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The map label for this gene is gyaR [H]

Identifier: 110632770

GI number: 110632770

Start: 454359

End: 455297

Strand: Reverse

Name: gyaR [H]

Synonym: Meso_0409

Alternate gene names: 110632770

Gene position: 455297-454359 (Counterclockwise)

Preceding gene: 110632780

Following gene: 110632769

Centisome position: 10.32

GC content: 62.73

Gene sequence:

>939_bases
ATGTCGAAGCCCTTCACAATTGCCAGCAGCCTTGTGCCTGCGCAGAATGAAGCGCTGGGGGCGGTGTCCGGGTGCCGGCT
CGTTCCGCTGGAAGAACAACCGTGGCTGGTCCCGGCCGACGCCGACGCTCTTTTCACCTATCAGACTCAATGGCGCAACG
CTCCCTCCGTGGCGCCGGAGGGTTGGCCATTCAACCTGCGCTGGATTCAGGTGGCCTCCGCGGGCGTCGATACCTTTCCG
GAATGGATCCATGCCGTGCCCCTGGTCACACGCGGGCGCGGTGTTCAGTCCCCGGCGATCGCCGAATATGTGATCGGCGC
CATCTATGCCCATGAGAAGCGCTTCTGGGACGAGCGCATACGCGGCGCCGGGCAATGGAGACATAAGATCCTGGGATCCG
TTGCCGGAAAGACGGTGGGCATCGCTGGCTTCGGTGCCATTGGCGCGGATGTGGCGCGCACGGCAATGGTGTTGCACATG
GATGTGGTTGCATTGAGCCGCACCAATCGCTTCGAGATGGATGGCGTGCAAGCGGCAGCGGACATGGACGACCTGATGCG
CCGCAGCGACCATCTGGTGCTGGCCATGCCGCTCACCGCCGACACACACGGAATCATAAACGCGGAGCGGTTGCAGAGCG
CCAAGCCTGGACTGCACCTGATCAATGTTGCACGCGGGCAACTGCTGGATAACGAGGCCCTGATCCACGCCTTTGATTCG
GGCTTACTTTCGGCCGCGACGCTGGATGTCACGGCTCCCGAGCCGCTGCCAGACGGACACCCGCTCTATACCCATCCGAA
GGTTCGGCTTACACCCCATGTCTCCGGCATGACGGAAGACAATGAAGAGCGGCTTTCCCGGCTGCTTGTCGCCAATCTCG
CGGATTTTCTCGCCGGTAGGGAGCTCTCCGGCGTTGTCCCGCCCGGGAGGGGTTATTGA

Upstream 100 bases:

>100_bases
ATGCGAATATATGGCGAATCGCTCCTGGGTGCCGGAAATCGGACATTGGCGGGATGCGCCGGTCTGGCCGTCCGGGGCGA
TACATGAGAAAGGAGGCCCG

Downstream 100 bases:

>100_bases
TGAGCGGGAGAATGGGTATTGTCAGCGGGCAGCCTCATCTGCGAAATGAAACCGTAAGGCGCGGAGAAGTGAACCCTCGG
GGACCAAGTGCGATGGATGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSKPFTIASSLVPAQNEALGAVSGCRLVPLEEQPWLVPADADALFTYQTQWRNAPSVAPEGWPFNLRWIQVASAGVDTFP
EWIHAVPLVTRGRGVQSPAIAEYVIGAIYAHEKRFWDERIRGAGQWRHKILGSVAGKTVGIAGFGAIGADVARTAMVLHM
DVVALSRTNRFEMDGVQAAADMDDLMRRSDHLVLAMPLTADTHGIINAERLQSAKPGLHLINVARGQLLDNEALIHAFDS
GLLSAATLDVTAPEPLPDGHPLYTHPKVRLTPHVSGMTEDNEERLSRLLVANLADFLAGRELSGVVPPGRGY

Sequences:

>Translated_312_residues
MSKPFTIASSLVPAQNEALGAVSGCRLVPLEEQPWLVPADADALFTYQTQWRNAPSVAPEGWPFNLRWIQVASAGVDTFP
EWIHAVPLVTRGRGVQSPAIAEYVIGAIYAHEKRFWDERIRGAGQWRHKILGSVAGKTVGIAGFGAIGADVARTAMVLHM
DVVALSRTNRFEMDGVQAAADMDDLMRRSDHLVLAMPLTADTHGIINAERLQSAKPGLHLINVARGQLLDNEALIHAFDS
GLLSAATLDVTAPEPLPDGHPLYTHPKVRLTPHVSGMTEDNEERLSRLLVANLADFLAGRELSGVVPPGRGY
>Mature_311_residues
SKPFTIASSLVPAQNEALGAVSGCRLVPLEEQPWLVPADADALFTYQTQWRNAPSVAPEGWPFNLRWIQVASAGVDTFPE
WIHAVPLVTRGRGVQSPAIAEYVIGAIYAHEKRFWDERIRGAGQWRHKILGSVAGKTVGIAGFGAIGADVARTAMVLHMD
VVALSRTNRFEMDGVQAAADMDDLMRRSDHLVLAMPLTADTHGIINAERLQSAKPGLHLINVARGQLLDNEALIHAFDSG
LLSAATLDVTAPEPLPDGHPLYTHPKVRLTPHVSGMTEDNEERLSRLLVANLADFLAGRELSGVVPPGRGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=188, Percent_Identity=31.3829787234043, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI6912396, Length=260, Percent_Identity=29.2307692307692, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI145580578, Length=188, Percent_Identity=28.7234042553192, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557499, Length=188, Percent_Identity=28.7234042553192, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI145580575, Length=188, Percent_Identity=28.7234042553192, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI61743967, Length=182, Percent_Identity=30.2197802197802, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4557497, Length=182, Percent_Identity=30.2197802197802, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI87081824, Length=262, Percent_Identity=32.0610687022901, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082289, Length=291, Percent_Identity=29.8969072164948, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=219, Percent_Identity=30.1369863013699, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=188, Percent_Identity=30.8510638297872, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147481, Length=182, Percent_Identity=32.4175824175824, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=218, Percent_Identity=27.5229357798165, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=218, Percent_Identity=27.0642201834862, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=175, Percent_Identity=28, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=179, Percent_Identity=29.0502793296089, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=132, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28574284, Length=251, Percent_Identity=30.6772908366534, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574286, Length=216, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45551003, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45552429, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585514, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574282, Length=251, Percent_Identity=30.6772908366534, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28571528, Length=175, Percent_Identity=35.4285714285714, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=28.3387622149837, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19921140, Length=196, Percent_Identity=28.0612244897959, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI62472511, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646446, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646448, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646452, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646450, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33790; Mature: 33659

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPFTIASSLVPAQNEALGAVSGCRLVPLEEQPWLVPADADALFTYQTQWRNAPSVAPE
CCCCCCHHHHCCCCCCCCHHHCCCCEEEECCCCCEEEECCCCEEEEEEHHCCCCCCCCCC
GWPFNLRWIQVASAGVDTFPEWIHAVPLVTRGRGVQSPAIAEYVIGAIYAHEKRFWDERI
CCCCEEEEEEEECCCCHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGAGQWRHKILGSVAGKTVGIAGFGAIGADVARTAMVLHMDVVALSRTNRFEMDGVQAAA
CCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
DMDDLMRRSDHLVLAMPLTADTHGIINAERLQSAKPGLHLINVARGQLLDNEALIHAFDS
CHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEEEEEHHCCCCCCHHHHHHHHC
GLLSAATLDVTAPEPLPDGHPLYTHPKVRLTPHVSGMTEDNEERLSRLLVANLADFLAGR
CCCEEEEEECCCCCCCCCCCCCEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
ELSGVVPPGRGY
CCCCCCCCCCCC
>Mature Secondary Structure 
SKPFTIASSLVPAQNEALGAVSGCRLVPLEEQPWLVPADADALFTYQTQWRNAPSVAPE
CCCCCHHHHCCCCCCCCHHHCCCCEEEECCCCCEEEECCCCEEEEEEHHCCCCCCCCCC
GWPFNLRWIQVASAGVDTFPEWIHAVPLVTRGRGVQSPAIAEYVIGAIYAHEKRFWDERI
CCCCEEEEEEEECCCCHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RGAGQWRHKILGSVAGKTVGIAGFGAIGADVARTAMVLHMDVVALSRTNRFEMDGVQAAA
CCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
DMDDLMRRSDHLVLAMPLTADTHGIINAERLQSAKPGLHLINVARGQLLDNEALIHAFDS
CHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEEEEEHHCCCCCCHHHHHHHHC
GLLSAATLDVTAPEPLPDGHPLYTHPKVRLTPHVSGMTEDNEERLSRLLVANLADFLAGR
CCCEEEEEECCCCCCCCCCCCCEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
ELSGVVPPGRGY
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA