Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 109947117

GI number: 109947117

Start: 450895

End: 452028

Strand: Direct

Name: pyrC [H]

Synonym: Hac_0524

Alternate gene names: 109947117

Gene position: 450895-452028 (Clockwise)

Preceding gene: 109947116

Following gene: 109947118

Centisome position: 29.02

GC content: 36.07

Gene sequence:

>1134_bases
GTGCTTTTAAAAAACGCTTCATTTTATGATGATGGTGGTTTAAAAAGAGCAGACATCCGCTTAAAAAATTCCCTTATTGC
AGAGATTAAAGAAAATTTAAACCCTAGTGGTAGCGAAGAAGTGATTGAATGCGAAAATTTATTCGTGTTGCCAAGTTTTA
TAGATTTGAGTGTTACTTGCTTGGAAGGCTATGAAAATTTAAAACAAAAGGCTTTTAAAGGGGGGGTAGGGTTACTCAAT
ATTTTTAATTGCAGTCAAAGCGGCATTAAAAATATCATGGCACTCAAAAACAACCAACTAGCCGACATCGCTACGCTTAA
AAAAGAAGGGGGGGAAATTTTAATTATAGAGTCCGATGCTTTTTTAGAGCTCATCAGCCATTATGCAAAATCCTACCATT
TACCCCTTTTAATCTCTTTAAAAAATTCTTTTGAAGCCTTAAATAGTGGGGCATTAGCCTATGAATTGGGGCAAAGCTTT
GTAGAAAATGCGTTTGAAAACACGCAACTAGTGCGTTTCATGGAGGTTTCTAGAGCGTTACAAATCCCTATGCTTTTAGA
TAAAGTGAATAGTACCACCACGCTCAAACTCATCAAAGCCTTTAATAATTTAGGAGCGAAATTGCAAGCCCAAGTGCCTT
TAAGCCATTTAGTGCTAGATGAAAGCATGTATGAATATTATGATCCAAGGTTTAAAATCGCCCCTCCTTTAAGGGACAAA
GAAGGTCAAAACGCCCTAAAAGACGCCTTAAAAAATAACGAAATTGCTATGCTCACAAGCCTTCATGTTTCTAAAAATTC
TAACGGAGAGCTTTTTGAAGAAAGCGCTTTTGGGTGTGAGAGCATAGAGGACGCTTTTAGCGTGGCTTACACTTTTTTGG
TTCAAAAAAAGGTTATTGGTTTGCAACAACTTATTAAGGTTATGGCATTTAATCAAGCGAAGTTTTTAAAACTCAACGCA
GGCGAGATTAAAGAAAATCAATTAGCCAACCTCATGATTGTGGATTTAAACGCTAAAATAAGAGTGAGTAATAAAAATTC
GCCCTTTTATGGTTTAGAATTGCATGGCGAAATTCAAAGAATGATCTTAAAAGGGCAAACCACATTTATTAAGGAGAATG
CATGCAAATCATAG

Upstream 100 bases:

>100_bases
TGAAATTATTTCAGGGTTAGTGCTTATTTTAATGGGGGTGTTGATTGTGACCAACTCTATGGAAAGCTTGACGAATTTCT
TACAAAAATAGGAGGAAATG

Downstream 100 bases:

>100_bases
GAGCGTCTTTAGTTTTTTTGTGTAATGAAAAATGCGAAGTGTTAGAAGATCATGGCGTAGTCTTTGATGAAAACATTATT
GAAGTGGGCGATTACCACAA

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLLKNASFYDDGGLKRADIRLKNSLIAEIKENLNPSGSEEVIECENLFVLPSFIDLSVTCLEGYENLKQKAFKGGVGLLN
IFNCSQSGIKNIMALKNNQLADIATLKKEGGEILIIESDAFLELISHYAKSYHLPLLISLKNSFEALNSGALAYELGQSF
VENAFENTQLVRFMEVSRALQIPMLLDKVNSTTTLKLIKAFNNLGAKLQAQVPLSHLVLDESMYEYYDPRFKIAPPLRDK
EGQNALKDALKNNEIAMLTSLHVSKNSNGELFEESAFGCESIEDAFSVAYTFLVQKKVIGLQQLIKVMAFNQAKFLKLNA
GEIKENQLANLMIVDLNAKIRVSNKNSPFYGLELHGEIQRMILKGQTTFIKENACKS

Sequences:

>Translated_377_residues
MLLKNASFYDDGGLKRADIRLKNSLIAEIKENLNPSGSEEVIECENLFVLPSFIDLSVTCLEGYENLKQKAFKGGVGLLN
IFNCSQSGIKNIMALKNNQLADIATLKKEGGEILIIESDAFLELISHYAKSYHLPLLISLKNSFEALNSGALAYELGQSF
VENAFENTQLVRFMEVSRALQIPMLLDKVNSTTTLKLIKAFNNLGAKLQAQVPLSHLVLDESMYEYYDPRFKIAPPLRDK
EGQNALKDALKNNEIAMLTSLHVSKNSNGELFEESAFGCESIEDAFSVAYTFLVQKKVIGLQQLIKVMAFNQAKFLKLNA
GEIKENQLANLMIVDLNAKIRVSNKNSPFYGLELHGEIQRMILKGQTTFIKENACKS
>Mature_377_residues
MLLKNASFYDDGGLKRADIRLKNSLIAEIKENLNPSGSEEVIECENLFVLPSFIDLSVTCLEGYENLKQKAFKGGVGLLN
IFNCSQSGIKNIMALKNNQLADIATLKKEGGEILIIESDAFLELISHYAKSYHLPLLISLKNSFEALNSGALAYELGQSF
VENAFENTQLVRFMEVSRALQIPMLLDKVNSTTTLKLIKAFNNLGAKLQAQVPLSHLVLDESMYEYYDPRFKIAPPLRDK
EGQNALKDALKNNEIAMLTSLHVSKNSNGELFEESAFGCESIEDAFSVAYTFLVQKKVIGLQQLIKVMAFNQAKFLKLNA
GEIKENQLANLMIVDLNAKIRVSNKNSPFYGLELHGEIQRMILKGQTTFIKENACKS

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 42046; Mature: 42046

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKNASFYDDGGLKRADIRLKNSLIAEIKENLNPSGSEEVIECENLFVLPSFIDLSVTC
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEEEHHHHHHHHH
LEGYENLKQKAFKGGVGLLNIFNCSQSGIKNIMALKNNQLADIATLKKEGGEILIIESDA
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECHH
FLELISHYAKSYHLPLLISLKNSFEALNSGALAYELGQSFVENAFENTQLVRFMEVSRAL
HHHHHHHHHHHCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QIPMLLDKVNSTTTLKLIKAFNNLGAKLQAQVPLSHLVLDESMYEYYDPRFKIAPPLRDK
CCCHHHHHCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCC
EGQNALKDALKNNEIAMLTSLHVSKNSNGELFEESAFGCESIEDAFSVAYTFLVQKKVIG
CCHHHHHHHHCCCCEEEEEEEEECCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LQQLIKVMAFNQAKFLKLNAGEIKENQLANLMIVDLNAKIRVSNKNSPFYGLELHGEIQR
HHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECCEEEECCCCCCEEEEEECHHHHH
MILKGQTTFIKENACKS
HHHCCCCCEECCCCCCC
>Mature Secondary Structure
MLLKNASFYDDGGLKRADIRLKNSLIAEIKENLNPSGSEEVIECENLFVLPSFIDLSVTC
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEEECCEEEEEHHHHHHHHH
LEGYENLKQKAFKGGVGLLNIFNCSQSGIKNIMALKNNQLADIATLKKEGGEILIIESDA
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECHH
FLELISHYAKSYHLPLLISLKNSFEALNSGALAYELGQSFVENAFENTQLVRFMEVSRAL
HHHHHHHHHHHCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
QIPMLLDKVNSTTTLKLIKAFNNLGAKLQAQVPLSHLVLDESMYEYYDPRFKIAPPLRDK
CCCHHHHHCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCC
EGQNALKDALKNNEIAMLTSLHVSKNSNGELFEESAFGCESIEDAFSVAYTFLVQKKVIG
CCHHHHHHHHCCCCEEEEEEEEECCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LQQLIKVMAFNQAKFLKLNAGEIKENQLANLMIVDLNAKIRVSNKNSPFYGLELHGEIQR
HHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECCEEEECCCCCCEEEEEECHHHHH
MILKGQTTFIKENACKS
HHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]