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The map label for this gene is pgl [H]

Identifier: 113474399

GI number: 113474399

Start: 847091

End: 847798

Strand: Reverse

Name: pgl [H]

Synonym: Tery_0535

Alternate gene names: 113474399

Gene position: 847798-847091 (Counterclockwise)

Preceding gene: 113474401

Following gene: 113474398

Centisome position: 10.94

GC content: 40.25

Gene sequence:

>708_bases
ATGGAAAAACAAGTTAAGTTACTAGAAGATAAAGAACAGTTGATCAAACAAGCTTTGGACATTTGCTTGGCGAAAATTCA
AGAGGCGATCAGAGAACGTAATCAATGTACAATAGCTTTAGCTGGTGGAAATACTCCAAGGCCACTTTATGAGTTCATAA
AAAATCAAAATATAGATTGGGATAAAATTCATGTATTTTGGGGCGACGAACGTTATGTAGCTCCTGACCATCCGGATAGT
AATCAAAAAATGGCCAGAGAAGCTTGGCTAGATCAAGTAACCATACCAGCAACAAATGTTCATCCTATGGAAACAGGGTC
GGGAGACCCGGAAGCTGATGCTTTAAAGCATGATGCTCATTTGCGAGATTTTTTTCAAGTCTCTACAGGGGAGTTTCCGA
GCTTTGATTTGATTTTACTAGGAATGGGAGGTGATGGTCATACAGCCTCCTTGTTTCCCCATACAAACGCTTTGAAAGTA
AGCGATCGCCTAATTACTGTAGGAAATAAAGATGGCCAACCGCGATTAACTTTCACGGTTCCATTAATCAATCAAGCACG
TTGCGTAATCTTTCTAGTTGCTGGTGCAGACAAACAAGCCGCGTTAGACGAAGTATTTGCAGAAAAAGGTGATGATATGA
ATTATCCCAGTCGCCTGATCCAACCTAAAGGAGAGCTACAATGGTTATTAACGGGTGTTAATATTTGA

Upstream 100 bases:

>100_bases
TCGAATCTCAATCAAAACCGCTACCGTATGGCCGTGATACCCAAATTTAGAAAAAATACTATTTTTTGGGGTGTAAACTT
TTAATCTTAACACAAATCAA

Downstream 100 bases:

>100_bases
GAATTGACATTCTCCAGTAGCTGTTAGGCCTGGGGGAGTTCTACTGAGCTGAGGCCTAGCTGTGTGAGTTAACATTTGGC
ACTTAGCATTAGCTCACTCA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MEKQVKLLEDKEQLIKQALDICLAKIQEAIRERNQCTIALAGGNTPRPLYEFIKNQNIDWDKIHVFWGDERYVAPDHPDS
NQKMAREAWLDQVTIPATNVHPMETGSGDPEADALKHDAHLRDFFQVSTGEFPSFDLILLGMGGDGHTASLFPHTNALKV
SDRLITVGNKDGQPRLTFTVPLINQARCVIFLVAGADKQAALDEVFAEKGDDMNYPSRLIQPKGELQWLLTGVNI

Sequences:

>Translated_235_residues
MEKQVKLLEDKEQLIKQALDICLAKIQEAIRERNQCTIALAGGNTPRPLYEFIKNQNIDWDKIHVFWGDERYVAPDHPDS
NQKMAREAWLDQVTIPATNVHPMETGSGDPEADALKHDAHLRDFFQVSTGEFPSFDLILLGMGGDGHTASLFPHTNALKV
SDRLITVGNKDGQPRLTFTVPLINQARCVIFLVAGADKQAALDEVFAEKGDDMNYPSRLIQPKGELQWLLTGVNI
>Mature_235_residues
MEKQVKLLEDKEQLIKQALDICLAKIQEAIRERNQCTIALAGGNTPRPLYEFIKNQNIDWDKIHVFWGDERYVAPDHPDS
NQKMAREAWLDQVTIPATNVHPMETGSGDPEADALKHDAHLRDFFQVSTGEFPSFDLILLGMGGDGHTASLFPHTNALKV
SDRLITVGNKDGQPRLTFTVPLINQARCVIFLVAGADKQAALDEVFAEKGDDMNYPSRLIQPKGELQWLLTGVNI

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=225, Percent_Identity=30.6666666666667, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI6912586, Length=233, Percent_Identity=30.0429184549356, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115533060, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533058, Length=231, Percent_Identity=25.974025974026, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321957, Length=232, Percent_Identity=28.8793103448276, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321687, Length=232, Percent_Identity=29.7413793103448, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324362, Length=207, Percent_Identity=29.951690821256, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319918, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24641119, Length=233, Percent_Identity=33.0472103004292, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26286; Mature: 26286

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQVKLLEDKEQLIKQALDICLAKIQEAIRERNQCTIALAGGNTPRPLYEFIKNQNIDW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCC
DKIHVFWGDERYVAPDHPDSNQKMAREAWLDQVTIPATNVHPMETGSGDPEADALKHDAH
EEEEEEECCCEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCHHHHHHHHH
LRDFFQVSTGEFPSFDLILLGMGGDGHTASLFPHTNALKVSDRLITVGNKDGQPRLTFTV
HHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCEEEECCEEEEECCCCCCCEEEEEE
PLINQARCVIFLVAGADKQAALDEVFAEKGDDMNYPSRLIQPKGELQWLLTGVNI
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEEECCC
>Mature Secondary Structure
MEKQVKLLEDKEQLIKQALDICLAKIQEAIRERNQCTIALAGGNTPRPLYEFIKNQNIDW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCC
DKIHVFWGDERYVAPDHPDSNQKMAREAWLDQVTIPATNVHPMETGSGDPEADALKHDAH
EEEEEEECCCEEECCCCCCCHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCHHHHHHHHH
LRDFFQVSTGEFPSFDLILLGMGGDGHTASLFPHTNALKVSDRLITVGNKDGQPRLTFTV
HHHHHHHCCCCCCCEEEEEEEECCCCCEEEECCCCCEEEECCEEEEECCCCCCCEEEEEE
PLINQARCVIFLVAGADKQAALDEVFAEKGDDMNYPSRLIQPKGELQWLLTGVNI
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]