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The map label for this gene is fabA

Identifier: 110636263

GI number: 110636263

Start: 4243401

End: 4243913

Strand: Reverse

Name: fabA

Synonym: Meso_3939

Alternate gene names: 110636263

Gene position: 4243913-4243401 (Counterclockwise)

Preceding gene: 110636265

Following gene: 110636262

Centisome position: 96.18

GC content: 59.26

Gene sequence:

>513_bases
ATGGCGCAGACGAAATCCAGCTACGATTACGAGGACCTTCTGGCCTGCGCCCGAGGCGAATTGTTCGGCCCGGGCAACGC
ACAGCTTCCGGCGCCGCCGATGTTGATGTTCGACCGCATCACTGAGGTGAGCGCAGAAGGCGGTGAATTCGGAAAAGGGT
TCATCCGTGCCGAACTTGATATCAAGCCGGATCTTTGGTTCTTTCCATGCCACTTTATCGGCGACCCGGTGATGCCGGGC
TGCCTCGGTCTTGATGCGCTTTGGCAAATGACCGGCTTTTTTCTCGGCTGGCTGGGCGAGCCGGGCAAAGGACGCGCCAT
TTCCACGGGCGAAGTCAAGTTCAGCGGCATGGTCACACCCGCTGTGAAAACCGTCGAGTATGGCGTCGATCTGAAGCGCG
TGATGCGCGGGCGCCTTGTGCTCGGCATCGGCGATGGATGGTTGAAGGCCGACGGGGAAACCATATACAGGGCTTCTGAC
CTGCGTGTCGGCCTTTTCAAGCAGGAAAGCTAG

Upstream 100 bases:

>100_bases
CTGTGATAGGAGAGTTTCCAAAATGCGGTGCCGTATCGGCAACGATGTGAATGGTTAGACGCCGGCCGGAAGAACCGGTC
GCCAGTGAGAATGGGAATTC

Downstream 100 bases:

>100_bases
GCTGCCGCCATCCTAAACATCAGCCTTGAAGCCCTAAGGAGAGCCATATGAGACGCGTCGTAGTCACCGGCCTCGGCATC
GTTTCCTCCATTGGCAATAA

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MAQTKSSYDYEDLLACARGELFGPGNAQLPAPPMLMFDRITEVSAEGGEFGKGFIRAELDIKPDLWFFPCHFIGDPVMPG
CLGLDALWQMTGFFLGWLGEPGKGRAISTGEVKFSGMVTPAVKTVEYGVDLKRVMRGRLVLGIGDGWLKADGETIYRASD
LRVGLFKQES

Sequences:

>Translated_170_residues
MAQTKSSYDYEDLLACARGELFGPGNAQLPAPPMLMFDRITEVSAEGGEFGKGFIRAELDIKPDLWFFPCHFIGDPVMPG
CLGLDALWQMTGFFLGWLGEPGKGRAISTGEVKFSGMVTPAVKTVEYGVDLKRVMRGRLVLGIGDGWLKADGETIYRASD
LRVGLFKQES
>Mature_169_residues
AQTKSSYDYEDLLACARGELFGPGNAQLPAPPMLMFDRITEVSAEGGEFGKGFIRAELDIKPDLWFFPCHFIGDPVMPGC
LGLDALWQMTGFFLGWLGEPGKGRAISTGEVKFSGMVTPAVKTVEYGVDLKRVMRGRLVLGIGDGWLKADGETIYRASDL
RVGLFKQES

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=170, Percent_Identity=60, Blast_Score=219, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_MESSB (Q11BB9)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_676471.1
- ProteinModelPortal:   Q11BB9
- SMR:   Q11BB9
- STRING:   Q11BB9
- GeneID:   4180244
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_3939
- NMPDR:   fig|266779.1.peg.3121
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   CHFKGDP
- ProtClustDB:   PRK05174
- BioCyc:   MSP266779:MESO_3939-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114
- PANTHER:   PTHR11712
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 18603; Mature: 18472

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTKSSYDYEDLLACARGELFGPGNAQLPAPPMLMFDRITEVSAEGGEFGKGFIRAELD
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEE
IKPDLWFFPCHFIGDPVMPGCLGLDALWQMTGFFLGWLGEPGKGRAISTGEVKFSGMVTP
CCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEECCCCCH
AVKTVEYGVDLKRVMRGRLVLGIGDGWLKADGETIYRASDLRVGLFKQES
HHHHHHHCCCHHHHHCCCEEEEECCCEEECCCCEEEEECCCEEEEEECCC
>Mature Secondary Structure 
AQTKSSYDYEDLLACARGELFGPGNAQLPAPPMLMFDRITEVSAEGGEFGKGFIRAELD
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEE
IKPDLWFFPCHFIGDPVMPGCLGLDALWQMTGFFLGWLGEPGKGRAISTGEVKFSGMVTP
CCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEECCCCCH
AVKTVEYGVDLKRVMRGRLVLGIGDGWLKADGETIYRASDLRVGLFKQES
HHHHHHHCCCHHHHHCCCEEEEECCCEEECCCCEEEEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA