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The map label for this gene is fabB [H]

Identifier: 110636262

GI number: 110636262

Start: 4242133

End: 4243353

Strand: Reverse

Name: fabB [H]

Synonym: Meso_3938

Alternate gene names: 110636262

Gene position: 4243353-4242133 (Counterclockwise)

Preceding gene: 110636263

Following gene: 110636261

Centisome position: 96.17

GC content: 60.44

Gene sequence:

>1221_bases
ATGAGACGCGTCGTAGTCACCGGCCTCGGCATCGTTTCCTCCATTGGCAATAACGCCCAGGAAGTCACGGCATCGCTGCG
CGAAGCCAAATCGGGCATCAGTTTCTCGCCAGATTTCGCCGAGCACGGCTTTCGCTGCCAGGTTTGGGGAGCGCCTAGCC
TCGATCCGACAGATCTTGTGGATCGCCGCGCGATGCGTTTTCTGTCCAAGGGCGGCGCCTGGAATCATGTGGCCATGGAA
CAGGCAATCGCCGACTCCGGGCTCGAAGAGCAGGACATCACCCACGAGCGCACCGGCATCATAATGGGTTCCGGCGGCCC
TTCGACGCGTATTATCGTGGAAGCCGCCGACACCACGCGCGAGAAAGGCAGCCCGAAACGCATCGGTCCCTTCGCCGTGC
CCAAAGCAATGTCCTCGACGGCTTCGGCAACGCTTGCAACCTGGTTCAAAATCCACGGCGTGAATTACTCGATCTCCTCT
GCCTGCTCCACATCCGCGCATTGCATCGGCAACGCCTACGAGCTGATCCAGTGGGGCAAGCAGGACATGATCTTCGCCGG
AGGCCACGAGGATCTCGACTGGACGATGTCGAACCTCTTCGACGCCATGGGCGCGATGTCCTCCAAACATAACGACACGC
CCTCCACGGCATCCCGCGCTTACGATGTAACGCGGGACGGCTTTGTGATTGCTGGCGGCGCCGGCGTCCTCGTGCTTGAA
GAACTTGAGCACGCCAAGGCGCGCGGCGCGAAGATCTATGCCGAAATCGTAGGCTATGGCGCCACTTCAGACGGGTACGA
CATGGTTGCGCTTTCCGGCGAGGGTGCCGTCCGCTGCATGCGCCAGGCGCTTTCCACCGTCAAAGGGAAGGTGGACTACA
TCAATACGCATGGCACCTCGACGCCGGTCGGGGATTCCGGCGAGATCGGCGCAGTACGCCAAGTGTTCGGGAACGAGATC
CCACCCATTTCCTCGACCAAATCGCTGACAGGTCATTCCCTGGGAGCGGCGGGTGCGCAGGAATCCATCTACTCGATCCT
GATGATGCAGGAAGGCTTCATCGGAGAGAGCGCGCATATTACCGAGCTAGACCCTGAATTCGAAGGGGTTCCCATCGTGC
GCAAGCGCATCGACAACGCAAAGATAGACACCGTTCTGTCGAACTCGTTCGGCTTCGGCGGCACCAATGCGACGCTGGTG
TTTCAGCGATACGCGGGCTGA

Upstream 100 bases:

>100_bases
CCATATACAGGGCTTCTGACCTGCGTGTCGGCCTTTTCAAGCAGGAAAGCTAGGCTGCCGCCATCCTAAACATCAGCCTT
GAAGCCCTAAGGAGAGCCAT

Downstream 100 bases:

>100_bases
GGGGATGATGGAATCTCTTATGAAGGGGAAGCGCGGCGTCATCATGGGCGTCGCGAACGATCATTCGATCGCCTGGGGCA
TTGCAAAGAAACTCGCCGAG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRRVVVTGLGIVSSIGNNAQEVTASLREAKSGISFSPDFAEHGFRCQVWGAPSLDPTDLVDRRAMRFLSKGGAWNHVAME
QAIADSGLEEQDITHERTGIIMGSGGPSTRIIVEAADTTREKGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISS
ACSTSAHCIGNAYELIQWGKQDMIFAGGHEDLDWTMSNLFDAMGAMSSKHNDTPSTASRAYDVTRDGFVIAGGAGVLVLE
ELEHAKARGAKIYAEIVGYGATSDGYDMVALSGEGAVRCMRQALSTVKGKVDYINTHGTSTPVGDSGEIGAVRQVFGNEI
PPISSTKSLTGHSLGAAGAQESIYSILMMQEGFIGESAHITELDPEFEGVPIVRKRIDNAKIDTVLSNSFGFGGTNATLV
FQRYAG

Sequences:

>Translated_406_residues
MRRVVVTGLGIVSSIGNNAQEVTASLREAKSGISFSPDFAEHGFRCQVWGAPSLDPTDLVDRRAMRFLSKGGAWNHVAME
QAIADSGLEEQDITHERTGIIMGSGGPSTRIIVEAADTTREKGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISS
ACSTSAHCIGNAYELIQWGKQDMIFAGGHEDLDWTMSNLFDAMGAMSSKHNDTPSTASRAYDVTRDGFVIAGGAGVLVLE
ELEHAKARGAKIYAEIVGYGATSDGYDMVALSGEGAVRCMRQALSTVKGKVDYINTHGTSTPVGDSGEIGAVRQVFGNEI
PPISSTKSLTGHSLGAAGAQESIYSILMMQEGFIGESAHITELDPEFEGVPIVRKRIDNAKIDTVLSNSFGFGGTNATLV
FQRYAG
>Mature_406_residues
MRRVVVTGLGIVSSIGNNAQEVTASLREAKSGISFSPDFAEHGFRCQVWGAPSLDPTDLVDRRAMRFLSKGGAWNHVAME
QAIADSGLEEQDITHERTGIIMGSGGPSTRIIVEAADTTREKGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISS
ACSTSAHCIGNAYELIQWGKQDMIFAGGHEDLDWTMSNLFDAMGAMSSKHNDTPSTASRAYDVTRDGFVIAGGAGVLVLE
ELEHAKARGAKIYAEIVGYGATSDGYDMVALSGEGAVRCMRQALSTVKGKVDYINTHGTSTPVGDSGEIGAVRQVFGNEI
PPISSTKSLTGHSLGAAGAQESIYSILMMQEGFIGESAHITELDPEFEGVPIVRKRIDNAKIDTVLSNSFGFGGTNATLV
FQRYAG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=35.1674641148325, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=24.702380952381, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI223972627, Length=136, Percent_Identity=41.1764705882353, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=61.8811881188119, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=37.7403846153846, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=33.9759036144578, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=39.3822393822394, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=338, Percent_Identity=24.2603550295858, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=25.5395683453237, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=31.5555555555556, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=36.3420427553444, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=27.0029673590504, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=27.0029673590504, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24581345, Length=341, Percent_Identity=23.7536656891496, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43054; Mature: 43054

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGNNAQEVTASLREAKSGISFSPDFAEHGFRCQVWGAPSLDPTDLV
CCEEEEECHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSKGGAWNHVAMEQAIADSGLEEQDITHERTGIIMGSGGPSTRIIVEAADTTR
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHCCCHHHCEEEEECCCCCEEEEEEECCCCC
EKGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNAYELIQWGK
CCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCEEHHHHCCCCHHHHHHHHHHHHCCC
QDMIFAGGHEDLDWTMSNLFDAMGAMSSKHNDTPSTASRAYDVTRDGFVIAGGAGVLVLE
CCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEECCCCCEEEECCCCEEEHH
ELEHAKARGAKIYAEIVGYGATSDGYDMVALSGEGAVRCMRQALSTVKGKVDYINTHGTS
HHHHHHHCCCEEEEEHEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCC
TPVGDSGEIGAVRQVFGNEIPPISSTKSLTGHSLGAAGAQESIYSILMMQEGFIGESAHI
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
TELDPEFEGVPIVRKRIDNAKIDTVLSNSFGFGGTNATLVFQRYAG
EECCCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGNNAQEVTASLREAKSGISFSPDFAEHGFRCQVWGAPSLDPTDLV
CCEEEEECHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCEEEECCCCCCCHHHHH
DRRAMRFLSKGGAWNHVAMEQAIADSGLEEQDITHERTGIIMGSGGPSTRIIVEAADTTR
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHCCCHHHCEEEEECCCCCEEEEEEECCCCC
EKGSPKRIGPFAVPKAMSSTASATLATWFKIHGVNYSISSACSTSAHCIGNAYELIQWGK
CCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCEEHHHHCCCCHHHHHHHHHHHHCCC
QDMIFAGGHEDLDWTMSNLFDAMGAMSSKHNDTPSTASRAYDVTRDGFVIAGGAGVLVLE
CCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEECCCCCEEEECCCCEEEHH
ELEHAKARGAKIYAEIVGYGATSDGYDMVALSGEGAVRCMRQALSTVKGKVDYINTHGTS
HHHHHHHCCCEEEEEHEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCC
TPVGDSGEIGAVRQVFGNEIPPISSTKSLTGHSLGAAGAQESIYSILMMQEGFIGESAHI
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
TELDPEFEGVPIVRKRIDNAKIDTVLSNSFGFGGTNATLVFQRYAG
EECCCCCCCCHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]