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The map label for this gene is hisZ

Identifier: 110632781

GI number: 110632781

Start: 463843

End: 464964

Strand: Reverse

Name: hisZ

Synonym: Meso_0420

Alternate gene names: 110632781

Gene position: 464964-463843 (Counterclockwise)

Preceding gene: 110632782

Following gene: 110632780

Centisome position: 10.54

GC content: 64.26

Gene sequence:

>1122_bases
ATGACCTCCCGCTATCCCTCCTTCGCTGCGGAAATTCTCGACCTCTTCGCCGAGCGCGAGGCGGTGCTGACGGACATTGC
CATCATTCAGCCAGCCGACCCCTTCCTCGATATGGCAGGCGAGGACTTGCGCCGGCGCATCTTCCTTACCGAGAGCGAAA
CCGGTGAGACGCTGTGTCTCAGGCCTGAATTCACCATTCCCGTCTGCCTCGACCATATTGAAAAGCGCGCGTCTACACCG
CGGCGTTATGCCTATCTTGGCGAGGTCTTCCGCCAGCATCGAGAGGGAAGCCCGGAGTTTTTCCAGGCGGGCGTTGAGGA
TCTTGGCGCAAAAGACCGTCCCGCCGCGGATGCGCGCTCGCTGGCCGATGCCCGCGCGATCCTGTCGTGCGTTCTGCCCA
ACACCGGTTTTCACGTCACGCTGGGCGACCAGGCGGTGTTCGAGGCCGTTCTGTCCGCGCTCGGCCTACCCCGCGGTTGG
CAAAAGCGGCTTGCCCGCGCATTCGGCTCACCGGCCATGCTTGAAGCGGCGATTGCCGAGTTTACCAGTCCTCAAGGCAC
GGCAAACCTGCCGCGCGAGGTGGCAAGCCTCGTTGCGCAAGGGAACGAGCAGCGGCTGACGCACCATATCGAGGAGGCCA
TGCAGGCTGCGGGCCATTCGCCGACAGCCGGTCGCGAGCCGGACGAGATCGCCCGCCGCCTCCTGGAAAAGGCCGCGCTG
CGCAGCGTCCGTCTCTCCGATGCCGCGCTTAACGCATTGAAGTCATTTCTCGCCATCAAAGTGCCGCTCGAACAGGCGGG
CGAGCGGCTAACGGCTTTTGCCGACGAAGCAGGGATTTTTCTCGACGAGGCACTGGCGGACTTCTCGGCGCGCGCCGAGC
GCATCGGGGATCACGCCCTGCCGCTTGACGAGATCCGCTATGATGCGGGCTTCGGCCGCCCGCTCGATTATTATACCGGC
TTCATCTTCGAGATTGGTGTGGAGGGCCTGCGCCAGCCGCTCGTCGGCGGCGGGCGCTATGACCGGCTCCTGACGCTTTT
AGGCGCGGAAGAGCCTATTCCCGGCGTCGGCTTTTCCATGTGGCTCGACCGCATCGCGACCGTGCGGGGGGAAAAACCGT
GA

Upstream 100 bases:

>100_bases
GCCGGCTGGGGCGTGGCATTTCTGACGGCGTAATCGCCCCCGCTGAGGGGGAGATGGGCGGCAGCCCAGAGGGGGGTGCC
TTAAGCTGGGCACCACTTCC

Downstream 100 bases:

>100_bases
CGGTTACACTGGCACTCCCCTCAAAGGGCCGCCTCAAGGATGCGACCGTCGAGTTGCTACGGGAAGCGGGCTATCCCATT
CGCCTGCCGGAAAACGAGCG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTSRYPSFAAEILDLFAEREAVLTDIAIIQPADPFLDMAGEDLRRRIFLTESETGETLCLRPEFTIPVCLDHIEKRASTP
RRYAYLGEVFRQHREGSPEFFQAGVEDLGAKDRPAADARSLADARAILSCVLPNTGFHVTLGDQAVFEAVLSALGLPRGW
QKRLARAFGSPAMLEAAIAEFTSPQGTANLPREVASLVAQGNEQRLTHHIEEAMQAAGHSPTAGREPDEIARRLLEKAAL
RSVRLSDAALNALKSFLAIKVPLEQAGERLTAFADEAGIFLDEALADFSARAERIGDHALPLDEIRYDAGFGRPLDYYTG
FIFEIGVEGLRQPLVGGGRYDRLLTLLGAEEPIPGVGFSMWLDRIATVRGEKP

Sequences:

>Translated_373_residues
MTSRYPSFAAEILDLFAEREAVLTDIAIIQPADPFLDMAGEDLRRRIFLTESETGETLCLRPEFTIPVCLDHIEKRASTP
RRYAYLGEVFRQHREGSPEFFQAGVEDLGAKDRPAADARSLADARAILSCVLPNTGFHVTLGDQAVFEAVLSALGLPRGW
QKRLARAFGSPAMLEAAIAEFTSPQGTANLPREVASLVAQGNEQRLTHHIEEAMQAAGHSPTAGREPDEIARRLLEKAAL
RSVRLSDAALNALKSFLAIKVPLEQAGERLTAFADEAGIFLDEALADFSARAERIGDHALPLDEIRYDAGFGRPLDYYTG
FIFEIGVEGLRQPLVGGGRYDRLLTLLGAEEPIPGVGFSMWLDRIATVRGEKP
>Mature_372_residues
TSRYPSFAAEILDLFAEREAVLTDIAIIQPADPFLDMAGEDLRRRIFLTESETGETLCLRPEFTIPVCLDHIEKRASTPR
RYAYLGEVFRQHREGSPEFFQAGVEDLGAKDRPAADARSLADARAILSCVLPNTGFHVTLGDQAVFEAVLSALGLPRGWQ
KRLARAFGSPAMLEAAIAEFTSPQGTANLPREVASLVAQGNEQRLTHHIEEAMQAAGHSPTAGREPDEIARRLLEKAALR
SVRLSDAALNALKSFLAIKVPLEQAGERLTAFADEAGIFLDEALADFSARAERIGDHALPLDEIRYDAGFGRPLDYYTGF
IFEIGVEGLRQPLVGGGRYDRLLTLLGAEEPIPGVGFSMWLDRIATVRGEKP

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISZ_MESSB (Q11LA1)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672989.1
- ProteinModelPortal:   Q11LA1
- STRING:   Q11LA1
- GeneID:   4182903
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0420
- NMPDR:   fig|266779.1.peg.2568
- eggNOG:   COG3705
- HOGENOM:   HBG334668
- OMA:   PAEPFLD
- ProtClustDB:   PRK12295
- BioCyc:   MSP266779:MESO_0420-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00125
- InterPro:   IPR004516
- PANTHER:   PTHR11476

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 40856; Mature: 40725

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRYPSFAAEILDLFAEREAVLTDIAIIQPADPFLDMAGEDLRRRIFLTESETGETLCL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHEEEEECCCCCEEEE
RPEFTIPVCLDHIEKRASTPRRYAYLGEVFRQHREGSPEFFQAGVEDLGAKDRPAADARS
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHH
LADARAILSCVLPNTGFHVTLGDQAVFEAVLSALGLPRGWQKRLARAFGSPAMLEAAIAE
HHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
FTSPQGTANLPREVASLVAQGNEQRLTHHIEEAMQAAGHSPTAGREPDEIARRLLEKAAL
HCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
RSVRLSDAALNALKSFLAIKVPLEQAGERLTAFADEAGIFLDEALADFSARAERIGDHAL
HHHHHHHHHHHHHHHHHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLDEIRYDAGFGRPLDYYTGFIFEIGVEGLRQPLVGGGRYDRLLTLLGAEEPIPGVGFSM
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHH
WLDRIATVRGEKP
HHHHHHHHCCCCC
>Mature Secondary Structure 
TSRYPSFAAEILDLFAEREAVLTDIAIIQPADPFLDMAGEDLRRRIFLTESETGETLCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHEEEEECCCCCEEEE
RPEFTIPVCLDHIEKRASTPRRYAYLGEVFRQHREGSPEFFQAGVEDLGAKDRPAADARS
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHH
LADARAILSCVLPNTGFHVTLGDQAVFEAVLSALGLPRGWQKRLARAFGSPAMLEAAIAE
HHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHH
FTSPQGTANLPREVASLVAQGNEQRLTHHIEEAMQAAGHSPTAGREPDEIARRLLEKAAL
HCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
RSVRLSDAALNALKSFLAIKVPLEQAGERLTAFADEAGIFLDEALADFSARAERIGDHAL
HHHHHHHHHHHHHHHHHHEECCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PLDEIRYDAGFGRPLDYYTGFIFEIGVEGLRQPLVGGGRYDRLLTLLGAEEPIPGVGFSM
CHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHH
WLDRIATVRGEKP
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA