Click here to switch to the map view.

The map label for this gene is lpxK

Identifier: 110632800

GI number: 110632800

Start: 485745

End: 486776

Strand: Direct

Name: lpxK

Synonym: Meso_0439

Alternate gene names: 110632800

Gene position: 485745-486776 (Clockwise)

Preceding gene: 110632799

Following gene: 110632804

Centisome position: 11.01

GC content: 64.83

Gene sequence:

>1032_bases
ATGGCCGCAAGCGAAGCGCCGCCCTTCTGGTGGGAGAAGCCGGATTGGCGCGCTTGGGCGCTCTGGCCTTTGTCGTCGGC
TTACGGATTCGCCGCCAGCGCGCGATTGCGGGCGGCTAAGCGTGAGAAGATTCCTGCCGCCGTCCTTTGTATAGGCAACC
TAACGGTCGGGGGCGAAGGCAAGACGCCGATTGCCATCGCGCTCGCCCGGCATGCCATGAGGAAGGGCCTGACGGTCGGA
TTCCTGAGCCGTGGCTATGGCGGCAGCCATTTTAAGCCGCACATTGTAAGCCCGGAGGACGATTCCGCTCGCGCAGTGGG
GGACGAACCTCTTCTTCTGGCGCGCCAGGCCCTGACCGTCATTTCCCGGGACCGGGCCGCAGGGGCGCGCCGTCTCGTTC
AGGCAGGCTGCAATCTCATCATCATGGACGACGGCTTTCAGAGCGCGCGGCTCCACATGGATTATGCGCTCATCGTTGTC
GATGCCATGCGCGGCCTCGGCAACGGGCACGTGTTTCCCGCCGGGCCGATGCGCGCTCCGCTCACGGAGCAGATGCGCTT
TGCCGACGGGGTGGTGACCATGGGGGAGGGGGATGCGGCCGACATCGTAGTGCGCAGCGCTTCGCGCGCCGGCCGGCCGG
TCTATTCGGCGCGCATCCGGCCGCGCTCCCGGAACGGCCTTAAAGGCAAGCGCGTGCTCGCCTTCGCGGGGATCGGCAAT
CCCCGGAAATTCTACGCCACGTTAAAAGCGTGCGGCGCGGACATCGTGTTGGAACGCTCCTTCCCCGATCATCATCTTTT
CACCGAAGAGGATGTGAGCGAGCTTTCGCGGGAGGCAGCAAAGGAATCCCTTCTGCTCGTCACCACGGAAAAGGATTTCG
TCCGGCTGCAGAACAGCATGCAGCCCATGCGGGATTTCGCCGCCTCCGTCCAGGCTCTGAAGGTTGAGGCGGTCTTCGAT
GAGCCCGGAGCGCCGGATGCCATCATCAACGCTGCCCAGCAGGCTTGGCGGGAGCGCATGCTGAAGCGCTGA

Upstream 100 bases:

>100_bases
TCGGGCGCACTCACGCGGACTTTGAGCGCGCTCGATCCCTTCATCCATCCGCTGACCGTCAAGGCCCGCCTGCAAGGCGG
CGATACAGGGGGGTGATCTG

Downstream 100 bases:

>100_bases
TGAGCTTGTGCGCCGTTCAGGACCCACAATGTGCTAGCGCCGCCGAAGCTCCGGATGCAGCTCGAGTTCTCTCTGGAAGG
AGATCTCGGCATTGAGATAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MAASEAPPFWWEKPDWRAWALWPLSSAYGFAASARLRAAKREKIPAAVLCIGNLTVGGEGKTPIAIALARHAMRKGLTVG
FLSRGYGGSHFKPHIVSPEDDSARAVGDEPLLLARQALTVISRDRAAGARRLVQAGCNLIIMDDGFQSARLHMDYALIVV
DAMRGLGNGHVFPAGPMRAPLTEQMRFADGVVTMGEGDAADIVVRSASRAGRPVYSARIRPRSRNGLKGKRVLAFAGIGN
PRKFYATLKACGADIVLERSFPDHHLFTEEDVSELSREAAKESLLLVTTEKDFVRLQNSMQPMRDFAASVQALKVEAVFD
EPGAPDAIINAAQQAWRERMLKR

