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The map label for this gene is kbl [C]

Identifier: 110632804

GI number: 110632804

Start: 489766

End: 490953

Strand: Direct

Name: kbl [C]

Synonym: Meso_0443

Alternate gene names: 110632804

Gene position: 489766-490953 (Clockwise)

Preceding gene: 110632800

Following gene: 110632805

Centisome position: 11.1

GC content: 60.44

Gene sequence:

>1188_bases
ATGACCGCTTCCTTTCTTCAGTATTTGTCCCGCGAAGTCGACGGCTTGAAAGAGGCCGGGCTCTATAAGAGCGAGCGCGT
GATCACCTCCATGCAATCCGCCAGGATCGAGAGCGGCGGCAAGAGGGTTCTCAATTTCTGTGCCAACAATTATCTGGGCC
TCGCCGACAATGAGGAATTGCGCGAGGCCGCCAAGGCAGCGCTCGACCGCTATGGCTATGGCATGGCCTCCGTCCGCTTC
ATCTGCGGCACGCAGGAGGAACACAAGGCGCTGGAGAAGCGCATTTCCTCTTTCCTGGGGTATGAGGATACGATCCTCTA
TTCATCCTGCTTCGACGCCAATGCGGGGCTTTTCGAAACGCTGCTGGCGCCTGAGGACGCGATCATCTCCGACGCGCTCA
ACCATGCGTCGATCATCGATGGAGTCCGGCTCTGCAAGGCACGCCGCTATCGCTATGCGAACAACGATATGGGAGAATTG
GAGGAGCGGCTGAAAGAGGCCGCCGATGCCCGCTTCCGCCTCATCGCCACCGACGGCGTGTTCTCCATGGACGGCATCAT
TGCCAATCTGAAGGCGATTTGCGATCTGGCTGAAAAATATGATGCCATGGTGATGGTGGATGACAGCCACGCGGTGGGCT
TCGTCGGCGCGCACGGGCGCGGCACGCCGGAATATTGCGGCGTCGAAGGCCGGGTCGATATTGCTACCGGCACGCTCGGG
AAGGCTCTGGGCGGCGCTTCCGGCGGCTATACCAGCGGTAAGAAAGAGGTGGTCGAGTGGCTGCGGCAGCGCTCGCGCCC
CTATCTTTTCTCCAACACGCTGGCGCCCGTCATCGCCGCGGCTTCCCTTAAGGTGTTCGAAATTGTCGAGAACGGCGACG
AGTTGCGCCGGAGGCTCTATGAAAATGCGGATCGCTTCCGCGACAGGATGACGAAGCTTGGCTTTACATTGGCCGGCAGC
GGGCATCCGATCATCCCCGTTATGATCGGTGAGGCCGGGCTGGCCGCGAAAATGGCCGAGCGCCTTCTGGACTACGGGAT
TTACGTGATCGGCTTTTCCTTTCCCGTGGTGCCCAAGGGCGAGGCACGCATCCGAACCCAAATGTCCGCCGCCCACTCGG
CTGAGGATATCGACCGCGCTGTGGAGGCTTTCGGCAAGGTGGGCAGGGAGCTGGGGGTGATTTCATGA

Upstream 100 bases:

>100_bases
GACCGCAGCTCCGCATTTGACGGATGGCGCGCGACATGTCTAAGCGAATAGCCCTAAACGGTCCGCTGCGGCGGTCTGTG
ATGTTGCCGATGAGGTTTAT

Downstream 100 bases:

>100_bases
TGCGGTTGCCTTCGATGTTTACGTTCCATCACGTGGAGATCATCTCATGACCAACATGATGAAGGCCTTGGTGAAGGCCA
AGCCCGAGGAAGGGCTTTGG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTASFLQYLSREVDGLKEAGLYKSERVITSMQSARIESGGKRVLNFCANNYLGLADNEELREAAKAALDRYGYGMASVRF
ICGTQEEHKALEKRISSFLGYEDTILYSSCFDANAGLFETLLAPEDAIISDALNHASIIDGVRLCKARRYRYANNDMGEL
EERLKEAADARFRLIATDGVFSMDGIIANLKAICDLAEKYDAMVMVDDSHAVGFVGAHGRGTPEYCGVEGRVDIATGTLG
KALGGASGGYTSGKKEVVEWLRQRSRPYLFSNTLAPVIAAASLKVFEIVENGDELRRRLYENADRFRDRMTKLGFTLAGS
GHPIIPVMIGEAGLAAKMAERLLDYGIYVIGFSFPVVPKGEARIRTQMSAAHSAEDIDRAVEAFGKVGRELGVIS

Sequences:

>Translated_395_residues
MTASFLQYLSREVDGLKEAGLYKSERVITSMQSARIESGGKRVLNFCANNYLGLADNEELREAAKAALDRYGYGMASVRF
ICGTQEEHKALEKRISSFLGYEDTILYSSCFDANAGLFETLLAPEDAIISDALNHASIIDGVRLCKARRYRYANNDMGEL
EERLKEAADARFRLIATDGVFSMDGIIANLKAICDLAEKYDAMVMVDDSHAVGFVGAHGRGTPEYCGVEGRVDIATGTLG
KALGGASGGYTSGKKEVVEWLRQRSRPYLFSNTLAPVIAAASLKVFEIVENGDELRRRLYENADRFRDRMTKLGFTLAGS
GHPIIPVMIGEAGLAAKMAERLLDYGIYVIGFSFPVVPKGEARIRTQMSAAHSAEDIDRAVEAFGKVGRELGVIS
>Mature_394_residues
TASFLQYLSREVDGLKEAGLYKSERVITSMQSARIESGGKRVLNFCANNYLGLADNEELREAAKAALDRYGYGMASVRFI
CGTQEEHKALEKRISSFLGYEDTILYSSCFDANAGLFETLLAPEDAIISDALNHASIIDGVRLCKARRYRYANNDMGELE
ERLKEAADARFRLIATDGVFSMDGIIANLKAICDLAEKYDAMVMVDDSHAVGFVGAHGRGTPEYCGVEGRVDIATGTLGK
ALGGASGGYTSGKKEVVEWLRQRSRPYLFSNTLAPVIAAASLKVFEIVENGDELRRRLYENADRFRDRMTKLGFTLAGSG
HPIIPVMIGEAGLAAKMAERLLDYGIYVIGFSFPVVPKGEARIRTQMSAAHSAEDIDRAVEAFGKVGRELGVIS

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=56.4102564102564, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI284448556, Length=414, Percent_Identity=53.1400966183575, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=33.7912087912088, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=33.7912087912088, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=33.7912087912088, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=34.1530054644809, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=33.6065573770492, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI4502025, Length=360, Percent_Identity=31.9444444444444, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI40316939, Length=360, Percent_Identity=31.9444444444444, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI5454084, Length=275, Percent_Identity=29.8181818181818, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1790046, Length=398, Percent_Identity=69.5979899497487, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=32.5648414985591, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71994529, Length=397, Percent_Identity=56.4231738035265, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=32.520325203252, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17560914, Length=364, Percent_Identity=32.6923076923077, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17560912, Length=364, Percent_Identity=32.6923076923077, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71982617, Length=296, Percent_Identity=26.6891891891892, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=296, Percent_Identity=26.6891891891892, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=375, Percent_Identity=30.9333333333333, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=32.1621621621622, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=280, Percent_Identity=27.1428571428571, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24662918, Length=394, Percent_Identity=60.6598984771574, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI17137420, Length=379, Percent_Identity=31.1345646437995, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17136286, Length=377, Percent_Identity=32.6259946949602, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24653280, Length=393, Percent_Identity=25.1908396946565, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24653276, Length=393, Percent_Identity=25.1908396946565, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24653278, Length=393, Percent_Identity=25.1908396946565, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43168; Mature: 43036

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASFLQYLSREVDGLKEAGLYKSERVITSMQSARIESGGKRVLNFCANNYLGLADNEEL
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHH
REAAKAALDRYGYGMASVRFICGTQEEHKALEKRISSFLGYEDTILYSSCFDANAGLFET
HHHHHHHHHHHCCCHHHHHEEECCCHHHHHHHHHHHHHCCCCHHEEEHHCCCCCCHHHHH
LLAPEDAIISDALNHASIIDGVRLCKARRYRYANNDMGELEERLKEAADARFRLIATDGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEEECCC
FSMDGIIANLKAICDLAEKYDAMVMVDDSHAVGFVGAHGRGTPEYCGVEGRVDIATGTLG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEECCHHH
KALGGASGGYTSGKKEVVEWLRQRSRPYLFSNTLAPVIAAASLKVFEIVENGDELRRRLY
HHHCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ENADRFRDRMTKLGFTLAGSGHPIIPVMIGEAGLAAKMAERLLDYGIYVIGFSFPVVPKG
HHHHHHHHHHHHHCEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCCCCC
EARIRTQMSAAHSAEDIDRAVEAFGKVGRELGVIS
CHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TASFLQYLSREVDGLKEAGLYKSERVITSMQSARIESGGKRVLNFCANNYLGLADNEEL
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHH
REAAKAALDRYGYGMASVRFICGTQEEHKALEKRISSFLGYEDTILYSSCFDANAGLFET
HHHHHHHHHHHCCCHHHHHEEECCCHHHHHHHHHHHHHCCCCHHEEEHHCCCCCCHHHHH
LLAPEDAIISDALNHASIIDGVRLCKARRYRYANNDMGELEERLKEAADARFRLIATDGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEEECCC
FSMDGIIANLKAICDLAEKYDAMVMVDDSHAVGFVGAHGRGTPEYCGVEGRVDIATGTLG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEECCHHH
KALGGASGGYTSGKKEVVEWLRQRSRPYLFSNTLAPVIAAASLKVFEIVENGDELRRRLY
HHHCCCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
ENADRFRDRMTKLGFTLAGSGHPIIPVMIGEAGLAAKMAERLLDYGIYVIGFSFPVVPKG
HHHHHHHHHHHHHCEEEECCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCCCCC
EARIRTQMSAAHSAEDIDRAVEAFGKVGRELGVIS
CHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]