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The map label for this gene is gltC [H]

Identifier: 110632858

GI number: 110632858

Start: 553036

End: 554034

Strand: Direct

Name: gltC [H]

Synonym: Meso_0498

Alternate gene names: 110632858

Gene position: 553036-554034 (Clockwise)

Preceding gene: 110632856

Following gene: 110632870

Centisome position: 12.53

GC content: 64.66

Gene sequence:

>999_bases
GTGCCGAGATCGAAGATCGAGCTGCGCCATGTGCGCTACATCATCGCCGCCGCGGAAAGCGGCAGCTTCCGGCGCGCGGC
GCAAGATCTCGGTGTCGAGCAGTCGGCGATCAGCCGCCGCATCCGGGATGTCGAGGATGAGATCGGCGCACAGCTGTTCC
GCCGTCATCCTGCCGGCGTCGACCTGACGGACATCGGCAAACAATTCCTGAATCAGGCCGCCCCTGGGGCTCGCCAGATC
GGATCGGCGCTCGACGGCGCAAGAACGGTGGCGAACAGAGGACGGCATCTTCGGATCGGCGTGTTCGGGCCTCTGACCAT
GGGCTTTCTGTCTGAGCTCTTCGGGGCCTTTCGGGGTGACCGCCCGGGGGTCAAGCTGCGGTTCAGCGAGGGCAGCTGTC
CCGAACTTATCGCGGCCGTGCGGCGGGGGCAGCTTGATGTCGGTGTCGTCGCCGAAGCTTCGCCCGGGAAGGGCTTTGAC
GTGACGCATTTGTGGGCCGAGCCCGTGTACGCGGCATTGCCGGACGGCGACCCACTCGCCGATCAGAAGGCGCTCCGGTG
GGATGACCTGCGTGATCGGCACTTTGTGGTGACTGATTTACCGACCGGCGATTTCGCGAAGGGTTACCTGATGCGAAACC
TCCAGACTTCGCCCGGAGACCTCCAGATCGAGCAATTGTCCGTCACTCGGGAATCTCTGATGCAGATCGTCGCGCATGGG
GACGGCGTCACCATCGCAGGTAGCGCGCATGTACGTCACGGAGTGCCAGGCATCACTTTTCGCCTGATCGAGGATGCAGT
TCTCCGCTATGGTGCTGTCCACCCGCGAGGGGCGCTCAATCGGAACCTCGAGCGCCTGCTGGCGCTGGCAAAGTCTTTCT
CGGAGCGAGATGACGCTTGGTTCGCCCGGCAACGGCTCATGCGCCCTGAGCATCGGCGCGTGCCGCACGTTGACTGCCAT
CGCGGCGCGCGCGGGCGAACCCCCGATCGGTTGCAATGA

Upstream 100 bases:

>100_bases
GGTAGCGAGGAGACGGAGAAGACCCATAATCTGATCGGAACAGTTCTCGGGGGCTGACGGGGCTACGTTTGCAAAGACCT
TTGCATCATGGGGAACCATC

Downstream 100 bases:

>100_bases
AGCGCTCGAGCATGGGCACAATCAGCTTCGTCGGGTCGCCGATGGTCTGGCCTTGTTCGCGGCCGAGTGCTGCGGCGTAG
GCGACGAGGTCCCGATGCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MPRSKIELRHVRYIIAAAESGSFRRAAQDLGVEQSAISRRIRDVEDEIGAQLFRRHPAGVDLTDIGKQFLNQAAPGARQI
GSALDGARTVANRGRHLRIGVFGPLTMGFLSELFGAFRGDRPGVKLRFSEGSCPELIAAVRRGQLDVGVVAEASPGKGFD
VTHLWAEPVYAALPDGDPLADQKALRWDDLRDRHFVVTDLPTGDFAKGYLMRNLQTSPGDLQIEQLSVTRESLMQIVAHG
DGVTIAGSAHVRHGVPGITFRLIEDAVLRYGAVHPRGALNRNLERLLALAKSFSERDDAWFARQRLMRPEHRRVPHVDCH
RGARGRTPDRLQ

Sequences:

>Translated_332_residues
MPRSKIELRHVRYIIAAAESGSFRRAAQDLGVEQSAISRRIRDVEDEIGAQLFRRHPAGVDLTDIGKQFLNQAAPGARQI
GSALDGARTVANRGRHLRIGVFGPLTMGFLSELFGAFRGDRPGVKLRFSEGSCPELIAAVRRGQLDVGVVAEASPGKGFD
VTHLWAEPVYAALPDGDPLADQKALRWDDLRDRHFVVTDLPTGDFAKGYLMRNLQTSPGDLQIEQLSVTRESLMQIVAHG
DGVTIAGSAHVRHGVPGITFRLIEDAVLRYGAVHPRGALNRNLERLLALAKSFSERDDAWFARQRLMRPEHRRVPHVDCH
RGARGRTPDRLQ
>Mature_331_residues
PRSKIELRHVRYIIAAAESGSFRRAAQDLGVEQSAISRRIRDVEDEIGAQLFRRHPAGVDLTDIGKQFLNQAAPGARQIG
SALDGARTVANRGRHLRIGVFGPLTMGFLSELFGAFRGDRPGVKLRFSEGSCPELIAAVRRGQLDVGVVAEASPGKGFDV
THLWAEPVYAALPDGDPLADQKALRWDDLRDRHFVVTDLPTGDFAKGYLMRNLQTSPGDLQIEQLSVTRESLMQIVAHGD
GVTIAGSAHVRHGVPGITFRLIEDAVLRYGAVHPRGALNRNLERLLALAKSFSERDDAWFARQRLMRPEHRRVPHVDCHR
GARGRTPDRLQ

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=263, Percent_Identity=30.0380228136882, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=32.7526132404181, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367136, Length=262, Percent_Identity=26.3358778625954, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI157672245, Length=199, Percent_Identity=30.6532663316583, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI145693105, Length=223, Percent_Identity=27.8026905829596, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=27.6381909547739, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790399, Length=244, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=28.0821917808219, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790262, Length=192, Percent_Identity=25.5208333333333, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=22.3140495867769, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36700; Mature: 36569

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSKIELRHVRYIIAAAESGSFRRAAQDLGVEQSAISRRIRDVEDEIGAQLFRRHPAGV
CCCCHHHHHHHEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLTDIGKQFLNQAAPGARQIGSALDGARTVANRGRHLRIGVFGPLTMGFLSELFGAFRGD
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCC
RPGVKLRFSEGSCPELIAAVRRGQLDVGVVAEASPGKGFDVTHLWAEPVYAALPDGDPLA
CCCEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHCCCEEECCCCCCCC
DQKALRWDDLRDRHFVVTDLPTGDFAKGYLMRNLQTSPGDLQIEQLSVTRESLMQIVAHG
CCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCC
DGVTIAGSAHVRHGVPGITFRLIEDAVLRYGAVHPRGALNRNLERLLALAKSFSERDDAW
CCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
FARQRLMRPEHRRVPHVDCHRGARGRTPDRLQ
HHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PRSKIELRHVRYIIAAAESGSFRRAAQDLGVEQSAISRRIRDVEDEIGAQLFRRHPAGV
CCCHHHHHHHEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLTDIGKQFLNQAAPGARQIGSALDGARTVANRGRHLRIGVFGPLTMGFLSELFGAFRGD
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCC
RPGVKLRFSEGSCPELIAAVRRGQLDVGVVAEASPGKGFDVTHLWAEPVYAALPDGDPLA
CCCEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHCCCEEECCCCCCCC
DQKALRWDDLRDRHFVVTDLPTGDFAKGYLMRNLQTSPGDLQIEQLSVTRESLMQIVAHG
CCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHCC
DGVTIAGSAHVRHGVPGITFRLIEDAVLRYGAVHPRGALNRNLERLLALAKSFSERDDAW
CCEEEECCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
FARQRLMRPEHRRVPHVDCHRGARGRTPDRLQ
HHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]