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The map label for this gene is mutL [H]

Identifier: 113474371

GI number: 113474371

Start: 806353

End: 808116

Strand: Reverse

Name: mutL [H]

Synonym: Tery_0504

Alternate gene names: 113474371

Gene position: 808116-806353 (Counterclockwise)

Preceding gene: 113474377

Following gene: 113474370

Centisome position: 10.43

GC content: 35.43

Gene sequence:

>1764_bases
ATGCAATCTCAAATTCAAACCTTACCTAAAGAAGTTGTCAGCTTAATTGCTGCTGGAGAAGTTATTGATTCTTTAGCAGC
AGTTGTGCGGGAATTAGTAGAAAACTCTCTTGATGCTGGAGCCACTCGCATCATAGTTTCTATCATTTCTGAACAGTGGC
GAGTACAAATTTCTGACAATGGAATGGGTATGAATTTAGCCAATTTAAAACGAGCAGCAAATCCTCATAGCACCAGTAAG
ATTACTAATCTTCAAGACCTCACAAAAATTAGTAGTTTAGGATTTCGTGGAGAAGCACTTCATAGTTTAGCTAATCTCTC
AAATTTAGAAATATTAAGTCGTCCTAAGTCACCCCTTTCAGAAAATGAAAATGAAGGTTGGCGAGTTGTTTATGATCAGC
AAGGAAAATCTGTTAAAGCTGAAAGAGTTGCCATTGCTCCTGGTACTATTGTTAAGGTTTCTCATATTTTTGGTAAATGG
CCTGTACGTCGAAAAGGAATGCCTTCTCCCCCACAACAAATGCGAGGTATACAATTAATTATTCAGCAAATAGCCCTTTG
CTATCCTGATGTTACTTGGCAAATTTGGCAGGGTAGTAAATTATGGATACAAATTAGTCCTGGGGCTACGGCAAAACAAA
TTTTACCTCAAATTTTATCTACAGTAAGATTGAATGATTTACAGTATATTCAACAAGAAATTGATGAGCAAGAAGCAGAA
GAATTAAATATTCAAACATCGAGTTTTTCCCAATCTCAAGATTCTCAACTTTTGGATAGACAATCATTAGAATTAGTGTT
AGGTTTGCCAGATAGATGTCATCGTAGACGACCTGATTGGGTAAAAGTTGGTATTAATGGTAGGGTAGTAAAAGTGCCAG
AATTAGAACAAACAATTATTCGTTCTTTAGCGCGGACTTGTCCTGGCGATCGCTATCCTCTATGTTTCATTCATTTACAA
ATTTTTCCCTATCAAATTAACTGGAACCGTCATCCGGCAAAAACAGAAATTTATCTAGATAATTTGAAATTTTGGCAACA
ACAAATCAATTTAGTAATTGGTAAAGCATTACAATTTAGTTCGGATATTATGCCAGAATTTCCTTTGTCAGAAAGAGTGG
AAAAACTCTTAAAAGTCTCAGAAAATACTGGGAATTATCAAGTTAGTCGAGCTATAGAAGTTTCTCCAGATAATACAGAA
CAAAAAAAATCAAAATTAGGACTAATAGAATTAAAAGCGATCGCTCAATTACACAATACTTATATAGTAGCAGAACATCC
AAGTGGCATTTGGTTGATTGAACAACATATTGCCCACGAAAGAATTTTATATGAAGAATTATGTGATGCTTGGGAAATAA
TTTTTTTAGAAACTCCGATTATTTTACATCATTTATCCCCAGCTCAAATAGAACAACTTCAACGCTTAAATATAGACATA
GAAACCTTCGGAGATTTACTTTGGGCTGCTCGTAGTGCTCCCAAAATGTTAGCAAAAAGAAATGACTGTGCTGATGCTTT
AATTGAACTTAGTAAAGGTGGCGATCTAGAATCTGCTAAAGTAGCCACTGCTTGTCGTAGTGCTATTAGAAATGGAACTC
CTTTAAGCCTACCGGAAATGCAAAGTTTATTAAATAAATGGCAACTTACCCATAACCCTCGTACTTGTCCCCACGGTAGA
CCAATTTATTTACCTTTAGAAGAATCAGCTTTATCTCGTTTCTTTCGTCGAAATTGGGTGATTGGAAAAAGTCATGGTAT
TTAA

Upstream 100 bases:

>100_bases
ATTAGTCTAATTAAGATCCTGAAAATACATAGGTTAAAAAACAAAATTACCTCCTGTTATTAACTATAGTTAGAAACTTT
TTGTTACTGCTTTTATATAA

Downstream 100 bases:

>100_bases
AATAAAAGACAAAAAGCAAAAATAAATAAATTTAAGATTTTGCACCAATTATCAAAATGAAAAAACCTTAACTATTGACT
GATTACCTGATACGAAAATA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MQSQIQTLPKEVVSLIAAGEVIDSLAAVVRELVENSLDAGATRIIVSIISEQWRVQISDNGMGMNLANLKRAANPHSTSK
ITNLQDLTKISSLGFRGEALHSLANLSNLEILSRPKSPLSENENEGWRVVYDQQGKSVKAERVAIAPGTIVKVSHIFGKW
PVRRKGMPSPPQQMRGIQLIIQQIALCYPDVTWQIWQGSKLWIQISPGATAKQILPQILSTVRLNDLQYIQQEIDEQEAE
ELNIQTSSFSQSQDSQLLDRQSLELVLGLPDRCHRRRPDWVKVGINGRVVKVPELEQTIIRSLARTCPGDRYPLCFIHLQ
IFPYQINWNRHPAKTEIYLDNLKFWQQQINLVIGKALQFSSDIMPEFPLSERVEKLLKVSENTGNYQVSRAIEVSPDNTE
QKKSKLGLIELKAIAQLHNTYIVAEHPSGIWLIEQHIAHERILYEELCDAWEIIFLETPIILHHLSPAQIEQLQRLNIDI
ETFGDLLWAARSAPKMLAKRNDCADALIELSKGGDLESAKVATACRSAIRNGTPLSLPEMQSLLNKWQLTHNPRTCPHGR
PIYLPLEESALSRFFRRNWVIGKSHGI

Sequences:

>Translated_587_residues
MQSQIQTLPKEVVSLIAAGEVIDSLAAVVRELVENSLDAGATRIIVSIISEQWRVQISDNGMGMNLANLKRAANPHSTSK
ITNLQDLTKISSLGFRGEALHSLANLSNLEILSRPKSPLSENENEGWRVVYDQQGKSVKAERVAIAPGTIVKVSHIFGKW
PVRRKGMPSPPQQMRGIQLIIQQIALCYPDVTWQIWQGSKLWIQISPGATAKQILPQILSTVRLNDLQYIQQEIDEQEAE
ELNIQTSSFSQSQDSQLLDRQSLELVLGLPDRCHRRRPDWVKVGINGRVVKVPELEQTIIRSLARTCPGDRYPLCFIHLQ
IFPYQINWNRHPAKTEIYLDNLKFWQQQINLVIGKALQFSSDIMPEFPLSERVEKLLKVSENTGNYQVSRAIEVSPDNTE
QKKSKLGLIELKAIAQLHNTYIVAEHPSGIWLIEQHIAHERILYEELCDAWEIIFLETPIILHHLSPAQIEQLQRLNIDI
ETFGDLLWAARSAPKMLAKRNDCADALIELSKGGDLESAKVATACRSAIRNGTPLSLPEMQSLLNKWQLTHNPRTCPHGR
PIYLPLEESALSRFFRRNWVIGKSHGI
>Mature_587_residues
MQSQIQTLPKEVVSLIAAGEVIDSLAAVVRELVENSLDAGATRIIVSIISEQWRVQISDNGMGMNLANLKRAANPHSTSK
ITNLQDLTKISSLGFRGEALHSLANLSNLEILSRPKSPLSENENEGWRVVYDQQGKSVKAERVAIAPGTIVKVSHIFGKW
PVRRKGMPSPPQQMRGIQLIIQQIALCYPDVTWQIWQGSKLWIQISPGATAKQILPQILSTVRLNDLQYIQQEIDEQEAE
ELNIQTSSFSQSQDSQLLDRQSLELVLGLPDRCHRRRPDWVKVGINGRVVKVPELEQTIIRSLARTCPGDRYPLCFIHLQ
IFPYQINWNRHPAKTEIYLDNLKFWQQQINLVIGKALQFSSDIMPEFPLSERVEKLLKVSENTGNYQVSRAIEVSPDNTE
QKKSKLGLIELKAIAQLHNTYIVAEHPSGIWLIEQHIAHERILYEELCDAWEIIFLETPIILHHLSPAQIEQLQRLNIDI
ETFGDLLWAARSAPKMLAKRNDCADALIELSKGGDLESAKVATACRSAIRNGTPLSLPEMQSLLNKWQLTHNPRTCPHGR
PIYLPLEESALSRFFRRNWVIGKSHGI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4505911, Length=344, Percent_Identity=25.5813953488372, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI189458898, Length=344, Percent_Identity=25.5813953488372, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI4557757, Length=338, Percent_Identity=25.7396449704142, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI310128478, Length=162, Percent_Identity=38.2716049382716, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4505913, Length=162, Percent_Identity=38.2716049382716, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI91992162, Length=195, Percent_Identity=33.8461538461538, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI91992160, Length=195, Percent_Identity=33.8461538461538, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI189458896, Length=191, Percent_Identity=29.3193717277487, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI310128480, Length=111, Percent_Identity=36.9369369369369, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790612, Length=337, Percent_Identity=31.7507418397626, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17562796, Length=350, Percent_Identity=26.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71991825, Length=348, Percent_Identity=25.8620689655172, Blast_Score=112, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323819, Length=341, Percent_Identity=25.8064516129032, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324247, Length=355, Percent_Identity=26.7605633802817, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=248, Percent_Identity=29.4354838709677, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=164, Percent_Identity=28.6585365853659, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136968, Length=350, Percent_Identity=26.5714285714286, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136970, Length=168, Percent_Identity=38.6904761904762, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 66398; Mature: 66398

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSQIQTLPKEVVSLIAAGEVIDSLAAVVRELVENSLDAGATRIIVSIISEQWRVQISDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEECCC
GMGMNLANLKRAANPHSTSKITNLQDLTKISSLGFRGEALHSLANLSNLEILSRPKSPLS
CCCCCHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCCCCCC
ENENEGWRVVYDQQGKSVKAERVAIAPGTIVKVSHIFGKWPVRRKGMPSPPQQMRGIQLI
CCCCCCEEEEECCCCCCEECCEEEECCCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IQQIALCYPDVTWQIWQGSKLWIQISPGATAKQILPQILSTVRLNDLQYIQQEIDEQEAE
HHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
ELNIQTSSFSQSQDSQLLDRQSLELVLGLPDRCHRRRPDWVKVGINGRVVKVPELEQTII
HCCCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHCCCCCEEEECCCCEEEECCCHHHHHH
RSLARTCPGDRYPLCFIHLQIFPYQINWNRHPAKTEIYLDNLKFWQQQINLVIGKALQFS
HHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
SDIMPEFPLSERVEKLLKVSENTGNYQVSRAIEVSPDNTEQKKSKLGLIELKAIAQLHNT
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHCC
YIVAEHPSGIWLIEQHIAHERILYEELCDAWEIIFLETPIILHHLSPAQIEQLQRLNIDI
EEEEECCCCEEEEHHHHHHHHHHHHHHHCHHEEEEEECCHHEECCCHHHHHHHHHCCCCH
ETFGDLLWAARSAPKMLAKRNDCADALIELSKGGDLESAKVATACRSAIRNGTPLSLPEM
HHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHH
QSLLNKWQLTHNPRTCPHGRPIYLPLEESALSRFFRRNWVIGKSHGI
HHHHHHHEECCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQSQIQTLPKEVVSLIAAGEVIDSLAAVVRELVENSLDAGATRIIVSIISEQWRVQISDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEECCC
GMGMNLANLKRAANPHSTSKITNLQDLTKISSLGFRGEALHSLANLSNLEILSRPKSPLS
CCCCCHHHHHHCCCCCCHHHHCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCCCCCC
ENENEGWRVVYDQQGKSVKAERVAIAPGTIVKVSHIFGKWPVRRKGMPSPPQQMRGIQLI
CCCCCCEEEEECCCCCCEECCEEEECCCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHH
IQQIALCYPDVTWQIWQGSKLWIQISPGATAKQILPQILSTVRLNDLQYIQQEIDEQEAE
HHHHHHHCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
ELNIQTSSFSQSQDSQLLDRQSLELVLGLPDRCHRRRPDWVKVGINGRVVKVPELEQTII
HCCCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHCCCCCEEEECCCCEEEECCCHHHHHH
RSLARTCPGDRYPLCFIHLQIFPYQINWNRHPAKTEIYLDNLKFWQQQINLVIGKALQFS
HHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
SDIMPEFPLSERVEKLLKVSENTGNYQVSRAIEVSPDNTEQKKSKLGLIELKAIAQLHNT
CCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHCC
YIVAEHPSGIWLIEQHIAHERILYEELCDAWEIIFLETPIILHHLSPAQIEQLQRLNIDI
EEEEECCCCEEEEHHHHHHHHHHHHHHHCHHEEEEEECCHHEECCCHHHHHHHHHCCCCH
ETFGDLLWAARSAPKMLAKRNDCADALIELSKGGDLESAKVATACRSAIRNGTPLSLPEM
HHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHH
QSLLNKWQLTHNPRTCPHGRPIYLPLEESALSRFFRRNWVIGKSHGI
HHHHHHHEECCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA