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The map label for this gene is waaD [H]

Identifier: 109947747

GI number: 109947747

Start: 1058272

End: 1059264

Strand: Reverse

Name: waaD [H]

Synonym: Hac_1222

Alternate gene names: 109947747

Gene position: 1059264-1058272 (Counterclockwise)

Preceding gene: 109947748

Following gene: 109947746

Centisome position: 68.17

GC content: 37.56

Gene sequence:

>993_bases
ATGCGTTATATTGATGATGAATTAGAAAATCAAACTATTTTAATTACCGGTGGGGCTGGTTTTGTGGGCAGTAATCTGGC
CTTTTATTTTCAAGATAACCACCCTAAAGCTAAAGTGATCGTTTTAGATAAATTCCGCAACAACACGCTTTTAAGTAATG
GTTGCCCGAGTTCTTTGGGGCATTTTAAAAATTTAATCGGTTTTAAGGGTGAAGTGATCACAGCTGATATTAATAACCCT
TTAGATTTAAGGCGTTTAGAAAAATTGCATTTTGATTATTTGTTCCACCAAGCCGCTATCTCTGATACAACCATGCTAGA
TCAAGAATTAGTGATGAAAACCAACTATCAGGCTTTTTTAAGGCTTTTAGAAATCGCCCAACCAAAAAAGGCTAAAGTGA
TTTACGCTTCTTCAGCAGGCGTTTATGGTAACACAAAAGCCCCCAATGTTGTAGGCTCAAACGAAAGCCCTGAAAATGTT
TATGGCTTTTCCAAGCTTTGCATGGACGAATTTGTCCGATCCTATTTAAGCGATAACATTCAAGTGGGCTTGCGATATTT
TAATGTCTATGGGCCTAGGGAATTTTATAAGGAAAAAACCGCCTCGATGATCTTACAGCTTGCTTTACAGGCGATGGCGT
TCAAGGAAGTTAAGCTTTTTGAATTTGGCGAGCAATTAAGGGATTTTGTCTATATTGAAGATGTGATCCAAGCGAATGTG
AAAGCGATGAAAGCTCAACAAAGCGGGGTTTATAATGTGGGCTATTCACAAGCTAGGAGCTATAATGAGATTGTTAGCAT
TTTAAAAGAGCATTTAGGGGATTTTGAAGTGAGTTATATTAAAAACCCTTATCCTTTTTTCCAAGAGCACACGCAAGCGC
ATCTTGAACCTACTATTTTGGATTTAGATTACACCCCCTTATACGATTTAGAAAGCGGTATTAAGGATTATTTACCCCAT
ATCTATACAATTTTTGAAGGAGGGAACGCATGA

Upstream 100 bases:

>100_bases
ATAATCTCTTATTGAGTGCAAATTTTTTAAAAACTTCTCATTCTTGGATACAATGTAAAAATCTTAAAGAGATGATTAAT
TGGATTAAATAAGGATAATA

Downstream 100 bases:

>100_bases
GAAAAATCTTAGTCATAGGGGATTTGATCGCTGATTATTATTTATGGGGGAAGAGCGAACGCCTTTCGCCTGAAGCCCCT
GTGCCTATTTTAGAAGTCAA

Product: ADP-L-glycero-D-mannoheptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQDNHPKAKVIVLDKFRNNTLLSNGCPSSLGHFKNLIGFKGEVITADINNP
LDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFLRLLEIAQPKKAKVIYASSAGVYGNTKAPNVVGSNESPENV
YGFSKLCMDEFVRSYLSDNIQVGLRYFNVYGPREFYKEKTASMILQLALQAMAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKAQQSGVYNVGYSQARSYNEIVSILKEHLGDFEVSYIKNPYPFFQEHTQAHLEPTILDLDYTPLYDLESGIKDYLPH
IYTIFEGGNA

Sequences:

>Translated_330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQDNHPKAKVIVLDKFRNNTLLSNGCPSSLGHFKNLIGFKGEVITADINNP
LDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFLRLLEIAQPKKAKVIYASSAGVYGNTKAPNVVGSNESPENV
YGFSKLCMDEFVRSYLSDNIQVGLRYFNVYGPREFYKEKTASMILQLALQAMAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKAQQSGVYNVGYSQARSYNEIVSILKEHLGDFEVSYIKNPYPFFQEHTQAHLEPTILDLDYTPLYDLESGIKDYLPH
IYTIFEGGNA
>Mature_330_residues
MRYIDDELENQTILITGGAGFVGSNLAFYFQDNHPKAKVIVLDKFRNNTLLSNGCPSSLGHFKNLIGFKGEVITADINNP
LDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFLRLLEIAQPKKAKVIYASSAGVYGNTKAPNVVGSNESPENV
YGFSKLCMDEFVRSYLSDNIQVGLRYFNVYGPREFYKEKTASMILQLALQAMAFKEVKLFEFGEQLRDFVYIEDVIQANV
KAMKAQQSGVYNVGYSQARSYNEIVSILKEHLGDFEVSYIKNPYPFFQEHTQAHLEPTILDLDYTPLYDLESGIKDYLPH
IYTIFEGGNA

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=325, Percent_Identity=25.8461538461538, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI7657641, Length=272, Percent_Identity=27.5735294117647, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790049, Length=318, Percent_Identity=31.4465408805031, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI48994969, Length=284, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=287, Percent_Identity=27.5261324041812, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=24.4648318042813, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356223, Length=327, Percent_Identity=28.4403669724771, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37571; Mature: 37571

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIDDELENQTILITGGAGFVGSNLAFYFQDNHPKAKVIVLDKFRNNTLLSNGCPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCEECCCCCHHHH
HFKNLIGFKGEVITADINNPLDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
RLLEIAQPKKAKVIYASSAGVYGNTKAPNVVGSNESPENVYGFSKLCMDEFVRSYLSDNI
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
QVGLRYFNVYGPREFYKEKTASMILQLALQAMAFKEVKLFEFGEQLRDFVYIEDVIQANV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMKAQQSGVYNVGYSQARSYNEIVSILKEHLGDFEVSYIKNPYPFFQEHTQAHLEPTIL
HHHHHHHCCCEECCHHHHCCHHHHHHHHHHHHCCEEEEHCCCCCCHHHHHHHHCCCCEEE
DLDYTPLYDLESGIKDYLPHIYTIFEGGNA
ECCCCCCHHHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure
MRYIDDELENQTILITGGAGFVGSNLAFYFQDNHPKAKVIVLDKFRNNTLLSNGCPSSLG
CCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCEECCCCCHHHH
HFKNLIGFKGEVITADINNPLDLRRLEKLHFDYLFHQAAISDTTMLDQELVMKTNYQAFL
HHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHH
RLLEIAQPKKAKVIYASSAGVYGNTKAPNVVGSNESPENVYGFSKLCMDEFVRSYLSDNI
HHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
QVGLRYFNVYGPREFYKEKTASMILQLALQAMAFKEVKLFEFGEQLRDFVYIEDVIQANV
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAMKAQQSGVYNVGYSQARSYNEIVSILKEHLGDFEVSYIKNPYPFFQEHTQAHLEPTIL
HHHHHHHCCCEECCHHHHCCHHHHHHHHHHHHCCEEEEHCCCCCCHHHHHHHHCCCCEEE
DLDYTPLYDLESGIKDYLPHIYTIFEGGNA
ECCCCCCHHHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA