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The map label for this gene is moeA [H]

Identifier: 110835243

GI number: 110835243

Start: 2705996

End: 2707237

Strand: Reverse

Name: moeA [H]

Synonym: ABO_2382

Alternate gene names: 110835243

Gene position: 2707237-2705996 (Counterclockwise)

Preceding gene: 110835244

Following gene: 110835242

Centisome position: 86.77

GC content: 59.82

Gene sequence:

>1242_bases
ATGCACGCAGGCAAGCAACCCTTAATGCCAGTGGCACAAGCGCTGGAGCGGTTACTGGATTCGGCGCGCCCGTTTCGGGC
AATTACCGAGGTGCCGTTGGCCGGTTGTCAGGGGCAGTATTTGGCTGAGCCCGTTACCTCACGGGTAGATGTGCCGGCGT
TTGATAACGCGGCCGTAGATGGTGTGGCGCTGCGCTATGCGGACCTGGGCGAGCCGGGGCTAACACGGCCCATGCCGCTG
CGTGTGGCGGCGGGTGATGCGCCTGCCACGATAGTTTCAGGTCAGGTGGCGCGGATTTTTACCGGTGCACCGGTGCCTGC
CGGGGCCGATACGGTATTGATGCAGGAAGACTGTGAAATTGCTGAACACCGGGTGCGTTTGCCGGGTAGAGACACGGTGA
CTGCCGGGCAAAATATTCGCCCGGCGGGGCAGGATGCTCGGCACGGCGAAGTGGTGCTGGCGCGGGGTGAGAGGCTGACC
CCCCAGGCGGTGGGGCTGACTGCTTCCGTTGGGATCGCGACGGTAAAAGTGTATTCCCCCAGGGTGTTGATTCTCACCAG
CGGCGATGAAATCCAGTCGCCGGAAGAGTCCCCGTTACCGGGAAAAATTTTCGACAGCAATGGCCCCCTGCTAACGCAGT
TGCTACAGCAAAGCGGCTTTGTGAATGTGCATCGGGAACATCTGCCCGATGACCCGGCCATTATCCGCGAAACTCTCAAT
GATTTACTCACCGATTCAGCGCAACGCCCGGATGTGATTATTTCTACCGGCGGGGTGTCTGTGGGCGAAGAAGATCATTT
GCGAGCGGTGCTTGCCGAGCAGGGGGAGTTAGATTTTTGGCGCCTCGCGATTAAGCCAGGTAAGCCGTTTACCTACGGCA
ACCTTGGCGGTATCCCCTTCTTTGGGCTGCCGGGAAACCCCTCTGCGGTGTTGGTGTGCTATCTGATGCTGGTGTTGCCA
ATGTTGCGGCGCTGTTGTGGCGCGGATGCGGTATTGCCAACGGCCATGTCTTTGCCGGCGGACTTCACTATCAACAAGCC
GGCCAAACGACAGGAATACCTGCGTGTGCGCTGCGTGGTTGACGCCGCTCAAGCGGTGCTGCAAAAGCACCCTAATCAGA
GTTCCGGCATGCTCAGCTCGGCCGTGTGGGCGGATGGCCTGGCCGTGGTTCCGGTGGGCTGTACGGTGGCTCCGGGAGAT
GCTTTGGCGTTCTTTTCATTTTCTGATTTGTTGTCGGGGTAG

Upstream 100 bases:

>100_bases
TTGTCGAGCAGCTGGATGCCCGTCATCGGCCCTGTAACTTTGTTGCCCAAGTGCGCCGATAAAGCGAATGTTGTCGCGGT
GATTTGAAAGGAAGAGAAAA

Downstream 100 bases:

>100_bases
GTTGCATGGTGAGCCATAGGTAGGGGGGGGCTTGACCATGGTTAGTGACGACTTTTTCCGGCAATGGCGTTCAAGGTGCC
CGCTGGGGGGCCGCAAATCG

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MHAGKQPLMPVAQALERLLDSARPFRAITEVPLAGCQGQYLAEPVTSRVDVPAFDNAAVDGVALRYADLGEPGLTRPMPL
RVAAGDAPATIVSGQVARIFTGAPVPAGADTVLMQEDCEIAEHRVRLPGRDTVTAGQNIRPAGQDARHGEVVLARGERLT
PQAVGLTASVGIATVKVYSPRVLILTSGDEIQSPEESPLPGKIFDSNGPLLTQLLQQSGFVNVHREHLPDDPAIIRETLN
DLLTDSAQRPDVIISTGGVSVGEEDHLRAVLAEQGELDFWRLAIKPGKPFTYGNLGGIPFFGLPGNPSAVLVCYLMLVLP
MLRRCCGADAVLPTAMSLPADFTINKPAKRQEYLRVRCVVDAAQAVLQKHPNQSSGMLSSAVWADGLAVVPVGCTVAPGD
ALAFFSFSDLLSG

Sequences:

>Translated_413_residues
MHAGKQPLMPVAQALERLLDSARPFRAITEVPLAGCQGQYLAEPVTSRVDVPAFDNAAVDGVALRYADLGEPGLTRPMPL
RVAAGDAPATIVSGQVARIFTGAPVPAGADTVLMQEDCEIAEHRVRLPGRDTVTAGQNIRPAGQDARHGEVVLARGERLT
PQAVGLTASVGIATVKVYSPRVLILTSGDEIQSPEESPLPGKIFDSNGPLLTQLLQQSGFVNVHREHLPDDPAIIRETLN
DLLTDSAQRPDVIISTGGVSVGEEDHLRAVLAEQGELDFWRLAIKPGKPFTYGNLGGIPFFGLPGNPSAVLVCYLMLVLP
MLRRCCGADAVLPTAMSLPADFTINKPAKRQEYLRVRCVVDAAQAVLQKHPNQSSGMLSSAVWADGLAVVPVGCTVAPGD
ALAFFSFSDLLSG
>Mature_413_residues
MHAGKQPLMPVAQALERLLDSARPFRAITEVPLAGCQGQYLAEPVTSRVDVPAFDNAAVDGVALRYADLGEPGLTRPMPL
RVAAGDAPATIVSGQVARIFTGAPVPAGADTVLMQEDCEIAEHRVRLPGRDTVTAGQNIRPAGQDARHGEVVLARGERLT
PQAVGLTASVGIATVKVYSPRVLILTSGDEIQSPEESPLPGKIFDSNGPLLTQLLQQSGFVNVHREHLPDDPAIIRETLN
DLLTDSAQRPDVIISTGGVSVGEEDHLRAVLAEQGELDFWRLAIKPGKPFTYGNLGGIPFFGLPGNPSAVLVCYLMLVLP
MLRRCCGADAVLPTAMSLPADFTINKPAKRQEYLRVRCVVDAAQAVLQKHPNQSSGMLSSAVWADGLAVVPVGCTVAPGD
ALAFFSFSDLLSG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=375, Percent_Identity=37.3333333333333, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI10880983, Length=375, Percent_Identity=37.3333333333333, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787049, Length=373, Percent_Identity=38.3378016085791, Blast_Score=215, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=30.9309309309309, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=233, Percent_Identity=29.1845493562232, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17136978, Length=408, Percent_Identity=30.1470588235294, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24638841, Length=408, Percent_Identity=30.1470588235294, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43734; Mature: 43734

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAGKQPLMPVAQALERLLDSARPFRAITEVPLAGCQGQYLAEPVTSRVDVPAFDNAAVD
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
GVALRYADLGEPGLTRPMPLRVAAGDAPATIVSGQVARIFTGAPVPAGADTVLMQEDCEI
CEEEEEECCCCCCCCCCCEEEEECCCCCCEECCCCEEEEEECCCCCCCCCEEEEHHHHHH
AEHRVRLPGRDTVTAGQNIRPAGQDARHGEVVLARGERLTPQAVGLTASVGIATVKVYSP
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCEEEECCEEEEEEECC
RVLILTSGDEIQSPEESPLPGKIFDSNGPLLTQLLQQSGFVNVHREHLPDDPAIIRETLN
EEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHH
DLLTDSAQRPDVIISTGGVSVGEEDHLRAVLAEQGELDFWRLAIKPGKPFTYGNLGGIPF
HHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCE
FGLPGNPSAVLVCYLMLVLPMLRRCCGADAVLPTAMSLPADFTINKPAKRQEYLRVRCVV
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEECCCHHHHHHHHHHHHH
DAAQAVLQKHPNQSSGMLSSAVWADGLAVVPVGCTVAPGDALAFFSFSDLLSG
HHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEECCEECCCCEEEHEEHHHHHCC
>Mature Secondary Structure
MHAGKQPLMPVAQALERLLDSARPFRAITEVPLAGCQGQYLAEPVTSRVDVPAFDNAAVD
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
GVALRYADLGEPGLTRPMPLRVAAGDAPATIVSGQVARIFTGAPVPAGADTVLMQEDCEI
CEEEEEECCCCCCCCCCCEEEEECCCCCCEECCCCEEEEEECCCCCCCCCEEEEHHHHHH
AEHRVRLPGRDTVTAGQNIRPAGQDARHGEVVLARGERLTPQAVGLTASVGIATVKVYSP
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHCEEEECCEEEEEEECC
RVLILTSGDEIQSPEESPLPGKIFDSNGPLLTQLLQQSGFVNVHREHLPDDPAIIRETLN
EEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHH
DLLTDSAQRPDVIISTGGVSVGEEDHLRAVLAEQGELDFWRLAIKPGKPFTYGNLGGIPF
HHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCE
FGLPGNPSAVLVCYLMLVLPMLRRCCGADAVLPTAMSLPADFTINKPAKRQEYLRVRCVV
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEECCCHHHHHHHHHHHHH
DAAQAVLQKHPNQSSGMLSSAVWADGLAVVPVGCTVAPGDALAFFSFSDLLSG
HHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEECCEECCCCEEEHEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]