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The map label for this gene is GSHPx [H]

Identifier: 110835499

GI number: 110835499

Start: 2984402

End: 2984878

Strand: Reverse

Name: GSHPx [H]

Synonym: ABO_2638

Alternate gene names: 110835499

Gene position: 2984878-2984402 (Counterclockwise)

Preceding gene: 110835500

Following gene: 110835494

Centisome position: 95.66

GC content: 49.27

Gene sequence:

>477_bases
ATGGGGATCTATGATTACAGCGCCATTACCCTGAGTGGTGAAGAAAAGTCCCTGGCCGATTTTCAAGGCAAGGTGCTGCT
GATCGTCAATACGGCCAGCAAGTGTGGTTTTACGCCTCAGTACAAAGGGCTGGAGGCGCTGTATAAAACGTTGCAACCAA
AAGGGCTGGAGGTTCTCGGATTCCCCTGTAACCAGTTTGGTAAACAGGAACCAGGGGCGGCGGATGAAATTGGTGCCTTT
TGTGAAAAGAATTACGGTGTCAGCTTCACCATGTTCGATAAGGTGGATGTGAATGGGGGCGATGCTCACCCGTTGTATGA
TTTTCTGAAAAAGGAAGCTCCGGGCGTATTGGGTAGCAAGGGTATCAAGTGGAACTTCACTAAGTTCCTAGTAAACAAGG
ACGGCAAGGTGGTGAAGCGTTACGCCCCTACTGACAAGCCGGAAGCAATTCAAAAGGATATTGAAGCGCTTCTGTAG

Upstream 100 bases:

>100_bases
GTGGCTTGCAGTATTGTTAGGCGCAACTTGCCTGCTATCGGCTTTTCTATTCAGGCATTCTGGTTATTCACGTTTGGGTT
TTAATTGTTCGGGAGAGAAC

Downstream 100 bases:

>100_bases
AAAATGGGCTAGCCACACGCTACAGCGCAACCCAGTCATGAACATACGGTAAGTTTGCCGCCTACGCTTTGAAAGGTGTG
GGCGGGTAGGGTTTTGCAGA

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MGIYDYSAITLSGEEKSLADFQGKVLLIVNTASKCGFTPQYKGLEALYKTLQPKGLEVLGFPCNQFGKQEPGAADEIGAF
CEKNYGVSFTMFDKVDVNGGDAHPLYDFLKKEAPGVLGSKGIKWNFTKFLVNKDGKVVKRYAPTDKPEAIQKDIEALL

Sequences:

>Translated_158_residues
MGIYDYSAITLSGEEKSLADFQGKVLLIVNTASKCGFTPQYKGLEALYKTLQPKGLEVLGFPCNQFGKQEPGAADEIGAF
CEKNYGVSFTMFDKVDVNGGDAHPLYDFLKKEAPGVLGSKGIKWNFTKFLVNKDGKVVKRYAPTDKPEAIQKDIEALL
>Mature_157_residues
GIYDYSAITLSGEEKSLADFQGKVLLIVNTASKCGFTPQYKGLEALYKTLQPKGLEVLGFPCNQFGKQEPGAADEIGAFC
EKNYGVSFTMFDKVDVNGGDAHPLYDFLKKEAPGVLGSKGIKWNFTKFLVNKDGKVVKRYAPTDKPEAIQKDIEALL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=156, Percent_Identity=44.2307692307692, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=45.8064516129032, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=45.8064516129032, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI192455698, Length=158, Percent_Identity=40.5063291139241, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI4557629, Length=181, Percent_Identity=41.9889502762431, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI41406084, Length=185, Percent_Identity=39.4594594594595, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI6006001, Length=181, Percent_Identity=39.2265193370166, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=44.6153846153846, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI33186887, Length=172, Percent_Identity=40.1162790697674, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=34.2541436464088, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788003, Length=157, Percent_Identity=47.7707006369427, Blast_Score=146, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=48.1012658227848, Blast_Score=151, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=158, Percent_Identity=46.8354430379747, Blast_Score=149, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=45.3416149068323, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=41.4012738853503, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17550320, Length=180, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193209493, Length=164, Percent_Identity=33.5365853658537, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=38.1578947368421, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507603, Length=101, Percent_Identity=37.6237623762376, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71993573, Length=94, Percent_Identity=37.2340425531915, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=54.140127388535, Blast_Score=183, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322228, Length=156, Percent_Identity=53.8461538461538, Blast_Score=181, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322826, Length=155, Percent_Identity=45.8064516129032, Blast_Score=142, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24656772, Length=159, Percent_Identity=49.0566037735849, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24656777, Length=158, Percent_Identity=49.3670886075949, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24656767, Length=158, Percent_Identity=49.3670886075949, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI85726443, Length=148, Percent_Identity=42.5675675675676, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17325; Mature: 17194

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIYDYSAITLSGEEKSLADFQGKVLLIVNTASKCGFTPQYKGLEALYKTLQPKGLEVLG
CCEECCEEEEECCCCCCHHCCCCCEEEEEECCHHCCCCCCCCCHHHHHHHCCCCCCEEEE
FPCNQFGKQEPGAADEIGAFCEKNYGVSFTMFDKVDVNGGDAHPLYDFLKKEAPGVLGSK
CCHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCC
GIKWNFTKFLVNKDGKVVKRYAPTDKPEAIQKDIEALL
CCCEEHEEEEECCCCCEEEECCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
GIYDYSAITLSGEEKSLADFQGKVLLIVNTASKCGFTPQYKGLEALYKTLQPKGLEVLG
CEECCEEEEECCCCCCHHCCCCCEEEEEECCHHCCCCCCCCCHHHHHHHCCCCCCEEEE
FPCNQFGKQEPGAADEIGAFCEKNYGVSFTMFDKVDVNGGDAHPLYDFLKKEAPGVLGSK
CCHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCC
GIKWNFTKFLVNKDGKVVKRYAPTDKPEAIQKDIEALL
CCCEEHEEEEECCCCCEEEECCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]