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The map label for this gene is guaB [H]

Identifier: 109947724

GI number: 109947724

Start: 1034027

End: 1035472

Strand: Reverse

Name: guaB [H]

Synonym: Hac_1197

Alternate gene names: 109947724

Gene position: 1035472-1034027 (Counterclockwise)

Preceding gene: 109947725

Following gene: 109947723

Centisome position: 66.64

GC content: 41.7

Gene sequence:

>1446_bases
ATGAGAATTTTACAAAGGGCTTTGACTTTTGAAGATGTGTTGATGGTGCCTAGAAAATCTAGCGTTTTACCTAAAGATGT
GAGTTTAAAATCTCGCTTGACTAAAAACATTAGCTTGAATATCCCCTTTATTAGCGCGGCTATGGATACGGTTACGGAGC
ATAAAACCGCTATTGCTATGGCGCGCCTTGGGGGTATTGGCATTGTGCATAAAAACATGGATATTGAAACGCAAGTTAAA
GAAATCGCTAAGGTTAAAAAAAGTGAGAGTGGGGTGATTAATGATCCTATTTTTATCCACGCGCACAAAACTCTAGCGGA
CGCTAAAGCTATAACGGATAATTACAAGATTTCAGGCGTGCCTGTGGTGGATGATAAGGGGCTGTTGATTGGGATTTTAA
CCAATAGAGATGTGCGTTTTGAAACGGATTTGAGTAAAAAAGTGGGCGATGTGATGACTAAAATGCCTTTAGTTACCGCT
CATGTGAGCATTAGTTTAGATGAAGCGAGCGATTTGATGCACAAGCACAAGATTGAAAAATTGCCTATTGTAGATAAAAA
CAATATCTTAAAAGGCTTGATTACGATTAAGGACATCCAAAAACGCATTGAATACCCTGATGCGAATAAAGATGATTTTG
GGAGACTAAGAGTAGGGGCGGCTATTGGAGTGGGGCAATTAGATAGGGCTGAAATGCTAGTTAAGGCTGGGGTTGATGCG
TTGGTGTTAGATAGTGCGCATGGGCATTCGGCGAATATTTTACACACTTTAGAAGAGATTAAAAAAAGCTTGGTGGTAGA
TGTCATTGTAGGGAATGTGGTAACTAAAGAGGCTACAAGCGATTTAATTAGTGTGGGAGCGGATGCTATTAAAGTGGGTA
TTGGGCCAGGAAGCATTTGCACCACTAGGATTGTAGCTGGAGTGGGAATGCCCCAAGTGAGTGCGATTGATAATTGCGTA
GAAGTGGCGTCTAAATTTGATATTCCCGTGATTGCAGATGGAGGGATACGTTATTCAGGAGATGTGGCTAAGGCTCTAGC
TTTAGGGGCATCAAGCGTGATGATAGGTTCTTTACTCGCTGGTACAGAAGAATCTCCTGGGGATTTTATAATTTATCAAG
GGAGACAATATAAAAGTTATAGGGGCATGGGCAGTATTGGGGCTATGACTAAAGGGAGCTCTGATAGGTATTTTCAAGAG
GGCGTTGCGAGTGAAAAATTAGTCCCTGAAGGTATTGAGGGGCGTGTGCCTTATCGTGGTAAGGTTTCAGATATGATTTT
CCAATTAGTAGGGGGCGTGCGCTCTTCTATGGGGTATCAGGGGGCGAAAAATATTTTGGAATTGTATCAAAACGCTGAAT
TTGTAGAAATCACTAGCGCTGGGTTGAAAGAAAGCCATGTGCATGGCGTAGATATTACTAAAGAAGCCCCTAATTATTAT
GGGTGA

Upstream 100 bases:

>100_bases
GATGCAATTCATTGCTAAGGCTTTTGATGAGCAAAGCCTTTTAGATGTTTCCTACGCTTTAGAGCAGGAATTAAAATTAA
AACTAGATTAAGGATAGAAA

Downstream 100 bases:

>100_bases
ATTTTAAAAGAAAACAAGACAAATCATTAAAAAACTCGTTAAAAAGCTTGGTTTAATGAGTTTTTAAAACTTAATTGCTA
CAATGAAGAAAATTTTCAAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIETQVK
EIAKVKKSESGVINDPIFIHAHKTLADAKAITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVSISLDEASDLMHKHKIEKLPIVDKNNILKGLITIKDIQKRIEYPDANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISVGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFIIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Sequences:

>Translated_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIETQVK
EIAKVKKSESGVINDPIFIHAHKTLADAKAITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVSISLDEASDLMHKHKIEKLPIVDKNNILKGLITIKDIQKRIEYPDANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISVGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFIIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G
>Mature_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIETQVK
EIAKVKKSESGVINDPIFIHAHKTLADAKAITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVSISLDEASDLMHKHKIEKLPIVDKNNILKGLITIKDIQKRIEYPDANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISVGADAIKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFIIYQGRQYKSYRGMGSIGAMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=39.4572025052192, Blast_Score=314, Evalue=2e-85,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=39.4572025052192, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=39.4572025052192, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=39.4572025052192, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=40.5010438413361, Blast_Score=312, Evalue=6e-85,
Organism=Homo sapiens, GI217035152, Length=486, Percent_Identity=39.3004115226337, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=38.8308977035491, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=36.7432150313152, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI50541954, Length=258, Percent_Identity=39.1472868217054, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541952, Length=258, Percent_Identity=39.1472868217054, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541948, Length=258, Percent_Identity=39.1472868217054, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=39.1472868217054, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=38.6178861788618, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=54.8654244306418, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.10407239819, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=36.9747899159664, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=39.2857142857143, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=254, Percent_Identity=38.1889763779528, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=481, Percent_Identity=40.7484407484407, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=41.7879417879418, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=39.9168399168399, Blast_Score=328, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=40.6528189910979, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=42.3728813559322, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=39.1666666666667, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=39.1666666666667, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.5454545454545, Blast_Score=271, Evalue=7e-73,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51688; Mature: 51688

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIETQVKEIAKVKKSESGVINDPIFIHAHKTLADAKAITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVSISLDEASDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHHCC
LPIVDKNNILKGLITIKDIQKRIEYPDANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISVGADAIKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFIIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIETQVKEIAKVKKSESGVINDPIFIHAHKTLADAKAITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVSISLDEASDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHHCC
LPIVDKNNILKGLITIKDIQKRIEYPDANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISVGADAIKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFIIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]