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The map label for this gene is tyrS [H]

Identifier: 113474316

GI number: 113474316

Start: 700843

End: 702060

Strand: Direct

Name: tyrS [H]

Synonym: Tery_0445

Alternate gene names: 113474316

Gene position: 700843-702060 (Clockwise)

Preceding gene: 113474314

Following gene: 113474317

Centisome position: 9.04

GC content: 40.39

Gene sequence:

>1218_bases
ATGATGACTGATAAATTTACATGGCTGCATCGTGGTATTAGCGAAATATTCCCAGATCAACCATATTCTCAAGACCCTAA
TGAAAACTTAATCCTGAAATTAACCACATTAGACCGTCCTTTGCGGGTTAAGTTAGGAATTGACCCGACAGGAGTTGATG
TCCATTTAGGCCATAGTATTCCGGTGAGAAAACTCCGGGCATTTCAAGATGCTGGACATACAGCAGTATTAATAATAGGA
GATTTTACCGCAAGAGTTGGTGATCCGACTGGAAAATCTGAAGCCCGACGCCAGTTGACTCCAGAGCAGGTACAGGAAAA
TGCCAAAACTTACTTAGATCAAGTCCGACCAATATTGGATTTTGATACCCCAGGACGGCTAGAAATTCGCTACAACTCAG
AATGGCTATCTAAACTAGATTTGGCAGATATTCTTGAGCTTCTGGCGACTATGACTGTGGGGCAGATGTTGGCGAAGGAA
GGTTTTGCCCTTCGTTATCAACAGGAAAATCCTATATATATCCATGAGTTTCTTTATCCTCTGATGCAAGGTTATGATTC
TGTAGCTGTGGATGCTGATGTGGAATTGGGTGGTACTGACCAAAAGTTTAATATTGCGGTGGGGCGAGATTTACAACGTC
ATTTTGGTAAGAGGACTCAGTTTGGTTTGTTAATGCCAATTTTGTTGGGGACTGATGGAGTCCAGAAAATGTCTAAGTCT
CTGGGAAATTATGTGGGTTTGTCGGAGGACCCTTTGAGTATGTATTCTAAGTTGGAGAAAATTCCTGATGACCAGGTAGA
AAACTATTTTGAATTATTGACAAATTTAAATATTAATGATATAGATAAAAATCCTCGTGAAAGACAAAAATTGTTGGCTT
TGGATATCGTGTCTCAGTATCACAGTCAGGAAGCTGCTTTGGAAGCTCAACAAACTGCAGTGAAAATGGTAATTAAGGGG
GATATGAGTCAAACTGAGGCAGTACCAGAATTTTCTTTGGCTTCTGTGGAGTTTCCAGCGAAGTTGTTTTATGTTGTTAG
CGCTAGTGGTTTGTGTAAGAGTAGCTCTGAAGCTAGGAAAAAAATTGCTGGGGGTGCTGTACGTTTGGATGATGAGCGTA
TTTCAGATCAGAATTTTACTTTAGATTCCCCAGCAGACCTTGATGGTAAGGTTTTACGGGTTGGTAAAAAGAATTTTGTT
CGCCTGGTAAAAAATTAA

Upstream 100 bases:

>100_bases
ATAGACTTCATATTTTTGATCAGTATAATTAGACTTCTCAGAGAAGACTAATAACTGAAATGACCCTCAGAGTTAAGCTG
TATATATTCATTAAGACTAG

Downstream 100 bases:

>100_bases
CTAATACTTTTGCTTAAGCTCAAACTCAAAGAAAAACTTCTTAGTTTTATAGCTTGACTGCTCAGAAATAGAAATGTGAG
AATTTTTCAGACTTTGGTCT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MMTDKFTWLHRGISEIFPDQPYSQDPNENLILKLTTLDRPLRVKLGIDPTGVDVHLGHSIPVRKLRAFQDAGHTAVLIIG
DFTARVGDPTGKSEARRQLTPEQVQENAKTYLDQVRPILDFDTPGRLEIRYNSEWLSKLDLADILELLATMTVGQMLAKE
GFALRYQQENPIYIHEFLYPLMQGYDSVAVDADVELGGTDQKFNIAVGRDLQRHFGKRTQFGLLMPILLGTDGVQKMSKS
LGNYVGLSEDPLSMYSKLEKIPDDQVENYFELLTNLNINDIDKNPRERQKLLALDIVSQYHSQEAALEAQQTAVKMVIKG
DMSQTEAVPEFSLASVEFPAKLFYVVSASGLCKSSSEARKKIAGGAVRLDDERISDQNFTLDSPADLDGKVLRVGKKNFV
RLVKN

Sequences:

>Translated_405_residues
MMTDKFTWLHRGISEIFPDQPYSQDPNENLILKLTTLDRPLRVKLGIDPTGVDVHLGHSIPVRKLRAFQDAGHTAVLIIG
DFTARVGDPTGKSEARRQLTPEQVQENAKTYLDQVRPILDFDTPGRLEIRYNSEWLSKLDLADILELLATMTVGQMLAKE
GFALRYQQENPIYIHEFLYPLMQGYDSVAVDADVELGGTDQKFNIAVGRDLQRHFGKRTQFGLLMPILLGTDGVQKMSKS
LGNYVGLSEDPLSMYSKLEKIPDDQVENYFELLTNLNINDIDKNPRERQKLLALDIVSQYHSQEAALEAQQTAVKMVIKG
DMSQTEAVPEFSLASVEFPAKLFYVVSASGLCKSSSEARKKIAGGAVRLDDERISDQNFTLDSPADLDGKVLRVGKKNFV
RLVKN
>Mature_405_residues
MMTDKFTWLHRGISEIFPDQPYSQDPNENLILKLTTLDRPLRVKLGIDPTGVDVHLGHSIPVRKLRAFQDAGHTAVLIIG
DFTARVGDPTGKSEARRQLTPEQVQENAKTYLDQVRPILDFDTPGRLEIRYNSEWLSKLDLADILELLATMTVGQMLAKE
GFALRYQQENPIYIHEFLYPLMQGYDSVAVDADVELGGTDQKFNIAVGRDLQRHFGKRTQFGLLMPILLGTDGVQKMSKS
LGNYVGLSEDPLSMYSKLEKIPDDQVENYFELLTNLNINDIDKNPRERQKLLALDIVSQYHSQEAALEAQQTAVKMVIKG
DMSQTEAVPEFSLASVEFPAKLFYVVSASGLCKSSSEARKKIAGGAVRLDDERISDQNFTLDSPADLDGKVLRVGKKNFV
RLVKN

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=403, Percent_Identity=27.0471464019851, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1787925, Length=396, Percent_Identity=31.0606060606061, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25145802, Length=308, Percent_Identity=29.2207792207792, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325160, Length=425, Percent_Identity=26.8235294117647, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130383, Length=401, Percent_Identity=26.1845386533666, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45445; Mature: 45445

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDKFTWLHRGISEIFPDQPYSQDPNENLILKLTTLDRPLRVKLGIDPTGVDVHLGHSI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCEEEECCCC
PVRKLRAFQDAGHTAVLIIGDFTARVGDPTGKSEARRQLTPEQVQENAKTYLDQVRPILD
CHHHHHHHHCCCCEEEEEEECCHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
FDTPGRLEIRYNSEWLSKLDLADILELLATMTVGQMLAKEGFALRYQQENPIYIHEFLYP
CCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEHHHHHHH
LMQGYDSVAVDADVELGGTDQKFNIAVGRDLQRHFGKRTQFGLLMPILLGTDGVQKMSKS
HHCCCCCEEEECCEEECCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
LGNYVGLSEDPLSMYSKLEKIPDDQVENYFELLTNLNINDIDKNPRERQKLLALDIVSQY
HHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
HSQEAALEAQQTAVKMVIKGDMSQTEAVPEFSLASVEFPAKLFYVVSASGLCKSSSEARK
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHH
KIAGGAVRLDDERISDQNFTLDSPADLDGKVLRVGKKNFVRLVKN
HHCCCCEEECHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHHHCC
>Mature Secondary Structure
MMTDKFTWLHRGISEIFPDQPYSQDPNENLILKLTTLDRPLRVKLGIDPTGVDVHLGHSI
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCEEEECCCC
PVRKLRAFQDAGHTAVLIIGDFTARVGDPTGKSEARRQLTPEQVQENAKTYLDQVRPILD
CHHHHHHHHCCCCEEEEEEECCHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
FDTPGRLEIRYNSEWLSKLDLADILELLATMTVGQMLAKEGFALRYQQENPIYIHEFLYP
CCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEHHHHHHH
LMQGYDSVAVDADVELGGTDQKFNIAVGRDLQRHFGKRTQFGLLMPILLGTDGVQKMSKS
HHCCCCCEEEECCEEECCCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
LGNYVGLSEDPLSMYSKLEKIPDDQVENYFELLTNLNINDIDKNPRERQKLLALDIVSQY
HHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
HSQEAALEAQQTAVKMVIKGDMSQTEAVPEFSLASVEFPAKLFYVVSASGLCKSSSEARK
HHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHH
KIAGGAVRLDDERISDQNFTLDSPADLDGKVLRVGKKNFVRLVKN
HHCCCCEEECHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]