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The map label for this gene is glmU

Identifier: 113474420

GI number: 113474420

Start: 878411

End: 879826

Strand: Direct

Name: glmU

Synonym: Tery_0560

Alternate gene names: 113474420

Gene position: 878411-879826 (Clockwise)

Preceding gene: 113474419

Following gene: 113474421

Centisome position: 11.33

GC content: 39.12

Gene sequence:

>1416_bases
ATGGTAGCGGTAGCAATTTTAGCGGCTGGACGTGGCACTAGAATGAAGTCAGACTTACCTAAGGTATTACACCAATTAGG
TTCTTGTACTTTAGTCAAACGAGTTATCAAAAGTTGTGTTTCTATTCAACCATCAAAAATAATGGTAATAGTTGGTTATC
GTGGGGGCCTTGTACAAAAGTCTCTCCTAGATAATAACAATAATATTGATAATGATAATACTCCTACACTAGAATTTGTA
GAACAGACGGAACAATTGGGAACTGGTCATGCTATTCAACAATTATTACCTTATCTGAAAGATTTTTCTGAGGAGCTGCT
GGTCTTAAATGGAGATGTACCATTATTACGACCCGAAACTATTAAGCAGTTAATTGATACCCATCAGCAAAATAAAAATT
CAGCGACTATCTTGACTGCTAATCTTCCTAATCCTAAAGGTTACGGTAGAATATTCTGTAATACAAATAATTTTGTGACT
CAAATAGTAGAAGAGCGAGACTGTACTGCTGCCCAAACAAAAAACCATCGCGTTAATGCCGGAGTTTACTGTTTTAACTG
GCCTGCTTTAGCAAATATATTGCCTAAACTAAAAGCAGACAATGACCAACAAGAGTATTATTTAACAGATGTGGTTCCTC
TTCTTGACCCTGTCATGGCAGTTGATGTGAATGACTATCAAGAAATTTTTGGTATTAATAACCGTAAACATTTAGCTAAA
GCTCATGAAATTTTGCAGGTGCGGGTCAAAGATGATTGGATGGAGGCCGGAGTCACGTTGATAGACCCTGATAGTATTAC
AATTGATGATACAGTTTTACTACAGCAGGATGTGATTGTTGAACCACAAACTCATATTCGGGGTTCGAGTATAATTGGTT
CTGGTAGTCGCATTGGGCCGGGAAGTTTGATTGAAAATAGTCATATAGGTAAAAATACTTCGGTTTTGTACTCTGTGATT
TCTGATAGTATGGTGGCCGACAATACTCGTATTGGTCCTTATGCACATTTACGGGGTGACTCTCAGGTGGGTTCTCACTG
TCGAATTGGCAATTTTGTGGAATTGAAAAAAGCAACGGTTGGCGATCGCTCTAATGCAGCTCATTTGTCCTATTTGGGGG
ACGCGACTTTGGGAGAAAAAGTAAATATTGGCGCTGGCACTATTACAGCTAATTATGATGGGGTGAAAAAGCATAAGACT
AAAATAGGCGATCGCTCGAAAACTGGGTCAAATAGTGTACTGGTTGCTCCTGTAACTTTAGGAGAAGATGTGACAGTAGC
TGCAGGTTCGGTAGTGACAAAGAATGTGGAAGATGATAGTTTAGTTATTGGTCGCGCTCGACAAGCTGTAAAAAAAGGTT
GGAGGTTGAAGCAGTCCGATGAAAGTAAGAAAGAAGAAAATAAGTCATCGCCCTGA

Upstream 100 bases:

>100_bases
TACTCCCATAGCTCTAATTGTCAGTCAAATATGAGAATATAAATACTGTAGATTCGTGATTAAACGTTTCTCAATTCAGA
AAGCAAATAATTCAAAAATT

Downstream 100 bases:

>100_bases
ATAATTTTCAAGTTTATGATCAACCGCGAAACTTCAATAACTTATGAGATCATACATAGCCATCAGTAACGCCTAATTTT
TTTTTAGATGTTGGTAGAAA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MVAVAILAAGRGTRMKSDLPKVLHQLGSCTLVKRVIKSCVSIQPSKIMVIVGYRGGLVQKSLLDNNNNIDNDNTPTLEFV
EQTEQLGTGHAIQQLLPYLKDFSEELLVLNGDVPLLRPETIKQLIDTHQQNKNSATILTANLPNPKGYGRIFCNTNNFVT
QIVEERDCTAAQTKNHRVNAGVYCFNWPALANILPKLKADNDQQEYYLTDVVPLLDPVMAVDVNDYQEIFGINNRKHLAK
AHEILQVRVKDDWMEAGVTLIDPDSITIDDTVLLQQDVIVEPQTHIRGSSIIGSGSRIGPGSLIENSHIGKNTSVLYSVI
SDSMVADNTRIGPYAHLRGDSQVGSHCRIGNFVELKKATVGDRSNAAHLSYLGDATLGEKVNIGAGTITANYDGVKKHKT
KIGDRSKTGSNSVLVAPVTLGEDVTVAAGSVVTKNVEDDSLVIGRARQAVKKGWRLKQSDESKKEENKSSP

Sequences:

>Translated_471_residues
MVAVAILAAGRGTRMKSDLPKVLHQLGSCTLVKRVIKSCVSIQPSKIMVIVGYRGGLVQKSLLDNNNNIDNDNTPTLEFV
EQTEQLGTGHAIQQLLPYLKDFSEELLVLNGDVPLLRPETIKQLIDTHQQNKNSATILTANLPNPKGYGRIFCNTNNFVT
QIVEERDCTAAQTKNHRVNAGVYCFNWPALANILPKLKADNDQQEYYLTDVVPLLDPVMAVDVNDYQEIFGINNRKHLAK
AHEILQVRVKDDWMEAGVTLIDPDSITIDDTVLLQQDVIVEPQTHIRGSSIIGSGSRIGPGSLIENSHIGKNTSVLYSVI
SDSMVADNTRIGPYAHLRGDSQVGSHCRIGNFVELKKATVGDRSNAAHLSYLGDATLGEKVNIGAGTITANYDGVKKHKT
KIGDRSKTGSNSVLVAPVTLGEDVTVAAGSVVTKNVEDDSLVIGRARQAVKKGWRLKQSDESKKEENKSSP
>Mature_471_residues
MVAVAILAAGRGTRMKSDLPKVLHQLGSCTLVKRVIKSCVSIQPSKIMVIVGYRGGLVQKSLLDNNNNIDNDNTPTLEFV
EQTEQLGTGHAIQQLLPYLKDFSEELLVLNGDVPLLRPETIKQLIDTHQQNKNSATILTANLPNPKGYGRIFCNTNNFVT
QIVEERDCTAAQTKNHRVNAGVYCFNWPALANILPKLKADNDQQEYYLTDVVPLLDPVMAVDVNDYQEIFGINNRKHLAK
AHEILQVRVKDDWMEAGVTLIDPDSITIDDTVLLQQDVIVEPQTHIRGSSIIGSGSRIGPGSLIENSHIGKNTSVLYSVI
SDSMVADNTRIGPYAHLRGDSQVGSHCRIGNFVELKKATVGDRSNAAHLSYLGDATLGEKVNIGAGTITANYDGVKKHKT
KIGDRSKTGSNSVLVAPVTLGEDVTVAAGSVVTKNVEDDSLVIGRARQAVKKGWRLKQSDESKKEENKSSP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=459, Percent_Identity=41.3943355119826, Blast_Score=332, Evalue=5e-92,
Organism=Drosophila melanogaster, GI21355443, Length=362, Percent_Identity=20.9944751381215, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644084, Length=362, Percent_Identity=20.9944751381215, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_TRIEI (Q118R6)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720481.1
- ProteinModelPortal:   Q118R6
- SMR:   Q118R6
- STRING:   Q118R6
- GeneID:   4242950
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0560
- NMPDR:   fig|203124.1.peg.5859
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q118R6
- ProtClustDB:   PRK14360
- BioCyc:   TERY203124:TERY_0560-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 51359; Mature: 51359

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 368-368 BINDING 82-82 BINDING 149-149 BINDING 164-164 BINDING 179-179 BINDING 392-392 BINDING 410-410 BINDING 428-428 BINDING 445-445

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVAILAAGRGTRMKSDLPKVLHQLGSCTLVKRVIKSCVSIQPSKIMVIVGYRGGLVQK
CEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHH
SLLDNNNNIDNDNTPTLEFVEQTEQLGTGHAIQQLLPYLKDFSEELLVLNGDVPLLRPET
HHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
IKQLIDTHQQNKNSATILTANLPNPKGYGRIFCNTNNFVTQIVEERDCTAAQTKNHRVNA
HHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHCCCCHHHCCCCEEEC
GVYCFNWPALANILPKLKADNDQQEYYLTDVVPLLDPVMAVDVNDYQEIFGINNRKHLAK
CEEEECCHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCEEEECCCHHHHHHCCCCHHHHHH
AHEILQVRVKDDWMEAGVTLIDPDSITIDDTVLLQQDVIVEPQTHIRGSSIIGSGSRIGP
HHHHEEEEECCHHHHCCCEEECCCCEEECCEEEEECCEEECCCHHCCCCCEECCCCCCCC
GSLIENSHIGKNTSVLYSVISDSMVADNTRIGPYAHLRGDSQVGSHCRIGNFVELKKATV
CCCCCCCCCCCCHHHHHHHHHCHHHCCCCCCCCEEEECCCCCCCCCCCCCCEEEEHHHCC
GDRSNAAHLSYLGDATLGEKVNIGAGTITANYDGVKKHKTKIGDRSKTGSNSVLVAPVTL
CCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEEEC
GEDVTVAAGSVVTKNVEDDSLVIGRARQAVKKGWRLKQSDESKKEENKSSP
CCCEEEECCCEEECCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MVAVAILAAGRGTRMKSDLPKVLHQLGSCTLVKRVIKSCVSIQPSKIMVIVGYRGGLVQK
CEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHH
SLLDNNNNIDNDNTPTLEFVEQTEQLGTGHAIQQLLPYLKDFSEELLVLNGDVPLLRPET
HHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHH
IKQLIDTHQQNKNSATILTANLPNPKGYGRIFCNTNNFVTQIVEERDCTAAQTKNHRVNA
HHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHCCCCHHHCCCCEEEC
GVYCFNWPALANILPKLKADNDQQEYYLTDVVPLLDPVMAVDVNDYQEIFGINNRKHLAK
CEEEECCHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCEEEECCCHHHHHHCCCCHHHHHH
AHEILQVRVKDDWMEAGVTLIDPDSITIDDTVLLQQDVIVEPQTHIRGSSIIGSGSRIGP
HHHHEEEEECCHHHHCCCEEECCCCEEECCEEEEECCEEECCCHHCCCCCEECCCCCCCC
GSLIENSHIGKNTSVLYSVISDSMVADNTRIGPYAHLRGDSQVGSHCRIGNFVELKKATV
CCCCCCCCCCCCHHHHHHHHHCHHHCCCCCCCCEEEECCCCCCCCCCCCCCEEEEHHHCC
GDRSNAAHLSYLGDATLGEKVNIGAGTITANYDGVKKHKTKIGDRSKTGSNSVLVAPVTL
CCCCCCEEEEECCCCCCCCEEECCCCEEEECCCCHHHHHHHCCCCCCCCCCCEEEEEEEC
GEDVTVAAGSVVTKNVEDDSLVIGRARQAVKKGWRLKQSDESKKEENKSSP
CCCEEEECCCEEECCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA