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The map label for this gene is gmd [H]

Identifier: 113474358

GI number: 113474358

Start: 784902

End: 785930

Strand: Direct

Name: gmd [H]

Synonym: Tery_0490

Alternate gene names: 113474358

Gene position: 784902-785930 (Clockwise)

Preceding gene: 113474357

Following gene: 113474359

Centisome position: 10.13

GC content: 36.05

Gene sequence:

>1029_bases
ATGAGTGAAAGGAAACGAGCGCTAATTACTGGTATTACAGGTCAAGACGGTTCATATTTAGCTGAACTTTTACTTGAGAA
AAACTATGAAGTTCATGGTATCATTAGACGTAGTTCTAGCTTTAATACAGATAGGATAGAGCATATATATCAAGATTCTC
ATTATCCAGATGCTAGATTATTTCTCCATTATGGAGACTTAACTGATGGGACTACTCTACGTCGAATTATTGAAGCAGTT
AAGCCATTAGAAATATACAACTTAGGTGCCCAGTCCCATGTTAGGGTGAGCTTTGATTCTCCAGAGTATACGGTAGATTC
AGTGGGAATGGGCACTCTACGTTTACTCGAAGCAATACGAGACTATCAACAACGTACTGGGATTGAAGTTCGTTTTTATC
AAGCTGGATCTTCGGAAATGTTTGGTAAAGTTCAAGAAATACCTCAGAAAGAAACTACACCTTTTTACCCCCGTAGTCCC
TATTCTTGTGCTAAAGTTTATGCCTACTGGCAAACAATAAATTATCGAGAGTCGTACAATCTATTTGCTTGTAATGGTAT
ATTATTCAACCATGAAAGTCCTCGTCGAGGTGAGACTTTTGTAACTCGTAAAATTACTCGTGCTGTAGCTAGAATTTTAG
CAGATAAACAAAAAAAACTTTATCTTGGTAATCTTGATGCTAAAAGAGATTGGGGATATGCAAAGGATTATGTTCGAGCT
ATGTGGATGATGCTACAGCAGGAAGCACCAGATGATTATGTGATTGCTACTAATGAAACTCATTCTATTAAAGAATTTCT
AGAAATAGCATTTACTTATGTAAATCTAGAGTGGCAAGATTATGTGGAGTTTGACCCTCGTTATCTACGTCCTACTGAGG
TTGATTTGTTAATTGGTGATTGTACAAAAGCACGAGAAAAGTTACATTGGAAACCATCAGTTACATTTACGGAGTTGGTA
CATTTGATGGTTGATTCTGATATTAAGGTTTTGGAAAAAGCTGTTATTAATAGTAATGGTTTTGATTAA

Upstream 100 bases:

>100_bases
TGGCTTGTATTATAGTAAAAAGAAATCTTAAATGTTACAGAAATTGGTGTATCTAAGGCCGAGAGTATGTAACTACGTTG
CGTTATGAATATTAACTATA

Downstream 100 bases:

>100_bases
AAATTTAGGACTAAGTTATTAAGAGGGTTAAATTATTGAGGTAATCCTTAATTTTTTTGAGGTGATAGTGCTTTTAGTTG
ACTTTTAGCACTATCAAAAT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSERKRALITGITGQDGSYLAELLLEKNYEVHGIIRRSSSFNTDRIEHIYQDSHYPDARLFLHYGDLTDGTTLRRIIEAV
KPLEIYNLGAQSHVRVSFDSPEYTVDSVGMGTLRLLEAIRDYQQRTGIEVRFYQAGSSEMFGKVQEIPQKETTPFYPRSP
YSCAKVYAYWQTINYRESYNLFACNGILFNHESPRRGETFVTRKITRAVARILADKQKKLYLGNLDAKRDWGYAKDYVRA
MWMMLQQEAPDDYVIATNETHSIKEFLEIAFTYVNLEWQDYVEFDPRYLRPTEVDLLIGDCTKAREKLHWKPSVTFTELV
HLMVDSDIKVLEKAVINSNGFD

Sequences:

>Translated_342_residues
MSERKRALITGITGQDGSYLAELLLEKNYEVHGIIRRSSSFNTDRIEHIYQDSHYPDARLFLHYGDLTDGTTLRRIIEAV
KPLEIYNLGAQSHVRVSFDSPEYTVDSVGMGTLRLLEAIRDYQQRTGIEVRFYQAGSSEMFGKVQEIPQKETTPFYPRSP
YSCAKVYAYWQTINYRESYNLFACNGILFNHESPRRGETFVTRKITRAVARILADKQKKLYLGNLDAKRDWGYAKDYVRA
MWMMLQQEAPDDYVIATNETHSIKEFLEIAFTYVNLEWQDYVEFDPRYLRPTEVDLLIGDCTKAREKLHWKPSVTFTELV
HLMVDSDIKVLEKAVINSNGFD
>Mature_341_residues
SERKRALITGITGQDGSYLAELLLEKNYEVHGIIRRSSSFNTDRIEHIYQDSHYPDARLFLHYGDLTDGTTLRRIIEAVK
PLEIYNLGAQSHVRVSFDSPEYTVDSVGMGTLRLLEAIRDYQQRTGIEVRFYQAGSSEMFGKVQEIPQKETTPFYPRSPY
SCAKVYAYWQTINYRESYNLFACNGILFNHESPRRGETFVTRKITRAVARILADKQKKLYLGNLDAKRDWGYAKDYVRAM
WMMLQQEAPDDYVIATNETHSIKEFLEIAFTYVNLEWQDYVEFDPRYLRPTEVDLLIGDCTKAREKLHWKPSVTFTELVH
LMVDSDIKVLEKAVINSNGFD

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=348, Percent_Identity=60.632183908046, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1788366, Length=368, Percent_Identity=58.4239130434783, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1788353, Length=351, Percent_Identity=24.2165242165242, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994969, Length=247, Percent_Identity=25.9109311740891, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=348, Percent_Identity=58.9080459770115, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539424, Length=347, Percent_Identity=57.3487031700288, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI133901788, Length=347, Percent_Identity=57.3487031700288, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17539422, Length=347, Percent_Identity=57.3487031700288, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI133901790, Length=347, Percent_Identity=57.3487031700288, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI133901786, Length=347, Percent_Identity=57.3487031700288, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24158427, Length=355, Percent_Identity=60, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 39815; Mature: 39683

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERKRALITGITGQDGSYLAELLLEKNYEVHGIIRRSSSFNTDRIEHIYQDSHYPDARL
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEE
FLHYGDLTDGTTLRRIIEAVKPLEIYNLGAQSHVRVSFDSPEYTVDSVGMGTLRLLEAIR
EEEECCCCCCHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCEEECCCCCHHHHHHHHHH
DYQQRTGIEVRFYQAGSSEMFGKVQEIPQKETTPFYPRSPYSCAKVYAYWQTINYRESYN
HHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
LFACNGILFNHESPRRGETFVTRKITRAVARILADKQKKLYLGNLDAKRDWGYAKDYVRA
EEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHH
MWMMLQQEAPDDYVIATNETHSIKEFLEIAFTYVNLEWQDYVEFDPRYLRPTEVDLLIGD
HHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHEECCHHHHHCCCCCCCCCCEEEEEECC
CTKAREKLHWKPSVTFTELVHLMVDSDIKVLEKAVINSNGFD
HHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SERKRALITGITGQDGSYLAELLLEKNYEVHGIIRRSSSFNTDRIEHIYQDSHYPDARL
CCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEE
FLHYGDLTDGTTLRRIIEAVKPLEIYNLGAQSHVRVSFDSPEYTVDSVGMGTLRLLEAIR
EEEECCCCCCHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCEEECCCCCHHHHHHHHHH
DYQQRTGIEVRFYQAGSSEMFGKVQEIPQKETTPFYPRSPYSCAKVYAYWQTINYRESYN
HHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
LFACNGILFNHESPRRGETFVTRKITRAVARILADKQKKLYLGNLDAKRDWGYAKDYVRA
EEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHH
MWMMLQQEAPDDYVIATNETHSIKEFLEIAFTYVNLEWQDYVEFDPRYLRPTEVDLLIGD
HHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHEECCHHHHHCCCCCCCCCCEEEEEECC
CTKAREKLHWKPSVTFTELVHLMVDSDIKVLEKAVINSNGFD
HHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]