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The map label for this gene is tdh

Identifier: 110632805

GI number: 110632805

Start: 491000

End: 492034

Strand: Direct

Name: tdh

Synonym: Meso_0444

Alternate gene names: 110632805

Gene position: 491000-492034 (Clockwise)

Preceding gene: 110632804

Following gene: 110632808

Centisome position: 11.13

GC content: 60.68

Gene sequence:

>1035_bases
ATGACCAACATGATGAAGGCCTTGGTGAAGGCCAAGCCCGAGGAAGGGCTTTGGATGGAGCGGGTGCCGCTTCCGGAGAT
CGGCCCGAACGACGTGCTGATCAAGGTGAGGAAAGCTGCCATCTGCGGCACGGACGTCCATATCTGGAACTGGGACGAAT
GGGCAAGAAAGACCGTGCCCGTGCCGCTCGTCACCGGCCATGAGTTCGTCGGCGAGGTCGTGGATGTCGGCTCAGCCGTG
ACCGAATACAGAATCGGGCAGCGTGTTTCGGGCGAGGGGCACATTGTCTGCGGCCATTGCCGCAACTGCCGGGCCGGGCG
TGGACATCTCTGCCGAAACACGCTGGGCGTCGGCGTTCACCGGCCGGGTGCCTTTGCCGAATATATCTCGCTGCCGCAGC
ACAATGTCGTGGCGATCCCCGACGACGTGCCGGACGAGATCGCCGCGATTTTCGATCCGCTTGGAAACGCGGTGCACACC
GCGCTCTCTTTCGATCTGGTGGGCGAGGATGTGCTGGTGACCGGAGCTGGCCCGATCGGCATTATGGGCGCGCTGGTGGC
GCAGTGCGTAGGTGCGCGCAAAGTGGTCATCACGGATATCAATCCGGGGCGACTTGCGCTCGCTAAGAAACTCGGCGTGC
GTCACGTGGTGAATGCCAGGGAAGAGAAGCTCACCGATGTAATGAGGAAGCTCGGCATGACCGAGGGCTTCGACGTGGGC
CTGGAGATGTCCGGCTCTGCCTCGGCGTTTCGCGACATGATCGATGTCATGAACAATGGCGGCAAAATAGCGATCCTCGG
CATAGCGCCGACGGGTTTCGAGATCGATTGGAACAAGGTGATTTTCAAGATGCTCCACCTGAAGGGCATCTACGGCCGGG
AGATGTTCGAAACCTGGTACAAGATGATCGCGCTTGTGCAGGGGCCTCTCGATATCTCCGGCCTGATCACGCACCGCATC
TCTGCCGATGATTACCGCGAAGGCTTTGCCGCCATGCGCAGCGGCGAGGCCGGTAAGGTTGTAATGGATTGGTGA

Upstream 100 bases:

>100_bases
CGCGCTGTGGAGGCTTTCGGCAAGGTGGGCAGGGAGCTGGGGGTGATTTCATGATGCGGTTGCCTTCGATGTTTACGTTC
CATCACGTGGAGATCATCTC

Downstream 100 bases:

>100_bases
TAAACCGGGTTAGTGACTCCGGGTAGGAAAGAGCCTCCCTAACATCTCTTTTGGATTGTATTCCTTGTTTGAGATTTCAA
CCTGAAGTATAGCGCGAGTC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTNMMKALVKAKPEEGLWMERVPLPEIGPNDVLIKVRKAAICGTDVHIWNWDEWARKTVPVPLVTGHEFVGEVVDVGSAV
TEYRIGQRVSGEGHIVCGHCRNCRAGRGHLCRNTLGVGVHRPGAFAEYISLPQHNVVAIPDDVPDEIAAIFDPLGNAVHT
ALSFDLVGEDVLVTGAGPIGIMGALVAQCVGARKVVITDINPGRLALAKKLGVRHVVNAREEKLTDVMRKLGMTEGFDVG
LEMSGSASAFRDMIDVMNNGGKIAILGIAPTGFEIDWNKVIFKMLHLKGIYGREMFETWYKMIALVQGPLDISGLITHRI
SADDYREGFAAMRSGEAGKVVMDW

Sequences:

>Translated_344_residues
MTNMMKALVKAKPEEGLWMERVPLPEIGPNDVLIKVRKAAICGTDVHIWNWDEWARKTVPVPLVTGHEFVGEVVDVGSAV
TEYRIGQRVSGEGHIVCGHCRNCRAGRGHLCRNTLGVGVHRPGAFAEYISLPQHNVVAIPDDVPDEIAAIFDPLGNAVHT
ALSFDLVGEDVLVTGAGPIGIMGALVAQCVGARKVVITDINPGRLALAKKLGVRHVVNAREEKLTDVMRKLGMTEGFDVG
LEMSGSASAFRDMIDVMNNGGKIAILGIAPTGFEIDWNKVIFKMLHLKGIYGREMFETWYKMIALVQGPLDISGLITHRI
SADDYREGFAAMRSGEAGKVVMDW
>Mature_343_residues
TNMMKALVKAKPEEGLWMERVPLPEIGPNDVLIKVRKAAICGTDVHIWNWDEWARKTVPVPLVTGHEFVGEVVDVGSAVT
EYRIGQRVSGEGHIVCGHCRNCRAGRGHLCRNTLGVGVHRPGAFAEYISLPQHNVVAIPDDVPDEIAAIFDPLGNAVHTA
LSFDLVGEDVLVTGAGPIGIMGALVAQCVGARKVVITDINPGRLALAKKLGVRHVVNAREEKLTDVMRKLGMTEGFDVGL
EMSGSASAFRDMIDVMNNGGKIAILGIAPTGFEIDWNKVIFKMLHLKGIYGREMFETWYKMIALVQGPLDISGLITHRIS
ADDYREGFAAMRSGEAGKVVMDW

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=333, Percent_Identity=29.4294294294294, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=25.0673854447439, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=25.4691689008043, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=25.4691689008043, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71743840, Length=374, Percent_Identity=22.7272727272727, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=23.3870967741935, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI71565154, Length=379, Percent_Identity=23.7467018469657, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=68.5294117647059, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1788075, Length=365, Percent_Identity=32.0547945205479, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1788073, Length=328, Percent_Identity=28.3536585365854, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=30.1115241635688, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082125, Length=355, Percent_Identity=30.7042253521127, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787863, Length=319, Percent_Identity=28.8401253918495, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790718, Length=268, Percent_Identity=27.2388059701493, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=27.5147928994083, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786825, Length=397, Percent_Identity=26.1964735516373, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=272, Percent_Identity=26.1029411764706, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=26.1333333333333, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786518, Length=261, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082401, Length=140, Percent_Identity=32.1428571428571, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=32.1533923303835, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=333, Percent_Identity=29.4294294294294, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=191, Percent_Identity=32.4607329842932, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=295, Percent_Identity=26.4406779661017, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=140, Percent_Identity=31.4285714285714, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=23.7967914438503, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=23.4501347708895, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=30.8823529411765, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=324, Percent_Identity=28.0864197530864, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=324, Percent_Identity=27.7777777777778, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=303, Percent_Identity=30.6930693069307, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=26.4, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=343, Percent_Identity=25.6559766763848, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=353, Percent_Identity=26.628895184136, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=341, Percent_Identity=28.4457478005865, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=360, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=318, Percent_Identity=27.0440251572327, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=250, Percent_Identity=30, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=319, Percent_Identity=26.6457680250784, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=28.3132530120482, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=27.1084337349398, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=25.4010695187166, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_MESSB (Q11L77)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673013.1
- ProteinModelPortal:   Q11L77
- SMR:   Q11L77
- STRING:   Q11L77
- GeneID:   4179985
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0444
- NMPDR:   fig|266779.1.peg.2591
- eggNOG:   COG1063
- HOGENOM:   HBG753318
- OMA:   MVDAPKP
- PhylomeDB:   Q11L77
- ProtClustDB:   PRK05396
- BioCyc:   MSP266779:MESO_0444-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37428; Mature: 37297

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNMMKALVKAKPEEGLWMERVPLPEIGPNDVLIKVRKAAICGTDVHIWNWDEWARKTVP
CCHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEEEHHEEECCCEEEECCHHHHHHCCC
VPLVTGHEFVGEVVDVGSAVTEYRIGQRVSGEGHIVCGHCRNCRAGRGHLCRNTLGVGVH
CEEECCHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCCCCCCCCCCHHHHHHCCCCC
RPGAFAEYISLPQHNVVAIPDDVPDEIAAIFDPLGNAVHTALSFDLVGEDVLVTGAGPIG
CCCHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHH
IMGALVAQCVGARKVVITDINPGRLALAKKLGVRHVVNAREEKLTDVMRKLGMTEGFDVG
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LEMSGSASAFRDMIDVMNNGGKIAILGIAPTGFEIDWNKVIFKMLHLKGIYGREMFETWY
EEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
KMIALVQGPLDISGLITHRISADDYREGFAAMRSGEAGKVVMDW
HHHHHHCCCCCHHHHHEECCCCHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
TNMMKALVKAKPEEGLWMERVPLPEIGPNDVLIKVRKAAICGTDVHIWNWDEWARKTVP
CHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEEEHHEEECCCEEEECCHHHHHHCCC
VPLVTGHEFVGEVVDVGSAVTEYRIGQRVSGEGHIVCGHCRNCRAGRGHLCRNTLGVGVH
CEEECCHHHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCCCCCCCCCCHHHHHHCCCCC
RPGAFAEYISLPQHNVVAIPDDVPDEIAAIFDPLGNAVHTALSFDLVGEDVLVTGAGPIG
CCCHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCHHH
IMGALVAQCVGARKVVITDINPGRLALAKKLGVRHVVNAREEKLTDVMRKLGMTEGFDVG
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LEMSGSASAFRDMIDVMNNGGKIAILGIAPTGFEIDWNKVIFKMLHLKGIYGREMFETWY
EEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
KMIALVQGPLDISGLITHRISADDYREGFAAMRSGEAGKVVMDW
HHHHHHCCCCCHHHHHEECCCCHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA