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The map label for this gene is parC [H]

Identifier: 110835354

GI number: 110835354

Start: 2825909

End: 2828146

Strand: Reverse

Name: parC [H]

Synonym: ABO_2493

Alternate gene names: 110835354

Gene position: 2828146-2825909 (Counterclockwise)

Preceding gene: 110835355

Following gene: 110835353

Centisome position: 90.64

GC content: 53.62

Gene sequence:

>2238_bases
ATGGCTGACGAATTTGAAAGTTTTCCGTTAAAGGAATACACCGAAAAAGCGTATCTGGATTACTCCATGTACGTGATTCT
AGATCGGGCTTTGCCCAATATTGGCGATGGTCTGAAGCCGGTGCAGCGGCGCATTGTTTACGCTATGAGCGAGCTGGGTC
TTAAAAATACGGCCAAATACAAAAAATCGGCCCGTACCGTGGGTGATGTATTGGGTAAGTATCACCCCCATGGTGATTCG
GCCTGTTACGAAGCCATGGTGTTGATGGCCCAGCCGTTCAGTTATCGCTATCCGCTGGTGGATGGCCAGGGTAATTGGGG
CAGCGCAGACGATCCAAAATCTTTTGCTGCCATGCGTTATACCGAGTCCAAATTGGCACCGTATGCGGAAGTGCTATTGT
CCGAGTTGGGGCAGGGGACAGTGGAGTGGCTGCCTAATTTTGATGGCACCATGGATGAGCCTAAGTTGTTGCCAGCTCGC
TTGCCCAATGTGTTACTCAATGGCACTACGGGTATCGCGGTGGGCATGAGTACCGATATTCCACCGCATAATTTGCGCGA
AGTAGCCAATGCCTGCATCCATTTGCTGAAAGATCCCGGCGCCTCGCTGGATGATTTGATGCAATACATTCAGGGCCCGG
ACTTCCCTACCGAAGCAGAAGTAATCACCCCAATCAACGACATCATTCGCATGTATGCACAGGGCAAAGGCTCTCTCAAG
CAGCGCGCGGTGTATGAGCGTGAAGAGGGTGATATTGTGGTGACGGCGCTGCCGTATCAGGTGTCTGGCGCCAAGGTGCT
GGAACAAATCGCGGACCAAATGAACAAGAAAAAGCTGCCCATGGTCAGCGATCTGCGTGATGAATCCGACCACGAAAACC
CCACCCGACTGGTGATCACGCCGCGCTCTAATCGGGTGGATGTGGAACAGTTGATGAGCCACCTTTTTGCCAGCACTGAC
CTGGAGAAAAACTACCGGGTTAATCTGAACATGATCGGCATCGATGGCCGCCCCCAGGTGAAAAGCCTGGACATGATTCT
CAACGAATGGCTGCAGTTCCGCATGGTGACGGTGCGTCGCCGGTTGCAACACCGCCTCGATAAAGTACTGGAACGTTTGC
ACATTTTGGAAGGCTTACTGGCAGCATTCCTTAATATCGATGAAGTGATTCACATCATCCGTACCGAGGATGCGCCAAAG
CCGGTATTGATGGAGCGCTTTGGTGTCAGTGATCGCCAGGCAGAAGCAATTCTGGAATTGAAGCTGCGCCACCTGGCGAA
ATTGGAAGAAATGAAAATTCGCGGTGAGCAAGATGAGCTCAACGAAGAACGCGAATACTTGGAAACCACTTTGGGCTCCA
TGGCGAAAATGAAGAAGCTGGTCGCCAAGGAATTGAAGGATGACGCCGAGAAATATGGCGATGACCGTCGCTCTCCATTG
GTGGAACGTGAGGACGCCAAGGCGTTGGATGAAAGCGATCTGCTCAGTGCCGATCCGATAACGGTAGTGCTCTCGGAAAA
AGGCTGGGTGCGAGCCGCTAAAGGCCATGAAGTGGATGTGGAAGGGCTGAGTTACAAGGCCGGTGATAAGTACAAGGCTT
GCGCCAAAGGTAAATCTAACCAGTCGGTGTGCTTTATCGACAGCACTGGGCGAACCTATTCTTTGCCCGCACATACTCTA
CCCAGTGCGCGGGGGCAGGGTGAGCCACTGTCTGGCCGAGTGAGCCCACCCTCCGGTGCCAGCTTTATGGCAGCAGTGAT
GGGTAAAGACAAGGACGCGTACCTGATGAGCACCGATGCAGGTTACGGTTTCGTGGTGCGTTATGCGGATTTGTTGGCCA
ACAAGAAAGCCGGTAAGACGGTACTTAATGTGCCTAAAGGCGCGCGTGTATTGCCGCCACAACCGATTGCCTCAACCACA
GATGATTTGATTGCCCTGGTGTCAAACGAAGGCCGGTTGTTGGTATTCCCCGTAAGCGAGTTGCCGGAAATGGTCCGCGG
TAAGGGCAACAAGATGATGTCGATTCCCGGCGCCCGCGTGGCGGATCGGGTGGAGTTCGTACAGGATGTTCAAGTAGTTG
GGCCGAATGACGCGTTGACCCTCTATGCGGGTAAGCGCCACCTGACCCTGAAAGCCAATGATCTGGAACACTACTATGGT
GAGCGGGGGCGCCGTGGCGCGAAGCTGCCCCGTGGTTTCCAGAATGTGGACGCCATGGCCGTGGAGCGTAAGGGCTGA

Upstream 100 bases:

>100_bases
ATAGAGCAGCTGACGTGCTGCGTTGATTGCAGAAAGGCAATGCAGAAAATGTGTTGCGTGACGCTATTAGCGTGCAGGCC
AGCGAGTATAGCGAGCAAAA

Downstream 100 bases:

>100_bases
TCGTGCGGGTGTAGACGGGATAAGGTCGGAAATGCGATCGGCCTTTTCTCGCTGTGCGCAGGGTATGCTGCTGTGGTGAG
TGCTCCCTTAATGGTAAAGG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MADEFESFPLKEYTEKAYLDYSMYVILDRALPNIGDGLKPVQRRIVYAMSELGLKNTAKYKKSARTVGDVLGKYHPHGDS
ACYEAMVLMAQPFSYRYPLVDGQGNWGSADDPKSFAAMRYTESKLAPYAEVLLSELGQGTVEWLPNFDGTMDEPKLLPAR
LPNVLLNGTTGIAVGMSTDIPPHNLREVANACIHLLKDPGASLDDLMQYIQGPDFPTEAEVITPINDIIRMYAQGKGSLK
QRAVYEREEGDIVVTALPYQVSGAKVLEQIADQMNKKKLPMVSDLRDESDHENPTRLVITPRSNRVDVEQLMSHLFASTD
LEKNYRVNLNMIGIDGRPQVKSLDMILNEWLQFRMVTVRRRLQHRLDKVLERLHILEGLLAAFLNIDEVIHIIRTEDAPK
PVLMERFGVSDRQAEAILELKLRHLAKLEEMKIRGEQDELNEEREYLETTLGSMAKMKKLVAKELKDDAEKYGDDRRSPL
VEREDAKALDESDLLSADPITVVLSEKGWVRAAKGHEVDVEGLSYKAGDKYKACAKGKSNQSVCFIDSTGRTYSLPAHTL
PSARGQGEPLSGRVSPPSGASFMAAVMGKDKDAYLMSTDAGYGFVVRYADLLANKKAGKTVLNVPKGARVLPPQPIASTT
DDLIALVSNEGRLLVFPVSELPEMVRGKGNKMMSIPGARVADRVEFVQDVQVVGPNDALTLYAGKRHLTLKANDLEHYYG
ERGRRGAKLPRGFQNVDAMAVERKG

Sequences:

>Translated_745_residues
MADEFESFPLKEYTEKAYLDYSMYVILDRALPNIGDGLKPVQRRIVYAMSELGLKNTAKYKKSARTVGDVLGKYHPHGDS
ACYEAMVLMAQPFSYRYPLVDGQGNWGSADDPKSFAAMRYTESKLAPYAEVLLSELGQGTVEWLPNFDGTMDEPKLLPAR
LPNVLLNGTTGIAVGMSTDIPPHNLREVANACIHLLKDPGASLDDLMQYIQGPDFPTEAEVITPINDIIRMYAQGKGSLK
QRAVYEREEGDIVVTALPYQVSGAKVLEQIADQMNKKKLPMVSDLRDESDHENPTRLVITPRSNRVDVEQLMSHLFASTD
LEKNYRVNLNMIGIDGRPQVKSLDMILNEWLQFRMVTVRRRLQHRLDKVLERLHILEGLLAAFLNIDEVIHIIRTEDAPK
PVLMERFGVSDRQAEAILELKLRHLAKLEEMKIRGEQDELNEEREYLETTLGSMAKMKKLVAKELKDDAEKYGDDRRSPL
VEREDAKALDESDLLSADPITVVLSEKGWVRAAKGHEVDVEGLSYKAGDKYKACAKGKSNQSVCFIDSTGRTYSLPAHTL
PSARGQGEPLSGRVSPPSGASFMAAVMGKDKDAYLMSTDAGYGFVVRYADLLANKKAGKTVLNVPKGARVLPPQPIASTT
DDLIALVSNEGRLLVFPVSELPEMVRGKGNKMMSIPGARVADRVEFVQDVQVVGPNDALTLYAGKRHLTLKANDLEHYYG
ERGRRGAKLPRGFQNVDAMAVERKG
>Mature_744_residues
ADEFESFPLKEYTEKAYLDYSMYVILDRALPNIGDGLKPVQRRIVYAMSELGLKNTAKYKKSARTVGDVLGKYHPHGDSA
CYEAMVLMAQPFSYRYPLVDGQGNWGSADDPKSFAAMRYTESKLAPYAEVLLSELGQGTVEWLPNFDGTMDEPKLLPARL
PNVLLNGTTGIAVGMSTDIPPHNLREVANACIHLLKDPGASLDDLMQYIQGPDFPTEAEVITPINDIIRMYAQGKGSLKQ
RAVYEREEGDIVVTALPYQVSGAKVLEQIADQMNKKKLPMVSDLRDESDHENPTRLVITPRSNRVDVEQLMSHLFASTDL
EKNYRVNLNMIGIDGRPQVKSLDMILNEWLQFRMVTVRRRLQHRLDKVLERLHILEGLLAAFLNIDEVIHIIRTEDAPKP
VLMERFGVSDRQAEAILELKLRHLAKLEEMKIRGEQDELNEEREYLETTLGSMAKMKKLVAKELKDDAEKYGDDRRSPLV
EREDAKALDESDLLSADPITVVLSEKGWVRAAKGHEVDVEGLSYKAGDKYKACAKGKSNQSVCFIDSTGRTYSLPAHTLP
SARGQGEPLSGRVSPPSGASFMAAVMGKDKDAYLMSTDAGYGFVVRYADLLANKKAGKTVLNVPKGARVLPPQPIASTTD
DLIALVSNEGRLLVFPVSELPEMVRGKGNKMMSIPGARVADRVEFVQDVQVVGPNDALTLYAGKRHLTLKANDLEHYYGE
RGRRGAKLPRGFQNVDAMAVERKG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=266, Percent_Identity=26.6917293233083, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI19913408, Length=172, Percent_Identity=28.4883720930233, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789396, Length=742, Percent_Identity=65.0943396226415, Blast_Score=1015, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=745, Percent_Identity=35.3020134228188, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=274, Percent_Identity=27.3722627737226, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535065, Length=172, Percent_Identity=29.0697674418605, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=376, Percent_Identity=25.2659574468085, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82907; Mature: 82776

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADEFESFPLKEYTEKAYLDYSMYVILDRALPNIGDGLKPVQRRIVYAMSELGLKNTAKY
CCCCCCCCCHHHHHHHHHHCCHHEEHEEHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGSADDPKSFAAMRY
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHH
TESKLAPYAEVLLSELGQGTVEWLPNFDGTMDEPKLLPARLPNVLLNGTTGIAVGMSTDI
HHHHCCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCHHHCCCEEECCCCCEEEECCCCC
PPHNLREVANACIHLLKDPGASLDDLMQYIQGPDFPTEAEVITPINDIIRMYAQGKGSLK
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHCCCCCHH
QRAVYEREEGDIVVTALPYQVSGAKVLEQIADQMNKKKLPMVSDLRDESDHENPTRLVIT
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEEE
PRSNRVDVEQLMSHLFASTDLEKNYRVNLNMIGIDGRPQVKSLDMILNEWLQFRMVTVRR
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
RLQHRLDKVLERLHILEGLLAAFLNIDEVIHIIRTEDAPKPVLMERFGVSDRQAEAILEL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHH
KLRHLAKLEEMKIRGEQDELNEEREYLETTLGSMAKMKKLVAKELKDDAEKYGDDRRSPL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VEREDAKALDESDLLSADPITVVLSEKGWVRAAKGHEVDVEGLSYKAGDKYKACAKGKSN
CCCCHHHHCCHHCCCCCCCEEEEECCCCCEEECCCCEECCCCCCCCCCCCHHHHHCCCCC
QSVCFIDSTGRTYSLPAHTLPSARGQGEPLSGRVSPPSGASFMAAVMGKDKDAYLMSTDA
CCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCC
GYGFVVRYADLLANKKAGKTVLNVPKGARVLPPQPIASTTDDLIALVSNEGRLLVFPVSE
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHEEECCCCCEEEEEHHH
LPEMVRGKGNKMMSIPGARVADRVEFVQDVQVVGPNDALTLYAGKRHLTLKANDLEHYYG
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHEEECCCCEEEEEECCEEEEEEECCHHHHHH
ERGRRGAKLPRGFQNVDAMAVERKG
HCCCCCCCCCCCCCCCCHHEEECCC
>Mature Secondary Structure 
ADEFESFPLKEYTEKAYLDYSMYVILDRALPNIGDGLKPVQRRIVYAMSELGLKNTAKY
CCCCCCCCHHHHHHHHHHCCHHEEHEEHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGSADDPKSFAAMRY
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHH
TESKLAPYAEVLLSELGQGTVEWLPNFDGTMDEPKLLPARLPNVLLNGTTGIAVGMSTDI
HHHHCCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCHHHCCCEEECCCCCEEEECCCCC
PPHNLREVANACIHLLKDPGASLDDLMQYIQGPDFPTEAEVITPINDIIRMYAQGKGSLK
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHCCCCCHH
QRAVYEREEGDIVVTALPYQVSGAKVLEQIADQMNKKKLPMVSDLRDESDHENPTRLVIT
HHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEEE
PRSNRVDVEQLMSHLFASTDLEKNYRVNLNMIGIDGRPQVKSLDMILNEWLQFRMVTVRR
CCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
RLQHRLDKVLERLHILEGLLAAFLNIDEVIHIIRTEDAPKPVLMERFGVSDRQAEAILEL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHH
KLRHLAKLEEMKIRGEQDELNEEREYLETTLGSMAKMKKLVAKELKDDAEKYGDDRRSPL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VEREDAKALDESDLLSADPITVVLSEKGWVRAAKGHEVDVEGLSYKAGDKYKACAKGKSN
CCCCHHHHCCHHCCCCCCCEEEEECCCCCEEECCCCEECCCCCCCCCCCCHHHHHCCCCC
QSVCFIDSTGRTYSLPAHTLPSARGQGEPLSGRVSPPSGASFMAAVMGKDKDAYLMSTDA
CCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCC
GYGFVVRYADLLANKKAGKTVLNVPKGARVLPPQPIASTTDDLIALVSNEGRLLVFPVSE
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHEEECCCCCEEEEEHHH
LPEMVRGKGNKMMSIPGARVADRVEFVQDVQVVGPNDALTLYAGKRHLTLKANDLEHYYG
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHEEECCCCEEEEEECCEEEEEEECCHHHHHH
ERGRRGAKLPRGFQNVDAMAVERKG
HCCCCCCCCCCCCCCCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]