVRDGNV
TLIVKKERSQDIKKVLKSLANHPKFKDLL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=359, Percent_Identity=35.0974930362117, Blast_Score=196, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 38538; Mature: 38538

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVILAGGKGERFWPLSRKHRPKQFLSLDGSGKSLLQTTAQRLLPLSNDWGGLWVVTSA
CCEEEEECCCCCEECCCCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
MLAAGVAQQLPQIPQENILAEPEGRDTAPAVAWTTIEAAHRYGEDIVVGFFPADHWIGEP
HHHHHHHHHHCCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECHHHCCCCH
EIFHKTLEAAAELATNQEAIVTLGVKPSFPSTGYGYIEQGKKAGNFGGFDVYQVARFTEK
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCC
PNREKAEEFLATGRFSWNGGIFVFRVGVMLAELRKYVPTMMTVLETMGPGGYSQLEKKSI
CCHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
DYAVMEKTDKAFVLPVAFGWDDLGDWNGLERLVKGDSVNVELANHLGLDTKRSIFFATDD
CCCEEECCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCCCCEEEEEECC
DDTIVTIGLEDVVVVRDGNVTLIVKKERSQDIKKVLKSLANHPKFKDLL
CCEEEEEECCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MIPVILAGGKGERFWPLSRKHRPKQFLSLDGSGKSLLQTTAQRLLPLSNDWGGLWVVTSA
CCEEEEECCCCCEECCCCCCCCCHHHEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHH
MLAAGVAQQLPQIPQENILAEPEGRDTAPAVAWTTIEAAHRYGEDIVVGFFPADHWIGEP
HHHHHHHHHHCCCCHHHCCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECHHHCCCCH
EIFHKTLEAAAELATNQEAIVTLGVKPSFPSTGYGYIEQGKKAGNFGGFDVYQVARFTEK
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHCC
PNREKAEEFLATGRFSWNGGIFVFRVGVMLAELRKYVPTMMTVLETMGPGGYSQLEKKSI
CCHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCC
DYAVMEKTDKAFVLPVAFGWDDLGDWNGLERLVKGDSVNVELANHLGLDTKRSIFFATDD
CCCEEECCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCCCCEEEEEECC
DDTIVTIGLEDVVVVRDGNVTLIVKKERSQDIKKVLKSLANHPKFKDLL
CCEEEEEECCEEEEEECCCEEEEEECCHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9673232; 11206551; 11258796 [H]