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The map label for this gene is pyrF

Identifier: 113474317

GI number: 113474317

Start: 702713

End: 703441

Strand: Direct

Name: pyrF

Synonym: Tery_0446

Alternate gene names: 113474317

Gene position: 702713-703441 (Clockwise)

Preceding gene: 113474316

Following gene: 113474324

Centisome position: 9.07

GC content: 42.66

Gene sequence:

>729_bases
ATGAATATTGATAATATTATAGTCCCTTTGGATGTTCCGAATGAGGCAGCAGCGATCGCTCTGATAGAAGAACTACCTGA
AATAATCTGGTGGAAGGTTGGTCTAGAATTGTTTGTTAGTTGTGGCCCTCAGATTTTCTCAATTCTTAAACAACGCCAGA
AAAGGATTTTTCTAGATTTAAAGTTCCATGATATCCCTAATACTGTTGCTGGAGTTTGTCGATCTGCTGCTAGTTATGGG
GTTGATTTGTTGACTATTCATGCTACTGCTGGTAGAGTAGCTCTGAGTAGGGCACAGCAAGCTGTTCTGGAAGGGGCAAA
AATTATAGGGCAAAAGCCACCAAGGTTAATAGCTATTACTATTTTGACAAGTTTGACTTCTCGTGATTTAGCTTTTGACC
TCAAAATTCCTTTGGAGTTACCAGAATATGTTTTACAGATGGCATTGTTGGCTCAGGAATCTGGTTTAAGTGGGGCAGTT
TGTTCTCCCCAAGAGGTAGAACAGTTGAGGCGGGTTTGTGGAGATGATTTTTTGTTAGTTTGTCCAGGAGTGAGGCCAAG
TTGGGCTGAAGTAGGAGACCAGAAGCGATCGCTAACTCCTGCTCAGGCCATTAAGGCTGGTGCTAATTATCTGGTTATAG
GCCGACCTATTACTGCTACTGCTGACCCAAGAGAAGCTTTGAGGCGCATTTGTCAGGAAATTTCAGGTGATCAGAAAGAG
GGGAGTTAG

Upstream 100 bases:

>100_bases
CTGATTAAGTTTGAAAGTCTTTGGTCTCTACAGCAGTTTTTGTCGGAGGCTCAGATTAAGCTAGAAATTTTATGGTCTCC
TATATCGTTTCCTGAAATTG

Downstream 100 bases:

>100_bases
AAGTTTAGTCCTCAGTTATTAGTGCCTTTGGCTAAAGTATTGGGATTGAAATTAGTATTACATTCAATAAAGATAGATTA
TCTCACCTGGTAAAAAAACC

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNIDNIIVPLDVPNEAAAIALIEELPEIIWWKVGLELFVSCGPQIFSILKQRQKRIFLDLKFHDIPNTVAGVCRSAASYG
VDLLTIHATAGRVALSRAQQAVLEGAKIIGQKPPRLIAITILTSLTSRDLAFDLKIPLELPEYVLQMALLAQESGLSGAV
CSPQEVEQLRRVCGDDFLLVCPGVRPSWAEVGDQKRSLTPAQAIKAGANYLVIGRPITATADPREALRRICQEISGDQKE
GS

Sequences:

>Translated_242_residues
MNIDNIIVPLDVPNEAAAIALIEELPEIIWWKVGLELFVSCGPQIFSILKQRQKRIFLDLKFHDIPNTVAGVCRSAASYG
VDLLTIHATAGRVALSRAQQAVLEGAKIIGQKPPRLIAITILTSLTSRDLAFDLKIPLELPEYVLQMALLAQESGLSGAV
CSPQEVEQLRRVCGDDFLLVCPGVRPSWAEVGDQKRSLTPAQAIKAGANYLVIGRPITATADPREALRRICQEISGDQKE
GS
>Mature_242_residues
MNIDNIIVPLDVPNEAAAIALIEELPEIIWWKVGLELFVSCGPQIFSILKQRQKRIFLDLKFHDIPNTVAGVCRSAASYG
VDLLTIHATAGRVALSRAQQAVLEGAKIIGQKPPRLIAITILTSLTSRDLAFDLKIPLELPEYVLQMALLAQESGLSGAV
CSPQEVEQLRRVCGDDFLLVCPGVRPSWAEVGDQKRSLTPAQAIKAGANYLVIGRPITATADPREALRRICQEISGDQKE
GS

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787537, Length=226, Percent_Identity=43.3628318584071, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PYRF_TRIEI (Q119B9)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720378.1
- ProteinModelPortal:   Q119B9
- SMR:   Q119B9
- STRING:   Q119B9
- GeneID:   4242224
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0446
- NMPDR:   fig|203124.1.peg.4581
- eggNOG:   COG0284
- HOGENOM:   HBG625253
- OMA:   TVHAYPQ
- PhylomeDB:   Q119B9
- ProtClustDB:   PRK00230
- BioCyc:   TERY203124:TERY_0446-MONOMER
- HAMAP:   MF_01200_B
- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00934
- TIGRFAMs:   TIGR01740

Pfam domain/function: PF00215 OMPdecase; SSF51366 RibP_bind_barrel

EC number: =4.1.1.23

Molecular weight: Translated: 26328; Mature: 26328

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00156 OMPDECASE

Important sites: ACT_SITE 61-61 BINDING 11-11 BINDING 32-32 BINDING 123-123 BINDING 185-185 BINDING 194-194 BINDING 214-214 BINDING 215-215

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDNIIVPLDVPNEAAAIALIEELPEIIWWKVGLELFVSCGPQIFSILKQRQKRIFLDL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEE
KFHDIPNTVAGVCRSAASYGVDLLTIHATAGRVALSRAQQAVLEGAKIIGQKPPRLIAIT
EECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
ILTSLTSRDLAFDLKIPLELPEYVLQMALLAQESGLSGAVCSPQEVEQLRRVCGDDFLLV
HHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
CPGVRPSWAEVGDQKRSLTPAQAIKAGANYLVIGRPITATADPREALRRICQEISGDQKE
ECCCCCCHHHHCCHHHCCCHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
GS
CC
>Mature Secondary Structure
MNIDNIIVPLDVPNEAAAIALIEELPEIIWWKVGLELFVSCGPQIFSILKQRQKRIFLDL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEE
KFHDIPNTVAGVCRSAASYGVDLLTIHATAGRVALSRAQQAVLEGAKIIGQKPPRLIAIT
EECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHH
ILTSLTSRDLAFDLKIPLELPEYVLQMALLAQESGLSGAVCSPQEVEQLRRVCGDDFLLV
HHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEE
CPGVRPSWAEVGDQKRSLTPAQAIKAGANYLVIGRPITATADPREALRRICQEISGDQKE
ECCCCCCHHHHCCHHHCCCHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA