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The map label for this gene is parE [H]

Identifier: 110835355

GI number: 110835355

Start: 2828346

End: 2830232

Strand: Reverse

Name: parE [H]

Synonym: ABO_2494

Alternate gene names: 110835355

Gene position: 2830232-2828346 (Counterclockwise)

Preceding gene: 110835356

Following gene: 110835354

Centisome position: 90.71

GC content: 55.75

Gene sequence:

>1887_bases
ATGACCAATAACTATACGTCCGAAAATATTGAAGTGTTGTCGGGCTTGGACCCGGTGCGTAAGCGCCCGGGCATGTACAC
CGATACTTCGCGCCCCAACCACCTTGCCCAGGAAGTGATCGATAACTCGGTGGATGAAGCGCTGGCAGGCCACGCCAAAT
CGATCAAAGTCACCCTATTCAAAGATGGCGGCGTGGAAGTGGAGGATGATGGTCGCGGCATGCCCGTGGATATGCATCCG
GTACAGAAAAAGCCCGGCGTGGAAGTGATTCTGTCCACCCTGCACTCCGGGGGTAAGTTCTCCAATAACAACTACCAGTT
TAGTGGCGGTCTGCACGGCGTAGGTGTGTCGGTGGTTAACGCCTTGTCCACTAAGCTGGAAATTCTGGTCAAGCGCGATG
GCCAACTGCACCGTATGGAATTCGGTGATGGCGAGAAACGCAGTGATCTGGAAGTAATCGATACGGTTGGTAAGCGCAAT
ACCGGCACCATCTTGCGCTTCTGGCCAGACAGTCAGTATTTCGACTCGCCGAAAATATCGGTGAGCCGTCTCAAACATTT
GCTGAGGGCTAAGGCGGTTCTCTGCCCCGGCTTGTTGGTGACGCTGGATAATCAGCAAACCGGTGAGAGCGATGCCTGGC
AGTTTGATGATGGCTTGATTGAATATCTACTGGAGTCCAGTACCGGGTGGGAACGGGTTCCTGCGGAGCCGTTTAACGGT
GCCATGAGCGCGGAAACAGAAGCGGTGGATTGGGCTGTCACCTGGCTACCTGAAGGCGGCGAACTGGTTCAGGAAGCCTA
TGTAAACCTGATCCCCACGGCCCAGGGCGGCACCCATGTAAACGGGCTGCGTTCCGGCCTGTTGGAGGCCATGCGCGAGT
TCTGTGAATTTAGAAATTTGTTGCCCCGGGGAGTCAAGCTGACGCCGGAAGATATTTGGGACCGGGCGGCCTTCGTGCTT
AGCGTGAAAATGCAGGACCCGCAATTCGCCGGGCAAACCAAAGAACGGTTGAGCTCCCGTCAGACCGCGGCGTTTGTTTC
CGGGGTGGTAAAAGACGCCTTCTCTCTGTGGCTGAACCAACATACCGATGAGGCCGAGAAGCTGGCGGATCTGTGCATCA
ATAATGCCCAGAAGCGACTACGGGCCGCCAAAAAAGTCACCCGAAAAAAAGTCACCAGTGGCCCGGCTTTGCCCGGCAAA
CTGGCAGATTGCACCAGTGATGACCCTTCCCAGAGTGAGATTTTCCTGGTGGAAGGGGATTCGGCGGGCGGCAGTGCCAA
GCAGGCCCGAGATCGGGTTTATCAGGCGATTATGCCGCTGCGAGGCAAGATCATGAATACCTGGGAAGTGGATTCCAACG
AGGTCTTGGGTAGCCAGGAAATTCACGATATCGCGGTGGCGCTTGGCATCGAGCCGGGCAGTGATGATCTCAGCAGCCTG
CGTTACGGCAAGGTGTGTATCCTTGCGGATGCGGACTCTGATGGTTTGCACATTGCCACGCTGATCTGCGCGCTGTTTCT
GCGTCATTTCCCCGCATTGGTGAAACAGGGCCATGTATTTGTGGCGATGCCGCCGTTGTATCGCATCGATGTGGGCAAAG
AAGTCTATTACGCCCTGGACAAGCAAGAGCGTGATGGCGTGCTGGATCGCATCAAGGCGGAGAAAAAACGCGGCAAGGTC
AACGTAACCCGCTTTAAAGGGCTGGGTGAAATGAACCCGTTGCAATTGCGCGAAACCACCATGGCCCGCGATACCCGCCG
CCTGGTGCGCTTGGATGTGTCCACCGACGACGGCACTCACCAGCTGATGGACATGCTGCTAAGCAAAAAACGGGCTTCTG
ATCGCAAGGTTTGGCTGGAAGAAAAAGGCAACCTGGCAGAGATATAG

Upstream 100 bases:

>100_bases
GGGATTGAAATACACGCCTGATGCCCGACGCTAGGGGCGGGACATGCGGTAGAGCATGTCTCGCCTCTGGCGCACTGCGT
GAGGTGCTGCTGGAAAATCT

Downstream 100 bases:

>100_bases
ACGCTGACACGCGACACGCCACCGCGCTCTAAGGCTGCATGTGCTGAAAGATGTAAGCATGATGGTTGTGCTGGCTTTTA
AATGGGTTCGAACTTAAAAA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MTNNYTSENIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHAKSIKVTLFKDGGVEVEDDGRGMPVDMHP
VQKKPGVEVILSTLHSGGKFSNNNYQFSGGLHGVGVSVVNALSTKLEILVKRDGQLHRMEFGDGEKRSDLEVIDTVGKRN
TGTILRFWPDSQYFDSPKISVSRLKHLLRAKAVLCPGLLVTLDNQQTGESDAWQFDDGLIEYLLESSTGWERVPAEPFNG
AMSAETEAVDWAVTWLPEGGELVQEAYVNLIPTAQGGTHVNGLRSGLLEAMREFCEFRNLLPRGVKLTPEDIWDRAAFVL
SVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDAFSLWLNQHTDEAEKLADLCINNAQKRLRAAKKVTRKKVTSGPALPGK
LADCTSDDPSQSEIFLVEGDSAGGSAKQARDRVYQAIMPLRGKIMNTWEVDSNEVLGSQEIHDIAVALGIEPGSDDLSSL
RYGKVCILADADSDGLHIATLICALFLRHFPALVKQGHVFVAMPPLYRIDVGKEVYYALDKQERDGVLDRIKAEKKRGKV
NVTRFKGLGEMNPLQLRETTMARDTRRLVRLDVSTDDGTHQLMDMLLSKKRASDRKVWLEEKGNLAEI

Sequences:

>Translated_628_residues
MTNNYTSENIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHAKSIKVTLFKDGGVEVEDDGRGMPVDMHP
VQKKPGVEVILSTLHSGGKFSNNNYQFSGGLHGVGVSVVNALSTKLEILVKRDGQLHRMEFGDGEKRSDLEVIDTVGKRN
TGTILRFWPDSQYFDSPKISVSRLKHLLRAKAVLCPGLLVTLDNQQTGESDAWQFDDGLIEYLLESSTGWERVPAEPFNG
AMSAETEAVDWAVTWLPEGGELVQEAYVNLIPTAQGGTHVNGLRSGLLEAMREFCEFRNLLPRGVKLTPEDIWDRAAFVL
SVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDAFSLWLNQHTDEAEKLADLCINNAQKRLRAAKKVTRKKVTSGPALPGK
LADCTSDDPSQSEIFLVEGDSAGGSAKQARDRVYQAIMPLRGKIMNTWEVDSNEVLGSQEIHDIAVALGIEPGSDDLSSL
RYGKVCILADADSDGLHIATLICALFLRHFPALVKQGHVFVAMPPLYRIDVGKEVYYALDKQERDGVLDRIKAEKKRGKV
NVTRFKGLGEMNPLQLRETTMARDTRRLVRLDVSTDDGTHQLMDMLLSKKRASDRKVWLEEKGNLAEI
>Mature_627_residues
TNNYTSENIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHAKSIKVTLFKDGGVEVEDDGRGMPVDMHPV
QKKPGVEVILSTLHSGGKFSNNNYQFSGGLHGVGVSVVNALSTKLEILVKRDGQLHRMEFGDGEKRSDLEVIDTVGKRNT
GTILRFWPDSQYFDSPKISVSRLKHLLRAKAVLCPGLLVTLDNQQTGESDAWQFDDGLIEYLLESSTGWERVPAEPFNGA
MSAETEAVDWAVTWLPEGGELVQEAYVNLIPTAQGGTHVNGLRSGLLEAMREFCEFRNLLPRGVKLTPEDIWDRAAFVLS
VKMQDPQFAGQTKERLSSRQTAAFVSGVVKDAFSLWLNQHTDEAEKLADLCINNAQKRLRAAKKVTRKKVTSGPALPGKL
ADCTSDDPSQSEIFLVEGDSAGGSAKQARDRVYQAIMPLRGKIMNTWEVDSNEVLGSQEIHDIAVALGIEPGSDDLSSLR
YGKVCILADADSDGLHIATLICALFLRHFPALVKQGHVFVAMPPLYRIDVGKEVYYALDKQERDGVLDRIKAEKKRGKVN
VTRFKGLGEMNPLQLRETTMARDTRRLVRLDVSTDDGTHQLMDMLLSKKRASDRKVWLEEKGNLAEI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=619, Percent_Identity=24.3941841680129, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI19913406, Length=626, Percent_Identity=22.5239616613419, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789408, Length=630, Percent_Identity=69.0476190476191, Blast_Score=927, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=561, Percent_Identity=39.7504456327986, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17535065, Length=627, Percent_Identity=24.5614035087719, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI212645845, Length=592, Percent_Identity=24.6621621621622, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=254, Percent_Identity=27.5590551181102, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=635, Percent_Identity=24.0944881889764, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17136538, Length=618, Percent_Identity=23.9482200647249, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 69465; Mature: 69334