Sequences:

>Translated_343_residues
MAASEAPPFWWEKPDWRAWALWPLSSAYGFAASARLRAAKREKIPAAVLCIGNLTVGGEGKTPIAIALARHAMRKGLTVG
FLSRGYGGSHFKPHIVSPEDDSARAVGDEPLLLARQALTVISRDRAAGARRLVQAGCNLIIMDDGFQSARLHMDYALIVV
DAMRGLGNGHVFPAGPMRAPLTEQMRFADGVVTMGEGDAADIVVRSASRAGRPVYSARIRPRSRNGLKGKRVLAFAGIGN
PRKFYATLKACGADIVLERSFPDHHLFTEEDVSELSREAAKESLLLVTTEKDFVRLQNSMQPMRDFAASVQALKVEAVFD
EPGAPDAIINAAQQAWRERMLKR
>Mature_342_residues
AASEAPPFWWEKPDWRAWALWPLSSAYGFAASARLRAAKREKIPAAVLCIGNLTVGGEGKTPIAIALARHAMRKGLTVGF
LSRGYGGSHFKPHIVSPEDDSARAVGDEPLLLARQALTVISRDRAAGARRLVQAGCNLIIMDDGFQSARLHMDYALIVVD
AMRGLGNGHVFPAGPMRAPLTEQMRFADGVVTMGEGDAADIVVRSASRAGRPVYSARIRPRSRNGLKGKRVLAFAGIGNP
RKFYATLKACGADIVLERSFPDHHLFTEEDVSELSREAAKESLLLVTTEKDFVRLQNSMQPMRDFAASVQALKVEAVFDE
PGAPDAIINAAQQAWRERMLKR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=303, Percent_Identity=33.993399339934, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_MESSB (Q11L82)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673008.1
- STRING:   Q11L82
- GeneID:   4179980
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0439
- NMPDR:   fig|266779.1.peg.2586
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   Q11L82
- BioCyc:   MSP266779:MESO_0439-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37399; Mature: 37268

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASEAPPFWWEKPDWRAWALWPLSSAYGFAASARLRAAKREKIPAAVLCIGNLTVGGEG
CCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECEEECCCC
KTPIAIALARHAMRKGLTVGFLSRGYGGSHFKPHIVSPEDDSARAVGDEPLLLARQALTV
CCHHHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
ISRDRAAGARRLVQAGCNLIIMDDGFQSARLHMDYALIVVDAMRGLGNGHVFPAGPMRAP
HHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCC
LTEQMRFADGVVTMGEGDAADIVVRSASRAGRPVYSARIRPRSRNGLKGKRVLAFAGIGN
HHHHHHHHCCEEEECCCCCHHHEEECHHHCCCCEEEEECCCCCCCCCCCCEEEEEECCCC
PRKFYATLKACGADIVLERSFPDHHLFTEEDVSELSREAAKESLLLVTTEKDFVRLQNSM
CHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHH
QPMRDFAASVQALKVEAVFDEPGAPDAIINAAQQAWRERMLKR
HHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AASEAPPFWWEKPDWRAWALWPLSSAYGFAASARLRAAKREKIPAAVLCIGNLTVGGEG
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECEEECCCC
KTPIAIALARHAMRKGLTVGFLSRGYGGSHFKPHIVSPEDDSARAVGDEPLLLARQALTV
CCHHHHHHHHHHHHCCCEEEEHHCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHH
ISRDRAAGARRLVQAGCNLIIMDDGFQSARLHMDYALIVVDAMRGLGNGHVFPAGPMRAP
HHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCC
LTEQMRFADGVVTMGEGDAADIVVRSASRAGRPVYSARIRPRSRNGLKGKRVLAFAGIGN
HHHHHHHHCCEEEECCCCCHHHEEECHHHCCCCEEEEECCCCCCCCCCCCEEEEEECCCC
PRKFYATLKACGADIVLERSFPDHHLFTEEDVSELSREAAKESLLLVTTEKDFVRLQNSM
CHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHH
QPMRDFAASVQALKVEAVFDEPGAPDAIINAAQQAWRERMLKR
HHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA