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The map label for this gene is moeA [H]

Identifier: 113474606

GI number: 113474606

Start: 1228281

End: 1229516

Strand: Reverse

Name: moeA [H]

Synonym: Tery_0767

Alternate gene names: 113474606

Gene position: 1229516-1228281 (Counterclockwise)

Preceding gene: 113474607

Following gene: 113474605

Centisome position: 15.86

GC content: 38.75

Gene sequence:

>1236_bases
ATGCTAGAAGTAAACCAAGCAGAGTCAATCATTTTAAGCCTTGTACAACCCCTAGATGCTGACAAGGATGTAGAGACAAT
AGACCTATTAAATTCATCAGGACGGATATTAGCTAACCCAGTTGTCAGTAAACTTGATTTTCCTCACTGGGATAATTCAG
CAATGGATGGCTATGCCCTCAAATTTGCAGATGTTAAAGACTGTAGCCCAGAAAATTCCATATCTTTGGAAATTGTAGAA
GAAATTCTTGCAGGGTCTAAGCCTCAAAAGCAAATTCAACCAGGGCAAACAGCTCGTATTTTTACAGGTGCTTGTATGCC
CATAGGAGCAGATACTATTGTTATACAGGAGGTGACCCAGCGAGAAGGTAATAGGGTACTTATCCTAGAAGCTCCAGAAC
CCCAAGCATTTGTGCGATATCGTGGATCATTCTACAAGGCAGGTACTCCTGTACTCAACCCGAGAATTTACTTAGGTGCT
GCTGAAATTGCTGTTTTAGCAGCACTCCAATGTACTCAAATTAACGTATATCGGCGAGTAAAAGTAGGAATTTTTTCTAC
TGGTAATGAATTGGTTAAACCAGATCAACCTCTAAAATATGGTCAGATAGTAGACTCAAATGAATATGCTTTAACTATAG
CTCTAGAGAAAATGGGGGTGGAAGTAATAAAATTTGGTATTCTGCCAGATGAACCAGAAATTTTGCAAAAGACTATTGCT
GAAGCTATTTTAAATACAGATTTTTTACTTTCTACTGGTGGAGTATCAGTGGGAGACTATGATTATATTGAGGAAATTAT
TACAGAGTTAGGAGCGGAAATTCATGTTCATTCTGTAGCGGTTAAACCAGGAAAACCATTAACAGTAGCAAGTTTTCCTA
ATACTAAATGTTTATATTTTGGTTTACCAGGAAATCCTGTTTCGGCTTTAGTGAGTTTTTGGCGGTTTGTGCAACCTGCG
CTGAAAAAGTTAGCTGGAGCGAATGAGGCAGAATGGGGACCGGAGTTTGTGAGGGCGCGGCTGCTTCAAGATTTAAATTC
TAAGAATAAACGGGAGACTTATCTCTGGGGTCAGTTAAATTTAGGAAATGATGGTTATGAATTTAAGCTTGCAGTTGGTA
GTCATTATTCGGGAAATTTAATTAATTTAGCAGGAGCGACAGGTTTAGCTGTTGTACCGTTGAATGAAAATTTTATTCCG
GCGGGTGAGTCTGTGCGAGTATTGAAAATTAATTAA

Upstream 100 bases:

>100_bases
TCTCTTTAAAAAAATAAATTTCCCATCTTATTTTATAGTCAAAATAGTCAAATCAGACTTATAATTATCAACAACCAAAA
TCCTAGTAAGCAAACTAGAA

Downstream 100 bases:

>100_bases
TGGTTATTATACTCCTAGGTGGAACTCAGAAGTCAGAAGGCGCGAATTCAAAAGTAATTCTTGAATAGGTTTGAGGATTT
ATAATTGTGCGCGTCTTGTT

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MLEVNQAESIILSLVQPLDADKDVETIDLLNSSGRILANPVVSKLDFPHWDNSAMDGYALKFADVKDCSPENSISLEIVE
EILAGSKPQKQIQPGQTARIFTGACMPIGADTIVIQEVTQREGNRVLILEAPEPQAFVRYRGSFYKAGTPVLNPRIYLGA
AEIAVLAALQCTQINVYRRVKVGIFSTGNELVKPDQPLKYGQIVDSNEYALTIALEKMGVEVIKFGILPDEPEILQKTIA
EAILNTDFLLSTGGVSVGDYDYIEEIITELGAEIHVHSVAVKPGKPLTVASFPNTKCLYFGLPGNPVSALVSFWRFVQPA
LKKLAGANEAEWGPEFVRARLLQDLNSKNKRETYLWGQLNLGNDGYEFKLAVGSHYSGNLINLAGATGLAVVPLNENFIP
AGESVRVLKIN

Sequences:

>Translated_411_residues
MLEVNQAESIILSLVQPLDADKDVETIDLLNSSGRILANPVVSKLDFPHWDNSAMDGYALKFADVKDCSPENSISLEIVE
EILAGSKPQKQIQPGQTARIFTGACMPIGADTIVIQEVTQREGNRVLILEAPEPQAFVRYRGSFYKAGTPVLNPRIYLGA
AEIAVLAALQCTQINVYRRVKVGIFSTGNELVKPDQPLKYGQIVDSNEYALTIALEKMGVEVIKFGILPDEPEILQKTIA
EAILNTDFLLSTGGVSVGDYDYIEEIITELGAEIHVHSVAVKPGKPLTVASFPNTKCLYFGLPGNPVSALVSFWRFVQPA
LKKLAGANEAEWGPEFVRARLLQDLNSKNKRETYLWGQLNLGNDGYEFKLAVGSHYSGNLINLAGATGLAVVPLNENFIP
AGESVRVLKIN
>Mature_411_residues
MLEVNQAESIILSLVQPLDADKDVETIDLLNSSGRILANPVVSKLDFPHWDNSAMDGYALKFADVKDCSPENSISLEIVE
EILAGSKPQKQIQPGQTARIFTGACMPIGADTIVIQEVTQREGNRVLILEAPEPQAFVRYRGSFYKAGTPVLNPRIYLGA
AEIAVLAALQCTQINVYRRVKVGIFSTGNELVKPDQPLKYGQIVDSNEYALTIALEKMGVEVIKFGILPDEPEILQKTIA
EAILNTDFLLSTGGVSVGDYDYIEEIITELGAEIHVHSVAVKPGKPLTVASFPNTKCLYFGLPGNPVSALVSFWRFVQPA
LKKLAGANEAEWGPEFVRARLLQDLNSKNKRETYLWGQLNLGNDGYEFKLAVGSHYSGNLINLAGATGLAVVPLNENFIP
AGESVRVLKIN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=401, Percent_Identity=33.4164588528678, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI10880983, Length=401, Percent_Identity=33.4164588528678, Blast_Score=192, Evalue=6e-49,
Organism=Escherichia coli, GI1787049, Length=382, Percent_Identity=38.7434554973822, Blast_Score=238, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI25147659, Length=381, Percent_Identity=30.7086614173228, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=329, Percent_Identity=25.2279635258359, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17136978, Length=415, Percent_Identity=30.6024096385542, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24638841, Length=415, Percent_Identity=30.6024096385542, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44839; Mature: 44839

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEVNQAESIILSLVQPLDADKDVETIDLLNSSGRILANPVVSKLDFPHWDNSAMDGYAL
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECHHHHHCCCCCCCCCCCCCEEE
KFADVKDCSPENSISLEIVEEILAGSKPQKQIQPGQTARIFTGACMPIGADTIVIQEVTQ
EECCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEEHHHH
REGNRVLILEAPEPQAFVRYRGSFYKAGTPVLNPRIYLGAAEIAVLAALQCTQINVYRRV
CCCCEEEEEECCCCHHHHHCCCCEEECCCCCCCCEEEECHHHHHHHHHHHHEEEEEEEEE
KVGIFSTGNELVKPDQPLKYGQIVDSNEYALTIALEKMGVEVIKFGILPDEPEILQKTIA
EEEEEECCCCCCCCCCCCCCCEEECCCCEEEEEEEHHCCEEEEEECCCCCCHHHHHHHHH
EAILNTDFLLSTGGVSVGDYDYIEEIITELGAEIHVHSVAVKPGKPLTVASFPNTKCLYF
HHHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCEEEEE
GLPGNPVSALVSFWRFVQPALKKLAGANEAEWGPEFVRARLLQDLNSKNKRETYLWGQLN
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEE
LGNDGYEFKLAVGSHYSGNLINLAGATGLAVVPLNENFIPAGESVRVLKIN
ECCCCEEEEEEECCCCCCCEEEECCCCCEEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MLEVNQAESIILSLVQPLDADKDVETIDLLNSSGRILANPVVSKLDFPHWDNSAMDGYAL
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECHHHHHCCCCCCCCCCCCCEEE
KFADVKDCSPENSISLEIVEEILAGSKPQKQIQPGQTARIFTGACMPIGADTIVIQEVTQ
EECCCCCCCCCCCCHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEEHHHH
REGNRVLILEAPEPQAFVRYRGSFYKAGTPVLNPRIYLGAAEIAVLAALQCTQINVYRRV
CCCCEEEEEECCCCHHHHHCCCCEEECCCCCCCCEEEECHHHHHHHHHHHHEEEEEEEEE
KVGIFSTGNELVKPDQPLKYGQIVDSNEYALTIALEKMGVEVIKFGILPDEPEILQKTIA
EEEEEECCCCCCCCCCCCCCCEEECCCCEEEEEEEHHCCEEEEEECCCCCCHHHHHHHHH
EAILNTDFLLSTGGVSVGDYDYIEEIITELGAEIHVHSVAVKPGKPLTVASFPNTKCLYF
HHHHCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCEEEEE
GLPGNPVSALVSFWRFVQPALKKLAGANEAEWGPEFVRARLLQDLNSKNKRETYLWGQLN
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEE
LGNDGYEFKLAVGSHYSGNLINLAGATGLAVVPLNENFIPAGESVRVLKIN
ECCCCEEEEEEECCCCCCCEEEECCCCCEEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]