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNYTSENIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHAKSIKVTLF
CCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCEEEEEEE
KDGGVEVEDDGRGMPVDMHPVQKKPGVEVILSTLHSGGKFSNNNYQFSGGLHGVGVSVVN
ECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSTKLEILVKRDGQLHRMEFGDGEKRSDLEVIDTVGKRNTGTILRFWPDSQYFDSPKIS
HHHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCCC
VSRLKHLLRAKAVLCPGLLVTLDNQQTGESDAWQFDDGLIEYLLESSTGWERVPAEPFNG
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCCCC
AMSAETEAVDWAVTWLPEGGELVQEAYVNLIPTAQGGTHVNGLRSGLLEAMREFCEFRNL
CCCCCCCEEEEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
LPRGVKLTPEDIWDRAAFVLSVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDAFSLWLNQ
CCCCCCCCHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HTDEAEKLADLCINNAQKRLRAAKKVTRKKVTSGPALPGKLADCTSDDPSQSEIFLVEGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDRVYQAIMPLRGKIMNTWEVDSNEVLGSQEIHDIAVALGIEPGSDDLSSL
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHEEEEEEECCCCCCHHHHC
RYGKVCILADADSDGLHIATLICALFLRHFPALVKQGHVFVAMPPLYRIDVGKEVYYALD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHEEEC
KQERDGVLDRIKAEKKRGKVNVTRFKGLGEMNPLQLRETTMARDTRRLVRLDVSTDDGTH
CCHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHH
QLMDMLLSKKRASDRKVWLEEKGNLAEI
HHHHHHHHHHCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TNNYTSENIEVLSGLDPVRKRPGMYTDTSRPNHLAQEVIDNSVDEALAGHAKSIKVTLF
CCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHCCCCEEEEEEE
KDGGVEVEDDGRGMPVDMHPVQKKPGVEVILSTLHSGGKFSNNNYQFSGGLHGVGVSVVN
ECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHH
ALSTKLEILVKRDGQLHRMEFGDGEKRSDLEVIDTVGKRNTGTILRFWPDSQYFDSPKIS
HHHHHHEEEEECCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCCC
VSRLKHLLRAKAVLCPGLLVTLDNQQTGESDAWQFDDGLIEYLLESSTGWERVPAEPFNG
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEECHHHHHHHHHHCCCCCCCCCCCCCCC
AMSAETEAVDWAVTWLPEGGELVQEAYVNLIPTAQGGTHVNGLRSGLLEAMREFCEFRNL
CCCCCCCEEEEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
LPRGVKLTPEDIWDRAAFVLSVKMQDPQFAGQTKERLSSRQTAAFVSGVVKDAFSLWLNQ
CCCCCCCCHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HTDEAEKLADLCINNAQKRLRAAKKVTRKKVTSGPALPGKLADCTSDDPSQSEIFLVEGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SAGGSAKQARDRVYQAIMPLRGKIMNTWEVDSNEVLGSQEIHDIAVALGIEPGSDDLSSL
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHEEEEEEECCCCCCHHHHC
RYGKVCILADADSDGLHIATLICALFLRHFPALVKQGHVFVAMPPLYRIDVGKEVYYALD
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCHHHEEEC
KQERDGVLDRIKAEKKRGKVNVTRFKGLGEMNPLQLRETTMARDTRRLVRLDVSTDDGTH
CCHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHH
QLMDMLLSKKRASDRKVWLEEKGNLAEI
HHHHHHHHHHCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]