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The map label for this gene is hisG

Identifier: 110632780

GI number: 110632780

Start: 463154

End: 463846

Strand: Reverse

Name: hisG

Synonym: Meso_0419

Alternate gene names: 110632780

Gene position: 463846-463154 (Counterclockwise)

Preceding gene: 110632781

Following gene: 110632770

Centisome position: 10.51

GC content: 64.36

Gene sequence:

>693_bases
GTGACGGTTACACTGGCACTCCCCTCAAAGGGCCGCCTCAAGGATGCGACCGTCGAGTTGCTACGGGAAGCGGGCTATCC
CATTCGCCTGCCGGAAAACGAGCGGCGTTACCGCGCGGGGATCGACGGGCTTGACGGGCTGGAGGTGACGTTCCTCTCCG
CCTCCGAGATCGCCCGCGAACTCGACCGGGGCAGCATCGATCTCGGCGTTACCGGCGAGGACCTTGTGCGCGAGACGATC
CCCGATTGGGAATCACGCGTGGAGATCGCCGCGCGGCTCGGCTTCGGTCACGCCGACGTGGTGGTTGCCGTCCCCGAAAT
CTGGTTCGACGTCTCGACCATGGCCGATCTCGATGATGTAGCGGCGGATTTCCGCCACCGCCACAGCCGGCGGCTGCGCA
TTGCGACGAAATACTGGCGGCTCACCCAACAATTCTTCTCGCAGAAGCACGGTATCCAGGTCTACCGCATCGTGGAGAGC
CTTGGCGCCACCGAGGGCGCACCGGCGGCGGGATCAGCCGATATTATCGTCGACATCACCTCCACAGGGTCGACGCTCAA
AGCCAATCATCTGAAAGTGCTGGACGACGGCGTCATCCTGCGTTCCCAGGCCTGCCTCGTCGTGGCCAAGAAGAAAAGGC
CGGCGGAGGATGCCCGGCTGATTGCGGAGCTGGCCAAGGCGGTGAGGCGGTAG

Upstream 100 bases:

>100_bases
ATGACCGGCTCCTGACGCTTTTAGGCGCGGAAGAGCCTATTCCCGGCGTCGGCTTTTCCATGTGGCTCGACCGCATCGCG
ACCGTGCGGGGGGAAAAACC

Downstream 100 bases:

>100_bases
GCAGGCCAGGGTTCGTTTGGCCGACGCTCGACAAATCATCGCCTCCAGCAAAGCTGCAAGGCATATAGGGGGCTGGTTTC
GCTGCGGCGCTTCACCGTTC

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MTVTLALPSKGRLKDATVELLREAGYPIRLPENERRYRAGIDGLDGLEVTFLSASEIARELDRGSIDLGVTGEDLVRETI
PDWESRVEIAARLGFGHADVVVAVPEIWFDVSTMADLDDVAADFRHRHSRRLRIATKYWRLTQQFFSQKHGIQVYRIVES
LGATEGAPAAGSADIIVDITSTGSTLKANHLKVLDDGVILRSQACLVVAKKKRPAEDARLIAELAKAVRR

Sequences:

>Translated_230_residues
MTVTLALPSKGRLKDATVELLREAGYPIRLPENERRYRAGIDGLDGLEVTFLSASEIARELDRGSIDLGVTGEDLVRETI
PDWESRVEIAARLGFGHADVVVAVPEIWFDVSTMADLDDVAADFRHRHSRRLRIATKYWRLTQQFFSQKHGIQVYRIVES
LGATEGAPAAGSADIIVDITSTGSTLKANHLKVLDDGVILRSQACLVVAKKKRPAEDARLIAELAKAVRR
>Mature_229_residues
TVTLALPSKGRLKDATVELLREAGYPIRLPENERRYRAGIDGLDGLEVTFLSASEIARELDRGSIDLGVTGEDLVRETIP
DWESRVEIAARLGFGHADVVVAVPEIWFDVSTMADLDDVAADFRHRHSRRLRIATKYWRLTQQFFSQKHGIQVYRIVESL
GATEGAPAAGSADIIVDITSTGSTLKANHLKVLDDGVILRSQACLVVAKKKRPAEDARLIAELAKAVRR

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=210, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320896, Length=227, Percent_Identity=28.6343612334802, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_MESSB (Q11LA2)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672988.1
- ProteinModelPortal:   Q11LA2
- SMR:   Q11LA2
- STRING:   Q11LA2
- GeneID:   4182902
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0419
- NMPDR:   fig|266779.1.peg.2567
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   RMRVATK
- ProtClustDB:   PRK13583
- BioCyc:   MSP266779:MESO_0419-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 25398; Mature: 25267

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTLALPSKGRLKDATVELLREAGYPIRLPENERRYRAGIDGLDGLEVTFLSASEIARE
CEEEEECCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHCCCCCCCCCEEEEECHHHHHHH
LDRGSIDLGVTGEDLVRETIPDWESRVEIAARLGFGHADVVVAVPEIWFDVSTMADLDDV
HCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHH
AADFRHRHSRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADIIVDIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEE
STGSTLKANHLKVLDDGVILRSQACLVVAKKKRPAEDARLIAELAKAVRR
CCCCEEECCCEEEECCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTLALPSKGRLKDATVELLREAGYPIRLPENERRYRAGIDGLDGLEVTFLSASEIARE
EEEEECCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHCCCCCCCCCEEEEECHHHHHHH
LDRGSIDLGVTGEDLVRETIPDWESRVEIAARLGFGHADVVVAVPEIWFDVSTMADLDDV
HCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHH
AADFRHRHSRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADIIVDIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEE
STGSTLKANHLKVLDDGVILRSQACLVVAKKKRPAEDARLIAELAKAVRR
CCCCEEECCCEEEECCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA