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The map label for this gene is yogA [H]

Identifier: 113474421

GI number: 113474421

Start: 880082

End: 881080

Strand: Direct

Name: yogA [H]

Synonym: Tery_0561

Alternate gene names: 113474421

Gene position: 880082-881080 (Clockwise)

Preceding gene: 113474420

Following gene: 113474422

Centisome position: 11.36

GC content: 40.04

Gene sequence:

>999_bases
ATGAAAGCTTTTGAAGTTAGAGAATTTGGCAACTTAGTTTGTACTGAAAGACCACAACCAGAACCAAAATTTGGAGAAGT
TTTAGTGAAAGTTAAAGCTGTCTCCCTTAACTATCGAGATATTTTAATGGTTAAAGGTGCTTACAACCCCCATCTACCTC
TACCTGTTATTCCATGCTCTGATGGAGTTGGAGAGGTTGTGTCAGTGGGGGAAGGTGTCACTAAAGTGAAACCTGGAGAT
AGAGTTGCTAGCATTTTTATGCAGAAATGGTTATCTGGTAACTTGACTAGAGAAGCAGCCAGGTCAGCTTTGGGTGGTGA
AATTGACGGAATGTTAGCAGAATATGTAATTTTGTCGGAAGATGGAGTGGTAAATATTCCATCTTACTTATCTGATATAG
AAGCAGCTACTTTACCTTGTGCGGCAGTAACAGCTTGGCACGCTTTAATAGAAGCTGGTTTAAAACCAGGGGAAACAGTA
TTAGTAATGGGAACAGGTGGAGTTTCCTTATTTGCCTTACAGTTTGCAGTGATGGCAGGAGCACGAGTCATCGCAACTTC
CAGTAGTGATGAAAAATTAGCGCGGGTGAAACAGTTGGGTGCATCTGATATGATTAATTATAAATCTGTACCTAAATGGG
AAAAACAAGTGTTAGCCTTGACTGAGGGCACTGGAGTTGACTATGTTGTGGAAGTTGGTGGAGCCAAGACTTTGAGTCAG
TCTTTAAAAGCAGTAAAGATAGGAGGTCAAATAAGTTTAATAGGTATATTGGCAGGAGCGCAAGCAGAATTTAATATTTT
ACCTGCACTCATGAAAGAAGTTCGGATACATGGTATTTTTGTGGGTTCCCGTCAAATGTTTGAAGCGATGAATAGGGCGA
TAGATCTTTCTCAGTTGCATCCGGTCTGTGATCGCATTTTTCCATTTGAGTCAGCTCCAGAAGCACTAAGTTATATGGAA
ATAGGTTCCCATTTTGGTAAAATTACAATTCAATTTTAG

Upstream 100 bases:

>100_bases
TATTCCCTTCTACCCTCTGCCTTCCTTCTATAAGTAAATAAATACTTAACCAGATTAATAATTAAGTATTTTGTCATACG
CAAACTTTGGAGATAATTTT

Downstream 100 bases:

>100_bases
TTTTTGATCAGGAGGTAAAGATGAAAGCATTAGTTTTAGAAAAACCGGGAATTCCTGATAGTTTATATATTACAGAAATA
CCTTTACCACAACCGGCAGC

Product: zinc-binding alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKAFEVREFGNLVCTERPQPEPKFGEVLVKVKAVSLNYRDILMVKGAYNPHLPLPVIPCSDGVGEVVSVGEGVTKVKPGD
RVASIFMQKWLSGNLTREAARSALGGEIDGMLAEYVILSEDGVVNIPSYLSDIEAATLPCAAVTAWHALIEAGLKPGETV
LVMGTGGVSLFALQFAVMAGARVIATSSSDEKLARVKQLGASDMINYKSVPKWEKQVLALTEGTGVDYVVEVGGAKTLSQ
SLKAVKIGGQISLIGILAGAQAEFNILPALMKEVRIHGIFVGSRQMFEAMNRAIDLSQLHPVCDRIFPFESAPEALSYME
IGSHFGKITIQF

Sequences:

>Translated_332_residues
MKAFEVREFGNLVCTERPQPEPKFGEVLVKVKAVSLNYRDILMVKGAYNPHLPLPVIPCSDGVGEVVSVGEGVTKVKPGD
RVASIFMQKWLSGNLTREAARSALGGEIDGMLAEYVILSEDGVVNIPSYLSDIEAATLPCAAVTAWHALIEAGLKPGETV
LVMGTGGVSLFALQFAVMAGARVIATSSSDEKLARVKQLGASDMINYKSVPKWEKQVLALTEGTGVDYVVEVGGAKTLSQ
SLKAVKIGGQISLIGILAGAQAEFNILPALMKEVRIHGIFVGSRQMFEAMNRAIDLSQLHPVCDRIFPFESAPEALSYME
IGSHFGKITIQF
>Mature_332_residues
MKAFEVREFGNLVCTERPQPEPKFGEVLVKVKAVSLNYRDILMVKGAYNPHLPLPVIPCSDGVGEVVSVGEGVTKVKPGD
RVASIFMQKWLSGNLTREAARSALGGEIDGMLAEYVILSEDGVVNIPSYLSDIEAATLPCAAVTAWHALIEAGLKPGETV
LVMGTGGVSLFALQFAVMAGARVIATSSSDEKLARVKQLGASDMINYKSVPKWEKQVLALTEGTGVDYVVEVGGAKTLSQ
SLKAVKIGGQISLIGILAGAQAEFNILPALMKEVRIHGIFVGSRQMFEAMNRAIDLSQLHPVCDRIFPFESAPEALSYME
IGSHFGKITIQF

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=327, Percent_Identity=29.3577981651376, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13236495, Length=327, Percent_Identity=29.3577981651376, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI22538446, Length=338, Percent_Identity=28.698224852071, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI22538444, Length=338, Percent_Identity=28.698224852071, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI41872631, Length=343, Percent_Identity=28.2798833819242, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28557745, Length=340, Percent_Identity=30.2941176470588, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=27.4666666666667, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI47519420, Length=347, Percent_Identity=28.5302593659942, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI194239676, Length=323, Percent_Identity=27.2445820433437, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI262073058, Length=340, Percent_Identity=27.3529411764706, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71743840, Length=339, Percent_Identity=26.8436578171091, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI71565154, Length=257, Percent_Identity=29.5719844357977, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI18379349, Length=333, Percent_Identity=25.2252252252252, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI67078404, Length=262, Percent_Identity=25.9541984732824, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI197927207, Length=176, Percent_Identity=30.1136363636364, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=27.8735632183908, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082125, Length=335, Percent_Identity=27.4626865671642, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788073, Length=284, Percent_Identity=31.3380281690141, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=26.1627906976744, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789651, Length=263, Percent_Identity=27.7566539923954, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790485, Length=262, Percent_Identity=27.8625954198473, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788407, Length=252, Percent_Identity=28.968253968254, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI226510992, Length=256, Percent_Identity=26.953125, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787863, Length=224, Percent_Identity=29.4642857142857, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=340, Percent_Identity=27.0588235294118, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=25.8160237388724, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=291, Percent_Identity=27.4914089347079, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=279, Percent_Identity=30.1075268817204, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=326, Percent_Identity=23.6196319018405, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI212642053, Length=327, Percent_Identity=25.9938837920489, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=27.4336283185841, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=329, Percent_Identity=27.0516717325228, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=30, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=340, Percent_Identity=30, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=26.1764705882353, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=339, Percent_Identity=25.9587020648968, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319520, Length=258, Percent_Identity=32.5581395348837, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=276, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19920632, Length=253, Percent_Identity=26.8774703557312, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221330659, Length=253, Percent_Identity=26.8774703557312, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581345, Length=340, Percent_Identity=24.4117647058824, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 35579; Mature: 35579

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFEVREFGNLVCTERPQPEPKFGEVLVKVKAVSLNYRDILMVKGAYNPHLPLPVIPCS
CCCCCHHHHCCEEECCCCCCCCCHHHEEEEEEEEEECCEEEEEEECCCCCCCCCEEEECC
DGVGEVVSVGEGVTKVKPGDRVASIFMQKWLSGNLTREAARSALGGEIDGMLAEYVILSE
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHEEEEECC
DGVVNIPSYLSDIEAATLPCAAVTAWHALIEAGLKPGETVLVMGTGGVSLFALQFAVMAG
CCEEECHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHC
ARVIATSSSDEKLARVKQLGASDMINYKSVPKWEKQVLALTEGTGVDYVVEVGGAKTLSQ
CEEEEECCCHHHHHHHHHCCHHHCCCCCCCCCHHHHEEEEECCCCCEEEEECCCHHHHHH
SLKAVKIGGQISLIGILAGAQAEFNILPALMKEVRIHGIFVGSRQMFEAMNRAIDLSQLH
HHHEEEECCEEEEEEEEECCCCCHHHHHHHHHHHEEEEEEECCHHHHHHHHHHCCHHHHH
PVCDRIFPFESAPEALSYMEIGSHFGKITIQF
HHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKAFEVREFGNLVCTERPQPEPKFGEVLVKVKAVSLNYRDILMVKGAYNPHLPLPVIPCS
CCCCCHHHHCCEEECCCCCCCCCHHHEEEEEEEEEECCEEEEEEECCCCCCCCCEEEECC
DGVGEVVSVGEGVTKVKPGDRVASIFMQKWLSGNLTREAARSALGGEIDGMLAEYVILSE
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHEEEEECC
DGVVNIPSYLSDIEAATLPCAAVTAWHALIEAGLKPGETVLVMGTGGVSLFALQFAVMAG
CCEEECHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHC
ARVIATSSSDEKLARVKQLGASDMINYKSVPKWEKQVLALTEGTGVDYVVEVGGAKTLSQ
CEEEEECCCHHHHHHHHHCCHHHCCCCCCCCCHHHHEEEEECCCCCEEEEECCCHHHHHH
SLKAVKIGGQISLIGILAGAQAEFNILPALMKEVRIHGIFVGSRQMFEAMNRAIDLSQLH
HHHEEEECCEEEEEEEEECCCCCHHHHHHHHHHHEEEEEEECCHHHHHHHHHHCCHHHHH
PVCDRIFPFESAPEALSYMEIGSHFGKITIQF
HHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]