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The map label for this gene is hemY [H]

Identifier: 110835180

GI number: 110835180

Start: 2646453

End: 2647685

Strand: Reverse

Name: hemY [H]

Synonym: ABO_2319

Alternate gene names: 110835180

Gene position: 2647685-2646453 (Counterclockwise)

Preceding gene: 110835181

Following gene: 110835172

Centisome position: 84.86

GC content: 58.8

Gene sequence:

>1233_bases
ATGAAGAAACTCGTCCTGCTGATTATTATTGCGTTGGTCGCCGCGTTGGCGCTGGGGCGTTGGATGGCAGCGGATTCCGG
TTATGTGCTGATTATCCGCGACACCATGTCAGTGGATACCACGCTGGGCTTCGTGGTTCTAATGGCCTTGCTGGGTGCGG
TGGCACTGGTGGTGCTGACTTTGCTGGGTAATACGGCCTGGAACCTTATGGAGCCAGTCCGCGCTACCCGTCGCTGGAAA
AGAAAGGTGGCTGAACGCCGCTTGCGCAGTGGTTTTCTGCAGTTGGTGGATGGCGAGCTCGAAAAAGCTGAGCGCTTGCT
GGCGGCGGCCGGTGAAGAAGGCGACTGGCCATTGGTTGCCTGGTTGTTAGCGGCGGAAGCGGCCCAAGAGCAGGACAAGG
TAGATGTTTCGCAGCAGTACCTTGAGCAGGCTAGCGCCGACCGCCGAGGAAGGCTGGTGGCGGGCCTGATGAAAGCCCGC
TTTGCACTGGATGATGGTCATCCGGAACAGGCCCGTAGTGAATTGAAGGTGCTGGCGGACATGGCGCCGCGCAACAAACG
CATTCTCAATACCTACGCCGAAGTGTTGGAACGCCAGAAAGACTGGCAAACACTGTGCGGCCTGATGCCACGTTTGAAAC
GCGCCTTTGGTGAAAACGATCAAGCCCGCCGTGAGCGCAAAGCGTGGTTGGCCTGGTTGCAAGAAACCGCCCGTAAACCG
GGGTTTAACGATGCCGATAGCCGCCGCGAAGAGCTGCGCAAACTGTGGAAAGACGTGCCGGTTCGTCTGAAAAACGACCC
GGCCATGGTGGCCCGTTACGCGGGTTTTTTGGCCCAGCTGGGTGGTGGCCGTGGTGCCCTGAATTTGGTCCGCGAGCAAC
TGGATAGCCAATGGGATGATCGCTTGCCGCCGGTGCTGGAAGCCATCGACGATATTTCCCCCGATGACCTGTTGCAGGTG
CTAGAAAAGTGGCTGGTAGAACGACCCGGCAATGCGGCGGTTTTGATCACCGCTGGCCGTGTTGCGTTGAAGGCGCGCCT
GTGGGGTAAGGCTCAAGGTTTCTTTGAGGCTGCGGCGAACTCTAGTCAGAGTGCCACGGCATTGGCTGAGTTAGCGCGGT
TGTACCGGGCACTGGGGGATACCAGCAAGGCCATGTCTGTCTTCGACCGACGTTTGGCTCAGCTTGAAGGGGATCTTCCA
GCCCTGCCGCAGCCTGATAAAAGCGTGCAGTAG

Upstream 100 bases:

>100_bases
CCCTGAAGGAAATGAGCGGCGCCCAAGTGGCCCAAGCGTTGCCGCAGATCGGTAATGGCTTGGCGGCAATTGAAGCTCTC
AAGCGCAAGGAGGGCGAGGC

Downstream 100 bases:

>100_bases
TGTTCTGATGTCGTTTTGTCGGGTTACGCCGCTACGCAGCTAACACGACCTACAAAAACCGCAGCACCTTGTAGGTCGTA
TTAGGCGAAGGCCGTAATCC

Product: hemY protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKKLVLLIIIALVAALALGRWMAADSGYVLIIRDTMSVDTTLGFVVLMALLGAVALVVLTLLGNTAWNLMEPVRATRRWK
RKVAERRLRSGFLQLVDGELEKAERLLAAAGEEGDWPLVAWLLAAEAAQEQDKVDVSQQYLEQASADRRGRLVAGLMKAR
FALDDGHPEQARSELKVLADMAPRNKRILNTYAEVLERQKDWQTLCGLMPRLKRAFGENDQARRERKAWLAWLQETARKP
GFNDADSRREELRKLWKDVPVRLKNDPAMVARYAGFLAQLGGGRGALNLVREQLDSQWDDRLPPVLEAIDDISPDDLLQV
LEKWLVERPGNAAVLITAGRVALKARLWGKAQGFFEAAANSSQSATALAELARLYRALGDTSKAMSVFDRRLAQLEGDLP
ALPQPDKSVQ

Sequences:

>Translated_410_residues
MKKLVLLIIIALVAALALGRWMAADSGYVLIIRDTMSVDTTLGFVVLMALLGAVALVVLTLLGNTAWNLMEPVRATRRWK
RKVAERRLRSGFLQLVDGELEKAERLLAAAGEEGDWPLVAWLLAAEAAQEQDKVDVSQQYLEQASADRRGRLVAGLMKAR
FALDDGHPEQARSELKVLADMAPRNKRILNTYAEVLERQKDWQTLCGLMPRLKRAFGENDQARRERKAWLAWLQETARKP
GFNDADSRREELRKLWKDVPVRLKNDPAMVARYAGFLAQLGGGRGALNLVREQLDSQWDDRLPPVLEAIDDISPDDLLQV
LEKWLVERPGNAAVLITAGRVALKARLWGKAQGFFEAAANSSQSATALAELARLYRALGDTSKAMSVFDRRLAQLEGDLP
ALPQPDKSVQ
>Mature_410_residues
MKKLVLLIIIALVAALALGRWMAADSGYVLIIRDTMSVDTTLGFVVLMALLGAVALVVLTLLGNTAWNLMEPVRATRRWK
RKVAERRLRSGFLQLVDGELEKAERLLAAAGEEGDWPLVAWLLAAEAAQEQDKVDVSQQYLEQASADRRGRLVAGLMKAR
FALDDGHPEQARSELKVLADMAPRNKRILNTYAEVLERQKDWQTLCGLMPRLKRAFGENDQARRERKAWLAWLQETARKP
GFNDADSRREELRKLWKDVPVRLKNDPAMVARYAGFLAQLGGGRGALNLVREQLDSQWDDRLPPVLEAIDDISPDDLLQV
LEKWLVERPGNAAVLITAGRVALKARLWGKAQGFFEAAANSSQSATALAELARLYRALGDTSKAMSVFDRRLAQLEGDLP
ALPQPDKSVQ

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=371, Percent_Identity=26.4150943396226, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 45687; Mature: 45687

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVLLIIIALVAALALGRWMAADSGYVLIIRDTMSVDTTLGFVVLMALLGAVALVVLT
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LLGNTAWNLMEPVRATRRWKRKVAERRLRSGFLQLVDGELEKAERLLAAAGEEGDWPLVA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
WLLAAEAAQEQDKVDVSQQYLEQASADRRGRLVAGLMKARFALDDGHPEQARSELKVLAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
MAPRNKRILNTYAEVLERQKDWQTLCGLMPRLKRAFGENDQARRERKAWLAWLQETARKP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
GFNDADSRREELRKLWKDVPVRLKNDPAMVARYAGFLAQLGGGRGALNLVREQLDSQWDD
CCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
RLPPVLEAIDDISPDDLLQVLEKWLVERPGNAAVLITAGRVALKARLWGKAQGFFEAAAN
CCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
SSQSATALAELARLYRALGDTSKAMSVFDRRLAQLEGDLPALPQPDKSVQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLVLLIIIALVAALALGRWMAADSGYVLIIRDTMSVDTTLGFVVLMALLGAVALVVLT
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LLGNTAWNLMEPVRATRRWKRKVAERRLRSGFLQLVDGELEKAERLLAAAGEEGDWPLVA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
WLLAAEAAQEQDKVDVSQQYLEQASADRRGRLVAGLMKARFALDDGHPEQARSELKVLAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
MAPRNKRILNTYAEVLERQKDWQTLCGLMPRLKRAFGENDQARRERKAWLAWLQETARKP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
GFNDADSRREELRKLWKDVPVRLKNDPAMVARYAGFLAQLGGGRGALNLVREQLDSQWDD
CCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
RLPPVLEAIDDISPDDLLQVLEKWLVERPGNAAVLITAGRVALKARLWGKAQGFFEAAAN
CCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
SSQSATALAELARLYRALGDTSKAMSVFDRRLAQLEGDLPALPQPDKSVQ
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]